Search

Your search keyword '"Tang, Shaoheng"' showing total 28 results
Start Over Author "Tang, Shaoheng"
28 results on '"Tang, Shaoheng"'

25. Effect of glutathione on in vivobiodistribution and clearance of surface-modified small Pd nanosheets

Author

Huang, Yizhuan, Chen, Xiaolan, Shi, Saige, Chen, Mei, Tang, Shaoheng, Mo, Shiguang, Wei, Jingping, and Zheng, Nanfeng

Abstract

Plasmonic Pd nanosheets have been emerging as promising materials for applying in near-infrared (NIR) photothermal therapy (PTT) of cancer. However, animal in mice studies indicated that the original synthesized poly(vinylpyrrolidone) (PVP)-protected small Pd nanosheets (Pd-PVP) and some further surface-modified small Pd nanosheets such as Pd-PEG(SH) easily accumulated in reticuloendothelial system (RES) organs (liver, spleen, etc.) and were difficult to be cleared from these organs quickly. In the work, we surprisingly found that glutathione (GSH) could promote the clearance of surface-modified small Pd nanosheets (e.g. Pd-PVP, Pd-PEG(SH) and Pd-GSH) from the RES organs efficiently. The effects of GSH on the biodistribution and clearance of different surface-modified Pd nanosheets were investigated. Our results indicated that these surface-modified Pd nanosheets with or without GSH added caused no morbidity at target primary organs, and GSH can promote the clearance of different surface-modified Pd nanosheets in the order of Pd-PVP≈Pd-PEG(SH)>Pd-GSH. This study suggests that glutathione could be an attractive reagent for promoting nanomaterials eliminated from the reticuloendothelial systems (RES).

Published
2015
Full Text
View/download PDF

26. Amphiphilic modification and asymmetric silica encapsulation of hydrophobic Au–Fe3O4 dumbbell nanoparticles.

Author

Wu, Binghui, Tang, Shaoheng, Chen, Mei, and Zheng, Nanfeng

Subjects
*SURFACE chemistry, *SILICA, *ENCAPSULATION (Catalysis), *METAL nanoparticles, *NANOCOMPOSITE materials, *WETTING
Abstract

A facile method is developed for amphiphilic surface modification and asymmetric silica encapsulation of hydrophobic Au–Fe3O4 dumbbell nanoparticles. The obtained asymmetric Janus nanocomposites display tunable wettability, enhanced catalysis and better cell internalization as compared to those with complete silica encapsulation. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

27. Synthesis of thiolated chitosan and preparation nanoparticles with sodium alginate for ocular drug delivery.

Author

Zhu X, Su M, Tang S, Wang L, Liang X, Meng F, Hong Y, and Xu Z

Subjects
Cell Survival drug effects, Cells, Cultured, Chitosan pharmacology, Dithionitrobenzoic Acid, Drug Carriers pharmacology, Drug Stability, Epithelial Cells cytology, Epithelial Cells drug effects, Epithelium, Corneal cytology, Epithelium, Corneal drug effects, Glucuronic Acid chemistry, Hexuronic Acids chemistry, Humans, Injections, Intraocular, Microscopy, Electron, Scanning, Nanoparticles chemistry, Nanoparticles ultrastructure, Particle Size, Spectroscopy, Fourier Transform Infrared, Alginates chemistry, Chitosan analogs & derivatives, Chitosan chemical synthesis, Drug Carriers chemical synthesis, Sulfhydryl Compounds chemistry
Abstract

Purpose: The goal of the present study was to synthesize mucoadhesive polymer - thiolated chitosan (TCS) from chitosan (CS), then prepared CS/TCS-sodium alginate nanoparticles (CS/TCS-SA NPs), determined which was more potential for ocular drug delivery., Methods: A new method for preparing TCS was developed, and the characteristics were determined using Fourier transform infrared spectroscopy and the degree of thiol immobilized was measured by Ellman's reagent. Human corneal epithelium (HCE) cells were incubated with different concentrations of TCS for 48 h to determine the cell viabilities. CS/TCS-SA NPs were prepared and optimized by a modified ionic gelation method. The particle sizes, zeta potentials, Scanning electron microscopy images, mucoadhesion, in vitro cell uptake and in vivo studies of the two types of NP were compared., Results: The new method enabled a high degree of thiol substitution of TCS, up to 1,411.01±4.02 μmol/g. In vitro cytocompatibility results suggest that TCS is nontoxic. Compared to CS-SA NPs, TCS-SA NPs were more stable, with higher mucoadhesive properties and could deliver greater amounts of drugs into HCE cells in vitro and cornea in vivo., Conclusions: TCS-SA NPs have better delivery capability, suggesting they have good potential for ocular drug delivery applications.

Published
2012

28. Freestanding palladium nanosheets with plasmonic and catalytic properties.

Author

Huang X, Tang S, Mu X, Dai Y, Chen G, Zhou Z, Ruan F, Yang Z, and Zheng N

Subjects
Carbon Monoxide chemistry, Catalysis, Formates metabolism, Materials Testing, Oxidation-Reduction, Surface Properties, Metals chemistry, Nanostructures chemistry, Palladium chemistry, Surface Plasmon Resonance methods
Abstract

Ultrathin metal films can exhibit quantum size and surface effects that give rise to unique physical and chemical properties. Metal films containing just a few layers of atoms can be fabricated on substrates using deposition techniques, but the production of freestanding ultrathin structures remains a significant challenge. Here we report the facile synthesis of freestanding hexagonal palladium nanosheets that are less than 10 atomic layers thick, using carbon monoxide as a surface confining agent. The as-prepared nanosheets are blue in colour and exhibit a well-defined but tunable surface plasmon resonance peak in the near-infrared region. The combination of photothermal stability and biocompatibility makes palladium nanosheets promising candidates for photothermal therapy. The nanosheets also exhibit electrocatalytic activity for the oxidation of formic acid that is 2.5 times greater than that of commercial palladium black catalyst.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results