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113 results on '"Tan, L.B."'

8. Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature. (Occasional Review)

Author

Kohnlein, T., Welte, T., Tan, L.B., and Elliott, M.W.

Subjects
Heart diseases -- Competitions -- Care and treatment -- Physiological aspects, Chronic diseases -- Competitions -- Care and treatment -- Physiological aspects, Sleep apnea syndromes -- Care and treatment -- Physiological aspects, Cardiac patients -- Physiological aspects -- Care and treatment, Health, Care and treatment, Physiological aspects, Competitions
Abstract

The prevalence, prognosis, clinical presentation, pathophysiology, diagnosis, and treatment of the central sleep apnoea syndrome (CSAS) are reviewed and its relationship with congestive heart failure (CHF) is discussed. Adequately powered [...]

Published
2002

14. Posters 159Misdiagnosed, misbelieved and misdirected; largest uk study casts doubt on some long held but poorly validated assumptions about the pots population and suggests improvements in care pathways and service provision60An acute comparison of different strategies for targeting the left ventricular lead for cardiac resynchronisation therapy61Relationship of phase singularities and high dominant frequency regions during persistent atrial fibrillation in humans62Restoration of sinus rhythm results in early and late improvements in the functional reserve of the heart following direct current cardioversion of persistent af: fresh-af63Non-concomitant hybrid ablation using the estech cobra device for the treatment of longstanding persistent atrial fibrillation: an initial single-centre experience64Artificial intelligence outperforms manual ecg scoring in the detection of arrhythmia substrate65Single centre experience and outcome of persistent af ablation using nmarq catheter: 2 year follow up66The growing burden of atrial fibrillation and management at a typical district general hospital67Haemodynamic effects of single-vein, simultaneous, multipoint pacing compared with bipolar pacing in patients undergoing cardiac resynchronisation therapy68Is multisite pacing of interest in cardiac resynchronization therapy? teachings from a long-term follow-up of a cohort of patients implanted with triventricular pacing systems69Differences in fractionated electrogram detection: a direct quantitative comparison between navx and carto: Table 1

Author

Kavi, L.A., primary, Gamble, J.H.P., primary, Dastagir, N., primary, Gilbert, K.A., primary, Furniss, G.O., primary, Rosengarten, J.A., primary, Shunmugam, S.R., primary, Signy, J.S.G., primary, Umar, F., primary, Providência, R., primary, Almeida, T.P, primary, Newton, J.L., additional, Nuttall, M., additional, Opie-Moran, M., additional, Low, D A, additional, Nicholson, L.M., additional, Toora, D., additional, Caldow, E., additional, Gregory, K., additional, Khiani, R., additional, Herring, N., additional, Foley, P.W.X., additional, Ginks, M.R., additional, Rajappan, K., additional, Bashir, Y., additional, Betts, T.R., additional, Salinet, J.L., additional, Li, X., additional, Vanheusden, F.J., additional, Almeida, T.P., additional, Chu, G.S., additional, Stafford, P.J., additional, Schlindwein, F.S., additional, Ng, G.A., additional, Hogarth, A.J., additional, MacDonald, W., additional, Lewis, N.T., additional, Tan, L.B., additional, Tayebjee, M.H., additional, Villaquiran, J., additional, Newcombe, D., additional, Lines, I., additional, Dalrymple-Hay, M., additional, Haywood, G.A., additional, Chui, K.H.O., additional, Dima, S.M., additional, Panagiotou, C., additional, Maharatna, K., additional, Curzen, N.P., additional, Morgan, J.M., additional, Veasey, R.A., additional, Sugihara, C., additional, Anderson, S., additional, Furniss, S., additional, Sulke, N., additional, Puri, N., additional, Steele, J., additional, Furniss, S.S., additional, Sulke, A.N., additional, Patel, N.R., additional, Taylor, R.J., additional, Stegemann, B., additional, Marshall, H., additional, Flannigan, S., additional, Leyva, F., additional, Rogers, D., additional, Cobb, V., additional, Babu, G., additional, Mann, I., additional, Bronis, K., additional, Posdziech, V., additional, Lambiase, P., additional, Ahsan, S., additional, Segal, O., additional, Lowe, M., additional, Rowland, E., additional, Khan, F., additional, Chow, A., additional, Tuan, J.H., additional, and Ng, G. André, additional

Published
2015
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23. Is early, low level, short term exercise cardiac rehabilitation following coronary bypass surgery beneficial? A randomised controlled trial. (Scientific Letter)

Author

Wright, D.J., Williams, S.G., Riley, R., Marshall, P., and Tan, L.B.

Subjects
Exercise -- Health aspects -- Physiological aspects, Coronary artery bypass -- Physiological aspects -- Health aspects, Cardiac patients -- Health aspects -- Physiological aspects, Health, Physiological aspects, Health aspects
Abstract

Heart 2002;88:83-84 Through the relief of myocardial ischaemia, the goal of coronary artery bypass grafting (CABG) is to preserve and if possible to restore cardiac function towards normality. Evaluation of [...]

Published
2002

36. Percutaneous Cardiopulmonary Bypass

Author

Whittaker, S., primary, Rees, M.R., additional, Hick, D.C., additional, Browne, T., additional, Tan, L.B., additional, Nair, U., additional, and Davies, G.A., additional

Published
1991
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39. Shifts in mortality curves: saving or extending lives?

Author

Tan, L.B. and Murphy, R.

