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2. Identification of antimalarial compounds from Leucas calostachys, using High Performance Liquid Chromatography and Electrospray Ionization Mass Spectrometry

Author

Mukungu, Nillian A., Okalbo, Faith A., Abuga, Kennedy O., Oyugi, Julius O., Ochola, Lucy, Tanabe, Maiko, Ohta, Marie, and Mwangi, Julius W.

Abstract

Leucas calostachys is widely used in traditional medicine in Kenya for management of various ailments including malaria. Bio-assay guided fractionation of Leucas calostachys extracts was carried out using in-vitro antiplasmodial and β-hematin inhibition assays with semi-preparative high performance liquid chromatography (HPLC). The active methanol fraction was subjected to liquid chromatography tandem mass spectrometry to identify constituent compounds. A total of twenty compounds consisting of eight flavonoids and 12 phenylethanoids were identified from this fraction. The flavonoids included, isorhamnetin, luteolin-7-O-glucoside, luteolin-4′-O-glucoside, luteolin diglucoside, apigenin-O-glucoside, genistein-O-glucoside, chrysoeriol-7-O-glucoside, and chrysoeriol-7-O-glucuronide. Seven of the phenylethanoids were identified as acteoside, isoactoeside, hydroxyacteoside, forthsoside B, samioside, alyssonoside and leucoseptoside A. The antimalarial activity of Leucas calostachys could be linked to presence of flavonoids and phenylethanoids.

Published
2022

3. Exploratory Research on Sportification of e-Sports : Universal e-Sports (Aoyama Gakuin University, Tokyo, September 5, 2019)

Author

Maruyama, Nobuhito, Oshima, Masatsugu, Kawamata, Keiko, Sato, Shigeo, Nishitani, Rei, Tanabe, Maiko, Watanabe, Shizuka, Takahashi, Daisuke, and Nara, Yasuhide

Subjects
e-Sports, People with disabilities, 障碍者, ユニバーサルデザイン, ダイバーシティ＆インクルージョン, eスポーツ, Women's empowerment, 女性活躍, Diversity & Inclusion, Universal design
Published
2020

4. The Possible Interplanetary Transfer of Microbes: Assessing the Viability of Deinococcus spp. Under the ISS Environmental Conditions for Performing Exposure Experiments of Microbes in the Tanpopo Mission

Author

Kawaguchi, Yuko, Yang, Yinjie, Kawashiri, Narutoshi, Shiraishi, Keisuke, Takasu, Masako, Narumi, Issay, Satoh, Katsuya, Hashimoto, Hirofumi, Nakagawa, Kazumichi, Tanigawa, Yoshiaki, Momoki, Yoh-hei, Tanabe, Maiko, Sugino, Tomohiro, Takahashi, Yuta, Shimizu, Yasuyuki, Yoshida, Satoshi, Kobayashi, Kensei, Yokobori, Shin-ichi, and Yamagishi, Akihiko

Published
2013
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8. From Structure-Function Analyses to Protein Engineering for Practical Applications of DNA Ligase

Author

Tanabe, Maiko, Ishino, Yoshizumi, and Nishida, Hirokazu

Subjects
Article Subject
Abstract

DNA ligases are indispensable in all living cells and ubiquitous in all organs. DNA ligases are broadly utilized in molecular biology research fields, such as genetic engineering and DNA sequencing technologies. Here we review the utilization of DNA ligases in a variety of in vitro gene manipulations, developed over the past several decades. During this period, fewer protein engineering attempts for DNA ligases have been made, as compared to those for DNA polymerases. We summarize the recent progress in the elucidation of the DNA ligation mechanisms obtained from the tertiary structures solved thus far, in each step of the ligation reaction scheme. We also present some examples of engineered DNA ligases, developed from the viewpoint of their three-dimensional structures.

Published
2015
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13. The Possible Interplanetary Transfer of Microbes: Assessing the Viability of Deinococcus spp. Under the ISS Environmental Conditions for Performing Exposure Experiments of Microbes in the Tanpopo Mission

