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12 results on '"Tan, Pisey"'

3. Elizabethkingia anophelis Infection in Infants, Cambodia, 2012-2018

Author

Reed, Thomas A.N., Watson, Gabriella, Kheng, Chheng, Tan, Pisey, Roberts, Tamalee, Ling, Clare L., Miliya, Thyl, and Turner, Paul

Subjects
Diseases, Oxidases, Infants, Imipenem, Pediatrics, Meropenem, Mortality, Microbiology, Resveratrol, Setting (Literature), Bacteremia, Pediatric diseases
Abstract

Elizabethkingia anophelis is a recently identified aerobic, nonmotile, oxidase-positive, indole-positive species of gram-negative bacillus (2,2) that has been implicated in nosocomial and community outbreaks and associated with high mortality rates [...]

Published
2020
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4. Pneumococcal colonisation and pneumonia severity in hospitalised Cambodian children following introduction of the 13-valent pneumococcal conjugate vaccine

Author

Miliya, Thyl, primary, Soputhy, Chansovannara, additional, Leab, Phana, additional, Tan, Pisey, additional, Sao, Sena, additional, Heffelfinger, James D., additional, Batmunkh, Nyambat, additional, Ork, Vichit, additional, Hossain, Md. Shafiqul, additional, Day, Nicholas PJ, additional, Turner, Claudia, additional, and Turner, Paul, additional

Published
2023
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5. Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in Southeast Asia

Author

Gysin, Marina, primary, Hon, Pei Yun, additional, Tan, Pisey, additional, Sengduangphachanh, Amphonesavanh, additional, Simmalavong, Manivone, additional, Hinfonthong, Pattaraporn, additional, Kaewphanderm, Napaporn, additional, Pham, Thai Duy, additional, Nguyen, Thanh Ha, additional, Haldimann, Klara, additional, Becker, Katja, additional, van Doorn, H. Rogier, additional, Hopkins, Jill, additional, Simpson, Andrew J.H., additional, Ashley, Elizabeth A., additional, Kesteman, Thomas, additional, Tran, Hoang Huy, additional, Vasoo, Shawn, additional, Ling, Clare L., additional, Roberts, Tamalee, additional, Turner, Paul, additional, and Hobbie, Sven N., additional

Published
2022
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6. Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in South-East Asia

Author

Gysin, Marina, Hon, Pei Yun, Tan, Pisey, Sengduangphachanh, Amphonesavanh, Simmalavong, Manivone, Hinfonthong, Pattaraporn, Kaewphanderm, Napaporn, Pham, Thai Duy, Nguyen, Thanh Ha, Haldimann, Klara, Becker, Katja, van Doorn, H Rogier, Hopkins, Jill, Simpson, Andrew J H, Ashley, Elizabeth A, Kesteman, Thomas, Tran, Hoang Huy, Vasoo, Shawn, Ling, Clare L, Roberts, Tamalee, Turner, Paul, Hobbie, Sven N, Gysin, Marina, Hon, Pei Yun, Tan, Pisey, Sengduangphachanh, Amphonesavanh, Simmalavong, Manivone, Hinfonthong, Pattaraporn, Kaewphanderm, Napaporn, Pham, Thai Duy, Nguyen, Thanh Ha, Haldimann, Klara, Becker, Katja, van Doorn, H Rogier, Hopkins, Jill, Simpson, Andrew J H, Ashley, Elizabeth A, Kesteman, Thomas, Tran, Hoang Huy, Vasoo, Shawn, Ling, Clare L, Roberts, Tamalee, Turner, Paul, and Hobbie, Sven N

Abstract

Bloodstream infections (BSIs) are a leading cause of sepsis, a life-threatening condition that contributes significantly to the mortality of bacterial infections. Aminoglycoside antibiotics such as gentamicin or amikacin are essential medicines in the treatment of BSIs, but their clinical efficacy is increasingly compromised by antimicrobial resistance. The aminoglycoside apramycin has demonstrated preclinical efficacy against aminoglycoside- and multidrug-resistant (MDR) Gram-negative bacilli (GNB) and is currently in clinical development for the treatment of critical systemic infections. Here, we collected a panel of 470 MDR GNB isolates from health care facilities in Cambodia, Laos, Singapore, Thailand, and Vietnam for a multi-centre assessment of their antimicrobial susceptibility to apramycin in comparison to other aminoglycosides and colistin by broth microdilution assays. Apramycin and amikacin MICs ≤ 16 µg/mL were found for 462 (98.3%) and 408 (86.8%) GNB isolates, respectively. Susceptibility to gentamicin and tobramycin (MIC ≤ 4 µg/mL) was significantly lower at 122 (26.0%) and 101 (21.5%) susceptible isolates, respectively. Of note, all carbapenem- and third-generation cephalosporin (3GC) resistant Enterobacterales, all Acinetobacter baumannii, and all Pseudomonas aeruginosa isolates tested in this study appeared to be susceptible to apramycin. Of the 65 colistin-resistant isolates tested, only four (6.2%) had an apramycin MIC > 16 µg/mL. Apramycin demonstrated best-in-class activity against a panel of GNB isolates with resistances to other aminoglycosides, carbapenems, 3GC, and colistin, warranting continued consideration of apramycin as a drug candidate for the treatment of multidrug-resistant BSIs. Keywords: Bloodstream infection; Gram negative; aminoglycoside; antimicrobial resistance; apramycin; blood culture isolates.

Published
2022

10. Transmission Dynamics of Hyper-Endemic Multi-Drug Resistant Klebsiella pneumoniae in a Southeast Asian Neonatal Unit: A Longitudinal Study With Whole Genome Sequencing

Author

Smit, Pieter W., primary, Stoesser, Nicole, additional, Pol, Sreymom, additional, van Kleef, Esther, additional, Oonsivilai, Mathupanee, additional, Tan, Pisey, additional, Neou, Leakhena, additional, Turner, Claudia, additional, Turner, Paul, additional, and Cooper, Ben S., additional

Published
2018
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11. Transmission patterns of hyper-endemic multi-drug resistant Klebsiella pneumoniae in a Cambodian neonatal unit: a longitudinal study with whole genome sequencing

Author

Smit, Pieter W., primary, Stoesser, Nicole, additional, Pol, Sreymom, additional, van Kleef, Esther, additional, Oonsivilai, Mathupanee, additional, Tan, Pisey, additional, Neou, Leakhena, additional, Turner, Claudia, additional, Turner, Paul, additional, and Cooper, Ben S, additional

Published
2017
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12. A retrospective analysis of melioidosis in Cambodian children, 2009–2013

Author

Turner, Paul, primary, Kloprogge, Sabine, additional, Miliya, Thyl, additional, Soeng, Sona, additional, Tan, Pisey, additional, Sar, Poda, additional, Yos, Pagnarith, additional, Moore, Catrin E., additional, Wuthiekanun, Vanaporn, additional, Limmathurotsakul, Direk, additional, Turner, Claudia, additional, Day, Nicholas P. J., additional, and Dance, David A. B., additional

Published
2016
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