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15 results on '"Tan, Ziwen"'

3. Zanubrutinib for the treatment of MYD88 wild-type Waldenström macroglobulinemia: a substudy of the phase 3 ASPEN trial

Author

Dimopoulos, Meletios, Sanz, Ramon Garcia, Lee, Hui-Peng, Trneny, Marek, Varettoni, Marzia, Opat, Stephen, D'Sa, Shirley, Owen, Roger G., Cull, Gavin, Mulligan, Stephen, Czyz, Jaroslaw, Castillo, Jorge J., Motta, Marina, Siddiqi, Tanya, Gironella Mesa, Mercedes, Granell Gorrochategui, Miquel, Talaulikar, Dipti, Zinzani, Pier Luigi, Askari, Elham, Grosicki, Sebastian, Oriol, Albert, Rule, Simon, Kloczko, Janusz, Tedeschi, Alessandra, Buske, Christian, Leblond, Veronique, Trotman, Judith, Chan, Wai Y., Michel, Jan, Schneider, Jingjing, Tan, Ziwen, Cohen, Aileen, Huang, Jane, and Tam, Constantine S.

Published
2020
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4. Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.

Author

Miller, Michelle S., Cowan, Angus D., Brouwer, Jason M., Smyth, Sean T., Peng, Liuyu, Wardak, Ahmad Z., Uren, Rachel T., Luo, Cindy, Roy, Michael J., Shah, Sayali, Tan, Ziwen, Reid, Gavin E., Colman, Peter M., and Czabotar, Peter E.

Subjects
APOPTOSIS, MEMBRANE lipids, LIPIDS, CYTOCHROME c, ATOMIC structure, HETERODIMERS
Abstract

The B‐cell lymphoma 2 (BCL2) family members, BCL2‐associated protein X (BAX) and BCL2 homologous antagonist killer (BAK), are required for programmed cell death via the mitochondrial pathway. When cells are stressed, damaged or redundant, the balance of power between the BCL2 family of proteins shifts towards BAX and BAK, allowing their transition from an inactive, monomeric state to a membrane‐active oligomeric form that releases cytochrome c from the mitochondrial intermembrane space. That oligomeric state has an essential intermediate, a symmetric homodimer of BAX or BAK. Here we describe crystal structures of dimers of the core domain of BAX, comprising its helices α2–α5. These structures provide an atomic resolution description of the interactions that drive BAX homo‐dimerisation and insights into potential interaction between core domain dimers and membrane lipids. The previously identified BAK lipid‐interacting sites are not conserved with BAX and are likely to determine the differences between them in their interactions with lipids. We also describe structures of heterodimers of BAK/BAX core domains, yielding further insight into the differences in lipid binding between BAX and BAK. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids

Author

Miller, Michelle S., primary, Cowan, Angus D., additional, Brouwer, Jason M., additional, Smyth, Sean T., additional, Peng, Liuyu, additional, Wardak, Ahmad Z., additional, Uren, Rachel T., additional, Luo, Cindy, additional, Roy, Michael J., additional, Shah, Sayali, additional, Tan, Ziwen, additional, Reid, Gavin E., additional, Colman, Peter M., additional, and Czabotar, Peter E., additional

Published
2023
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6. Zanubrutinib monotherapy for relapsed or refractory non-germinal center diffuse large B-cell lymphoma

Author

Yang, Haiyan, primary, Xiang, Bing, additional, Song, Yuqin, additional, Zhang, Huilai, additional, Zhao, Weili, additional, Zou, Dehui, additional, Lv, Fangfang, additional, Guo, Wei, additional, Liu, Aichun, additional, Li, Caixia, additional, Tan, Ziwen, additional, Liu, Yang, additional, Fu, Lina, additional, Guo, Haiyi, additional, Novotny, William, additional, Huang, Jane, additional, and Li, Yufu, additional

Published
2022
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7. Are cause of death data for Shanghai fit for purpose? A retrospective study of medical records

