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1. Simplex slicing: an asymptotically-sharp lower bound

Author

Tang, Colin

Subjects
Mathematics - Metric Geometry, Mathematics - Functional Analysis
Abstract

We show that for the regular n-simplex, the 1-codimensional central slice that's parallel to a facet will achieve the minimum area (up to a 1-o(1) factor) among all 1-codimensional central slices, thus improving the previous best known lower bound (Brzezinski 2013) by a factor of $\frac{2\sqrt{3}}{e} \approx 1.27$. In addition to the standard technique of interpreting geometric problems as problems about probability distributions and standard Fourier-analytic techniques, we rely on a new idea, mainly \emph{changing the contour of integration} of a meromorphic function.

Published
2024
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2. Stability of simplex slicing

Author

Myroshnychenko, Serhii, Tang, Colin, Tatarko, Kateryna, and Tkocz, Tomasz

Subjects
Mathematics - Metric Geometry, Mathematics - Functional Analysis
Abstract

We establish dimension-free stability of Webb's sharp simplex slicing (1996). Incidentally, we investigate Lipschitzness of volume of hyperplane central sections of arbitrary convex bodies.

Published
2024

4. A randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)

Author

Wigg, Alan, Tibballs, Jonathan, Woodman, Richard, Stuart, Katherine, Le, Hien, Roberts, Stuart K., Olynyk, John K., Strasser, Simone I., Wallace, Michael, Martin, Jarad, Haworth, Annette, Hardcastle, Nicholas, Loo, Kee Fong, Tang, Colin, Lee, Yoo Young, Chu, Julie, De Abreu Lourenco, Richard, Koukourou, Adam, De Boo, Diederick, McLean, Kate, Buck, Jackie, Sawhney, Rohit, Nicoll, Amanda, Dev, Anouk, Wood, Marnie, Braund, Alicia, Weltman, Martin, Khor, Richard, Levy, Miriam, Wang, Tim, Potter, Michael, Haridy, James, Raj, Ashok, Duncan, Oliver, Zekry, Amany, Collier, Natalie, O’Beirne, James, Holliday, Catherine, Trada, Yuvnik, Tronidjaja, Jaw, George, Jacob, and Pryor, David

Published
2024
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5. Hinged-rulers fold in $2-\Theta(\frac{1}{2^{n/4}})$

Author

Tang, Colin

Subjects
Mathematics - Combinatorics, 52C99
Abstract

A hinged-ruler is a sequence of line segments in the plane joined end-to-end with hinges, so each hinge joins exactly two segments, the first segment and last segment are adjacent to only one hinge each, and all other segments are adjacent to exactly two hinges. Hopcroft, Joseph, and Whitesides first posed the hinged-ruler-folding problem in their 1985 paper "On the Movement of Robot Arms in 2-Dimensional Bounded Regions": given a hinged-ruler and a real number $K$, can the hinged-ruler be folded so as to fit within a one-dimensional interval of length $K$? We show that if the segment lengths are constrained to be real numbers in the interval $[0,1]$, then we can always fold the hinged-ruler so as to fit within a one-dimensional interval of length $2-\Omega(\frac{1}{2^{n/4}})$. On the other hand, we give a construction for a hinged-ruler which cannot be folded into some one-dimensional interval of length $2-O(\frac{1}{2^{n/4}})$., Comment: 6 pages, 4 figures

Published
2023

7. Pembrolizumab with Chemoradiation as Treatment for Muscle-invasive Bladder Cancer: Analysis of Safety and Efficacy of the PCR-MIB Phase 2 Clinical Trial (ANZUP 1502)

Author

Weickhardt, Andrew, Foroudi, Farshad, Lawrentschuk, Nathan, Xie, Jing, Sidhom, Mark, Pal, Abhijit, Grimison, Peter, Zhang, Alison, Ng, Siobhan, Tang, Colin, Hovey, Elizabeth, Chen, Colin, Hruby, George, Guminski, Alexander, McJannett, Margaret, Conduit, Ciara, Tran, Ben, Davis, Ian D., and Hayne, Dickon

