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4. The Chinese consensus for surgical treatment of traumatic rib fractures 2021 (C-STTRF 2021)

Author

Bai, Xiang-Jun, Cheng, Li-Ming, Cui, Shu-Sen, Du, Ding-Yuan, Du, Gong-Liang, Deng, Jin, Dai, Ji-Gang, Dang, Xing-Bo, Fu, Xiao-Bing, Fu, Yong, Ge, Bing, Gao, Jin-Mou, Hou, Li-Jun, Hu, Pei-Yang, Hou, Zhi-Yong, Jiang, Bao-Guo, Jiang, Jian-Xin, Jia, Yan-Fei, Jing, Jue-Hua, Kong, Ling-Wen, Li, Chun-Ming, Lv, De-Cheng, Liu, Guo-Dong, Liang, Gui-You, Lian, Hong-Kai, Li, Kai-Nan, Li, Lei, Liu, Liang-Ming, Lin, Yi-Dan, Li, Zhan-Fei, Liu, Zhong-Min, Shao, Biao, Shen, Yan, Tao, Ning, Tang, Pei-Fu, Tan, Qun-You, Huang, Guang-Bin, Hu, Ping, Wang, Cheng, Wu, Chun, Wang, Da-Li, Wang, Gang, Wang, Hai-Dong, Wu, Jing-Lan, Wu, Qing-Chen, Wang, Ru-Wen, Wang, Tian-Bing, Wu, Xu, Wang, Zheng-Guo, Xu, Feng, Xiao, Ren-Ju, Xiao, Ying-Bin, Yu, An-Yong, Yu, Bin, Yang, Jun, Yang, Xiao-Feng, Yi, Yun-Feng, Zhu, Dong-Bo, Zeng, Jun, Zhou, Ji-Hong, Zhang, Lian-Yang, Zhao, Xing-Ji, and Zhong, Yong-Fu

Published
2021
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16. Multi‐center experience in an optimized right upper lobectomy surgical procedure in China.

Author

Mei, Long‐Yong, Liu, Wen‐Zhou, Xiu, Yu‐Chi, Tao, Shao‐Lin, Feng, Yong‐Geng, Tan, Qun‐You, Xu, Shi‐Guang, Xian, Lei, and Deng, Bo

Subjects
SURGICAL robots, LUNG tumors, RETROSPECTIVE studies, TREATMENT effectiveness, RESEARCH funding, THORACOSCOPY, VIDEO-assisted thoracic surgery, PROGRESSION-free survival, PNEUMONECTOMY, PATIENT safety, LONGITUDINAL method
Abstract

Background: This multi‐center study was aimed at retrospectively evaluating the feasibility, safety, clinical outcomes, and surgical learning curve of an optimized procedure for right upper lobectomy (RUL), which is challenging because of the anatomical structures and features of this lobe. Methods: This study included 45 RUL cases of robot‐assisted thoracoscopy (RATS) in a pilot cohort and 187 RUL cases of video‐assisted thoracoscopy (VATS) in three cohorts. A total of 121 and 111 patients underwent traditional and optimized RUL, respectively. The optimized surgical procedure was performed to consecutively transect the superior arterial trunk and bronchus, and finally disconnect the pulmonary vein and posterior ascending artery with interlobar fissures. Clinical and radiological data were reviewed retrospectively. Results: Optimized RUL can be performed successfully by RATS or VATS. The optimized procedure yielded better clinical outcomes than the traditional procedure, including shorter operation times, less blood loss, fewer complications, shorter hospital times, lower costs, and a lower likelihood of postoperative intermedius bronchial kinking. Additionally, for calcified interlobar lymph nodes, the optimized VATS group was less likely to be converted to thoracotomy than the traditional group. The skills required to perform optimized VATS RUL can be gained by surgeons after 12 to 15 cases. The two RUL procedures in the pilot cohort showed similar disease‐free survival. Conclusions: The optimized RUL was safe, economical, and feasible, with a short learning curve and satisfactory disease‐free survival. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Robot‐assisted thymectomy in large anterior mediastinal tumors: A comparative study with video‐assisted thymectomy and open surgery.

