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1. Pancreatitis, very early compared with normal start of enteral feeding (PYTHON trial): design and rationale of a randomised controlled multicenter trial

Author

Schaapherder Alexander F, van Ramshorst Bert, Nieuwenhuijs Vincent B, Manusama Eric R, Karsten Thom M, Jansen Jeroen M, Houdijk Alexander P, Heisterkamp Joos, van Goor Harry, van Geenen Erwin J, Dejong Cornelis H, Brink Menno A, Bosscha Koop, Bollen Thomas L, Boermeester Marja A, Besselink Marc G, Ali Usama, van Brunschot Sandra, van Santvoort Hjalmar C, Bakker Olaf J, van der Schelling George P, Spanier Marcel BM, Tan Adriaan, Vecht Juda, Weusten Bas L, Witteman Ben J, Akkermans Louis M, and Gooszen Hein G

Subjects
Medicine (General), R5-920
Abstract

Abstract Background In predicted severe acute pancreatitis, infections have a negative effect on clinical outcome. A start of enteral nutrition (EN) within 24 hours of onset may reduce the number of infections as compared to the current practice of starting an oral diet and EN if necessary at 3-4 days after admission. Methods/Design The PYTHON trial is a randomised controlled, parallel-group, superiority multicenter trial. Patients with predicted severe acute pancreatitis (Imrie-score ≥ 3 or APACHE-II score ≥ 8 or CRP > 150 mg/L) will be randomised to EN within 24 hours or an oral diet and EN if necessary, after 72 hours after hospital admission. During a 3-year period, 208 patients will be enrolled from 20 hospitals of the Dutch Pancreatitis Study Group. The primary endpoint is a composite of mortality or infections (bacteraemia, infected pancreatic or peripancreatic necrosis, pneumonia) during hospital stay or within 6 months following randomisation. Secondary endpoints include other major morbidity (e.g. new onset organ failure, need for intervention), intolerance of enteral feeding and total costs from a societal perspective. Discussion The PYTHON trial is designed to show that a very early (< 24 h) start of EN reduces the combined endpoint of mortality or infections as compared to the current practice of an oral diet and EN if necessary at around 72 hours after admission for predicted severe acute pancreatitis. Trial Registration ISRCTN: ISRCTN18170985

Published
2011
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2. Overuse and Misuse of Antibiotics and the Clinical Consequence in Necrotizing Pancreatitis: An Observational Multicenter Study

Author

Timmerhuis, Hester C., van den Berg, Fons F., Noorda, Paula C., van Dijk, Sven M., van Grinsven, Janneke, Sperna Weiland, Christina J., Umans, Devica S., Mohamed, Yasmin A., Curvers, Wouter L., Bouwense, Stefan A.W., Hadithi, Muhammed, Inderson, Akin, Issa, Yama, Jansen, Jeroen M., de Jonge, Pieter Jan F., Quispel, Rutger, Schwartz, Matthijs P., Stommel, Martijn W.J., Tan, Adriaan C.I.T.L., Venneman, Niels G., Besselink, Marc G., Bruno, Marco J., Bollen, Thomas L., Sieswerda, Elske, Verdonk, Robert C., Voermans, Rogier P., and van Santvoort, Hjalmar C.

Published
2023
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3. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J, Smeets, Xavier J N M, Kievit, Wietske, Verdonk, Robert C, Poen, Alexander C, Bhalla, Abha, Venneman, Niels G, Witteman, Ben J M, da Costa, David W, van Eijck, Brechje C, Schwartz, Matthijs P, Römkens, Tessa E H, Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M C J, Baak, Lubbertus C, Thijs, Willem J, van Wanrooij, Roy L, Tan, Adriaan C I T L, Seerden, Tom C J, Keulemans, Yolande C A, de Wijkerslooth, Thomas R, van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M, Hallensleben, Nora D L, Sperna Weiland, Ruud L, Timmerhuis, Hester C, Umans, Devica S, van Hooft, Jeanin E, van Goor, Harry, van Santvoort, Hjalmar C, Besselink, Marc G, Bruno, Marco J, Fockens, Paul, Drenth, Joost P H, and van Geenen, Erwin J M

Published
2021
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4. Validation and update of a prediction model for risk of relapse after cessation of anti-TNF treatment in Crohn’s disease

Author

ten Bokkel Huinink, Sebastiaan, de Jong, Djuna C., Nieboer, Daan, Thomassen, Doranne, Steyerberg, Ewout W., Dijkgraaf, Marcel G.W., Bodelier, Alexander G.L., West, Rachel L., Römkens, Tessa E.H., Hoentjen, Frank, Mallant, Rosalie C., van Tuyl, Bas A.C., Mares, Wout G.N., Wolfhagen, Frank H.J., Dijkstra, Gerard, Reijnders, Jurriën G.P., de Boer, Nanne K., Tan, Adriaan C.I.T.L., van Boeckel, Petra G.A., Tack, Greetje J., van Asseldonk, Dirk P., D’Haens, Geert R.A.M., van der Woude, C Janneke, Duijvestein, Marjolijn, and de Vries, Annemarie C

Published
2022
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6. Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life

