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3. Increase in creatinine levels associated with niraparib maintenance therapy in ovarian cancer.

Author

Takahashi, Yoshifumi, Taguchi, Masahiro, Tamura, Kohei, Shinohara, Miki, Koyanagi, Takahiro, Takahashi, Suzuyo, Taneichi, Akiyo, Takei, Yuji, Saga, Yasushi, and Fujiwara, Hiroyuki

Subjects
GLOMERULAR filtration rate, DRUG efficacy, OVARIAN tumors, ANTINEOPLASTIC agents, RETROSPECTIVE studies, ACQUISITION of data, REGRESSION analysis, MEDICAL records, DESCRIPTIVE statistics, ENZYME inhibitors, CREATININE, PATIENT safety, PHARMACODYNAMICS
Abstract

Aim: In Japan, Niraparib maintenance therapy for primary and recurrent ovarian cancer was approved in September 2020 and is expected to improve the prognosis of ovarian cancer. However, the safety of niraparib maintenance therapy in Japanese patients has not been fully evaluated. Methods: Patients with ovarian cancer (including fallopian tube and peritoneal cancer) treated with niraparib at Jichi Medical University Hospital from September 2020 to August 2022 were enrolled in this study. Patient background, starting dose, rates of interruption, reduction, or discontinuation, adverse events (AEs) during treatment, and estimated glomerular filtration rate (eGFR) trends were retrospectively analyzed. Results: Twenty‐nine patients received niraparib maintenance therapy during the study period, including 21 with primary cancer and 8 patients with recurrent cancer. Seventeen patients (58.6%) required dose interruptions and 16 patients (55.2%) required dose reductions. Only two patients (6.9%) discontinued treatment due to fatigue and nausea. The most frequent AE was creatinine increases in 18 patients (62.1%, all grades). Although eGFR levels decreased significantly after niraparib therapy compared to before niraparib therapy (59.3 vs. 50.3 mL/min/1.73 m2, p < 0.001), the levels returned to pre‐niraparib initiation levels after discontinuation of niraparib (64.6 vs. 64.6 mL/min/1.73 m2, p = 0.96). Multivariate regression analysis showed that diabetes was independently associated with decreased eGFR (p = 0.013). Conclusions: Niraparib maintenance therapy frequently increased serum creatinine, but the change was reversible. Further studies are needed to determine the effects of niraparib on renal function in Japanese patients. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Stroke in Patients With Common Noncancerous Gynecologic Diseases

Author

Yamashiro, Kazuo, primary, Sato, Takeo, additional, Nito, Chikako, additional, Ueno, Yuji, additional, Kawano, Hiroyuki, additional, Chiba, Tetsuya, additional, Nishihira, Takahito, additional, Mizuno, Takafumi, additional, Ishizuka, Kentaro, additional, Iguchi, Yasuyuki, additional, Kimura, Kazumi, additional, Kitagawa, Kazuo, additional, Koga, Masatoshi, additional, Hirano, Teruyuki, additional, Kameda, Tomoaki, additional, Takekawa, Hidehiro, additional, Urabe, Takao, additional, Taneichi, Akiyo, additional, Fujiwara, Hiroyuki, additional, Fujimoto, Shigeru, additional, Hattori, Nobutaka, additional, and Tanaka, Ryota, additional

Published
2023
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10. Durable response after the discontinuation of pembrolizumab treatment due to an adverse event in a patient with advanced endometrial cancer: A case report

Author

Umihira, Shuntaro, primary, Koyanagi, Takahiro, additional, Tamura, Kohei, additional, Takahashi, Yoshifumi, additional, Yoshiba, Takahiro, additional, Takahashi, Suzuyo, additional, Taneichi, Akiyo, additional, Saga, Yasushi, additional, Takei, Yuji, additional, and Fujiwara, Hiroyuki, additional

Published
2022
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16. Knockout of vasohibin‐2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer

Author

Koyanagi, Takahiro, primary, Saga, Yasushi, additional, Takahashi, Yoshifumi, additional, Tamura, Kohei, additional, Yoshiba, Takahiro, additional, Takahashi, Suzuyo, additional, Taneichi, Akiyo, additional, Takei, Yuji, additional, Urabe, Masashi, additional, Mizukami, Hiroaki, additional, and Fujiwara, Hiroyuki, additional

Published
2021
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21. Efficacy and toxicity of pegylated liposomal doxorubicin as therapy for recurrent ovarian cancer in relation to the number of previous chemotherapy regimens: Comparison with gemcitabine

Author

Takahashi, Yoshifumi, primary, Takei, Yuji, additional, Machida, Shizuo, additional, Taneichi, Akiyo, additional, Takahashi, Suzuyo, additional, Yoshiba, Takahiro, additional, Koyanagi, Takahiro, additional, Tamura, Kohei, additional, Saga, Yasushi, additional, and Fujiwara, Hiroyuki, additional

Published
2020
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22. NGS-based molecular profiling (a multi-center collaborative, observation study in Japan) highlights pathogenic variants of DNA-repair genes in advanced or recurrent endometrial cancer.

