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Haemangioma of the retroperitoneal space is a rare benign capillary malformation, which can grow significantly in pregnancy due to the multiple associated cardiovascular changes. We herein describe the case of a pregnant woman with an extensive right retroperitoneal haemangioma extending from the level of the renal hilum, across the lateral anterior abdominal wall and into the thigh. We also highlight the challenges faced in the management of the patient's delivery process. To the best of our knowledge, this is the first case of such nature and severity described in the English literature. [ABSTRACT FROM AUTHOR]

Three cases with age-related cerebral small vessel disease and normal pressure hydrocephalus in the Department of Neurology of Sun Yat-sen University were retrospectively reviewed. All the patients exhibited gait disturbance, cognitive impairment and urinary incontinence. Meanwhile, the Craniocerebral imaging demonstrated cerebral small vessel disease and communicating hydrocephalus. The cerebralspinal fluid (CSF) Aβ42 levels decreased, and apolipoprotein E (APOE) genotypes were ε3/ε4,ε3/ε3,ε2/ε3, respectively. After treatment in an all-cause individualized manner, the symptoms of 3 patients were stable or improved.

Multidrug resistance (MDR) is one of the key barriers in chemotherapy, leading to the generation of insensitive cancer cells towards administered therapy. Genetic and epigenetic alterations of the cells are the consequences of MDR, resulted in drug resistivity, which reflects in impaired delivery of cytotoxic agents to the cancer site. Nanotechnology-based nanocarriers have shown immense shreds of evidence in overcoming these problems, where these promising tools handle desired dosage load of hydrophobic chemotherapeutics to facilitate designing of safe, controlled and effective delivery to specifically at tumor microenvironment. Therefore, encapsulating drugs within the nano-architecture have shown to enhance solubility, bioavailability, drug targeting, where co-administered P-gp inhibitors have additionally combat against developed MDR. Moreover, recent advancement in the stimuli-sensitive delivery of nanocarriers facilitates a tumor-targeted release of the chemotherapeutics to reduce the associated toxicities of chemotherapeutic agents in normal cells. The present article is focused on MDR development strategies in the cancer cell and different nanocarrier-based approaches in circumventing this hurdle to establish an effective therapy against deadliest cancer disease., (Copyright © 2019 Elsevier B.V. All rights reserved.)

The study was carried out in 25 postmenopausal women with coronary heart disease (CHD) and 25 matched controls. Age, menopausal time, body mass index, hypertension, smoking and occupation in CHD were not different from those in the control group. Serum lipids, apolipoproteins (apo), sex hormones and gonadotropin hormones were measured. Serum TG and apo AI/apoB100 ratio increased more significantly in CHD than in the control group. Serum apo A II decreased more significantly in CHD than in the control group. Other serum factors in CHD were not significantly different from those in the control group. Matched logistic regression analysis showed that serum TG and apo A I were probable risk factor, serum apo A II was a protected factor of CHD, and all of them were important predictors for CHD in postmenopausal women. Our results suggest that sex hormones seem to have important effects on the occurrence of CHD by esterone (E1) and progesterone (P) interrupting serum lipid and apolipoprotein metabolism. Serum E1 is related with TG, P is positively related with apo B100.