Author

Hollemans, Robbert A, primary, Timmerhuis, Hester C, additional, Besselink, Marc G, additional, Bouwense, Stefan A W, additional, Bruno, Marco, additional, van Duijvendijk, Peter, additional, van Geenen, Erwin-Jan, additional, Hadithi, Muhammed, additional, Hofker, Sybrand, additional, Van-Hooft, Jeanin E, additional, Kager, Liesbeth M, additional, Manusama, Eric R, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, Römkens, Tessa, additional, van der Schelling, George P, additional, Schwartz, Matthijs P, additional, Spanier, Bernhard W M, additional, Stommel, Martijn, additional, Tan, Adriaan, additional, Venneman, Niels G, additional, Vleggaar, Frank, additional, van Wanrooij, Roy L J, additional, Bollen, Thomas L, additional, Voermans, Rogier P, additional, Verdonk, Robert C, additional, and van Santvoort, Hjalmar C, additional

Published
2024
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7. Small cyst size and slow growth rate are soothing features in individuals with pancreatic cysts undergoing surveillance

Author

Levink, Iris, primary, Koopmann, Brechtje, additional, Jaarsma, Sanne, additional, van Riet, Priscilla, additional, Overbeek, Kasper, additional, Meziani, Jihane, additional, Sprij, Marloes, additional, Gorris, Myrte, additional, Van Hooft, Jeanin, additional, Casadei, Riccardo, additional, Ingaldi, Carlo, additional, Wallace, Michael, additional, Hoogenboom, Sanne, additional, Honkoop, Pieter, additional, Polkowski, Marcin, additional, Carrara, Silvia, additional, Schoon, Erik, additional, Gemma, Rossi, additional, van der Waaij, Laurens, additional, Beyer, Georg, additional, Bergmann, Jilling, additional, Pando, Elizabeth, additional, Venneman, Niels, additional, Laukkarinen, Johanna, additional, Berkel, Anne-Marie van, additional, Van Vilsteren, Frederike, additional, Schwartz, Thijs, additional, Azopardi, Neville, additional, Hoge, Chantal, additional, van Soest, Ellert, additional, Smits, Marianne, additional, Quispel, Rutger, additional, Vos, Patrick, additional, Tan, Adriaan, additional, Czacko, Laszlo, additional, Leeuwenburgh, Ivonne, additional, Bruno, Marco, additional, and Cahen, Djuna, additional

Published
2023
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9. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, Dutch Pancreatitis Study Group, Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, and Dutch Pancreatitis Study Group

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and comp

Published
2023

10. The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program

Author

Levink, Iris J.M., Jaarsma, Sanne C., Koopmann, Brechtje D.M., van Riet, Priscilla A., Overbeek, Kasper A., Meziani, Jihane, Sprij, Marloes L.J.A., Casadei, Riccardo, Ingaldi, Carlo, Polkowski, Marcin, Engels, Megan M.L., van der Waaij, Laurens A., Carrara, Silvia, Pando, Elizabeth, Vornhülz, Marlies, Honkoop, Pieter, Schoon, Erik J., Laukkarinen, Johanna, Bergmann, Jilling F., Rossi, Gemma, van Vilsteren, Frederike G.I., van Berkel, Anne Marie, Tabone, Trevor, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., van Hooft, Jeanin E., Quispel, Rutger, van Soest, Ellert, Czacko, Laszlo, Bruno, Marco J., Cahen, Djuna L., Levink, Iris J.M., Jaarsma, Sanne C., Koopmann, Brechtje D.M., van Riet, Priscilla A., Overbeek, Kasper A., Meziani, Jihane, Sprij, Marloes L.J.A., Casadei, Riccardo, Ingaldi, Carlo, Polkowski, Marcin, Engels, Megan M.L., van der Waaij, Laurens A., Carrara, Silvia, Pando, Elizabeth, Vornhülz, Marlies, Honkoop, Pieter, Schoon, Erik J., Laukkarinen, Johanna, Bergmann, Jilling F., Rossi, Gemma, van Vilsteren, Frederike G.I., van Berkel, Anne Marie, Tabone, Trevor, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., van Hooft, Jeanin E., Quispel, Rutger, van Soest, Ellert, Czacko, Laszlo, Bruno, Marco J., and Cahen, Djuna L.

Abstract

Background:Surveillance of pancreatic cysts focuses on the detection of (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for surgery. We aimed to evaluate the role of CA19.9 monitoring for early detection and management in a cyst surveillance population. Methods: The PACYFIC-registry is a prospective collaboration that investigates the yield of pancreatic cyst surveillance performed at the discretion of the treating physician. We included participants for whom at least one serum CA19.9 value was determined by a minimum follow-up of 12 months.Results: Of 1865 PACYFIC participants, 685 met the inclusion criteria for this study (mean age 67 years, SD 10; 61% female). During a median follow-up of 25 months (IQR 24, 1966 visits), 29 participants developed high-grade dysplasia (HGD) or pancreatic cancer. At baseline, CA19.9 ranged from 1 to 591 kU/L (median 10 kU/L [IQR 14]), and was elevated (≥37 kU/L) in 64 participants (9%). During 191 of 1966 visits (10%), an elevated CA19.9 was detected, and these visits more often led to an intensified follow-up (42%) than those without an elevated CA19.9 (27%; p < 0.001). An elevated CA19.9 was the sole reason for surgery in five participants with benign disease (10%). The baseline CA19.9 value was (as continuous or dichotomous variable at the 37 kU/L threshold) not independently associated with HGD or pancreatic cancer development, whilst a CA19.9 of ≥ 133 kU/L was (HR 3.8, 95% CI 1.1–13, p = 0.03). Conclusions: In this pancreatic cyst surveillance cohort, CA19.9 monitoring caused substantial harm by shortening surveillance intervals (and performance of unnecessary surgery). The current CA19.9 cutoff was not predictive of HGD and pancreatic cancer, whereas a higher cutoff may decrease false-positive values. The role of CA19.9 monitoring should be critically appraised prior to imp