Author

Fujiwara, Hiroyuki, primary, Oda, Katsutoshi, additional, Takahashi, Nobutaka, additional, Sakata, Jun, additional, Taneichi, Akiyo, additional, Ikeda, Masae, additional, Tanikawa, Michihiro, additional, Kusakabe, Misako, additional, Mitsuhashi, Akira, additional, Kobayashi, Yoichi, additional, Yamashita, Hiroshi, additional, Suzuki, Nao, additional, Akiyama, Azusa, additional, Tokunaga, Hideki, additional, Tanaka, Naotake, additional, and Mikami, Mikio, additional

Published
2020
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34. Efficacy and toxicity of pegylated liposomal doxorubicin as therapy for recurrent ovarian cancer in relation to the number of previous chemotherapy regimens: Comparison with gemcitabine.

Author

Takahashi, Yoshifumi, Takei, Yuji, Machida, Shizuo, Taneichi, Akiyo, Takahashi, Suzuyo, Yoshiba, Takahiro, Koyanagi, Takahiro, Tamura, Kohei, Saga, Yasushi, and Fujiwara, Hiroyuki

Subjects
THERAPEUTIC use of antimetabolites, ANEMIA, CANCER chemotherapy, COMPARATIVE studies, DOXORUBICIN, DRUG resistance, DRUG side effects, MEDICAL records, NEUTROPENIA, OVARIAN tumors, PLATINUM, STOMATITIS, DISEASE relapse, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, HAND-foot syndrome
Abstract

Aim: Pegylated liposomal doxorubicin (PLD) is one of the second‐line chemotherapy regimens for platinum‐resistant recurrent ovarian cancer, but in clinical practice, it is also used for third or subsequent lines of chemotherapy. There is no report on the efficacy and toxicity of PLD in relation to the number of previous chemotherapy regimens. The purpose of this study was to clarify these points and compare with the results of gemcitabine (GEM) therapy we reported previously. Methods: We retrospectively reviewed the medical records of patients with platinum‐resistant recurrent ovarian cancer who underwent two or more cycles of PLD therapy between July 2009 and March 2017 at our institution. We used our reported data of GEM for comparison analysis. Results: Seventy‐eight patients were enrolled in this study. The overall response rate was 19.2% and the disease control rate (DCR) was 53.8%. The DCR with 1, 2, 3, and 4 or more previous regimens was 53.8%, 48.6%, 63.6% and 66.7%, respectively. Grade 3/4 neutropenia and anemia developed in 59.0% and 12.8%, respectively. Grade 2 or higher hand ‐foot syndrome, stomatitis, and liver dysfunction developed in 25.6%, 25.6% and 2.6%, respectively. When the number of previous regimens was 3 or higher, the DCR of PLD was significantly higher than that of GEM (64.7% vs 30.8%, P = 0.037). Conclusion: The DCR did not decrease with a greater number of previous regimens. When the number of previous regimens was 3 or higher, PLD therapy had a superior DCR to GEM therapy. Toxicity was tolerable in PLD therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Perinatal outcome of pregnancy after adenomyomectomy: summary of 10 cases with a brief literature review.

Author

Sugiyama, Mizuho, Takahashi, Hironori, Baba, Yosuke, Taneichi, Akiyo, Suzuki, Hirotada, Usui, Rie, Takei, Yuji, Ohkuchi, Akihide, Fujiwara, Hiroyuki, and Matsubara, Shigeki

Subjects
CESAREAN section, LITERATURE reviews, UTERINE contraction, PREGNANCY, PREGNANT women, UTERINE rupture, TOCOLYTIC agents, RETROSPECTIVE studies, PREGNANCY outcomes, HUMAN reproductive technology
Abstract

Objectives: The purpose of this study was the perinatal outcomes of patients who became pregnant after adenomyomectomy.Study design: The retrospective cohort study was performed involving pregnant women with a history of adenomyomectomy between 1 January 2011 and 31 December 2018. At 24-26 weeks, the patients were admitted even without symptoms or signs. When regular uterine contractions were observed, tocolysis was performed.Results: Ten patients were included. Elective and emergent cesarean section (CS) was performed in seven and three patients, respectively. Emergent CS was performed due to onset of labor (tocolytic failure) at 28, 24, and 32 weeks. Although no patients suffered uterine rupture, myometrial thinning was observed at the site corresponding to that of adenomyomectomy in three patients. Of these three patients, two required emergent CS due to tocolytic failure with cervical length (CL) shortening. In contrast, CLs were stable in the other seven patients with elective CS.Conclusions: Three patients after adenomyomectomy showed preterm delivery, and three had a very thin uterus to the extent that the fetus could be observed through the uterine wall. A short CL should be paid special attention in pregnant women with a history of adenomyomectomy. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Disseminated Intravascular Coagulopathy Caused by Uterine Leiomyoma with Sarcoma-Like Findings on Magnetic Resonance Imaging