Author

河口, 優子, Yang, Yinjie, 川尻, 成俊, 白石, 啓祐, 高須, 昌子, 鳴海, 一成, 佐藤, 勝也, 橋本, 博文, 中川, 和道, 谷川, 能章, 桃木, 洋平, 田邊, 真依子, 杉野, 朋弘, 高橋, 勇太, 清水, 康之, 吉田, 聡, 小林, 憲正, 横堀, 伸一, 山岸, 明彦, Kawaguchi, Yuko, Kawashiri, Narutoshi, Shiraishi, Keisuke, Takasu, Masako, Narumi, Issay, Satoh, Katsuya, Hashimoto Hirofumi, Nakagawa, Kazumichi, Tanigawa, Yoshiaki, Momoki, Yoh-hei, Tanabe, Maiko, Sugino, Tomohiro, Takahashi, Yuta, Shimizu, Yasuyuki, Yoshida, Satoshi, Kobayashi, Kensei, Yokobori, Shin-ichi, Yamagishi, Akihiko, 河口, 優子, Yang, Yinjie, 川尻, 成俊, 白石, 啓祐, 高須, 昌子, 鳴海, 一成, 佐藤, 勝也, 橋本, 博文, 中川, 和道, 谷川, 能章, 桃木, 洋平, 田邊, 真依子, 杉野, 朋弘, 高橋, 勇太, 清水, 康之, 吉田, 聡, 小林, 憲正, 横堀, 伸一, 山岸, 明彦, Kawaguchi, Yuko, Kawashiri, Narutoshi, Shiraishi, Keisuke, Takasu, Masako, Narumi, Issay, Satoh, Katsuya, Hashimoto Hirofumi, Nakagawa, Kazumichi, Tanigawa, Yoshiaki, Momoki, Yoh-hei, Tanabe, Maiko, Sugino, Tomohiro, Takahashi, Yuta, Shimizu, Yasuyuki, Yoshida, Satoshi, Kobayashi, Kensei, Yokobori, Shin-ichi, and Yamagishi, Akihiko

Abstract

会議情報: 国際アストロバイオロジーワークショップ2013（第6回日本アストロバイオロジーネットワーク年次研究会）（2013年11月28日-30日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)（ISAS)）, 相模原市, 神奈川県, Meeting Information: International Astrobiology Workshop 2013 (November 28-30, 2013. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 著者人数: 19名

Published
2015

14. The Possible Interplanetary Transfer of Microbes: Assessing the Viability of Deinococcus spp. Under the ISS Environmental Conditions for Performing Exposure Experiments of Microbes in the Tanpopo Mission

Author

Yang, Yinjie, Kawaguchi, Yuko, Kawashiri, Narutoshi, Shiraishi, Keisuke, Takasu, Masako, Narumi, Issay, Satoh, Katsuya, Hashimoto, Hirofumi, Nakagawa, Kazumichi, Tanigawa, Yoshiaki, Momoki, Yoh-hei, Tanabe, Maiko, Sugino, Tomohiro, Takahashi, Yuta, Shimizu, Yasuyuki, Yoshida, Satoshi, Kobayashi, Kensei, Yokobori, Shin-ichi, and Yamagishi, Akihiko

Abstract

国際アストロバイオロジーワークショップ2013（第6回日本アストロバイオロジーネットワーク年次研究会）（2013年11月28日-30日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)（ISAS)）, 相模原市, 神奈川県, International Astrobiology Workshop 2013 (November 28-30, 2013. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 著者人数: 19名, 資料番号: SA6000008043, レポート番号: 1013

Published
2013

27. Intravenous administration of 2,7,8-trimethyl-2-( β-carboxyethyl)-6-hydroxy chroman ( γ-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion.

Author

Tanabe, Maiko, Fukushima, Takeshi, Usui, Noriko, Aoyama, Nozomi, Tsunoda, Makoto, and Imai, Kazuhiro

Abstract

A natriuretic hormone, 2,7,8-trimethyl-2-( β-carboxyethyl)-6-hydroxy chroman ( γ-CEHC) was administered intravenously to male Sprague-Dawley rats and the plasma concentration of γ-CEHC along with urinary sodium (Na+) excretion was investigated. The plasma γ-CEHC concentrations were fluorimetrically determined by a column-switching HPLC method consisting of both phenyl and octadecyl silica columns, following a pre-column fluorescence derivatization with a fluorescence reagent, 4- N, N-dimethylaminosulfonyl-7-piperazino-2,1,3-benzoxadiazole (DBD-PZ). In rats fed with a high-NaCl (8.0%) diet, plasma γ-CEHC concentrations rapidly decreased by 20% in 15-45 min after the adminstration of γ-CEHC, while Na+ excretion gradually increased with time. Considering these results, the Na+ excretion effect appeared not to be associated with plasma γ-CEHC concentration. In addition, attempts were made to examine a main urinary metabolite of γ-CEHC, a large amount of 6- O-sulfated γ-CEHC found to be present in the urine using an HPLC-tandem mass spectrometry. Thus, it is plausible that γ-CEHC was easily metabolized to 6- O-sulfated metabolite and excreted into urine in rats. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2004
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29. Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC.