Author

Jiang, Bin, Tan, Qun‐You, Deng, Bo, Mei, Long‐Yong, Lin, Yi‐Dan, and Zhu, Long‐Fei

Subjects
*THYMUS surgery, *SURGICAL blood loss, *LENGTH of stay in hospitals, *THORACIC surgery, *SURGICAL robots, *SURGICAL complications, *MEDICAL care costs, *TREATMENT effectiveness, *VIDEO-assisted thoracic surgery, MEDIASTINAL tumors
Abstract

Background: The aim of this study was to evaluate the safety and effectiveness of robot‐assisted thymectomy (RAT) in large anterior mediastinal tumors (AMTs) (size ≥6 cm) compared with video‐assisted thymectomy (VAT) and open surgery. Methods: A total of 132 patients with large AMTs who underwent surgical resection from January 2016 to June 2022 were included in this study. A total of 61 patients underwent RAT, 36 patients underwent VAT and 35 patients underwent open surgery. Perioperative outcomes were compared. Results: There were no significant differences in tumor size (p = 0.141), or pathological types (p = 0.903). Compared with the open group, the RAT and VAT groups were associated with a shorter operation time (115.00 vs. 160.00, p = 0.012; 122.50 vs. 160.00, p = 0.071), and less blood loss (50.00 vs. 200.00, p < 0.001; 50.00 vs. 200.00, p < 0.001), respectively. The rate of conversion in the RAT group was similar to that in the VAT group (6.56% vs. 13.89%, p = 0.229). Concomitant resection was less frequently performed in the VAT group than in the RAT and open groups (5.56% vs. 31.15%, p = 0.040; 5.56% vs. 31.43%, p = 0.006). VAT patients had a lower drainage volume (365.00 vs. 700.00 and 910.00 mL, p < 0.001), shorter duration of chest tube (2.00 vs. 3.00 and 4.00, p < 0.001), and shorter hospital stay (5.00 vs. 6.00 and 7.00, p < 0.001) than the RAT and open groups. There was no 30‐day mortality in any group. No difference was seen in R0 resection rates (p = 0.846). The postoperative complication rates were similar among the three groups (p = 0.309). Total in‐hospital costs (66493.90 vs. 33581.05 and 42876.40, p < 0.001) were significantly higher in the RAT group. Conclusions: RAT is safe and effective for the resection of large AMTs compared to VAT and open surgery. Vascular resection in RAT is technically feasible. A long‐term follow‐up is required. [ABSTRACT FROM AUTHOR]

Published
2023
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18. The Chinese consensus for surgical treatment of traumatic rib fractures 2021 (C-STTRF 2021)

Author

Kong, Ling-Wen, primary, Huang, Guang-Bin, additional, Yi, Yun-Feng, additional, Du, Ding-Yuan, additional, Bai, Xiang-Jun, additional, Cheng, Li-Ming, additional, Cui, Shu-Sen, additional, Du, Gong-Liang, additional, Deng, Jin, additional, Dai, Ji-Gang, additional, Dang, Xing-Bo, additional, Fu, Xiao-Bing, additional, Fu, Yong, additional, Ge, Bing, additional, Gao, Jin-Mou, additional, Hou, Li-Jun, additional, Hu, Pei-Yang, additional, Hou, Zhi-Yong, additional, Jiang, Bao-Guo, additional, Jiang, Jian-Xin, additional, Jia, Yan-Fei, additional, Jing, Jue-Hua, additional, Kong, Ling-Wen, additional, Li, Chun-Ming, additional, Lv, De-Cheng, additional, Liu, Guo-Dong, additional, Liang, Gui-You, additional, Lian, Hong-Kai, additional, Li, Kai-Nan, additional, Li, Lei, additional, Liu, Liang-Ming, additional, Lin, Yi-Dan, additional, Li, Zhan-Fei, additional, Liu, Zhong-Min, additional, Shao, Biao, additional, Shen, Yan, additional, Tao, Ning, additional, Tang, Pei-Fu, additional, Tan, Qun-You, additional, Hu, Ping, additional, Wang, Cheng, additional, Wu, Chun, additional, Wang, Da-Li, additional, Wang, Gang, additional, Wang, Hai-Dong, additional, Wu, Jing-Lan, additional, Wu, Qing-Chen, additional, Wang, Ru-Wen, additional, Wang, Tian-Bing, additional, Wu, Xu, additional, Wang, Zheng-Guo, additional, Xu, Feng, additional, Xiao, Ren-Ju, additional, Xiao, Ying-Bin, additional, Yu, An-Yong, additional, Yu, Bin, additional, Yang, Jun, additional, Yang, Xiao-Feng, additional, Zhu, Dong-Bo, additional, Zeng, Jun, additional, Zhou, Ji-Hong, additional, Zhang, Lian-Yang, additional, Zhao, Xing-Ji, additional, and Zhong, Yong-Fu, additional

Published
2021
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28. BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma

Author

Mao, Chun-Guo, primary, Jiang, Sha-sha, additional, Wang, Xiao-yang, additional, Tao, Shao-Lin, additional, Jiang, Bin, additional, Mao, Cheng-Yi, additional, Yang, Yan-Lian, additional, Hu, Zhi-Yuan, additional, Long, Tan, additional, Jin, Hua, additional, Tan, Qun-You, additional, Huang, Yi, additional, and Deng, Bo, additional

Published
2021
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39. GRP75‐mediated upregulation of HMGA1 stimulates stage I lung adenocarcinoma progression by activating JNK/c‐JUN signaling.

