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1. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, and Lewthwaite, Hayley

Published
2024
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2. The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study

Author

Knox-Brown, Ben, Patel, Jaymini, Potts, James, Ahmed, Rana, Aquart-Stewart, Althea, Barbara, Cristina, Buist, A. Sonia, Cherkaski, Hamid Hacene, Denguezli, Meriam, Elbiaze, Mohammed, Erhabor, Gregory E., Franssen, Frits M. E., Al Ghobain, Mohammed, Gislason, Thorarinn, Janson, Christer, Kocabaş, Ali, Mannino, David, Marks, Guy, Mortimer, Kevin, Nafees, Asaad Ahmed, Obaseki, Daniel, Paraguas, Stefanni Nonna M., Loh, Li Cher, Rashid, Abdul, Salvi, Sundeep, Seemungal, Terence, Studnicka, Michael, Tan, Wan C., Wouters, Emiel F. M., Abozid, Hazim, Mueller, Alexander, Burney, Peter, and Amaral, Andre F. S.

Published
2023
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3. Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

Author

Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Cherkaski, Hamid Hacene, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Chandra Das, Shyamal, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Lawin, Herve, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Tan, Wan C., Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jin-ping, Zhou, Yumin, Jogi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, SchwedaLinow, Alexandra, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jorundsdottir, Kristin, Lovisa Gudmundsdottir, Gudmundsdottir, Sigrun, Gudmundsson, Gunnar, Rao, Mahesh, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Aquart-Stewart, Althea, Aikman, Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mortimer, Kevin, Nyapigoti, Wezzie, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Loh, Li-Cher, Rashid, Abdul, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Wouters, E.F.M., Wesseling, G.J., Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Nafees, Asaad A., Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr., Sanchez, Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Barbara, Cristina, Rodrigues, Fatima, Dias, Herminia, Cardoso, Joao, Almeida, João, Matos, Maria Joao, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Al Ghobain, M., Alorainy, H., El-Hamad, E., Al Hajjaj, M., Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsony, Asma, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Akasha Ahmed Osman, Hasab Alrasoul, Moham ed Elhassan, Namarig, El Zain, Abdel Mu’is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, SpetzNystrom, Ulrike, Hagg, Gunilla, Lund, GunMarie, Seemungal, Terence, Lutchmansingh, Fallon, Conyette, Liane, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabas, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Burney, Peter G.J., Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, Buist, A. Sonia, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Abozid, Hazim, Burney, Peter, Hartl, Sylvia, Breyer-Kohansal, Robab, Al Ghobain, Mohammed, Denguezli, Meriam, Loh, Li Cher, Paraguas, Stefanni Nonna, Franssen, Frits M.E., Mannino, David, Anand, Mahesh Padukudru, Buist, Sonia, El Sony, Asma, Breyer, Marie-Kathrin, Burghuber, Otto C., Wouters, Emiel F.M., and Amaral, Andre F.S.

Published
2024
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5. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study

Author

FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Bourbeau, Jean, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candace, Krishnan, Suurya, Tan, Wan C., Farias, Raquel, and Aaron, Shawn D.

Published
2023
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7. Impaired Sleep Quality in COPD Is Associated With Exacerbations The CanCOLD Cohort Study

Author

Shorofsky, Matthew, Bourbeau, Jean, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Tan, Wan C, Aaron, Shawn D, Sin, Don D, Road, Jeremy, Chapman, Kenneth R, O’Donnell, Denis E, Maltais, François, Hernandez, Paul, Walker, Brandie L, Marciniuk, Darcy, Kaminska, Marta, FitzGerald, J Mark, Sin, DD, Marciniuk, DD, O'Donnell, DE, Cowie, Robert, Aaron, Shawn, Maltais, F, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C, Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, and Clemens, Ron