Author

Taneichi, Akiyo, Fujiwara, Hiroyuki, Mizoguchi, Yukako, Machida, Shizuo, Nonaka, Hiroaki, Takei, Yuji, Saga, Yasushi, and Suzuki, Mitsuaki

Subjects
Article Subject, hemic and lymphatic diseases, circulatory and respiratory physiology
Abstract

A leiomyoma rarely causes disseminated intravascular coagulopathy (DIC). In the present report, we describe a case of DIC caused by leiomyoma. A 36-year-old nulliparous woman presented with hypermenorrhea and a lower abdominal mass. On magnetic resonance imaging, we detected a 14 cm uterine tumor, which was suspected to be a sarcoma. Blood tests at the preoperative examination indicated platelet count of 9.6 × 104/μL, fibrin degradation product level of 107.1 μg/mL (normal value, 0–5.0 μg/mL), and fibrinogen level of 54 mg/dL (normal value, 129–271 mg/dL). Based on these findings, we diagnosed the patient with DIC. The patient was treated with nafamostat mesilate and fresh frozen plasma, but the DIC did not show any improvement. Subsequently, a hysterectomy was performed, after which the DIC improved. Clinicopathological findings indicated the presence of a leiomyoma with multiple vessels containing thromboemboli, and suggested that the DIC was caused by the leiomyoma. Therefore, it is essential to consider that that a benign leiomyoma may be a cause of DIC.

Published
2014
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42. Successful laparotomy tumor resection and levonorgestrel‐releasing intrauterine system for atypical polypoid adenomyoma.

Author

Narumi, Risa, Takei, Yuji, Morisawa, Hiroyuki, Taneichi, Akiyo, Matsubara, Shigeki, and Fujiwara, Hiroyuki

Subjects
LEVONORGESTREL, ABDOMINAL surgery, CANCER cells, HISTOLOGICAL techniques, HYSTEROSCOPY, INTRAUTERINE contraceptives, MICROSCOPY, POSTOPERATIVE period, UTERINE tumors, WOMEN'S health services, TREATMENT effectiveness, MEDICAL device removal, SURGERY, DIAGNOSIS, THERAPEUTICS
Abstract

Hysteroscopic transcervical resection (TCR) is often performed as fertility sparing treatment for atypical polypoid adenomyoma (APA) patients. However, TCR has the risk of uterine wall perforation, especially when the tumor extends deeply into the uterine muscle layer. We report an APA patient in whom it was impossible to completely resect the tumor by TCR, but laparotomy tumor resection followed by levonorgestrel‐releasing intrauterine system (LNG‐IUS) was successful. The patient was a 35‐year‐old nulligravida woman. We performed laparotomy tumor resection and inserted the LNG‐IUS into uterine cavity just after surgery. Microscopic residual tumor was suspected based on histopathological findings. However, the patient has not relapsed for 26 months, even though the LNG‐IUS was removed after 6 months. Laparotomy tumor resection may be one fertility sparing treatment option for APA patients. Furthermore, it may be effective to use the LNG‐IUS after surgery for two purposes that are adhesion prevention and tumor disappearance. [ABSTRACT FROM AUTHOR]

Published
2019
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45. The effects of message framing on cervical cancer screening: A randomized controlled trial.

Author

Fujiwara, Hiroyuki, primary, Shimoda, Akihiro, additional, Ishikawa, Yoshiki, additional, Takei, Yuji, additional, Machida, Shizuo, additional, Taneichi, Akiyo, additional, Ohashi, Mai, additional, Takahashi, Yoshifumi, additional, Morisawa, Hiroyuki, additional, Koyanagi, Takahiro, additional, Saga, Yasushi, additional, and Suzuki, Mitsuaki, additional

Published
2015
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47. Effect of providing risk information on undergoing cervical cancer screening: a randomized controlled trial

Author

Fujiwara, Hiroyuki, primary, Shimoda, Akihiro, additional, Ishikawa, Yoshiki, additional, Taneichi, Akiyo, additional, Ohashi, Mai, additional, Takahashi, Yoshifumi, additional, Koyanagi, Takahiro, additional, Morisawa, Hiroyuki, additional, Takahashi, Suzuyo, additional, Sato, Naoto, additional, Machida, Shizuo, additional, Takei, Yuji, additional, Saga, Yasushi, additional, and Suzuki, Mitsuaki, additional

Published
2015
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