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134 results on '"Tang, Honglin"'

16. Multi-GNSS Kinematic Relative Positioning of Multiple Base Stations and Its Application in Deformation Monitoring

Author

Tang, Honglin, Xu, Tianhe, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Sun, Jiadong, editor, Yang, Changfeng, editor, and Yang, Yuanxi, editor

Published
2019
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19. Programmable Singlet Oxygen Battery for Automated Photodynamic Therapy Enabled by Pyridone–Pyridine Tautomer Engineering

Author

Tian, Jianwu, Li, Bowen, Wu, Chongzhi, Li, Zhiyao, Tang, Honglin, Song, Wentao, Qi, Guo-Bin, Tang, Yufu, Ping, Yuan, and Liu, Bin

Abstract

The efficacy of photodynamic therapy is hindered by the hypoxic environment in tumors and limited light penetration depth. The singlet oxygen battery (SOB) has emerged as a promising solution, enabling oxygen- and light-independent 1O2release. However, conventional SOBsystems typically exhibit an “always-ON” 1O2release, leading to potential 1O2leakage before and after treatment. This not only compromises therapeutic outcomes but also raises substantial biosafety concerns. In this work, we introduce a programmable singlet oxygen battery, engineered to address all the issues discussed above. The concept is illustrated through the development of a tumor-microenvironment-responsive pyridone–pyridine switch, PyAce, which exists in two tautomeric forms: PyAce-0(pyridine) and PyAce(pyridone) with different 1O2storage half-lives. In its native state, PyAceremains in the pyridone form, capable of storing 1O2(t1/2= 18.5 h). Upon reaching the tumor microenvironment, PyAceis switched to the pyridine form, facilitating rapid and thorough 1O2release (t1/2= 16 min), followed by quenched 1O2release post-therapy. This mechanism ensures suppressed 1O2production pre- and post-therapy with selective and rapid 1O2release at the tumor site, maximizing therapeutic efficacy while minimizing side effects. The achieved “OFF–ON–OFF” 1O2therapy showed high spatiotemporal selectivity and was independent of the oxygen supply and light illumination.

Published
2024
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24. Supplementary Data from CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer

Author

Chen, Xuehan, primary, Liu, Yanzhuo, primary, Wang, Yang, primary, Wang, Chenlong, primary, Chen, Xuewei, primary, Xiong, Yu, primary, Liu, Lilong, primary, Yuan, Xi, primary, Tang, Honglin, primary, Shu, Chong, primary, Zhang, Jing, primary, Guo, Austin M., primary, Chen, Honglei, primary, and Yang, Jing, primary

Published
2023
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25. Data from CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer

Author

Chen, Xuehan, primary, Liu, Yanzhuo, primary, Wang, Yang, primary, Wang, Chenlong, primary, Chen, Xuewei, primary, Xiong, Yu, primary, Liu, Lilong, primary, Yuan, Xi, primary, Tang, Honglin, primary, Shu, Chong, primary, Zhang, Jing, primary, Guo, Austin M., primary, Chen, Honglei, primary, and Yang, Jing, primary

Published
2023
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27. Intent Capturing through Multimodal Inputs

Author

Guo, Weimin, Cheng, Cheng, Cheng, Mingkai, Jiang, Yonghan, Tang, Honglin, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Kurosu, Masaaki, editor

Published
2013
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29. CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer

Author

Chen, Xuehan, primary, Liu, Yanzhuo, additional, Wang, Yang, additional, Wang, Chenlong, additional, Chen, Xuewei, additional, Xiong, Yu, additional, Liu, Lilong, additional, Yuan, Xi, additional, Tang, Honglin, additional, Shu, Chong, additional, Zhang, Jing, additional, Guo, Austin M., additional, Chen, Honglei, additional, and Yang, Jing, additional

Published
2022
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30. Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma

Author

Tang, Honglin, primary, Xue, Yanan, additional, Li, Bowen, additional, Xu, Xiaojie, additional, Zhang, Fu, additional, Guo, Jiajing, additional, Li, Qijun, additional, Yuan, Tingting, additional, Chen, Yuan, additional, Pan, Yubin, additional, Ping, Yuan, additional, and Li, Da, additional

Published
2022
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34. Intracellular regulation of zinc by metal–organic framework-mediated genome editing for prostate cancer therapyElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3bm00002h

Author

Xue, Yanan, Tang, Honglin, Chen, Guangpeng, Pan, Yubin, Li, Da, and Ping, Yuan

Abstract

Normal prostate tissues generally exhibit a higher level of zinc to maintain their special “citrate-producing” metabolism, while its level dramatically decreases during prostate tumorigenesis. Despite the significant antitumor effects, the intracellular accumulation of zinc in prostate cancer cells also promotes the expression of ZNT1, which in turn results in the efflux of zinc and attenuated cytotoxicity against cancer cells. To solve the dilemma, we developed a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA)-decorated zeolitic imidazolate framework-8 (ZIF8), which is able to load plasmid DNA encoding the Cas9 editor and single-guide RNA to form Cas9@ZIF8-DUPA nanocomplexes. The intracellular delivery of Cas9@ZIF8-DUPA simultaneously increases the level of zinc and inhibits the ZNT-1 function by disrupting the SLC30A1gene to prevent the efflux of zinc in prostate cancer cells. Due to the high affinity between DUPA and the prostate-specific membrane antigen, Cas9@ZIF8-DUPA nanocomplexes exhibit excellent prostate tumor-targeting ability. The internalization and degradation of Cas9@ZIF8-DUPA not only release free zinc and Cas9 editors, but also reduce zinc efflux through Cas9-mediated genome editing that disables the function of ZNT1. As a result, Cas9@ZIF8-DUPA nanocomplexes exhibit significant antitumor activity and extended survival in the mouse model bearing prostate tumors. The current platform offers an alternative therapeutic strategy and holds tremendous translational potential as an anticancer nanomedicine for prostate cancer treatment.