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Sleep Research, Lung, Behavioral and Social Science, Clinical Research, Chronic Obstructive Pulmonary Disease, Respiratory, Aged, Cohort Studies, Disease Progression, Dyspnea, Female, Health Services, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Sleep, Sleep Wake Disorders, Sputum, Time Factors, acute exacerbation of chronic bronchitis, COPD, sleep medicine, Canadian Respiratory Research Network, CanCOLD Collaborative Research group, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundCOPD increases susceptibility to sleep disturbances, which may in turn predispose to increased respiratory symptoms. The objective of this study was to evaluate, in a population-based sample, the relationship between subjective sleep quality and risk of COPD exacerbations.MethodsData were obtained from the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Participants with COPD who had completed 18 months of follow-up were included. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a three-factor analysis. Symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) exacerbations were assessed. Association of PSQI with exacerbation rate was assessed by using negative binomial regression. Exacerbation-free survival was also assessed.ResultsA total of 480 participants with COPD were studied, including 185 with one or more exacerbations during follow-up and 203 with poor baseline sleep quality (PSQI score > 5). Participants with subsequent symptom-based exacerbations had higher median baseline PSQI scores than those without (6.0 [interquartile range, 3.0-8.0] vs 5.0 [interquartile range, 2.0-7.0]; P = .01), and they were more likely to have baseline PSQI scores > 5 (50.3% vs 37.3%; P = .01). Higher PSQI scores were associated with increased symptom-based exacerbation risk (adjusted rate ratio, 1.09; 95% CI, 1.01-1.18; P = .02) and event-based exacerbation risk (adjusted rate ratio, 1.10; 95% CI, 1.00-1.21; P = .048). The association occurred mainly in those with undiagnosed COPD. Strongest associations were with Factor 3 (sleep disturbances and daytime dysfunction). Time to symptom-based exacerbation was shorter in participants with poor sleep quality (adjusted hazard ratio, 1.49; 95% CI, 1.09-2.03).ConclusionsHigher baseline PSQI scores were associated with increased risk of COPD exacerbation over 18 months' prospective follow-up.

Published
2019

8. Small airways obstruction and its risk factors in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

Author

Knox-Brown, Ben, Patel, Jaymini, Potts, James, Ahmed, Rana, Aquart-Stewart, Althea, Cherkaski, Hamid Hacene, Denguezli, Meriam, Elbiaze, Mohammed, Elsony, Asma, Franssen, Frits M E, Ghobain, Mohammed Al, Harrabi, Imed, Janson, Christer, Jõgi, Rain, Juvekar, Sanjay, Lawin, Herve, Mannino, David, Mortimer, Kevin, Nafees, Asaad Ahmed, Nielsen, Rune, Obaseki, Daniel, Paraguas, Stefanni Nonna M, Rashid, Abdul, Loh, Li-Cher, Salvi, Sundeep, Seemungal, Terence, Studnicka, Michael, Tan, Wan C, Wouters, Emiel E F M, Barbara, Cristina, Gislason, Thorarinn, Gunasekera, Kirthi, Burney, Peter, and Amaral, Andre F S

Published
2023
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11. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation.

Author

Ekström, Magnus, Li, Pei Zhi, Lewthwaite, Hayley, Bourbeau, Jean, Tan, Wan C., and Jensen, Dennis

Subjects
TREADMILL exercise, DYSPNEA, EXERCISE tests, AIR flow, SYMPTOM burden, OBSTRUCTIVE lung diseases, SYMPTOMS
Abstract

Exertional breathlessness is a cardinal symptom of cardiorespiratory disease. How does breathlessness abnormality, graded using normative reference equations during cardiopulmonary exercise testing (CPET), relate to self-reported and physiologic responses in people with chronic airflow limitation (CAL)? An analysis was done of people aged ≥ 40 years with CAL undergoing CPET in the Canadian Cohort Obstructive Lung Disease study. Breathlessness intensity ratings (Borg CR10 scale [0-10 category-ratio scale for breathlessness intensity rating]) were evaluated in relation to power output, rate of oxygen uptake, and minute ventilation at peak exercise, using normative reference equations as follows: (1) probability of breathlessness normality (probability of having an equal or greater Borg CR10 rating among healthy people; lower probability reflecting more severe breathlessness) and (2) presence of abnormal breathlessness (rating above the upper limit of normal). Associations with relevant participant-reported and physiologic outcomes were evaluated. We included 330 participants (44% women): mean ± SD age, 64 ± 10 years (range, 40–89 years); FEV 1 /FVC, 57.3% ± 8.2%; FEV 1 , 75.6% ± 17.9% predicted. Abnormally low exercise capacity (peak rate of oxygen uptake < lower limit of normal) was present in 26%. Relative to peak power output, rate of oxygen uptake, and minute ventilation, abnormally high breathlessness was present in 26%, 25%, and 18% of participants. For all equations, abnormally high exertional breathlessness was associated with worse lung function, exercise capacity, self-reported symptom burden, physical activity, and health-related quality of life; and greater physiologic abnormalities during CPET. Abnormal breathlessness graded using CPET normative reference equations was associated with worse clinical, physiological, and functional outcomes in people with CAL, supporting construct validity of abnormal exertional breathlessness. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Airway tree caliber heterogeneity and airflow obstruction among older adults

