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7 results on '"Tan, Hanbo"'

1. Quantitative Analysis of Molecular Transport in the Extracellular Space Using Physics-Informed Neural Network

Author

Xie, Jiayi, Li, Hongfeng, Cheng, Jin, Cai, Qingrui, Tan, Hanbo, Zu, Lingyun, Qu, Xiaobo, and Han, Hongbin

Subjects
Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Mathematics - Analysis of PDEs
Abstract

The brain extracellular space (ECS), an irregular, extremely tortuous nanoscale space located between cells or between cells and blood vessels, is crucial for nerve cell survival. It plays a pivotal role in high-level brain functions such as memory, emotion, and sensation. However, the specific form of molecular transport within the ECS remain elusive. To address this challenge, this paper proposes a novel approach to quantitatively analyze the molecular transport within the ECS by solving an inverse problem derived from the advection-diffusion equation (ADE) using a physics-informed neural network (PINN). PINN provides a streamlined solution to the ADE without the need for intricate mathematical formulations or grid settings. Additionally, the optimization of PINN facilitates the automatic computation of the diffusion coefficient governing long-term molecule transport and the velocity of molecules driven by advection. Consequently, the proposed method allows for the quantitative analysis and identification of the specific pattern of molecular transport within the ECS through the calculation of the Peclet number. Experimental validation on two datasets of magnetic resonance images (MRIs) captured at different time points showcases the effectiveness of the proposed method. Notably, our simulations reveal identical molecular transport patterns between datasets representing rats with tracer injected into the same brain region. These findings highlight the potential of PINN as a promising tool for comprehensively exploring molecular transport within the ECS.

Published
2024

5. Analysis of heat dissipation for power module of electric air conditioner

Author

Xue Jingwei, Gao Yibo, Tan Hanbo, and Liang Jianing

Subjects
Reliability (semiconductor), Materials science, Thermal conductivity, business.industry, Air conditioning, Thermal resistance, Power module, Thermal, Electrical engineering, Mechanical engineering, Thermal analysis, business, Finite element method
Abstract

In this paper, the principle of heat dissipation for power module of electric air conditioner is analyzed mathmatically, and the method of optimizing the heat dissipation structure is proposed. The thermal analysis model of the power module is built by the finite element method. Simulation results show that the proposed method can optimize the thermal performance of the power module, extend the life cycle of the power module and increase the reliability of the system.

Published
2017

7. [Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice].

Author

Long R, Mao X, Gao T, Xie Q, Tan H, Li Z, Han H, and Yuan L

Subjects
Animals, Mice, Female, Dizocilpine Maleate, Aquaporin 4 metabolism, Triterpenes therapeutic use, Triterpenes pharmacology, Schizophrenia drug therapy, Mice, Inbred C57BL, Disease Models, Animal, Demyelinating Diseases drug therapy, Extracellular Fluid drug effects, Extracellular Fluid metabolism, Ursolic Acid
Abstract

Objective: To unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ., Methods: Female C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na). The SZ model group was subjected to ip injection of 2 mg/kg dizocilpine maleate (MK-801) and ig administration of 1% CMC-Na. The UA treatment group underwent ig administration of 25 mg/kg UA and ip injection of 2 mg/kg MK-801. The treatment group received UA pretreatment via ig administration for one week, followed by a two-week drug intervention for all the three groups. Behavioral assessments, including the open field test and prepulse inhibition experiment, were conducted post-modeling. Subsequently, changes in the ISF partition drainage were investigated through fluorescent tracer injection into specific brain regions. Immunofluorescence analysis was employed to examine alterations in aquaporin 4 (AQP4) polarity distribution in the brain and changes in protein expression. Myelin reflex imaging using Laser Scanning Confocal Microscopy (LSCM) was utilized to study modifications in myelin within the mouse brain. Quantitative data underwent one-way ANOVA, followed by TukeyHSD for post hoc pairwise comparisons between the groups., Results: The open field test revealed a significantly longer total distance [(7 949.39±1 140.55) cm vs . (2 831.01±1 212.72) cm, P < 0.001] and increased central area duration [(88.43±22.06) s vs . (56.85±18.58) s, P =0.011] for the SZ model group compared with the controls. The UA treatment group exhibited signifi-cantly reduced total distance [(2 415.80±646.95) cm vs . (7 949.39±1 140.55) cm, P < 0.001] and increased central area duration [(54.78±11.66) s vs . (88.43±22.06) s, P =0.007] compared with the model group. Prepulse inhibition test results demonstrated a markedly lower inhibition rate of the startle reflex in the model group relative to the controls ( P < 0.001 for both), with the treatment group displaying significant improvement ( P < 0.001 for both). Myelin sheath analysis indicated significant demyelination in the model group, while UA treatment reversed this effect. Fluorescence tracing exhibited a significantly larger tracer diffusion area towards the rostral cortex and reflux area towards the caudal thalamus in the model group relative to the controls [(13.93±3.35) mm 2 vs . (2.79±0.94) mm 2 , P < 0.001 for diffusion area; (2.48±0.38) mm 2 vs . (0.05±0.12) mm 2 , P < 0.001 for reflux area], with significant impairment of drainage in brain regions. The treatment group demonstrated significantly reduced tracer diffusion and reflux areas [(7.93±2.48) mm 2 vs . (13.93±3.35) mm 2 , P < 0.001 for diffusion area; (0.50±0.30) mm 2 vs . (2.48±0.38) mm 2 , P < 0.001 for reflux area]. Immunofluorescence staining revealed disrupted AQP4 polarity distribution and reduced AQP4 protein expression in the model group compared with the controls [(3 663.88±733.77) μm 2 vs . (13 354.92±4 054.05) μm 2 , P < 0.001]. The treatment group exhibited restored AQP4 polarity distribution and elevated AQP4 protein expression [(11 104.68±3 200.04) μm 2 vs . (3 663.88±733.77) μm 2 , P < 0.001]., Conclusion: UA intervention ameliorates behavioral performance in SZ mice, Thus alleviating hyperactivity and anxiety symptoms and restoring sensorimotor gating function. The underlying mechanism may involve the improvement of demyelination and ISF drainage dysregulation in SZ mice.

Published
2024

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