Published
2023
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36. Cancer Immunotherapy: Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy (Adv. Mater. 12/2021)

Author

Tang, Honglin, primary, Xu, Xiaojie, additional, Chen, Yuxuan, additional, Xin, Huhu, additional, Wan, Tao, additional, Li, Bowen, additional, Pan, Hongming, additional, Li, Da, additional, and Ping, Yuan, additional

Published
2021
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37. Construction and Analysis of Battery Equivalent Circuit Model Considering Liquid Phase Lithium Ion Diffusion Under High-Rate Conditions

Author

Chen, Yan, Lin, Jian, Tang, Yuwei, Qi, Ziyi, and Tang, Honglin

Abstract

In order to obtain the internal state of lithium-ion battery quickly and accurately, the problem that the internal state of the battery is difficult to estimate quickly and accurately is solved. The discharge performance of lithium ion is affected by the electrode current during the charge and discharge process. This paper analyzes the key factors of the electrochemical model at high rate, considers the change of lithium ion concentration in the liquid phase of the battery, integrates the electrochemical mechanism and the equivalent circuit, and establishes a mechanism equivalent circuit model with more computational advantages through circuit elements. The equivalent circuit model can describe the physical characteristics of the lithium battery. Under high rate constant current and dynamic conditions, the model shows good electrical characteristics. Compared with the traditional empirical equivalent circuit model, the accuracy of the model is improved, and the state quantity is reduced by 15 compared with the electrochemical model. The model is of great significance in practical application.

Published
2024
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43. Chemically modified magnetic immobilized phospholipase A1 and its application for soybean oil degumming.

Author

Weining, Wang, Tang, Honglin, Chen, Yan, Liu, Jingyang, Yu, Dianyu, Yang, Fuming, and Elfalleh, Walid

Abstract

In this paper, the free Phospholipase A1 (PLA1) was immobilized on a magnetic carrier. The average particle diameter of the magnetic carrier was 97 ± 1.3 nm, and the average particle diameter of the magnetically immobilized PLA1 was 105 nm ± 1.3 nm. The enzyme activity was 1940.5 U/g. The magnetic enzyme was chemically modified with formaldehyde, dextran-aldehyde, and dextran-aldehyde-glycine. The proportions of primary amino groups in the modified magnetic immobilized enzyme PLA1 were 0, 53.5% and 47.3%, respectively. The optimum pH of the enzyme after chemical modification was 6.5. When the system temperature was 60 °C, the magnetically immobilized PLA1 modified with dextran-aldehyde-glycine had the optimal activity and stability. This chemically modified magnetic immobilized PLA1 was applied to soybean oil degumming at 60 °C, 6.5 h (reaction time), and 0.10 mg/kg (enzyme dosage). The phosphorus content in the degummed oil was 9.2 mg/kg. The relative enzyme activity was 77.6% after 7 reuses which would be potentially advantageous for industrial applications. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Delivery of a system xc− inhibitor by a redox-responsive levodopa prodrug nanoassembly for combination ferrotherapy.

Author

Xin, Huhu, Huang, Yong, Tang, Honglin, Chen, Yuan, Xia, Hongguang, Zhang, Fu, Li, Bowen, and Ping, Yuan

Abstract

A comprehensive understanding of ferroptosis signaling pathways significantly contributes to the advances in cancer ferrotherapy. Herein, we constructed a self-assembled prodrug nanosystem targeting system xc−, a key regulator for ferroptosis, to amplify the therapeutic efficacy of cancer ferrotherapy. The prodrug nanosystem is assembled between sulfasalazine (SSZ, a ferroptosis resistance inhibitor) and disulfide-bridged levodopa (DSSD) that can chelate Fe2+ ions to form SSZ–Fe2+@DSSD, and the resulting nanoassembly can not only inhibit ferroptosis resistance, but also generate ROS in the tumor microenvironment. Whereas the prodrug nanosystem is stable in the physiological environment, it becomes unstable in the tumoral and intracellular reductive microenvironment, where the disulfide linkers are disrupted by high levels of glutathione (GSH), triggering the release of active Fe2+ and SSZ. Under the Fenton reaction, the released Fe2+ thus can induce ferroptosis, which is amplified by SSZ-mediated inhibition of ferroptosis resistance to synergistically improve the therapeutic efficacy of ferroptosis. Our study thus provides an innovative prodrug strategy to advance anticancer ferroptosis. [ABSTRACT FROM AUTHOR]

Published
2021
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