Published
2023

11. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

MS MDL 1, Cancer, MS CGO, Timmerhuis, Hester C., Van Dijk, Sven M., Hollemans, Robbert A., Sperna Weiland, Christina J., Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., Van Der Sluijs, Rogier, Brouwer, Lieke, Van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan Werner, De Ridder, Rogier, Römkens, Tessa E.H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., Venneman, Niels G., Vleggaar, Frank P., Van Wanrooij, Roy L.J., Witteman, Ben J., Van Geenen, Erwin J., Molenaar, I. Quintus, Bruno, Marco J., Van Hooft, Jeanin E., Besselink, Marc G., Voermans, Rogier P., Bollen, Thomas L., Verdonk, Robert C., Van Santvoort, Hjalmar C., MS MDL 1, Cancer, MS CGO, Timmerhuis, Hester C., Van Dijk, Sven M., Hollemans, Robbert A., Sperna Weiland, Christina J., Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., Van Der Sluijs, Rogier, Brouwer, Lieke, Van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan Werner, De Ridder, Rogier, Römkens, Tessa E.H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., Venneman, Niels G., Vleggaar, Frank P., Van Wanrooij, Roy L.J., Witteman, Ben J., Van Geenen, Erwin J., Molenaar, I. Quintus, Bruno, Marco J., Van Hooft, Jeanin E., Besselink, Marc G., Voermans, Rogier P., Bollen, Thomas L., Verdonk, Robert C., and Van Santvoort, Hjalmar C.

Published
2023

12. Short- and long-term outcomes of a disruption and disconnection of the pancreatic duct in necrotizing pancreatitis: a multicenter cohort study in 896 patients : Disrupted pancreatic duct in acute pancreatitis

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, RS: FHML non-thematic output, MUMC+: MA Maag Darm Lever (9), and Interne Geneeskunde

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and complications. Central and subtotal pancreatic necrosis and high levels of serum C-reactive protein in the first 48 hours are independent predictors for DPD.

Published
2023

13. Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study

Author

Hallensleben, Nora D, primary, Stassen, Pauline M C, additional, Schepers, Nicolien J, additional, Besselink, Marc G, additional, Anten, Marie-Paule G F, additional, Bakker, Olaf J, additional, Bollen, Thomas L, additional, da Costa, David W, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, Dijkgraaf, Marcel G W, additional, van Eijck, Brechje, additional, van Eijck, Casper H J, additional, Erkelens, Willemien, additional, Erler, Nicole S, additional, Fockens, Paul, additional, van Geenen, Erwin-Jan M, additional, van Grinsven, Janneke, additional, Hazen, Wouter L, additional, Hollemans, Robbert A, additional, van Hooft, Jeanin E, additional, Jansen, Jeroen M, additional, Kubben, Frank J G M, additional, Kuiken, Sjoerd D, additional, Poen, Alexander C, additional, Quispel, Rutger, additional, de Ridder, Rogier J, additional, Römkens, Tessa E H, additional, Schoon, Erik J, additional, Schwartz, Matthijs P, additional, Seerden, Tom C J, additional, Smeets, Xavier J N M, additional, Spanier, B W Marcel, additional, Tan, Adriaan C I T L, additional, Thijs, Willem J, additional, Timmer, Robin, additional, Umans, Devica S, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, Vleggaar, Frank P, additional, van de Vrie, Wim, additional, van Wanrooij, Roy L J, additional, Witteman, Ben J, additional, van Santvoort, Hjalmar C, additional, Bouwense, Stefan A W, additional, and Bruno, Marco J, additional

Published
2023
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14. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Smeets, Xavier J. N. M., da Costa, David W., Fockens, Paul, Mulder, Chris J. J., Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J., Besselink, Marc G. H., Vleggaar, Frank P., van der Hulst, Rene W. M., Poen, Alexander C., Heine, Gerbrand D. N., Venneman, Niels G., Kolkman, Jeroen J., Baak, Lubbertus C., Römkens, Tessa E. H., van Dijk, Sven M., Hallensleben, Nora D. L., van de Vrie, Wim, Seerden, Tom C. J., Tan, Adriaan C. I. T. L., Voorburg, Annet M. C. J., Poley, Jan-Werner, Witteman, Ben J., Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J., Schwartz, Matthijs P., Vrolijk, Jan Maarten, Verdonk, Robert C., van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P. H., van Geenen, Erwin J. M., and for the Dutch Pancreatitis Study Group

Published
2018
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15. The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program

Author

Levink, Iris J. M., Jaarsma, Sanne C., Koopmann, Brechtje D. M., Riet, Priscilla A., Overbeek, Kasper A., Meziani, Jihane, Sprij, Marloes L. J. A., Casadei, Riccardo, Ingaldi, Carlo, Polkowski, Marcin, Engels, Megan M. L., Waaij, Laurens A., Carrara, Silvia, Pando, Elizabeth, Vornhülz, Marlies, Honkoop, Pieter, Schoon, Erik J., Laukkarinen, Johanna, Bergmann, Jilling F., Rossi, Gemma, Vilsteren, Frederike G. I., Berkel, Anne‐Marie, Tabone, Trevor, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., Hooft, Jeanin E., Quispel, Rutger, Soest, Ellert, Czacko, Laszlo, Bruno, Marco J., and Cahen, Djuna L.

