1. Effect on Survival of Concurrent Hemoconcentration and Increase in Creatinine During Treatment of Acute Decompensated Heart Failure
- Author
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Griffin, Matthew, Rao, Veena S, Fleming, James, Raghavendra, Parinita, Turner, Jeffrey, Mahoney, Devin, Wettersten, Nicholas, Maisel, Alan, Ivey-Miranda, Juan B, Inker, Lesley, Tang, Wai Hong Wilson, Wilson, Francis Perry, and Testani, Jeffrey M
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Clinical Research ,Acute Disease ,Aged ,Biomarkers ,Creatinine ,Diuretics ,Female ,Heart Failure ,Hospital Mortality ,Humans ,Male ,Prognosis ,Retrospective Studies ,Survival Rate ,United States ,Water-Electrolyte Imbalance ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Hemoconcentration during the treatment of acute decompensated heart failure is a surrogate for plasma volume reduction and is associated with improved survival, but most definitions only allow for hemoconcentration to be determined retrospectively. An increase in serum creatinine can also be a marker of aggressive decongestion, but in isolation is not specific. Our objective was to determine if combined hemoconcentration and worsening creatinine could better identify patients that were aggressively treated and, as such, may have improved postdischarge outcomes. A total of 4,181 patients hospitalized with acute decompensated heart failure were evaluated. Those who experienced both hemoconcentration and worsening creatinine at any point had a profile consistent with aggressive in-hospital treatment and longer length of stay (p
- Published
- 2019