Author

Vameghestahbanati, Motahareh, primary, Kingdom, Leina, additional, Hoffman, Eric A., additional, Kirby, Miranda, additional, Allen, Norrina B., additional, Angelini, Elsa, additional, Bertoni, Alain, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Jacobs, David R., additional, Laine, Andrew, additional, Maltais, François, additional, Michos, Erin D., additional, Sack, Coralynn, additional, Sin, Don, additional, Watson, Karol E., additional, Wysoczanksi, Artur, additional, Couper, David, additional, Cooper, Christopher, additional, Han, MeiLan, additional, Woodruff, Prescott, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Barr, R. Graham, additional, and Smith, Benjamin M., additional

Published
2024
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14. Physiological Characterization of Preserved Ratio Impaired Spirometry in the CanCOLD Study: Implications for Exertional Dyspnea and Exercise Intolerance

Author

Phillips, Devin B, primary, James, Matthew D., additional, Vincent, Sandra G, additional, Elbehairy, Amany F, additional, Neder, J Alberto, additional, Kirby, Miranda, additional, Ora, Josuel, additional, Day, Andrew G, additional, Tan, Wan C, additional, Bourbeau, Jean, additional, and O'Donnell, Denis E., additional

Published
2024
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15. Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing

Author

Ekström, Magnus, primary, Li, Pei Zhi, additional, Lewthwaite, Hayley, additional, Bourbeau, Jean, additional, Tan, Wan C., additional, Schiöler, Linus, additional, Brotto, Andrew, additional, Stickland, Michael K., additional, Jensen, Dennis, additional, FitzGerald, J. Mark, additional, Sin, Don D., additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Aaron, Shawn, additional, Maltais, François, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Doiron, Dany, additional, Mancino, Palmina, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Benedetti, Andrea, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2024
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16. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Junior, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Shorofsky, Matthew, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Aaron, Shawn D., Sin, Don D., O’Donnell, Denis E., Maltais, François, Walker, Brandie L., and Kaminska, Marta

Published
2019
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17. Overdiagnosis of COPD in Subjects With Unobstructed Spirometry: A BOLD Analysis

Author

Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jingping, Zhou, Yumin, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Sator, Lea, Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Tan, Wan C., Wang, Wen, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Francisco, Norberto A., Garcia, Gerard S., de Guia, Teresita S., Idolor, Luisito F., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr., Sanchez, Ma. Flordeliza, Simpao, Leander P., Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Burney, Peter G.J., Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Wouters, E.F.M., Wesseling, G.J., Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Jõgi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr., Reyes, Maria Teresita N., Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Horner, Andreas, Kaiser, Bernhard, McBurnie, Mary Ann, Buist, A. Sonia, Gnatiuc, Luisa, Bateman, Eric D., and Burney, Peter

Published
2019
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19. Dysanapsis is not associated with exertional dyspnoea in healthy male and female never-smokers aged 40 years and older.

Author

Molgat-Seon, Yannick, Sawatzky, Mathieu A.T., Dominelli, Paolo B., Kirby, Miranda, Guenette, Jordan A., Bourbeau, Jean, Tan, Wan C., and Sheel, A. William

Subjects
LUNG physiology, RESPIRATORY organ anatomy, EXERCISE tests, NON-smokers, LUNGS, LUNG diseases, CARDIOPULMONARY system, RESPIRATORY measurements, TRACHEA, DYSPNEA, SEX distribution, OBSTRUCTIVE lung diseases, DESCRIPTIVE statistics, PULMONARY function tests, BRONCHI, RESEARCH funding, COMPUTED tomography, ADULTS, OLD age
Abstract