Published
2024
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10. Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD

Author

Heerspink, Hiddo J.L., Inker, Lesley A., Tighiouart, Hocine, Collier, Willem H., Haaland, Benjamin, Luo, Jiyu, Appel, Gerald B., Chan, Tak Mao, Estacio, Raymond O., Fervenza, Fernando, Floege, Jürgen, Imai, Enyu, Jafar, Tazeen H., Lewis, Julia B., Kam-Tao Li, Philip, Locatelli, Francesco, Maes, Bart D., Perna, Annalisa, Perrone, Ronald D., Praga, Manuel, Schena, Francesco P., Wanner, Christoph, Xie, Di, Greene, Tom, Schrier, Robert W., Hanratty, Rebecca, Maschio, Giuseppe, Carlo, Manno, Saddelli, Mauro, Brenner, Barry M., Lewis, Edmund, von Eynatten, Maximilian, de Jong, Paul E., van Essen, GG, Hou, Fan Fan, Chapman, Arlene, Torres, Vicente, Yu, Alan, Brosnahan, Godela, Chow, Kai-Ming, Szeto, Cheuk-Chun, Leung, Chi-Bon, Hunsicker, Lawrence G., Dwyer, Jamie, Pohl, Marc, Raz, Itamar, Del Vecchio, Lucia, Andrulli, Simeone, Pozzi, Claudio, Casartelli, Donatella, Malfait, Thomas, Vanacker, An, Caravaca-Fontán, Fernando, Trujillo, Hernando, Cavero, Teresa, Gutierrez, Eduardo, Beck, Gerald, Kusek, John, Eknoyan, Garabed, Ponticelli, Claudio, Montagnino, Giuseppe, Passerini, Patrizia, Moroni, Gabriella, Kobayashi, Fumiaki, Makino, Hirofumi, Ito, Sadayoshi, Chan, Juliana CN, Tang, Colin, Gaspari, Flavio, Lesti, Maria Domenica, Gherardi, Giulia, Gamba, Sara, Keane, William, Donadio, James, Rauen, Thomas, Seikrit, Claudia, Wied, Stefanie, Dwyer, Jamie, and Becker, Gavin J.

Published
2023
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17. Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial

Author

Kneebone, Andrew, Fraser-Browne, Carol, Duchesne, Gillian M, Fisher, Richard, Frydenberg, Mark, Herschtal, Alan, Williams, Scott G, Brown, Chris, Delprado, Warick, Haworth, Annette, Joseph, David J, Martin, Jarad M, Matthews, John H L, Millar, Jeremy L, Sidhom, Mark, Spry, Nigel, Tang, Colin I, Turner, Sandra, Wiltshire, Kirsty L, Woo, Henry H, Davis, Ian D, Lim, Tee S, and Pearse, Maria

Published
2020
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18. Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition

Author

Rowdo, Florencia P. Madorsky, primary, Martini, Rachel, additional, Ackermann, Sarah, additional, Tang, Colin, additional, Tranquille, Marvel, additional, Irizarry, Adriana, additional, Us, Ilkay, additional, Alawa, Omar, additional, Moyer, Jenna, additional, Sigouros, Michael, additional, Nguyen, John, additional, Assaad, Majd Al, additional, Cheng, Esther, additional, Ginter, Paula S., additional, Manohar, Jyothi, additional, Stonaker, Brian, additional, Boateng, Richard, additional, Oppong, Joseph K., additional, Adjei, Ernest K., additional, Awuah, Baffour, additional, Kyei, Ishmael, additional, Aitpillah, Frances S., additional, Adinku, Michael O., additional, Ankomah, Kwasi, additional, Osei-Bonsu, Ernest B., additional, Gyan, Kofi K., additional, Hoda, Syed, additional, Newman, Lisa, additional, Mosquera, Juan Miguel, additional, Sboner, Andrea, additional, Elemento, Olivier, additional, Dow, Lukas E., additional, Davis, Melissa B., additional, and Martin, M. Laura, additional

Published
2023
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21. Dosimetric Comparison of Proton Therapy and CyberKnife in Stereotactic Body Radiation Therapy for Liver Cancers