Abstract

Surveillance of pancreatic cysts focuses on the detection of (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for surgery. We aimed to evaluate the role of CA19.9 monitoring for early detection and management in a cyst surveillance population. The PACYFIC‐registry is a prospective collaboration that investigates the yield of pancreatic cyst surveillance performed at the discretion of the treating physician. We included participants for whom at least one serum CA19.9 value was determined by a minimum follow‐up of 12 months. Of 1865 PACYFIC participants, 685 met the inclusion criteria for this study (mean age 67 years, SD 10; 61% female). During a median follow‐up of 25 months (IQR 24, 1966 visits), 29 participants developed high‐grade dysplasia (HGD) or pancreatic cancer. At baseline, CA19.9 ranged from 1 to 591 kU/L (median 10 kU/L [IQR 14]), and was elevated (≥37 kU/L) in 64 participants (9%). During 191 of 1966 visits (10%), an elevated CA19.9 was detected, and these visits more often led to an intensified follow‐up (42%) than those without an elevated CA19.9 (27%; p< 0.001). An elevated CA19.9 was the sole reason for surgery in five participants with benign disease (10%). The baseline CA19.9 value was (as continuous or dichotomous variable at the 37 kU/L threshold) not independently associated with HGD or pancreatic cancer development, whilst a CA19.9 of ≥ 133 kU/L was (HR 3.8, 95% CI 1.1–13, p= 0.03). In this pancreatic cyst surveillance cohort, CA19.9 monitoring caused substantial harm by shortening surveillance intervals (and performance of unnecessary surgery). The current CA19.9 cutoff was not predictive of HGD and pancreatic cancer, whereas a higher cutoff may decrease false‐positive values. The role of CA19.9 monitoring should be critically appraised prior to implementation in surveillance programs and guidelines.

Published
2023
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18. Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: a randomized controlled trial

Author

Walter, Daisy, van Boeckel, Petra G.A., Groenen, Marcel J.M., Weusten, Bas L.A.M., Witteman, Ben J., Tan, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., van der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frans T.M., Scheffer, Robbert C.H., Steyerberg, Ewout W., May, Anne M., Leenders, Max, Hirdes, Meike M.C., Vleggaar, Frank P., and Siersema, Peter D.

Published
2017
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19. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients.

Author

Timmerhuis, Hester C., van Dijk, Sven M., Hollemans, Robbert A., Weiland, Christina J. Sperna, Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa E. H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., Venneman, Niels G., and Vleggaar, Frank P.

Published
2023
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22. ID: 3520219 A RANDOMIZED TRIAL OF AGGRESSIVE FLUID HYDRATION TO PREVENT POST-ERCP PANCREATITIS (FLUYT)

Author

Sperna Weiland, Christa J., primary, Smeets, Xavier, additional, Kievit, Wietske, additional, Verdonk, Robert C., additional, Poen, A.C., additional, Bhalla, Abha, additional, Venneman, Niels G., additional, Witteman, Ben, additional, da Costa, David W., additional, van Eijck, Brechje, additional, Schwartz, Matthijs P., additional, Romkens, Tessa, additional, Vrolijk, Jan, additional, Hadithi, Muhammed, additional, Voorburg, Annet, additional, Baak, Lubbertus C., additional, Thijs, Willem, additional, Wanrooij, Roy V., additional, Tan, Adriaan C., additional, Seerden, Tom, additional, Keulemans, Yolande, additional, De Wijkerslooth, Thomas R., additional, Van De Vrie, W., additional, Van Der Schaar, Peter J., additional, Van Dijk, Sven M., additional, Hallensleben, Nora D., additional, Sperna Weiland, Ruud L., additional, Timmerhuis, Hester C., additional, Umans, Devica S., additional, van Hooft, Jeanin E., additional, van Goor, Harry, additional, Van Santvoort, Hjalmar C., additional, Besselink, Marc G., additional, Bruno, Marco J., additional, Fockens, Paul, additional, Drenth, Joost, additional, and Van Geenen, Erwin-Jan M., additional

Published
2021
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23. Web-Based Educational Intervention for Patients With Uninvestigated Dyspepsia Referred for Upper Gastrointestinal Tract Endoscopy

Author

de Jong, Judith J., primary, Lantinga, Marten A., additional, Tan, Adriaan C. I. T. L., additional, Aquarius, Michel, additional, Scheffer, Robert C. H., additional, Uil, Jan J., additional, de Reuver, Philip R., additional, Keszthelyi, Daniel, additional, Westert, Gert P., additional, Masclee, Ad A. M., additional, and Drenth, Joost P. H., additional

Published
2021
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24. Additional file 2 of Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Turan, Ayla S., Moons, Leon M. G., Ramon-Michel Schreuder, Schoon, Erik J., Jochim S. Terhaar Sive Droste, Schrauwen, Ruud W. M., Straathof, Jan Willem, Bastiaansen, Barbara A. J., Schwartz, Matthijs P., Hazen, Wouter L., Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, Spek, Bas W. Van Der, Heine, Dimitri G. D. N., Tan, Adriaan C. I. T. L., Graaf, Wilmar De, Boonstra, Jurjen J., Voogd, Fia J., Roomer, Robert, Ridder, Rogier J. J. De, Kievit, Wietske, Siersema, Peter D., Didden, Paul, and Geenen, Erwin J. M. Van

Abstract

Additional file 2. List of parameters collected in the Case Record Form.

