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706 results on '"Tanaka, Mitsuru"'

1. Gravitational form factors of pion from top-down holographic QCD

Author

Fujii, Daisuke, Iwanaka, Akihiro, and Tanaka, Mitsuru

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Lattice, High Energy Physics - Theory, Nuclear Theory
Abstract

The gravitational form factors (GFFs) of pions has been calculated from a top-down holographic QCD approach with momentum transfer dependence for the first time. It is important because the GFFs of hadrons have information on the internal stress distribution that may provide insight into the mechanism of how QCD forms hadrons. The forward limit value of this GFFs, i.e. the D-term, was also obtained. Furthermore, in this approach, we observe the so-called glueball dominance, in which pions have gravitational interactions via infinite glueball spectra., Comment: 8 pages, 1 figures

Published
2024

2. Mass and decay width of $T_{ccs}$ from symmetries

Author

Tanaka, Mitsuru, Yamaguchi, Yasuhiro, and Harada, Masayasu

Subjects
High Energy Physics - Phenomenology, Nuclear Theory
Abstract

We analyze the mass and width of the doubly heavy tetraquark $T_{ccs}$ composed of a heavy diquark and a light-quark cloud with strangeness with assuming that a color antitriplet heavy diquark is a dominant component of the doubly charmed tetraquarks $T_{cc}$ and $T_{ccs}$. We construct an effective Lagrangian for masses of heavy hadrons based on the superflavor symmetry between the doubly heavy tetraquarks and the singly heavy baryons by including the terms that simultaneously break the heavy-quark and light-flavor symmetries, and predict the mass of $T_{ccs}$ as $M(T_{ccs}) = 4047\pm11$\,MeV. The comparison of this prediction with future experimental observation will give a clue to understand the color structure of the heavy diquark. We also predict the mass of $\Omega_{cc}$ as $M(\Omega_{cc}) = 3706^{+14}_{-15}\,$MeV. We next calculate the decay width of $T_{ccs}$, based on solely the light-flavor symmetry, as $\Gamma(T_{ccs}) = 42\pm 24$\,MeV.

Published
2024
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16. Morphing Numerical Simulation of Incompressible Flows Using Seamless Immersed Boundary Method

Author

Tajiri, Kyohei, Tanaka, Mitsuru, Yamakawa, Masashi, Nishida, Hidetoshi, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Krzhizhanovskaya, Valeria V., editor, Závodszky, Gábor, editor, Lees, Michael H., editor, Dongarra, Jack J., editor, Sloot, Peter M. A., editor, Brissos, Sérgio, editor, and Teixeira, João, editor

Published
2020
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18. Application of graphite carbon black assisted-laser desorption ionization-mass spectrometry for soy sauce product discrimination.

Author

Tanaka, Mitsuru, Arima, Keishiro, Ide, Haruna, Koshi, Mariko, Ohno, Naoto, Imamura, Miho, and Matsui, Toshiro

Subjects
*SOY sauce, *SOYBEAN products, *DESORPTION ionization mass spectrometry, *CARBON-black, *MATRIX-assisted laser desorption-ionization, *ELECTROSPRAY ionization mass spectrometry, *GRAPHITE
Abstract

In a previous study, we developed a novel analytical method to directly and simultaneously detect taste- and odor-active compounds using graphite carbon black (GCB)-assisted laser desorption ionization mass spectrometry (LDI-MS). In this study, we aimed to evaluate food quality using a variety of soy sauces using the method to discriminate each product. Graphite carbon black-laser desorption ionization-mass spectrometry allowed the provision of hundreds of MS peaks derived from soy sauces in both positive and negative modes without any tedious sample pretreatments. Principal component analysis using the obtained MS peaks clearly distinguished three soy sauce products based on the manufacturing countries (Japan, China, and India). Moreover, this method identified distinct MS peaks for discrimination, which significantly correlated with their quantitative amounts in the products. Thus, GCB-LDI-MS analysis was established as a simple and rapid technique for food analysis, illustrating the chemical patterns of food products. [ABSTRACT FROM AUTHOR]

Published
2024
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24. List of contributors