Author

Shyllon, Samuel, primary, Penfold, Scott, additional, Dalfsen, Ray, additional, Kirkness, Elsebe, additional, Hug, Ben, additional, Rowshanfarzad, Pejman, additional, Devlin, Peter, additional, Tang, Colin, additional, Le, Hien, additional, Gorayski, Peter, additional, Grogan, Garry, additional, Kearvell, Rachel, additional, and Ebert, Martin A, additional

Published
2023
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23. Effects of supervised exercise and self-managed psychosexual therapy on sexual health in men with prostate cancer: A randomized clinical trial.

Author

Galvao, Daniel Abido, primary, Chambers, Suzanne K, additional, Taaffe, Dennis R, additional, Cormie, Prue, additional, Schumacher, Oliver, additional, Gardiner, Robert Alexander, additional, Spry, Nigel, additional, Lopez, Pedro, additional, Joseph, David John, additional, Tang, Colin, additional, Hayne, Dickon, additional, and Newton, Robert Usher, additional

Published
2023
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25. Reporting Attendance and Resistance Exercise Compliance in Men with Localized Prostate Cancer

Author

Lopez, Pedro, Taaffe, D.R., Newton, R.U., Spry, Nigel, Joseph, David, Tang, Colin, Buffart, L.M., and Galvao, D.A.

Subjects
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine
Abstract

Resistance exercise is a well-established intervention to counteract musculoskeletal and metabolic toxicities from prostate cancer treatment. In this study, we reported resistance exercise attendance and compliance, and examine if these variables can influence changes in outcomes of interest in men with localised or locally advanced prostate cancer.A total of 83 prostate cancer patients (age: 68.2 ± 7.0 years, body mass index: 27.7 ± 3.8 kg.m-2) who had undergone 6 months of resistance-based exercise and had data available on exercise training from logbook records were examined. Attendance outcomes such as missed sessions, interruptions and permanent discontinuation, and metrics such as dosage completed (sessions x number of exercises x sets x repetitions x external load), compliance, tolerance, reductions and escalations were assessed. Outcomes assessed were body composition, physical function and muscle strength.Median resistance exercise attendance was 80.6%, with a median resistance exercise compliance of 88.5% (IQR: 61.1 to 107.1%) per participant. Median of 11 (IQR: 1 to 26) and 0 (IQR: 0 to 2) sessions were escalated or reduced, respectively. Significant improvements were observed in whole-body lean mass, 400-m walk, repeated chair rise, leg press and chest press strength following 6 months of intervention (P0.05) regardless of resistance exercise compliance (Ptrend = 0.199 to 0.950). Participants with higher levels of resistance exercise compliance presented greater improvements in trunk fat mass (Ptrend = 0.026) and appendicular lean mass (Ptrend = 0.047).A higher resistance exercise compliance led to greater improvements in regional fat and lean mass, while physical function and muscle strength improvements were achieved with lower compliance. Additionally, patients experienced a high number of dose escalations during the intervention. These findings are important to improve the reproducibility/precision of exercise medicine prescription.

Published
2022

27. Abstract 1768: Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models

Author

Gardner, Thomas J., primary, Litterman, Adam, additional, Singh, Brenal K., additional, Silva, Luisa, additional, Hari, Mukund, additional, Zhou, Stanley, additional, Tang, Colin, additional, Joshi, Sahil, additional, Gagnon, John, additional, Takacsi-Nagy, Oliver, additional, Hall, Jason, additional, Pope, Hans, additional, Zhang, James, additional, Gomez, Alma, additional, Chen, Jeremy, additional, Mohanty, Suchismita, additional, Thomas, Vince, additional, Quant, Nicholas, additional, Millare, Beatriz, additional, Casbon, Amy-Jo, additional, Bezman, Natalie, additional, Gray-Rupp, Levi, additional, Boroughs, Angela C., additional, and Haining, W. Nicholas, additional

Published
2023
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29. Multimodal exercise in older patients with advanced pancreatic cancer undergoing first-line chemotherapy: A case series examining feasibility and preliminary efficacy

Author

Luo, Hao, Galvão, Daniel A., Newton, Robert U., Tang, Colin I., Spry, Nigel, Taaffe, Dennis R., Luo, Hao, Galvão, Daniel A., Newton, Robert U., Tang, Colin I., Spry, Nigel, and Taaffe, Dennis R.