In healthy adults, airway-to-lung (i.e., dysanapsis) ratio is lower and dyspnoea during exercise at a given minute ventilation (V̇E) is higher in females than in males. We investigated the relationship between dysanapsis and sex on exertional dyspnoea in healthy adults. We hypothesized that females would have a smaller airway-to-lung ratio than males and that exertional dyspnoea would be associated with airway-to-lung ratio in males and females. We analyzed data from n = 100 healthy never-smokers aged ≥40 years enrolled in the Canadian Cohort Obstructive Lung Disease (CanCOLD) study who underwent pulmonary function testing, a chest computed tomography scan, and cardiopulmonary exercise testing. The luminal area of the trachea, right main bronchus, left main bronchus, right upper lobe, bronchus intermedius, left upper lobe, and left lower lobe were 22%–37% smaller (all p < 0.001) and the airway-to-lung ratio (i.e., average large conducting airway diameter relative to total lung capacity) was lower in females than in males (0.609 ± 0.070 vs. 0.674 ± 0.082; p < 0.001). During exercise, there was a significant effect of V̇E, sex, and their interaction on dyspnoea (all p < 0.05), indicating that dyspnoea increased as a function of V̇E to a greater extent in females than in males. However, after adjusting for age and total lung capacity, there were no significant associations between airway-to-lung ratio and measures of exertional dyspnoea, regardless of sex (all r < 0.34; all p > 0.05). Our findings suggest that sex differences in airway size do not contribute to sex differences in exertional dyspnoea. [ABSTRACT FROM AUTHOR]

Published
2024
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23. The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency

Author

Cressman, Sonya, Peacock, Stuart J., Tammemägi, Martin C., Evans, William K., Leighl, Natasha B., Goffin, John R., Tremblay, Alain, Liu, Geoffrey, Manos, Daria, MacEachern, Paul, Bhatia, Rick, Puksa, Serge, Nicholas, Garth, McWilliams, Annette, Mayo, John R., Yee, John, English, John C., Pataky, Reka, McPherson, Emily, Atkar-Khattra, Sukhinder, Johnston, Michael R., Schmidt, Heidi, Shepherd, Frances A., Soghrati, Kam, Amjadi, Kayvan, Burrowes, Paul, Couture, Christian, Sekhon, Harmanjatinder S., Yasufuku, Kazuhiro, Goss, Glenwood, Ionescu, Diana N., Hwang, David M., Martel, Simon, Sin, Don D., Tan, Wan C., Urbanski, Stefan, Xu, Zhaolin, Tsao, Ming-Sound, and Lam, Stephen

Published
2017
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25. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Haynes, Nancy, Chuang, Junior, Zheng, Liyun, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Gupta, Nisha, Pinto, Lancelot, Li, Pei Zhi, Aaron, Shawn D., Marciniuk, Darcy D., Maltais, François, O'Donnell, Denis E., and Walker, Brandie L.

Published
2016
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26. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease

Author

Krishnan, Suurya, primary, Tan, Wan C., additional, Farias, Raquel, additional, Aaron, Shawn D., additional, Benedetti, Andrea, additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Sin, Don D., additional, Walker, Brandie, additional, Bourbeau, Jean, additional, FitzGerald, J. Mark, additional, Aaron, Shawn, additional, Doiron, Dany, additional, Mancino, Palmina, additional, Li, Pei Zhi, additional, Jensen, Dennis, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Sin, Don, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Song, Zhi, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, O’Donnell, Denis, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candace, additional

Published
2023
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28. Physical Activity and Symptom Burden in COPD: The Canadian Obstructive Lung Disease Study

Author

Oostrik, Loes, primary, Bourbeau, Jean, additional, Doiron, Dany, additional, Ross, Bryan, additional, Zhi-Li, Pei, additional, Aaron, Shawn D., additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis, additional, Tan, Wan C., additional, Sin, Don D., additional, Walker, Brandie, additional, and Janaudis-Ferreira, Tania, additional

Published
2023
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29. Factors Associated with Attrition in a Longitudinal Cohort of Older Adults in the Community