Published
2021
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25. Additional file 1 of Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Turan, Ayla S., Moons, Leon M. G., Ramon-Michel Schreuder, Schoon, Erik J., Jochim S. Terhaar Sive Droste, Schrauwen, Ruud W. M., Straathof, Jan Willem, Bastiaansen, Barbara A. J., Schwartz, Matthijs P., Hazen, Wouter L., Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, Spek, Bas W. Van Der, Heine, Dimitri G. D. N., Tan, Adriaan C. I. T. L., Graaf, Wilmar De, Boonstra, Jurjen J., Voogd, Fia J., Roomer, Robert, Ridder, Rogier J. J. De, Kievit, Wietske, Siersema, Peter D., Didden, Paul, and Geenen, Erwin J. M. Van

Abstract

Additional file 1. Definitions of Secondary Endpoints. *Severity of DB was defined according to the ASGE working party document for adverse events in colonoscopy [20].

Published
2021
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26. Additional file 3 of Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Turan, Ayla S., Moons, Leon M. G., Ramon-Michel Schreuder, Schoon, Erik J., Jochim S. Terhaar Sive Droste, Schrauwen, Ruud W. M., Straathof, Jan Willem, Bastiaansen, Barbara A. J., Schwartz, Matthijs P., Hazen, Wouter L., Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, Spek, Bas W. Van Der, Heine, Dimitri G. D. N., Tan, Adriaan C. I. T. L., Graaf, Wilmar De, Boonstra, Jurjen J., Voogd, Fia J., Roomer, Robert, Ridder, Rogier J. J. De, Kievit, Wietske, Siersema, Peter D., Didden, Paul, and Geenen, Erwin J. M. Van

Abstract

Additional file 3. SPIRIT Checklist.

Published
2021
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27. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT):a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., van Geenen, Erwin J.M., Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., and van Geenen, Erwin J.M.

Abstract

Background: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Prophylactic rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) is considered as standard of care to reduce the risk of post-ERCP pancreatitis. It has been suggested that aggressive hydration might further reduce this risk. Guidelines already recommend aggressive hydration in patients who are unable to receive rectal NSAIDs, although it is laborious and time consuming. We aimed to evaluate the added value of aggressive hydration in patients receiving prophylactic rectal NSAIDs. Methods: FLUYT, a multicentre, open-label, randomised, controlled trial done across 22 Dutch hospitals, included patients aged between 18 and 85 years with moderate to high risk of post-ERCP pancreatitis. Patients were randomly assigned (1:1) by a web-based module with varying block sizes to a combination of aggressive hydration and rectal NSAIDs (100 mg diclofenac or indomethacin; aggressive hydration group) or rectal NSAIDs (100 mg diclofenac or indomethacin) alone (control group). Randomisation was stratified according to treatment centre. Aggressive hydration comprised 20 mL/kg intravenous Ringer's lactate solution within 60 min from the start of ERCP, followed by 3 mL/kg per h for 8 h. The control group received normal intravenous saline with a maximum of 1·5 mL/kg per h and 3 L per 24 h. The primary endpoint was post-ERCP pancreatitis and was analysed on a modified intention-to-treat basis (including all patients who underwent randomisation and an ERCP and for whom data regarding the primary outcome were available). The trial is registered with the ISRCTN registry, ISRCTN13659155. Findings: Between June 5, 2015, and June 6, 2019, 826 patients were randomly assigned, of whom 388 in the aggressive hydration group and 425 in the control group were included in the modified intention-to-treat analysis. Post-ERCP pancreatitis occurred in 30 (8%) patients i

Published
2021

28. Pain patterns in chronic pancreatitis:A nationwide longitudinal cohort study

Author

Kempeneers, Marinus A., Issa, Yama, Verdonk, Robert C., Bruno, Marco, Fockens, P., Van Goor, Harry, Alofs, Eline, Bollen, Thomas L., Bouwense, Stefan, Van Dalen, Anne S.H.M., Van Dieren, Susan, Van Dullemen, Hendrik M., Van Geenen, Erwin Jan, Hoge, Chantal, Van Hooft, Jeanin E., Kager, Liesbeth M., Keulemans, Yolande, Nooijen, Lynn E., Poley, Jan Werner, Seerden, Tom C.J., Tan, Adriaan, Thijs, Willem, Timmer, Robin, Vleggaar, Frank, Witteman, Ben, Ahmed Ali, Usama, Besselink, Marc G., Boermeester, Marja A., Van Santvoort, Hjalmar C., Kempeneers, Marinus A., Issa, Yama, Verdonk, Robert C., Bruno, Marco, Fockens, P., Van Goor, Harry, Alofs, Eline, Bollen, Thomas L., Bouwense, Stefan, Van Dalen, Anne S.H.M., Van Dieren, Susan, Van Dullemen, Hendrik M., Van Geenen, Erwin Jan, Hoge, Chantal, Van Hooft, Jeanin E., Kager, Liesbeth M., Keulemans, Yolande, Nooijen, Lynn E., Poley, Jan Werner, Seerden, Tom C.J., Tan, Adriaan, Thijs, Willem, Timmer, Robin, Vleggaar, Frank, Witteman, Ben, Ahmed Ali, Usama, Besselink, Marc G., Boermeester, Marja A., and Van Santvoort, Hjalmar C.