Abstract

Purpose. Exercise is emerging as an adjunct therapy to cancer treatment; however, its role in older patients with advanced pancreatic cancer undergoing first-line chemotherapy is unclear. The aim of this study was to primarily provide evidence on feasibility with an exploratory examination of the initial efficacy of exercise in this clinical setting. Materials and Methods. Six patients aged 60–75 years with de novo or recurrent advanced pancreatic cancer undergoing first-line chemotherapy consented to participate in twice-weekly exercise that included resistance and aerobic training and boxing-related activities for up to 12 weeks. Patients were monitored for attendance, adherence, and adverse events. Body composition, muscle strength, functional ability, patient-reported outcome measures, and patient-reported experience measures were assessed at baseline and/or postintervention. Results. Of the 6 patients, 1 withdrew after baseline testing and 5 attended 42%–95% of planned sessions and adhered to 28%–83% of the prescribed exercise. There were no serious exercise-emergent adverse events. All 5 patients increased or maintained lean mass (0.1%–4.4%) and 4 reduced fat mass (−0.4%–−8.6%). Improvements were observed in 4 or all 5 patients for muscle strength (7.1%–75%), 5 times sit-to-stand (1.3%–21.4%), 6-m backward walk (16.5%–35.8%), and patient-reported outcomes. Furthermore, all patients perceived exercise as very helpful in managing their cancer and expressed a strong willingness to continue exercise in the future. Conclusion. A multimodal exercise program appears feasible with potential physical and psychological benefits for older patients with advanced pancreatic cancer undergoing first-line chemotherapy. Further research including a larger sample size is warranted.

Published
2023

31. Hinged-rulers fold in $2-Θ(\frac{1}{2^{n/4}})$

Author

Tang, Colin

Subjects
FOS: Mathematics, Combinatorics (math.CO), 52C99
Abstract

A hinged-ruler is a sequence of line segments in the plane joined end-to-end with hinges, so each hinge joins exactly two segments, the first segment and last segment are adjacent to only one hinge each, and all other segments are adjacent to exactly two hinges. Hopcroft, Joseph, and Whitesides first posed the hinged-ruler-folding problem in their 1985 paper "On the Movement of Robot Arms in 2-Dimensional Bounded Regions": given a hinged-ruler and a real number $K$, can the hinged-ruler be folded so as to fit within a one-dimensional interval of length $K$? We show that if the segment lengths are constrained to be real numbers in the interval $[0,1]$, then we can always fold the hinged-ruler so as to fit within a one-dimensional interval of length $2-Ω(\frac{1}{2^{n/4}})$. On the other hand, we give a construction for a hinged-ruler which cannot be folded into some one-dimensional interval of length $2-O(\frac{1}{2^{n/4}})$., 6 pages, 4 figures

Published
2023
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32. Prostate Carcinoma Surveillance Counterpoint: Canada

Author

Loblaw, Andrew, Tang, Colin, Johnson, Frank E., editor, Maehara, Yoshihiko, editor, Browman, George P., editor, Margenthaler, Julie A., editor, Audisio, Riccardo A., editor, Thompson, John F., editor, Johnson, David Y., editor, Earle, Craig C., editor, and Virgo, Katherine S., editor

Published
2013
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35. Phase 3 Trial of Domiciliary Humidification to Mitigate Acute Mucosal Toxicity During Radiation Therapy for Head-and-Neck Cancer: First Report of Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Study

Author

Macann, Andrew, Fua, Tsien, Milross, Chris G., Porceddu, Sandro V., Penniment, Michael, Wratten, Chris, Krawitz, Hedley, Poulsen, Michael, Tang, Colin I., Morton, Randall P., Hay, K. David, Thomson, Vicki, Bell, Melanie L., King, Madeleine T., Fraser-Browne, Carol L., and Hockey, Hans-Ulrich P.