Author

Katsuno, Noah, primary, Li, Pei Z., additional, Bourbeau, Jean, additional, Aaron, Shawn, additional, Maltais, Francois, additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Marciniuk, Darcy D., additional, ODonnell, Denis D., additional, Sin, Don D., additional, Hogg, James C., additional, Cheng, Michael, additional, Road, Jeremy, additional, and Tan, Wan C., additional

Published
2023
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30. Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada

Author

Cressman, Sonya, Lam, Stephen, Tammemagi, Martin C., Evans, William K., Leighl, Natasha B., Regier, Dean A., Bolbocean, Corneliu, Shepherd, Frances A., Tsao, Ming-Sound, Manos, Daria, Liu, Geoffrey, Atkar-Khattra, Sukhinder, Cromwell, Ian, Johnston, Michael R., Mayo, John R., McWilliams, Annette, Couture, Christian, English, John C., Goffin, John, Hwang, David M., Puksa, Serge, Roberts, Heidi, Tremblay, Alain, MacEachern, Paul, Burrowes, Paul, Bhatia, Rick, Finley, Richard J., Goss, Glenwood D., Nicholas, Garth, Seely, Jean M., Sekhon, Harmanjatinder S., Yee, John, Amjadi, Kayvan, Cutz, Jean-Claude, Ionescu, Diana N., Yasufuku, Kazuhiro, Martel, Simon, Soghrati, Kamyar, Sin, Don D., Tan, Wan C., Urbanski, Stefan, Xu, Zhaolin, and Peacock, Stuart J.

Published
2014
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31. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study

Author

Bourbeau, Jean, primary, Doiron, Dany, additional, Biswas, Sharmistha, additional, Smith, Benjamin M., additional, Benedetti, Andrea, additional, Brook, Jeffrey R., additional, Aaron, Shawn D., additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis, additional, Sin, Don D., additional, Walker, Brandie, additional, Dsilva, Liesel, additional, Nadeau, Gilbert, additional, Coats, Valérie, additional, Compton, Chris, additional, Miller, Bruce E., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, FitzGerald, J. Mark, additional, O’Donnell, Denis E., additional, Aaron, Shawn, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Mancino, Palmina, additional, Li, Pei Zhi, additional, Jensen, Dennis, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Kirby, Miranda, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonté, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, Vincent, Sandra, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2022
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36. Quantitative CT Lung Imaging and Machine Learning Improves Prediction of Emergency Room Visits and Hospitalizations in COPD.

Author

Moslemi, Amir, Makimoto, Kalysta, Tan, Wan C., Bourbeau, Jean, Hogg, James C., Coxson, Harvey O., and Kirby, Miranda

Abstract

Predicting increased risk of future healthcare utilization in chronic obstructive pulmonary disease (COPD) patients is an important goal for improving patient management. Our objective was to determine the importance of computed tomography (CT) lung imaging measurements relative to other demographic and clinical measurements for predicting future health services use with machine learning in COPD. In this retrospective study, lung function measurements and chest CT images were acquired from Canadian Cohort of Obstructive Lung Disease study participants from 2010 to 2017 (https://clinicaltrials.gov , NCT00920348). Up to two follow-up visits (1.5- and 3-year follow-up) were performed and participants were asked for details related to healthcare utilization. Healthcare utilization was defined as any COPD hospitalization or emergency room visit due to respiratory problems in the 12 months prior to the follow-up visits. CT analysis was performed (VIDA Diagnostics Inc.); a total of 108 CT quantitative emphysema, airway and vascular measurements were investigated. A hybrid feature selection method with support vector machine classifier was used to predict healthcare utilization. Performance was determined using accuracy, F1-measure and area under the receiver operating characteristic curve (AUC) and Matthews's correlation coefficient (MC). Of the 527 COPD participants evaluated, 179 (35%) used healthcare services at follow-up. There were no significant differences between the participants with or without healthcare utilization at follow-up for age (p = 0.50), sex (p = 0.44), BMI (p = 0.05) or pack-years (p = 0.76). The accuracy for predicting subsequent healthcare utilization was 80% ± 3% (F1-measure = 74%, AUC = 0.80, MC = 0.6) when all measurements were considered, 76% ± 6% (F1-measure = 72%, AUC = 0.77, MC = 0.55) for CT measurements alone and 65% ± 5% (F1-measure = 60%, AUC = 0.67, MC = 0.34) for demographic and lung function measurements alone. The combination of CT lung imaging and conventional measurements leads to greater prediction accuracy of subsequent health services use than conventional measurements alone, and may provide needed prognostic information for patients suffering from COPD. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study