Abstract

Objective Pain in chronic pancreatitis is subdivided in a continuous or intermittent pattern, each thought to represent a different entity, requiring specific treatment. Because evidence is missing, we studied pain patterns in a prospective longitudinal nationwide study. Design 1131 patients with chronic pancreatitis (fulfilling M-ANNHEIM criteria) were included between 2011 and 2018 in 30 Dutch hospitals. Patients with continuous or intermittent pain were compared for demographics, pain characteristics, quality of life (Short-Form 36), imaging findings, disease duration and treatment. Alternation of pain pattern and associated variables were longitudinally assessed using a multivariable multinomial logistic regression model. Results At inclusion, 589 patients (52%) had continuous pain, 231 patients (20%) had intermittent pain and 311 patients (28%) had no pain. Patients with continuous pain had more severe pain, used more opioids and neuropathic pain medication, and had a lower quality of life. There were no differences between pain patterns for morphological findings on imaging, disease duration and treatment. During a median follow-up of 47 months, 552 of 905 patients (61%) alternated at least once between pain patterns. All alternations were associated with the Visual Analogue Scale pain intensity score and surgery was only associated with the change from pain to no pain. Conclusion Continuous and intermittent pain patterns in chronic pancreatitis do not seem to be the result of distinctly different pathophysiological entities. The subjectively reported character of pain is not related to imaging findings or disease duration. Pain patterns often change over time and are merely a feature of how severity of pain is experienced.

Published
2021

29. Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

MS MDL 1, Cancer, Turan, Ayla S, Moons, Leon M G, Schreuder, Ramon-Michel, Schoon, Erik J, Terhaar Sive Droste, Jochim S, Schrauwen, Ruud W M, Straathof, Jan Willem, Bastiaansen, Barbara A J, Schwartz, Matthijs P, Hazen, Wouter L, Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, van der Spek, Bas W, Heine, Dimitri G D N, Tan, Adriaan C I T L, de Graaf, Wilmar, Boonstra, Jurjen J, Voogd, Fia J, Roomer, Robert, de Ridder, Rogier J J, Kievit, Wietske, Siersema, Peter D, Didden, Paul, van Geenen, Erwin J M, Dutch EMR Study Group, MS MDL 1, Cancer, Turan, Ayla S, Moons, Leon M G, Schreuder, Ramon-Michel, Schoon, Erik J, Terhaar Sive Droste, Jochim S, Schrauwen, Ruud W M, Straathof, Jan Willem, Bastiaansen, Barbara A J, Schwartz, Matthijs P, Hazen, Wouter L, Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, van der Spek, Bas W, Heine, Dimitri G D N, Tan, Adriaan C I T L, de Graaf, Wilmar, Boonstra, Jurjen J, Voogd, Fia J, Roomer, Robert, de Ridder, Rogier J J, Kievit, Wietske, Siersema, Peter D, Didden, Paul, van Geenen, Erwin J M, and Dutch EMR Study Group

Published
2021

30. Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease

Author

Arts-assistenten Kinderen, MS MDL 1, Infection & Immunity, Cancer, Mahmmod, Shaden, Schultheiss, Johannes P D, van Bodegraven, Ad A, Dijkstra, Gerard, Gilissen, Lennard P L, Hoentjen, Frank, Lutgens, Maurice W M D, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Smits, Lisa J T, Tan, Adriaan C I T L, Oldenburg, Bas, Fidder, Herma H, Arts-assistenten Kinderen, MS MDL 1, Infection & Immunity, Cancer, Mahmmod, Shaden, Schultheiss, Johannes P D, van Bodegraven, Ad A, Dijkstra, Gerard, Gilissen, Lennard P L, Hoentjen, Frank, Lutgens, Maurice W M D, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Smits, Lisa J T, Tan, Adriaan C I T L, Oldenburg, Bas, and Fidder, Herma H

Published
2021

33. Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis

Author

Bakker, Olaf J., van Brunschot, Sandra, van Santvoort, Hjalmar C., Besselink, Marc G., Bollen, Thomas L., Boermeester, Marja A., Dejong, Cornelis H., van Goor, Harry, Bosscha, Koop, Ali, Usama Ahmed, Bouwense, Stefan, van Grevenstein, Wilhelmina M., Heisterkamp, Joos, Houdijk, Alexander P., Jansen, Jeroen M., Karsten, Thom M., Manusama, Eric R., Nieuwenhuijs, Vincent B., Schaapherder, Alexander F., van der Schelling, George P., Schwartz, Matthijs P., Spanier, Marcel B.W., Tan, Adriaan, Vecht, Juda, Weusten, Bas L., Witteman, Ben J., Akkermans, Louis M., Bruno, Marco J., Dijkgraaf, Marcel G., van Ramshorst, Bert, and Gooszen, Hein G.