Published
2014
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36. Evaluation of a Clinic-Based Exercise Program in Patients with Pancreatic Cancer Undergoing Nonsurgical Treatment

Author

LUO, HAO, primary, GALVÃO, DANIEL A., additional, NEWTON, ROBERT U., additional, TANG, COLIN I., additional, HART, NICOLAS H., additional, SINGH, FAVIL, additional, DEAN, ANDREW, additional, JASAS, KEVIN, additional, JOHANSSON, MIKAEL, additional, YUSOFF, IAN, additional, SPRY, NIGEL, additional, and TAAFFE, DENNIS R., additional

Published
2022
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39. Event‐free survival after radical prostatectomy according to prostate‐specific membrane antigen‐positron emission tomography and European Association of Urology biochemical recurrence risk groups

Author

Roberts, Matthew J., primary, Chatfield, Mark D., additional, Hruby, George, additional, Nandurkar, Rohan, additional, Roach, Paul, additional, Watts, Jo Anne, additional, Cusick, Thomas, additional, Kneebone, Andrew, additional, Eade, Thomas, additional, Ho, Bao, additional, Nguyen, Andrew, additional, Tang, Colin, additional, McCarthy, Michael, additional, Francis, Roslyn, additional, Stricker, Phillip, additional, and Emmett, Louise, additional

Published
2022
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41. Weight loss for overweight and obese patients with prostate cancer: a study protocol of a randomised trial comparing clinic-based versus Telehealth delivered EXercise and nutrition intervention (the TelEX trial)

Author

Galvão, Daniel A, primary, Taaffe, Dennis R, additional, Hayne, Dickon, additional, Lopez, Pedro, additional, Lyons-Wall, P, additional, Tang, Colin I, additional, Chambers, Suzanne K, additional, Devine, Amanda, additional, Spry, Nigel, additional, Jeffery, Emily, additional, Kudiarasu, Christine, additional, Joseph, David, additional, and Newton, Robert U, additional

Published
2022
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44. Nationwide industry-led community exercise program for men with locally advanced, relapsed, or metastatic prostate cancer on androgen-deprivation therapy

Author

Schumacher, Oliver, Galvao, Daniel A., Taaffe, Dennis R., Spry, Nigel, Hayne, Dickon, Tang, Colin, Chee, Raphael, Newton, Robert U., Schumacher, Oliver, Galvao, Daniel A., Taaffe, Dennis R., Spry, Nigel, Hayne, Dickon, Tang, Colin, Chee, Raphael, and Newton, Robert U.

Abstract

Purpose Androgen-deprivation therapy in patients with prostate cancer (PCa) is associated with considerable side effects and secondary comorbidities such as overweight/obesity and cardiovascular disease. The aim of thisstudy was to investigate the effectiveness of an industry-led, treatment-integrated, community-based exercise program on outcomes of body weight, cardiovascular health, and physical function. Patients and Methods PCa patients with locally advanced, relapsed, or metastatic disease receiving leuprorelin acetate were enrolled across multiple sites in Australia and assigned supervised group exercise undertaken weekly or biweekly (ie, 16 exercise sessions in total) for 10-18 weeks, consisting of aerobic and resistance training performed at moderate-to-vigorous intensity. Results Between 2014 and 2020, 760 participants completed the baseline and follow-up assessment. Participants were age 48-94 years, and most were either overweight (42.1%) or obese (38.1%). Program compliance was high, with 90% of participants completing all 16 exercise sessions. There was a small but significant reduction in waist circumference (–0.9 cm; 95% CI [–1.2 to –0.5]; P < .001) and no change in weight or body mass index. Systolic (–3.7 mmHg; 95% CI [–4.8 to –2.6]; P < .001) and diastolic (–1.7 mmHg; 95% CI [–2.3 to –1.0]; P < .001) blood pressure were significantly lower after the program. Furthermore, significant improvements were seen in cardiorespiratory fitness and muscle strength (P < .001). For most of the investigated outcomes, participants with poorer initial measures had the greatest benefit from participating in the program. Conclusion The community exercise program was feasible and effective in preventing weight gain, reducing blood pressure, and improving physical function in patients with PCa on androgen-deprivation therapy.