Author

Phillips, Devin B., primary, Elbehairy, Amany F., additional, James, Matthew D., additional, Vincent, Sandra G., additional, Milne, Kathryn M., additional, de-Torres, Juan P., additional, Neder, J. Alberto, additional, Kirby, Miranda, additional, Jensen, Dennis, additional, Stickland, Michael K., additional, Guenette, Jordan A., additional, Smith, Benjamin M., additional, Aaron, Shawn D., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, O’Donnell, Denis E., additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hogg, James C., additional, Hamid, Qutayba, additional, Doiron, Dany, additional, Mancino, Palmina, additional, Li, Pei-Zhi, additional, Song, Zhi, additional, Fortier, Yvan, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Duke, Jane, additional, Gershon, Andrea S., additional, Toh, Teresa, additional, Sadatsafavi, Mohsen, additional, Sin, Don, additional, Fitzgerald, J. Mark, additional, Road, Jeremy, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Cheng, Michael, additional, Fung, Cynthia, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Choi, Rena, additional, Comeau, Joe, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Walker, Brandie, additional, Dumonceaux, Curtis, additional, Hernandez, Paul, additional, Fulton, Scott, additional, Vandemheen, Kathy, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Maltais, Francois, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, and Baran, Janet, additional

Published
2022
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43. The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD

Author

Xu, Feng, primary, Vasilescu, Dragoş M., additional, Kinose, Daisuke, additional, Tanabe, Naoya, additional, Ng, Kevin W., additional, Coxson, Harvey O., additional, Cooper, Joel D., additional, Hackett, Tillie-Louise, additional, Verleden, Stijn E., additional, Vanaudenaerde, Bart M., additional, Stevenson, Christopher S., additional, Lenburg, Marc E., additional, Spira, Avrum, additional, Tan, Wan C., additional, Sin, Don D., additional, Ng, Raymond T., additional, and Hogg, James C., additional

Published
2021
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44. Dysanapsis and the Spirometric Response to Inhaled Bronchodilators

Author

Vameghestahbanati, Motahareh, primary, Kirby, Miranda, additional, Maltais, François, additional, Jensen, Dennis, additional, Doiron, Dany, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Smith, Benjamin M., additional, Lacasse, Yves, additional, O’Donnell, Denis, additional, Cowie, Robert, additional, Chapman, Kenneth, additional, Goldstein, Roger, additional, Marciniuk, Darcy, additional, Shawn, Aaron, additional, Benedetti, Andrea, additional, Hernandez, Paul, additional, Fitzgerald, Mark, additional, To, Teresa, additional, Perrault, Hélène, additional, Taivassalo, Tanja, additional, Sheel, William, additional, Pare, Peter, additional, and C. Hogg, James, additional

Published
2021
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45. Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: results from a population-based study

Author

Tan, W C, Bourbeau, J, Hernandez, P, Chapman, K R, Cowie, R, FitzGerald, J M, Marciniuk, D D, Maltais, F, Buist, A S, OʼDonnell, D E, Sin, D D, Aaron, S D, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C, Bourbeau, Jean, Tan, Wan C, Jabet, Carole, Sedona, Maria, Mancino, Palmina, Fortier, Yvan, Sin, Don, Li, Yuexin, Tam, Sheena, Comeau, Joe, Ng, Adrian, Coxson, Harvey, Candido, Tara, Leipsic, Jonathon, Hague, Cameron, Road, Jeremy, Benedetti, Andrea, Mara, Carlo, Savafi, Mohsen, Gershon, Andrea, To, Teresa, Tan, Wan C, Coxson, Harvey, Bourbeau, Jean, Pei, Zhi L, Jensen, Denis, O’Donnell, Denis, Tan, Wan C, Lo, Christine, Min, Jeong, Moy, Carly, Lau, Anna La, Sran, Ashleigh, Swanson, Ebony, Yuan, Ying, Chen, Daniel, Zheng, Lu, Yang, Tina, Chuang, Junior, Guo, Best, Li, Licong, Chan, Kendall, Khanam, Rahmath, Maslennikova, Daria, Cheng, Sarah, Peng, Catherine, Chiang, Bryan, Guo, Sarah, Payne, Kyrsten, Bourbeau, Jean, Mancino, Palmina, Sedona, Maria, Darauay, Carmen, Costa, Myriam, Chapman, Kenneth, McClean, Patricia, Sporn, Heather, Cowie, Robert, Cowie, Ann, Dumonceaux, Curtis, Moore, Jessica, Hernandez, Paul, Fulton, Scott, Yorke, Maria, Fiorotos, Natalie, Rowe, Ashley, Aaron, Shawn, Vandemheen, Kathy, Pratt, Gay, Srighanthan, Jeevitha, O’Donnell, Denis, Webb, Kathy, Amornputtisathaporn, Naparat, Cheung, Kate, Whelan, Kate, Cheng, Jenny, Maltais, Francois, Couture, Joanie, Garcia Pereira, Luciana, Breton, Marie-Josée, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, and Baran, Janet

