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1. Crystal structures of the binary and ternary complexes of 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli

Author

Tanaka, Nobutada, Nonaka, Takamasa, Tanabe, Tetsurou, Yoshimoto, Tadashi, Tsuru, Daisuke, and Mitsui, Yukio

Subjects
Dehydrogenases -- Research, Escherichia coli -- Research, Biological sciences, Chemistry
Abstract

The crystal structures of the binary complex of 7-alpha-hydroxysteroid dehydrogenase (HSDH) from Escherichia coli at 2.3 angstroms resolution and a ternary complex of 7-alpha HSDH, complexed with NADH, 7-oxoglycochenodeoxycholic acid at 1.8 angstroms resolution are presented. There are large conformation changes upon substrate binding. The side chains of a tyrosine and a serine residue indirectly interact with the substrate.

Published
1996

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