Published
2014
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35. Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients with Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial: The ESCAPE Randomized Clinical Trial

Author

Issa, Yama, Kempeneers, Marinus A., Bruno, Marco J., Fockens, Paul, Poley, Jan-Werner, Ahmed Ali, Usama, Bollen, Thomas L., Busch, Olivier R., Dejong, Cees H., van Duijvendijk, Peter, van Dullemen, Hendrik M., van Eijck, Casper H., van Goor, Harry, Hadithi, Muhammed, Haveman, Jan-Willem, Keulemans, Yolande, Nieuwenhuijs, Vincent B., Poen, Alexander C., Rauws, Erik A., Tan, Adriaan C., Thijs, Willem, Timmer, Robin, Witteman, Ben J., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., Dijkgraaf, Marcel G., Boermeester, Marja A., AII - Inflammatory diseases, AII - Infectious diseases, Graduate School, Gastroenterology and Hepatology, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, Surgery, AGEM - Endocrinology, metabolism and nutrition, Epidemiology and Data Science, APH - Methodology, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Organ Transplantation (GIOT), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
DUODENUM-PRESERVING RESECTION, SURGICAL DRAINAGE, MANAGEMENT, DUCT, HEAD, GUIDELINES, DIAGNOSIS, THERAPY
Abstract

Importance: For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could mitigate disease progression, providing better pain control and preserving pancreatic function. Objective: To determine whether early surgery is more effective than the endoscopy-first approach in terms of clinical outcomes. Design, Setting, and Participants: The ESCAPE trial was an unblinded, multicenter, randomized clinical superiority trial involving 30 Dutch hospitals participating in the Dutch Pancreatitis Study Group. From April 2011 until September 2016, a total of 88 patients with chronic pancreatitis, a dilated main pancreatic duct, and who only recently started using prescribed opioids for severe pain (strong opioids for ≤2 months or weak opioids for ≤6 months) were included. The 18-month follow-up period ended in March 2018. Interventions: There were 44 patients randomized to the early surgery group who underwent pancreatic drainage surgery within 6 weeks after randomization and 44 patients randomized to the endoscopy-first approach group who underwent medical treatment, endoscopy including lithotripsy if needed, and surgery if needed. Main Outcomes and Measures: The primary outcome was pain, measured on the Izbicki pain score and integrated over 18 months (range, 0-100 [increasing score indicates more pain severity]). Secondary outcomes were pain relief at the end of follow-up; number of interventions, complications, hospital admissions; pancreatic function; quality of life (measured on the 36-Item Short Form Health Survey [SF-36]); and mortality. Results: Among 88 patients who were randomized (mean age, 52 years; 21 (24%) women), 85 (97%) completed the trial. During 18 months of follow-up, patients in the early surgery group had a lower Izbicki pain score than patients in the group randomized to receive the endoscopy-first approach group (37 vs 49; between-group difference, -12 points [95% CI, -22 to -2]; P =.02). Complete or partial pain relief at end of follow-up was achieved in 23 of 40 patients (58%) in the early surgery vs 16 of 41 (39%)in the endoscopy-first approach group (P =.10). The total number of interventions was lower in the early surgery group (median, 1 vs 3; P

Published
2020

36. Risk factors and clinical outcomes of endoscopic dilation in benign esophageal strictures: a long-term follow-up study

Author

MS MDL 1, Cancer, Vermeulen, Bram D., de Zwart, Merle, Sijben, Jasmijn, Soons, Elsa, van der Weerd, Lucie, Arese, Daniele, von den Hoff, Daan W., Craviotto, Vincenzo, Tan, Adriaan C.I.T.L., Groenen, Marcel J.M., Bogte, Auke, Repici, Alessandro, Spaander, Manon C.W., Siersema, Peter D., MS MDL 1, Cancer, Vermeulen, Bram D., de Zwart, Merle, Sijben, Jasmijn, Soons, Elsa, van der Weerd, Lucie, Arese, Daniele, von den Hoff, Daan W., Craviotto, Vincenzo, Tan, Adriaan C.I.T.L., Groenen, Marcel J.M., Bogte, Auke, Repici, Alessandro, Spaander, Manon C.W., and Siersema, Peter D.

Published
2020

37. Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease

Author

Mahmmod, Shaden, primary, Schultheiss, Johannes P D, additional, van Bodegraven, Ad A, additional, Dijkstra, Gerard, additional, Gilissen, Lennard P L, additional, Hoentjen, Frank, additional, Lutgens, Maurice W M D, additional, Mahmmod, Nofel, additional, van der Meulen–de Jong, Andrea E, additional, Smits, Lisa J T, additional, Tan, Adriaan C I T L, additional, Oldenburg, Bas, additional, and Fidder, Herma H, additional

Published
2021
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39. 607 DEVELOPMENT OF PANCREATIC DISEASES DURING LONG-TERM FOLLOW-UP OF PATIENTS WITH ACUTE PANCREATITIS IN A PROSPECTIVE NATIONWIDE MULTICENTER COHORT

Author

de Rijk, Florence E., Sissingh, Noor J., Boel, Thomas T., Timmerhuis, Hester C., de Jong, Mike J., Pauw, Hannah A., van Veldhuisen, Charlotte L., Hallensleben, Nora D., Anten, Marie-Paule, Brink, Menno A., Curvers, Wouter, van Duijvendijk, Peter, Hazen, Wouter L., Kuiken, Sjoerd D., Poen, A.C., Quispel, Rutger, Römkens, Tessa E., Spanier, B.W. Marcel, Tan, Adriaan C., Vleggaar, Frank P., Voorburg, Annet, Witteman, Ben, Ali, U Ahmed, Issa, Yama, Bouwense, Stefan A., Voermans, Rogier P., Van Geenen, Erwin-Jan M., Van Hooft, Jeanin E., De Jonge, P.J.F., van Goor, Harry, Boermeester, Marja A., Besselink, Marc G., Bruno, Marco J., Verdonk, Robert C., and Van Santvoort, Hjalmar C.

