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Compounds comprising S–S bonds serve as significant pharmacological scaffolds in medicinal chemistry and natural products. We have devised an efficient electrochemical method for the construction of asymmetric disulfide bonds, leading to the synthesis of unsymmetric thiosulfonates. Compared with existing synthesis methods, our work not only avoids the use of metals and oxidants, but also realizes the operation of a one-pot three-component method, which makes this strategy extremely attractive. [ABSTRACT FROM AUTHOR]

A mild and efficient electrochemical method for radical addition, cyclization, and migration reaction was described in this work. A difluoromethyl radical was produced by anodizing CF2HSO2Na. The resulting product was then added to olefin, underwent Smiles cyclization, and migrated to form β-difluoromethamide compounds after the release of SO2. The process was free from metals and catalysts, gram-grade, and resistant to a variety of electron-rich substrates. [ABSTRACT FROM AUTHOR]

This article explores the use of N-heterocyclic carbenes (NHCs) in photochemical and electrochemical catalysis for organic synthesis. NHCs have unique catalytic properties and are cost-effective and environmentally friendly. The article discusses various reactions mediated by NHCs, including the formation of C-O and C-N bonds. It also highlights the combination of NHC catalysis with photoredox catalysis for radical reactions, such as alkylation and benzylation of alkenes. The article emphasizes the potential of NHC and photoredox catalysis in enabling the construction of diverse organic compounds under mild conditions. Additionally, it presents examples of NHC-mediated reactions and discusses future research opportunities in this field. [Extracted from the article]

Alkenylboronates are highly versatile building blocks and valuable reagents in the synthesis of complex molecules. Compared with that of monosubstituted alkenylboronates, the synthesis of multisubstituted alkenylboronates is challenging. The copper‐catalyzed carboboration of alkynes is an operationally simple and straightforward method for synthesizing bis/trisubstituted alkenylboronates. In this work, a series of copper‐metallized N‐Heterocyclic Carbene (NHC) ligand porous polymer catalysts are designed and synthesized in accordance with the mechanism of carboboration. By using CuCl@POL‐NHC‐Ph as the optimal nanocatalyst, this study realizes the β‐regio‐ and stereoselective (syn‐addition) 1,2‐carboboration of alkynes (regioselectivity up to >99:1) with satisfactory yields and a wide range of substrates. This work not only overcomes the selectivity of carboboration but also provides a new strategy for the design of nanocatalysts and their application in organic synthesis. [ABSTRACT FROM AUTHOR]

The oxygen evolution reaction (OER), characterized by a four‐electron transfer kinetic process, represents a significant bottleneck in improving the efficiency of hydrogen production from water electrolysis. Consequently, extensive research efforts have been directed towards identifying single‐atom electrocatalysts with exceptional OER performance. Despite the comprehensive understanding of the OER mechanism, its application to other valuable synthetic reactions has been limited. Herein, we leverage the MOOH intermediate, a key species in the Mn−N−C single‐atom catalyst (Mn‐SA@NC), which can be cyclically delivered in the OER. We exploit this intermediate' s capability to facilitate electrophilic transfer with silane, enabling efficient silane oxidation under electrochemical conditions. The SAC electrocatalytic system exhibits remarkable performance with catalyst loadings as low as 600 ppm and an exceptional turnover number of 9132. Furthermore, the catalytic method demonstrates stability under a 10 mmol flow chemistry setup. By serving as an OER electrocatalyst, the Mn‐SA@NC drives the entire reaction, establishing a practical Mn SAC‐catalyzed organic electrosynthesis system. This synthesis approach not only presents a promising avenue for the utilization of electrocatalytic OER but also highlights the potential of SACs as an attractive platform for organic electrosynthesis investigations. [ABSTRACT FROM AUTHOR]

Methanol is an important C1 source in organic synthesis because of its low cost, abundance, and biodegradability. Therefore, using methanol as a C1 source to synthesize high-value-added compounds is crucial. This review highlights the recent advances in various electrochemical and photochemical reactions using methanol as a sustainable source. This study mainly introduces the reaction of methylation, methoxylation, hydroxymethylation, and cyclization under the conditions of light and electricity. The reaction mechanisms of these reactions are also discussed. This study provides a reference for the future application of this kind of reaction in organic synthesis. [ABSTRACT FROM AUTHOR]