Author

Qiao, Guo‐Bing, Wang, Ren‐Tao, Wang, Shu‐Nan, Tao, Shao‐Lin, Tan, Qun‐You, and Jin, Hua

Subjects
GLUCOSE metabolism, BIOCHEMISTRY, PROTEINS, ADENOCARCINOMA, LUNG cancer, DISEASE progression, BIOMARKERS, IN vitro studies, IN vivo studies, SEQUENCE analysis, PHOSPHOTRANSFERASES, ANIMAL experimentation, HEAT shock proteins, PHENOMENOLOGY, CELLULAR signal transduction, TUMOR classification, GENE expression, MESSENGER RNA, BIOLOGICAL assay, MICE
Abstract

Background: Recurrence is a major challenge in early‐stage lung adenocarcinoma (LUAD) treatment. Here, we investigated the role and mechanism of high‐mobility group AT‐hook 1 (HMGA1) and glucose‐regulated protein 75‐kDa (GRP75) in stage I LUAD and evaluated their potential as biomarkers for predicting the recurrence and prognosis of stage I LUAD. Methods: The TCGA dataset was used to investigate the clinical significance of HMGA1 and GRP75 in early‐stage LUAD. The biological functions of HMGA1 and GRP75 in LUAD were investigated both in vitro and in vivo through overexpression and knockdown experiments. The interaction and regulation between HMGA1 and GRP75 were evaluated with coimmunoprecipitation and ubiquitination assays. The downstream signaling pathway of the GRP75/HMGA1 axis was investigated by mRNA‐sequencing analysis. Results: Both HMGA1 expression levels and GRP75 expression levels were associated with recurrence in stage I LUAD patients. In particular, HMGA1 had potential as an independent prognostic factor in stage I LUAD patients. Overexpression of GRP75 or HMGA1 significantly stimulated LUAD cell growth and metastasis, while silencing GRP75 or HMGA1 inhibited LUAD cell growth and metastasis in vitro and in vivo. Importantly, GRP75 inhibited ubiquitination‐mediated HMGA1 degradation by directly binding to HMGA1, thereby causes HMGA1 upregulation in LUAD. In addition, the GRP75/HMGA1 axis played its role by activating JNK/c‐JUN signaling in LUAD. Conclusions: The activation of GRP75/HMGA1/JNK/c‐JUN signaling is an important mechanism that promotes the progression of stage I LUAD, and a high level of HMGA1 is a novel biomarker for predicting recurrence and a poor prognosis in stage I LUAD patients. [ABSTRACT FROM AUTHOR]

Published
2021
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40. CCR7 enhances the angiogenic capacity of esophageal squamous carcinoma cells in vitro via activation of the NF-κB/VEGF signaling pathway

Author

Cai, Qing-Yong, Liang, Gui-You, Zheng, Yi-Feng, Tan, Qun-You, Wang, Ru-Wen, and Li, Kun

Subjects
Original Article
Abstract

High levels of angiogenesis are associated with poor prognosis and a highly invasive phenotype in esophageal squamous carcinoma. C-C chemokine receptor type 7 (CCR7) is overexpressed in multiple tumor types and has been suggested to act as an oncogene and pro-angiogenic factor. This study aimed to elucidate the effect of CCR7 on the angiogenic capacity of esophageal squamous carcinoma cells in vitro. Expression of CCR7 in esophageal squamous carcinoma cell lines and normal human esophageal epithelial cell line was examined by western blotting and quantitative real-time PCR. CCR7 was stably overexpressed or transiently knocked down in esophageal squamous carcinoma cell lines. Overexpressing CCR7 enhanced the capacity of esophageal squamous carcinoma cell conditioned media to induce human umbilical vein endothelial cells (HUVEC) proliferation and migration and neovascularization in the chicken chorioallantoic membrane (CAM) assay. While silencing CCR7 caused an opposite outcome. Moreover, we demonstrated that CCR7 activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and regulated its targets, including vascular endothelial growth factor A (VEGF-A), VEGF-C, tumor necrosis factor-α (TNFα), interleukin (IL)-6, IL-8 and transforming growth factor-β (TGF-β) expression. Additionally, CCR7 down-regulation reduced tumor volume and weight in xenograft mouse model, and significantly decreased NF-κB signaling pathway. This study suggests that CCR7 plays an important pro-angiogenic role in esophageal squamous carcinoma via a mechanism linked to activation of the NF-κB pathway; CCR7 may represent a potential target for anti-angiogenic therapy in esophageal squamous carcinoma.