Author

Takata, Jiro, Hidaka, Ryoji, Yamasaki, Akihiko, Hattori, Akihiro, Fukushima, Takeshi, Tanabe, Maiko, Matsunaga, Kazuhisa, Karube, Yoshiharu, and Imai, Kazuhiro

Abstract

d-gamma-Tocopherol (gamma-Toc) and its major metabolite, 2, 7, 8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC), are currently receiving attention concerning their unique pharmacological activities. In order to achieve the efficient delivery of gamma-Toc and S-gamma-CEHC in vivo, we synthesized d-gamma-tocopheryl N,N-dimethylglycinate hydrochloride (gamma-TDMG) as a water-soluble prodrug of gamma-Toc and a two-step prodrug of S-gamma-CEHC. gamma-TDMG is a solid (mp 161-163 degrees C) and is quite soluble in water over 50 mM. The hydrolysis of gamma-TDMG was effectively catalyzed by esterases in rat and human liver microsomes. The disposition of gamma-TDMG after iv administration in rats was compared with that of gamma-Toc solubilized with the surfactant, polyoxyethylene hydrogenated castor oil. The plasma and liver levels of gamma-Toc rapidly increased after the iv administration of the gamma-TDMG. The liver availability of gamma-Toc after the administration of gamma-TDMG was two times higher than that of the gamma-Toc administration. The relative systemic availability of S-gamma-CEHC after the gamma-TDMG administration was an equivalent value (102%), and the mean residence time of S-gamma-CEHC was eight times longer than the racemic gamma-CEHC administration. Based on these results, gamma-TDMG was identified as the most promising water-soluble prodrug of gamma-Toc and the two-step prodrug of S-gamma-CEHC.

Published
2002

30. Pho85 kinase, a yeast cyclin‐dependent kinase, regulates the expression of UGP1encoding UDP‐glucose pyrophosphorylase

Author

Nishizawa, Masafumi, Tanabe, Maiko, Yabuki, Nami, Kitada, Kunio, and Toh‐e, Akio

Abstract

The PHO85gene is a negative regulator of the PHOsystem in the yeast Saccharomyces cerevisiaeand encodes a protein kinase (Pho85) highly homologous to the Cdc28 kinase (Cdc28). Ten cyclin‐like proteins are known to interact with Pho85, and combination with different cyclins is believed to be responsible for distinct Pho85 functions, including phosphate metabolism, carbon source utilization and cell cycle regulation. However, only a limited number of substrates of Pho85 kinase, including Pho4, Gsy2 and Sicl, have so far been identified. To search for more targets of Pho85 and to clarify the genetic control mechanisms by Pho85 kinase in these cellular functions, we carried out a genome‐wide analysis of the effect of a pho85Δmutation on gene expression. We found that expression of various genes involved in carbon metabolism are affected by the mutation and that among them, UGP1promoter activity was increased in the absence of Pho85 kinase. This increase in the promoter activity was not observed in a pho4Δmutant or with a mutant UGP1promoter that is devoid of putative Pho4 and Bas2 binding sites, suggesting that UGP1expression is modulated by Pho85 through Pho4. We also found that expression of several Pho85–cyclin genes were altered by the carbon source, the growth phase and Pho85 kinase itself. Copyright © 2000 John Wiley & Sons, Ltd.

Published
2001
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32. Intravenous administration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (gamma-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion.

Author

Tanabe M, Fukushima T, Usui N, Aoyama N, Tsunoda M, and Imai K

Subjects
Animals, Calibration, Chromatography, High Pressure Liquid, Male, Mass Spectrometry, Rats, Rats, Sprague-Dawley, Chromans administration & dosage, Chromans blood, Propionates administration & dosage, Propionates blood, Sodium urine
Abstract

A natriuretic hormone, 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (gamma-CEHC) was administered intravenously to male Sprague-Dawley rats and the plasma concentration of gamma-CEHC along with urinary sodium (Na+) excretion was investigated. The plasma gamma-CEHC concentrations were fluorimetrically determined by a column-switching HPLC method consisting of both phenyl and octadecyl silica columns, following a pre-column fluorescence derivatization with a fluorescence reagent, 4-N,N-dimethylaminosulfonyl-7-piperazino-2,1,3-benzoxadiazole (DBD-PZ). In rats fed with a high-NaCl (8.0%) diet, plasma gamma-CEHC concentrations rapidly decreased by 20% in 15-45 min after the administration of gamma-CEHC, while Na+ excretion gradually increased with time. Considering these results, the Na+ excretion effect appeared not to be associated with plasma gamma-CEHC concentration. In addition, attempts were made to examine a main urinary metabolite of gamma-CEHC, a large amount of 6-O-sulfated gamma-CEHC found to be present in the urine using an HPLC-tandem mass spectrometry. Thus, it is plausible that gamma-CEHC was easily metabolized to 6-O-sulfated metabolite and excreted into urine in rats., (2004 John Wiley & Sons, Ltd.)

Published
2004
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