Author

Aguilar-Toalá, J.E., primary, Aiello, Gilda, additional, Aita, Sara Elsa, additional, Aluko, Rotimi E., additional, Amigo-Benavent, Miryam, additional, Amin, Mohammad Sadiq, additional, Arihara, Keizo, additional, Arnoldi, Anna, additional, Audenaert, Kurt, additional, Bak, Kathrine H., additional, Barba de la Rosa, Ana Paulina, additional, Batista, Patrícia, additional, Bhullar, Khushwant S., additional, Bollati, Carlotta, additional, Borges, Sandra, additional, Bouhallab, Said, additional, Brassesco, María Emilia, additional, Campbell, Emily P., additional, Canabady-Rochelle, Laetitia, additional, Capriotti, Anna Laura, additional, Centner, C., additional, Cerrato, Andrea, additional, Chen, Hui, additional, Chen, Liang, additional, Coscueta, Ezequiel R., additional, Csire, Gizella, additional, Cui, Xin-Yue, additional, Darewicz, Małgorzata, additional, De León-Rodríguez, Antonio, additional, De Spiegeleer, Bart, additional, Desobry, Stéphane, additional, Dia, Vermont P., additional, Du, Ming, additional, El Hajj, Sarah, additional, Fan, Fengjiao, additional, FitzGerald, Richard J., additional, Fu, Yu, additional, Ganguly, Advaita, additional, Gaucher, Caroline, additional, Giblin, Linda, additional, Girardet, Jean-Michel, additional, Giraud, Tristan, additional, Gonzalez de Mejia, Elvira, additional, Gu, Rui-Zeng, additional, Hall, F.G., additional, Heffernan, Shauna, additional, Huang, En, additional, Hussein, Walaa E., additional, Iwaniak, Anna, additional, Jahandideh, Forough, additional, Janssens, Yorick, additional, Jerger, S., additional, Khalesi, Mohammadreza, additional, Kohl, J., additional, Kondrashina, Alina, additional, König, D, additional, Laganà, Aldo, additional, Lametsch, René, additional, Lammi, Carmen, additional, Li, Guo-Ming, additional, Li, Qian, additional, Liceaga, A.M., additional, Liu, Wen-Ying, additional, Liu, Yan, additional, Lu, Jun, additional, Majumder, Kaustav, additional, Matsui, Toshiro, additional, Mine, Yoshinori, additional, Minkiewicz, Piotr, additional, Montone, Carmela Maria, additional, Mora, Leticia, additional, Muhr, Laurence, additional, Ohata, Motoko, additional, Okagu, Ogadimma D., additional, O’Brien, Nora, additional, Paris, Cédric, additional, Pintado, Manuela, additional, Piovesana, Susy, additional, Qin, Xiu-Yuan, additional, Sato, Kenji, additional, Selmeczi, Katalin, additional, Sepulveda-Rincon, Tatiana, additional, Shahidi, Fereidoon, additional, Shang, Nan, additional, Sharma, Kumakshi, additional, Shi, Pujie, additional, Stefan, Loic, additional, Sun, Xiaohong, additional, Tanaka, Mitsuru, additional, Thapa, Ganesh, additional, Toldrá, Fidel, additional, Udenigwe, Chibuike C., additional, Urbizo-Reyes, U., additional, Vázquez-Rodríguez, Gabriela, additional, Velarde-Salcedo, Aída Jimena, additional, Wang, Yu-Chen, additional, Wang, Yu-Qing, additional, Wei, Ying, additional, Wu, Di, additional, Wu, Jianping, additional, Wynendaele, Evelien, additional, Xu, Feiran, additional, Xu, Zhe, additional, Yeo, JuDong, additional, Yokoyama, Issei, additional, Yousef, Ahmed E., additional, and Zhang, Hua, additional

Published
2021
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45. Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pharmaceutical and food-related compounds

Author

Kitaguchi, Takashi, primary, Horiuchi, Shinichiro, additional, Kuroda, Yukie, additional, Ohno, Katsutoshi, additional, Kobayashi, Kazuhiro, additional, Tanaka, Mitsuru, additional, and Ishida, Seiichi, additional

Published
2023
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48. Identification of characteristic compounds of moderate volatility in breast cancer cell lines

Author

Tanaka, Mitsuru, Hsuan, Chung, Oeki, Masataka, Shen, Weilin, Goda, Asuka, Tahara, Yusuke, Onodera, Takeshi, Sanematsu, Keisuke, Rikitake, Tomotsugu, Oki, Eiji, Ninomiya, Yuzo, Kurebayashi, Rintaro, Sonoda, Hideto, Maehara, Yoshihiko, Toko, Kiyoshi, Matsui, Toshiro, Tanaka, Mitsuru, Hsuan, Chung, Oeki, Masataka, Shen, Weilin, Goda, Asuka, Tahara, Yusuke, Onodera, Takeshi, Sanematsu, Keisuke, Rikitake, Tomotsugu, Oki, Eiji, Ninomiya, Yuzo, Kurebayashi, Rintaro, Sonoda, Hideto, Maehara, Yoshihiko, Toko, Kiyoshi, and Matsui, Toshiro

