499 results on '"Tan, Jia-Heng"'
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2. Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells
3. Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry
4. Development of a fluorescent chemical probe with the ability to visualize nascent phase-separated stress granules
5. Dual-color imaging of DNA and RNA simultaneously with an aggregation/monomer-based deep-red fluorescent probe
6. L‐aspartate ameliorates diet‐induced obesity by increasing adipocyte energy expenditure.
7. Efficient and rational development of a new fluorescent probe specific for RNA G-quadruplex imaging in cells
8. Recent advances in fluorescent probes for G-quadruplex nucleic acids
9. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex
10. Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders
11. Chapter 5 - Cholesterol-lowering drug atorvastatin
12. Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere
13. Development of a multitasking fluorescent probe for differentiating G-Quadruplex structures
14. Development of Novel N‑Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group.
15. Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA
16. Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex
17. Selective targeting of parallel G-quadruplex structure using L-RNA aptamer
18. Interaction of Quindoline derivative with telomeric repeat–containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
19. Curcusone C induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
20. Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[c]acridine derivatives as new c-KIT promoter G-quadruplex binding ligands
21. Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment
22. Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening
23. Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes
24. Design, synthesis and biological evaluation of 4-anilinoquinazoline derivatives as new c-myc G-quadruplex ligands
25. Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole
26. Blocking the binding of WT1 to bcl-2 promoter by G-quadruplex ligand SYUIQ-FM05
27. Complicated behavior of G-quadruplexes and evaluating G-quadruplexes' ligands in various systems mimicking cellular circumstance
28. A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes
29. Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5′-UTR RNA G‑Quadruplexes.
30. Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer
31. Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c-MYC Transcription Inhibitors
32. Fluorescent Quinolinium Derivative as Novel Mitochondria Probe and Function Modulator by Targeting Mitochondrial RNA
33. Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes
34. Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives
35. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors
36. Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease
37. Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer
38. Rapid and Highly Sensitive Immunosorbent Assay to Monitor Helicases Unwinding Diverse Nucleic Acid Structures
39. Cladogenetic Orthogonal Light-Up Aptamers for Simultaneous Detection of Multiple Small Molecules in Cells
40. Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet–Mitochondrion Interactions in Live Cells and In Vivo
41. Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative
42. Synthesis and evaluation of new BODIPY-benzofuroquinoline conjugates for sensitive and selective DNA detection
43. G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression
44. Cellular nucleic acid binding protein suppresses tumor cell metastasis and induces tumor cell death by downregulating heterogeneous ribonucleoprotein K in fibrosarcoma cells
45. β-Biguanidinium-cyclodextrin: a supramolecular mimic of mitochondrial ADP/ATP carrier protein
46. An RNA G‐Quadruplex Structure within the ADAR 5′UTR Interacts with DHX36 Helicase to Regulate Translation
47. Development of a Highly Selective and Sensitive Fluorescent Probe for Imaging RNA Dynamics in Live Cells
48. Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex
49. Color-Switchable Nanosilicon Fluorescent Probes
50. Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer
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