Published
2014
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46. Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study

Author

Ratanachina, Jate, Amaral, Andre F.S., De Matteis, Sara, Lawin, Herve, Mortimer, Kevin, Obaseki, Daniel O., Harrabi, Imed, Denguezli, Meriam, Wouters, Emiel F.M., Janson, Christer, Nielsen, Rune, Gulsvik, Amund, Cherkaski, Hamid Hacene, Mejza, Filip, Mahesh, Padukudru Anand, Elsony, Asma, Ahmed, Rana, Tan, Wan C., Loh, Li Cher, Rashid, Abdul, Studnicka, Michael, Nafees, Asaad A., Seemungal, Terence, Aquart-Stewart, Althea, Al Ghobain, Mohammed, Zheng, Jinping, Juvekar, Sanjay, Salvi, Sundeep, Jogi, Rain, Mannino, David M., Gislason, Thorarinn, Buist, A. Sonia, Cullinan, Paul, Burney, Peter G.J., Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, NN, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Das, Shyamal Chandra, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zhou, Yumin, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Brashier, Sundeep Bill, Londhe, Jyoti, Madas, Sapna, Aikman, Althea Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Franssen, F.F.E., Wesseling, G.J., Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Endresen, Tina, Svendsen, Lene Løvendahl, Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Sanchez, Ma. Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Alorainy, H., El-Hamad, E., Al Hajjaj, Hajjaj, Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Osman, Hasab Alrasoul Akasha Ahmed, ed Elhassan, Namarig Moham, El Zain, Abdel Mu'is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Kamal, Rashid, Eltigani, Hind, Umar, Stephen's, Abdeen, Aya, Osman, Mihad, Mohamed, Malaz, Eltayeb, Roa, Abelazeez, Mohamed, Altaher, Hoyam, Mohamed, Lina, Abdarahman, Rabee, Mohamed, Rayan, Haram, NN, Ismaeel, Rimaz, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Lutchmansingh, Fallon, Conyette, Liane, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, and RS: NUTRIM - R3 - Respiratory & Age-related Health

Subjects
Pulmonary and Respiratory Medicine, Arbetsmedicin och miljömedicin, Respiratory Medicine and Allergy, Occupational Health and Environmental Health, Lungmedicin och allergi
Abstract

BackgroundChronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.MethodsWe analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)/FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income.ResultsOverall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19–1.94), wheeze (OR 1.37, 95% CI 1.16–1.63) and dyspnoea (OR 1.83, 95% CI 1.53–2.20), but not lower FVC (β=0.02 L, 95% CI −0.02–0.06 L) or lower FEV1/FVC (β=0.04%, 95% CI −0.49–0.58%). Some findings differed by sex and gross national income.ConclusionAt a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.

Published
2022

50. Factors Associated With Nonreceipt of Recommended COPD Medications

Author

Gershon, Andrea S., primary, Pequeno, Priscila, additional, Alberga Machado, Amanda, additional, Aaron, Shawn D., additional, Kendzerska, Tetyana, additional, Luo, Jin, additional, Stanbrook, Matthew B., additional, Tan, Wan C., additional, Porter, Joan, additional, and To, Teresa, additional

Published
2021
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