Author

Chen, Lei, primary, Xia, Tian, additional, Yuan, Zheng-An, additional, Rampatige, Rasika, additional, Chen, Jun, additional, Li, Hang, additional, Adair, Timothy, additional, Yu, Hui-Ting, additional, Bratschi, Martin, additional, Setel, Philip, additional, Rajasekhar, Megha, additional, Chowdhury, H R, additional, Gamage, Saman Hattotuwa, additional, Fang, Bo, additional, Azam, Omair, additional, Santon, Romain, additional, Gu, Zhen, additional, Tan, Ziwen, additional, Wang, Chunfang, additional, Lopez, Alan D, additional, and Wu, Fan, additional

Published
2022
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8. Zanubrutinib for the treatment of patients with Waldenström macroglobulinemia: 3 years of follow-up

Author

Trotman, Judith, primary, Opat, Stephen, additional, Gottlieb, David, additional, Simpson, David, additional, Marlton, Paula, additional, Cull, Gavin, additional, Munoz, Javier, additional, Tedeschi, Alessandra, additional, Roberts, Andrew W., additional, Seymour, John F., additional, Atwal, Siminder Kaur, additional, Yu, Yiling, additional, Novotny, William, additional, Holmgren, Eric, additional, Tan, Ziwen, additional, Hilger, James D., additional, Huang, Jane, additional, and Tam, Constantine S., additional

Published
2020
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9. Zanubrutinib monotherapy for patients with relapsed or refractory non-germinal center diffuse large B-cell lymphoma: Results from a phase II, single-arm, multicenter, study.

Author

Yang, Haiyan, primary, Xiang, Bing, additional, Song, Yuqin, additional, Zhang, Huilai, additional, Zhao, Weili, additional, Zou, Dehui, additional, Lv, Fangfang, additional, Bai, Ou, additional, Liu, Aichun, additional, Li, Caixia, additional, Tan, Ziwen, additional, Wang, Weige, additional, Guo, Haiyi, additional, Novotny, William, additional, Huang, Jane E., additional, and Li, Yufu, additional

Published
2020
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10. Three-year follow-up of treatment-naïve and previously treated patients with Waldenström macroglobulinemia (WM) receiving single-agent zanubrutinib.

Author

Tam, Constantine Si Lun, primary, Opat, Stephen, additional, Marlton, Paula, additional, Gottlieb, David, additional, Simpson, David, additional, Cull, Gavin, additional, Ritchie, David, additional, Verner, Emma, additional, Munoz, Javier, additional, Tedeschi, Alessandra, additional, Huang, Jane, additional, Novotny, William, additional, Tan, Ziwen, additional, Holmgren, Eric, additional, Atwal, Siminder K., additional, Seymour, John Francis, additional, Roberts, Andrew Warwick, additional, and Trotman, Judith, additional

Published
2020
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14. Estimation of a partially linear additive model for data from an outcome-dependent sampling design with a continuous outcome.

Author

ZIWEN TAN, GUOYOU QIN, HAIBO ZHOU, Tan, Ziwen, Qin, Guoyou, and Zhou, Haibo

Subjects
SAMPLING (Process), EXPERIMENTAL design, ESTIMATION theory, LINEAR statistical models, COST effectiveness, EMPIRICAL research, PARAMETRIC modeling, POLYCHLORINATED biphenyls, CHILD development, INTELLECT, MATHEMATICAL models, RESEARCH funding, STATISTICS, THEORY, DATA analysis, PRENATAL exposure delayed effects, STANDARDS
Abstract

Outcome-dependent sampling (ODS) designs have been well recognized as a cost-effective way to enhance study efficiency in both statistical literature and biomedical and epidemiologic studies. A partially linear additive model (PLAM) is widely applied in real problems because it allows for a flexible specification of the dependence of the response on some covariates in a linear fashion and other covariates in a nonlinear non-parametric fashion. Motivated by an epidemiological study investigating the effect of prenatal polychlorinated biphenyls exposure on children's intelligence quotient (IQ) at age 7 years, we propose a PLAM in this article to investigate a more flexible non-parametric inference on the relationships among the response and covariates under the ODS scheme. We propose the estimation method and establish the asymptotic properties of the proposed estimator. Simulation studies are conducted to show the improved efficiency of the proposed ODS estimator for PLAM compared with that from a traditional simple random sampling design with the same sample size. The data of the above-mentioned study is analyzed to illustrate the proposed method. [ABSTRACT FROM AUTHOR]

Published
2016
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