Published
2017

41. The effect of high Sox3 expression on lymphangiogenesis and lymph node metastasis in esophageal squamous cell carcinoma

Author

Zheng, Yi-Feng, Li, Kun, Cai, Qing-Yong, Yang, Lie, Tan, Qun-You, Guo, Wei, and Wang, Ru-Wen

Subjects
Original Article
Abstract

Objective: This study aimed to investigate the effect of Sox3 expression on biological behaviors of esophageal squamous cell carcinoma (ESCC) and explore its possible mechanism. Methods: ESCC cell lines that highly expressed Sox3 were selected and transfected with lentivirus carrying sox3 siRNA to establish ESCC cell lines which expressed Sox3 of different levels. Using in vitro experiments including cell invasion, cell scratch, cell proliferation and tube formation of lymphatic endothelial cells, as well as an in vivo experiment of axillary lymph node metastasis in a nude mouse model of a xenotransplanted tumor, the effect of Sox3 expression variation on lymphangiogenesis and lymph node metastasis in ESCC cells was investigated. In addition, ELISA, Western blot and immunohistochemical methods were used to study the regulatory effects of Sox3 on relevant molecules such as VEGF-C/D and to explore the potential mechanisms that affected lymphatic metastasis. Results: The high expression of Sox3 in ESCC cells in vitro could significantly promote the proliferation, invasion, migration and tube formation of lymphatic endothelial cells. High expression of Sox3 in vivo could significantly promote lymph node metastasis of ESCC cells, and we have demonstrated that the upregulation of Sox-3 expression could promote the expression and secretion of VEGF-C and VEGF-D both in vivo and in vitro. After blocking the VEGFR-3 receptors on lymphatic endothelial cells, the effect of Sox3 on promoting lymphangiogenesis has decreased significantly, confirming that Sox3 acts through VEGF-C/D to promote lymphangiogenesis. Conclusions: It is suggested that Sox3 possibly induces lymphangiogenesis by increasing the expression of VEGF-C/D in ESCC cells, thereby promoting the lymph node metastasis of the tumor. Thus, Sox-3 may become a new prognostic marker and therapeutic target in ESCC.

Published
2017

49. Improved biological properties and hypouricemic effects of uricase from Candida utilis loaded in novel alkaline enzymosomes

Author

Tan,Qun-You, Zhang,Jing-Qing, Wang,Na, Yang,Hong, Li,Xiaoling, Xiong,Hua-Rong, Wu,Jian-Yong, Zhao,Chun-Jing, Wang,Hong, Yin,Hua-Feng, Tan,Qun-You, Zhang,Jing-Qing, Wang,Na, Yang,Hong, Li,Xiaoling, Xiong,Hua-Rong, Wu,Jian-Yong, Zhao,Chun-Jing, Wang,Hong, and Yin,Hua-Feng

Abstract

Qun-You Tan,1,* Jing-Qing Zhang,2,* Na Wang,3,* Hong Yang,4 Xiaoling Li,5 Hua-Rong Xiong,2 Jian-Yong Wu,2 Chun-Jing Zhao,3 Hong Wang,2 Hua-Feng Yin2 1Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 2Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, 3School of Pharmacy, Second Affiliated Hospital, Chongqing Medical University, Chongqing, 4School of Pharmacy, Medical College of Soochow University, Soochow, People's Republic of China; 5TJ Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA, USA*These authors contributed equally to this workObjective: Previous studies on various enzymosomes (functional lipid vesicles encapsulating an enzyme) have been mostly carried out in vitro and have focused on preserving catalytic activity and improving the stability of the enzyme. Until now, few studies have focused on their in vivo fate. Similarly, although we have previously reported the increased in vitro uricolytic activity (about 2.2 times higher than that of free uricase, or three times higher than that of PEGylated uricase, Puricase®, under physiological pH and temperature) and improved stability of the novel alkaline enzymosomes (functional lipid vesicles encapsulating uricase from Candida utilis: uricase-containing lipid vesicles, UOXLVs), it is still necessary to study the biological properties and hypouricemic effects of UOXLVs in vivo.Methods: The enzyme kinetics, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary safety of UOXLVs were evaluated.Results: The Michaelis constant (Km) value of the UOXLVs was slightly lower than that of the free enzyme. The enzyme release from the UOXLVs lasted over 12 hours and their circulation half-life was about sevenfold longer than that of the free uricase. Meanwhile, the UOXLVs had a 22-fol

Published
2012

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