Published
2022

45. Weight loss for overweight and obese patients with prostate cancer: A study protocol of a randomised trial comparing clinic-based versus telehealth delivered exercise and nutrition intervention (the TelEX trial)

Author

Galvão, Daniel A., Taaffe, Dennis R., Hayne, Dickon, Lopez, Pedro, Lyons-Wall, Philippa, Tang, Colin I., Chambers, Suzanne K., Devine, Amanda, Spry, Nigel, Jeffery, Emily, Kudiarasu, Christine, Joseph, David, Newton, Robert U., Galvão, Daniel A., Taaffe, Dennis R., Hayne, Dickon, Lopez, Pedro, Lyons-Wall, Philippa, Tang, Colin I., Chambers, Suzanne K., Devine, Amanda, Spry, Nigel, Jeffery, Emily, Kudiarasu, Christine, Joseph, David, and Newton, Robert U.

Abstract

Introduction Obese men with prostate cancer have an increased risk of biochemical recurrence, metastatic disease and mortality. For those undergoing androgen deprivation therapy (ADT), substantial increases in fat mass are observed in the first year of treatment. Recently, we showed that a targeted supervised clinic-based exercise and nutrition intervention can result in a substantial reduction in fat mass with muscle mass preserved in ADT-treated patients. However, the intervention needs to be accessible to all patients and not just those who can access a supervised clinic-based programme. The purpose of this study was to evaluate the efficacy of telehealth delivered compared with supervised clinic-based delivered exercise and nutrition intervention in overweight/obese patients with prostate cancer. Methods and analysis A single-blinded, two-arm parallel group, non-inferiority randomised trial will be undertaken with 104 overweight/obese men with prostate cancer (body fat percentage ≥ 25%) randomly allocated in a ratio of 1:1 to a telehealth-delivered, virtually supervised exercise and nutrition programme or a clinic-based, face-to-face supervised exercise and nutrition programme. Exercise will consist of supervised resistance and aerobic exercise performed three times a week plus additional self-directed aerobic exercise performed 4 days/week for the first 6 months. Thereafter, for months 7-12, the programmes will be self-managed. The primary endpoint will be fat mass. Secondary endpoints include lean mass and abdominal aortic calcification, anthropometric measures and blood pressure assessment, objective measures of physical function and physical activity levels, patient-reported outcomes and blood markers. Measurements will be undertaken at baseline, 6 months (post intervention), and at 12 months of follow-up. Data will be analysed using intention-to-treat and per protocol approaches. Ethics and dissemination Ethics approval has been obtained from the Edith Cowa

Published
2022

46. In Reply to Carpenter et al.

Author

Schumacher, Oliver, primary, Luo, Hao, additional, Taaffe, Dennis R., additional, Galvão, Daniel A., additional, Tang, Colin, additional, Chee, Raphael, additional, Spry, Nigel, additional, and Newton, Robert U., additional

Published
2022
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47. Randomised controlled trial on the effect of simethicone bowel preparation on rectal variability during image‐guided radiation therapy for prostate cancer ( SPoRT study)

Author

Ward, Jennifer, primary, Gill, Suki, additional, Armstrong, Kevin, additional, Fogarty, Tamara, additional, Tan, Daren, additional, Scott, Alison, additional, Yahya, Aylin, additional, Dhaliwal, Satvinder Singh, additional, Jacques, Angela, additional, and Tang, Colin, additional

Published
2022
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50. GCN2 kinase activation by ATP-competitive kinase inhibitors

Author

Tang, Colin P., primary, Clark, Owen, additional, Ferrarone, John R., additional, Campos, Carl, additional, Lalani, Alshad S., additional, Chodera, John D., additional, Intlekofer, Andrew M., additional, Elemento, Olivier, additional, and Mellinghoff, Ingo K., additional

Published
2021
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