Subjects
*CLINICAL drug trials, *CLINICAL medicine, *CLINICAL trials, *PHARMACEUTICAL research, *DATABASES, *METHODOLOGY, *STATISTICS
Abstract

Discusses how the way survival data is analysed statistically and presented can affect clinicians' perception of drug efficacy. Flaws in the presentation of the benefits of drugs by stating the relative risk reduction achieved by the investigational drug, illustrated by Kaplan-Meier survival curves; Example; Need to include presentation of data in terms of extension of lives, not just the saving of lives.

Published
1999
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40. LETTERS.

Author

Collins, Simon, Hall, A.S., Tan, L.B., Ball, S.G., Swedberg, Karl, Kjekshus, John, Najeeb, M. Afzal, O'Keeffe, Leonard, Lawson, Andrew, Cohen, Juliet, Mohanty, K.C., Lehmann, O.J., McLeod, D., Dowling, C., Carroll, R.N.P., Bland, J. Martin, Altman, Douglas G., Barlow, Philip, and Bingham, James

Subjects
MEDICAL education, ENDOMETRIOSIS, EPIDEMIOLOGY
Abstract

Presents several letters on medical education in Great Britain. Effect of health prevention messages to the public; Epidemiology of endometriosis; Increase of patients knowledge of secondary contraception.

Published
1993

42. The role of exercise testing in the evaluation and management of heart failure

Author

Wright, D.J. and Tan, L.B.

Abstract

SummaryThe clinical syndrome of heart failure has been investigated so extensively that it may now almost be regarded as a metabolic disorder. Although an initial insult reduces cardiac pump efficacy, the resultant physiological response culminates in complex neurohormonal dysfunction. This has created confusion and prevented the acceptance of a universal definition of cardiac failure. With much current research concentrating on the pharmacological modification of neuro-endocrine imbalance, it is easy to lose sight of the fundamental principles behind heart failure management, namely, to improve cardiac function. In attempting to achieve this, the issues of morbidity and mortality must be addressed jointly; they are not mutually exclusive entities. Discrepant results between mortality studies and changes in exercise capacity have undermined the value of exercise testing. Because a treatment enhances longevity we should not ignore its effect on symptomatic status, and likewise we should not discard a therapy, which improves function because adverse events result in occasional premature deaths. Informed patient choice must exist.Historically, exercise testing has been quintessential in our understanding and evaluation of heart failure. Peak oxygen consumption remains the best overall indicator of symptomatic status, exercise capacity, prognosis and hospitalisation. Unfortunately, muddling of surrogate and true end-points has confused many of these issues. Improved comprehension may be gained by applying the concept of cardiac reserve which has been described in a variety of heart conditions and used in cardiac failure patients to provide an indication of prognosis and functional capacity.

Published
1999

43. Safety and efficacy of computerized closed-loop delivery of arbutamine: A new pharmacologic myocardial stress modality for the assessment of coronary artery disease

Author

Cramer, M.J.M., Jaarsma, W., Sutherland, G.R., Nihoyannopoulos, P., Fioretti, P., Tan, L.B., Schroder, K., and Visser, C.A.

Abstract

This study evaluated the efficacy of computer-controlled closed-loop delivery of a new synthetic catecholamine, arbutamine, when given to induce myocardial ischemia detected by electrocardiography and echocardiography with a high (10 beats/min/min) and low (6 beats/min/min) rate of increase in heart rate (heart rate slope) in 70 patients with coronary artery disease. The electrocardiographic sensitivity for the detection of myocardial ischemia was 52% for the low slope and 51% for the high slope. The corresponding figures for echocardiographic sensitivity were 83% and 79% for the low and high slopes, respectively. There were no significant differences in changes from baseline to maximum in pharmacodynamic variables, although the mean times to reach maximum heart rate and systolic blood pressure were 1.4 minutes shorter (p=0.001) and 3.7 minutes shorter (p<0.05), respectively, for the high-slope regimen. The duration of the infusion was shorter (p<0.001) for the high slope. In this study, closed-loop arbutamine administration was effective and safe in the detection of coronary artery disease for both heart rate slope regimens.

Published
1995
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44. Physiological cardiac reserve: development of a non-invasive method and first estimates in man

Author

Cooke, G.A., Marshall, P., Al-Timman, J.K., Wright, D.J., Riley, R., Hainsworth, R., and Tan, L.B.

Abstract

Objective To investigate whether physiological cardiac reserve can be measured in man without invasive procedures and whether it is a major determinant of exercise capacity. Design Development of method of measurement and an observational study. Setting A regional cardiothoracic centre. Subjects 70 subjects with a wide range of cardiac function, from heart failure patients to athletes. Methods Subjects underwent treadmill, symptom limited cardiopulmonary exercise tests to measure aerobic exercise capacity (represented by |$$|APVo 2max) and cardiac reserve. Cardiac output was measured non-invasively using the CO 2 rebreathing technique. Results Cardiac power output (CPO max) at peak exercise was found to be significantly related to aerobic capacity: CPO max (W) = 0.35 + 1.5|$$|APVo 2max (l/min), r = 0.87, p &lt; 0.001. It also correlated well with exercise duration (r = 0.62, p &lt; 0.001), suggesting that cardiac reserve is a major determinant of exercise capacity. In the study, cardiac reserve ranged from 0.27 to 5.65 W, indicating a 20-fold difference between the most impaired cardiac function and that of the fittest subject. Conclusions A non-invasive method of estimating physiological cardiac reserve was developed. The reserve was found to be a major determinant of exercise capacity in a population of normal subjects and patients with heart disease. This method may thus be used to provide a clearer definition of the extent of cardiac impairment in patients with heart failure.

Published
1998

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