Abstract

type:RESEARCH ARTICLE, In this study, we were challenging to identify characteristic compounds in breast cancer cell lines. GC analysis of extracts from the culture media of breast cancer cell lines (MCF-7, SK-BR-3, and YMB-1) using a solid-phase Porapak Q extraction revealed that two compounds of moderate volatility, 1-hexadecanol and 5-(Z)-dodecenoic acid, were detected with markedly higher amount than those in the medium of fibroblast cell line (KMST-6). Furthermore, LC-TOF/MS analysis of the extracts clarified that in addition to the above two fatty acids, the amounts of five unsaturated fatty acids [decenoic acid (C10:1), decadienoic acid (C10:2), 5-(Z)-dodecenoic acid (C12:1), 5-(Z)-tetradecenoic acid (C14:1), and tetradecadienoic acid (C14:2)] in MCF-7 medium were higher than those in medium of KMST-6. Interestingly, H2O2-oxidation of 5-(Z)-dodecenoic acid and 5-(Z)-tetradecenoic acid produced volatile aldehydes that were reported as specific volatiles in breath from various cancer patients, such as heptanal, octanal, nonanal, decanal, 2-(E)-nonenal, and 2-(E)-octenal. Thus, we concluded that these identified compounds over-produced in breast cancer cells in this study could serve as potential precursors producing reported cancer-specific volatiles.

Published
2022

49. Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle

Author

Nakao, Reiko, Shen, Weilin, Shimajiri, Yasuka, Kainou, Kumiko, Sato, Yuki, Ulla, Anayt, Ohnishi, Kohta, Ninomiya, Miyuki, Ohno, Ayako, Uchida, Takayuki, Tanaka, Mitsuru, Akama, Kazuhito, Matsui, Toshiro, Nikawa, Takeshi, Nakao, Reiko, Shen, Weilin, Shimajiri, Yasuka, Kainou, Kumiko, Sato, Yuki, Ulla, Anayt, Ohnishi, Kohta, Ninomiya, Miyuki, Ohno, Ayako, Uchida, Takayuki, Tanaka, Mitsuru, Akama, Kazuhito, Matsui, Toshiro, and Nikawa, Takeshi

Abstract

type:Article, We previously reported that intramuscular injections of ubiquitin ligase CBLB inhibitory pentapeptide (Cblin; Asp-Gly-pTyr-Met-Pro) restored lost muscle mass caused by sciatic denervation. Here, we detected Cblin on the basolateral side of Caco-2 cells after being placed on the apical side, and found that cytochalasin D, a tight junction opener, enhanced Cblin transport. Orally administered Cblin was found in rat plasma, indicating that intact Cblin was absorbed in vitro and in vivo. Furthermore, transgenic Cblin peptide-enriched rice (CbR) prevented the denervation-induced loss of muscle mass and the upregulation of muscle atrophy-related ubiquitin ligases in mice. These findings indicated that CbR could serve as an alternative treatment for muscle atrophy.

Published
2022

50. In vitro and in silico characterization of adiponectin-receptor agonist dipeptides

Author

Lee, Yuna, Nakano, Akihiro, Nakamura, Saya, Sakai, Kenta, Tanaka, Mitsuru, Sanematsu, Keisuke, Shigemura, Noriatsu, Matsui, Toshiro, Lee, Yuna, Nakano, Akihiro, Nakamura, Saya, Sakai, Kenta, Tanaka, Mitsuru, Sanematsu, Keisuke, Shigemura, Noriatsu, and Matsui, Toshiro

Abstract

type:Article, The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on the structure of the AdipoR1 agonist, AdipoRon, 15 synthetic dipeptides were targeted to promote glucose uptake in L6 myotubes. Tyr-Pro showed a significant increase in glucose uptake among the dipeptides, while other dipeptides, including Pro-Tyr, failed to exert this effect. Tyr-Pro induces glucose transporter 4 (Glut4) expression in the plasma membrane, along with adenosine monophosphate-activated protein kinase (AMPK) activation. In AdipoR1-knocked down cells, the promotion by Tyr-Pro was ameliorated, indicating that Tyr-Pro may directly interact with AdipoR1 as an agonist, followed by the activation of AMPK/Glut4 translocation in L6 myotubes. Molecular dynamics simulations revealed that a Tyr-Pro molecule was stably positioned in the two potential binding pockets (sites 1 and 2) of the seven-transmembrane receptor, AdipoR1, anchored in a virtual 1-palmitoyl-2-oleoyl-phosphatidylcholine membrane. In conclusion, we demonstrated the antidiabetic function of the Tyr-Pro dipeptide as a possible AdipoR1 agonist.

Published
2022

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