Published
2023
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43. Pain patterns in chronic pancreatitis: a nationwide longitudinal cohort study

Author

Kempeneers, Marinus A, primary, Issa, Yama, additional, Verdonk, Robert C, additional, Bruno, Marco, additional, Fockens, P, additional, van Goor, Harry, additional, Alofs, Eline, additional, Bollen, Thomas L, additional, Bouwense, Stefan, additional, van Dalen, Anne S H M, additional, van Dieren, Susan, additional, van Dullemen, Hendrik M, additional, van Geenen, Erwin-Jan, additional, Hoge, Chantal, additional, van Hooft, Jeanin E, additional, Kager, Liesbeth M, additional, Keulemans, Yolande, additional, Nooijen, Lynn E, additional, Poley, Jan-Werner, additional, Seerden, Tom C J, additional, Tan, Adriaan, additional, Thijs, Willem, additional, Timmer, Robin, additional, Vleggaar, Frank, additional, Witteman, Ben, additional, Ahmed Ali, Usama, additional, Besselink, Marc G, additional, Boermeester, Marja A, additional, and van Santvoort, Hjalmar C, additional

Published
2020
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44. Clinical Outcomes of Covid-19 in Patients With Inflammatory Bowel Disease: A Nationwide Cohort Study

Author

Derikx, Lauranne A A P, primary, Lantinga, Marten A, additional, de Jong, Dirk J, additional, van Dop, Willemijn A, additional, Creemers, Rob H, additional, Römkens, Tessa E H, additional, Jansen, Jeroen M, additional, Mahmmod, Nofel, additional, West, Rachel L, additional, Tan, Adriaan C I T L, additional, Bodelier, Alexander G L, additional, Gorter, Moniek H P, additional, Boekema, Paul J, additional, Halet, Eric R C, additional, Horjus, Carmen S, additional, van Dijk, Maarten A, additional, Hirdes, Meike M C, additional, Epping Stippel, Ludger S M, additional, Jharap, Bindia, additional, Lutgens, Maurice W M D, additional, Russel, Maurice G, additional, Gilissen, Lennard P L, additional, Nauta, Sjoukje, additional, van Bodegraven, Adriaan A, additional, and Hoentjen, Frank, additional

Published
2020
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45. Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS): study protocol for a nationwide prospective cohort study

Author

Umans, Devica S, primary, Timmerhuis, Hester C, additional, Hallensleben, Nora D, additional, Bouwense, Stefan A, additional, Anten, Marie-Paule GF, additional, Bhalla, Abha, additional, Bijlsma, Rina A, additional, Boermeester, Marja A, additional, Brink, Menno A, additional, Hol, Lieke, additional, Bruno, Marco J, additional, Curvers, Wouter L, additional, van Dullemen, Hendrik M, additional, van Eijck, Brechje C, additional, Erkelens, G Willemien, additional, Fockens, Paul, additional, van Geenen, Erwin J M, additional, Hazen, Wouter L, additional, Hoge, Chantal V, additional, Inderson, Akin, additional, Kager, Liesbeth M, additional, Kuiken, Sjoerd D, additional, Perk, Lars E, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, Römkens, Tessa EH, additional, van Santvoort, Hjalmar C, additional, Tan, Adriaan CITL, additional, Thijssen, Annemieke Y, additional, Venneman, Niels G, additional, Vleggaar, Frank P, additional, Voorburg, Annet MCJ, additional, van Wanrooij, Roy LJ, additional, Witteman, Ben J, additional, Verdonk, Robert C, additional, Besselink, Marc G, additional, and van Hooft, Jeanin E, additional

Published
2020
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46. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial

Author

Schepers, Nicolien J, primary, Hallensleben, Nora D L, additional, Besselink, Marc G, additional, Anten, Marie-Paule G F, additional, Bollen, Thomas L, additional, da Costa, David W, additional, van Delft, Foke, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, Dijkgraaf, Marcel G W, additional, van Eijck, Casper H J, additional, Erkelens, G Willemien, additional, Erler, Nicole S, additional, Fockens, Paul, additional, van Geenen, Erwin J M, additional, van Grinsven, Janneke, additional, Hollemans, Robbert A, additional, van Hooft, Jeanin E, additional, van der Hulst, Rene W M, additional, Jansen, Jeroen M, additional, Kubben, Frank J G M, additional, Kuiken, Sjoerd D, additional, Laheij, Robert J F, additional, Quispel, Rutger, additional, de Ridder, Rogier J J, additional, Rijk, Marno C M, additional, Römkens, Tessa E H, additional, Ruigrok, Carola H M, additional, Schoon, Erik J, additional, Schwartz, Matthijs P, additional, Smeets, Xavier J N M, additional, Spanier, B W Marcel, additional, Tan, Adriaan C I T L, additional, Thijs, Willem J, additional, Timmer, Robin, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, Vleggaar, Frank P, additional, van de Vrie, Wim, additional, Witteman, Ben J, additional, van Santvoort, Hjalmar C, additional, Bakker, Olaf J, additional, and Bruno, Marco J, additional

Published
2020
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48. Impact of multidisciplinary tumor board discussion on palliation of patients with esophageal or gastro-esophageal junction cancer: a population-based study

Author

Vermeulen, Bram D., primary, Bruggeman, Lukas, additional, Bac, Dirk J., additional, Schrauwen, Ruud W. M., additional, Epping, Ludger S. M., additional, Scheffer, Robert C. H., additional, Tan, Adriaan C. I. T. L., additional, Groenen, Marcel J. M., additional, Verhoeven, Rob H. A., additional, and Siersema, Peter D., additional

Published
2020
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