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5. Clinical relevance of PD-1 positive CD8 T-cells in gastric cancer

Author

Choo, Joan, Kua, Ley Fang, Soe, Mu Yar, Asuncion, Bernadette Reyna, Tan, Benjamin Kye Jyn, Teo, Chong Boon, Tay, Ryan Yong Kiat, So, Jimmy, Shabbir, Asim, Guowei, Kim, Tan, Hon Lyn, Chan, Gloria, Ma, Haoran, Ramachandran, Gokula Krishnan, Lum, Jeffrey H. Y., Chee, Cheng Ean, Sridharan, Sriram, Tan, Patrick, Sundar, Raghav, and Yong, Wei Peng

Published
2023
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14. Large language models approach expert-level clinical knowledge and reasoning in ophthalmology: A head-to-head cross-sectional study

Author

Thirunavukarasu, Arun James, primary, Mahmood, Shathar, additional, Malem, Andrew, additional, Foster, William Paul, additional, Sanghera, Rohan, additional, Hassan, Refaat, additional, Zhou, Sean, additional, Wong, Shiao Wei, additional, Wong, Yee Ling, additional, Chong, Yu Jeat, additional, Shakeel, Abdullah, additional, Chang, Yin-Hsi, additional, Tan, Benjamin Kye Jyn, additional, Jain, Nikhil, additional, Tan, Ting Fang, additional, Rauz, Saaeha, additional, Ting, Daniel Shu Wei, additional, and Ting, Darren Shu Jeng, additional

Published
2024
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15. Serum Biomarkers after Adenotonsillectomy for Pediatric OSA: A Systematic Review and Meta‐Analysis.

Author

Ding, Yichen, Koh, Jin Hean, Cheah, Xing Yi, Yeo, Brian Sheng Yep, Leong, Darien W.J., Teo, Yao Hao, Tan, Benjamin Kye Jyn, See, Anna, and Toh, Song Tar

Abstract

Objective: To assess whether adenotonsillectomy improves levels of inflammatory and cardiometabolic markers in children with polysomnographically diagnosed obstructive sleep apnea (OSA). Data Sources: Two authors independently searched PubMed, Embase, and Cochrane databases up to August 16, 2022, for studies relating to pre‐ and post‐operative levels of serum markers in pediatric patients undergoing adenotonsillectomy. Review Methods: Data were extracted from included articles into a structured proforma. Meta‐analyses of the standardized mean difference (SMD) were conducted in random‐effects models. We calculated the probability of benefit (POB) and number needed to treat (NNT) for outcomes that demonstrated a statistically significant effect after adenotonsillectomy. The primary outcomes were changes in serum markers including C‐reactive protein (CRP), high‐sensitivity CRP (hs‐CRP), Insulin‐like growth factor 1 (IGF‐1), interleukin‐10 (IL‐10), interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), Brain natriuretic peptide (BNP), insulin, glucose, total cholesterol, triglyceride, low‐density lipoprotein (LDL), high‐density lipoprotein (HDL). Results: We screened 1616 studies and included 26 studies with 1331 participants. Meta‐analysis was performed on 20 of the included studies. Adenotonsillectomy was associated with a significant decrease in insulin levels (SMD = −0.322, 95% Confidence Interval (CI) = −0.583 to −0.061), CRP (SMD = −0.946, 95% CI = −1.578 to −0.314), and BNP (SMD = −1.416, 95% CI = −2.355 to −0.477) and significant increase in levels of IGF‐1 (SMD = 0.691, 95% CI = 0.207 to 1.176). There were no significant changes in levels of triglyceride, total cholesterol, TNF‐α, LDL, HDL, glucose, IL‐10, and IL‐6. Conclusion: In children with polysomnographically diagnosed OSA, adenotonsillectomy was associated with improvements in serum biomarkers, comprising lower CRP, insulin, and BNP, and higher IGF‐1. Laryngoscope, 134:3030–3037, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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16. Association Between Smoking and Chronic Rhinosinusitis: A Systematic Review and Meta‐Analysis.

Author

Tan, Claire Jing‐Wen, Leow, Bryan Hao Wei, Tan, Benjamin Kye Jyn, Tan, Sean Fong‐Jun, Teo, Neville Wei Yang, and Charn, Tze Choong

Abstract

Objective: Chronic rhinosinusitis (CRS) is a prevalent inflammatory disease of the upper airway. The impact of smoking on CRS has not been clearly established. We aim to clarify the association between first‐hand cigarette smoking and the prevalence and prognoses of CRS. Review Methods: PubMed, Embase, SCOPUS, and Cochrane Library were searched from inception until May 15, 2022. Three blinded reviewers selected relevant studies, extracted data, and evaluated study bias following a PROSPERO‐registered protocol (CRD42022345585). We used random‐effects meta‐analyses to pool the prevalence of smoking in CRS, association between smoking status and CRS, and association of smoking with quality of life (QOL) before and after functional endoscopic sinus surgery (FESS). We also performed descriptive analyses of olfactory function, CT scores, and endoscopy scores before and after FESS. Results: We included 23 cross‐sectional studies, 19 cohort studies, two case–control studies, and one prospective clinical trial. The pooled prevalence of ever‐smokers was 40% (95% CI = 0.30–0.51) and 33% (95% CI = 0.25–0.43) in patients with and without CRS. Compared to never‐smokers, active smokers and past smokers had 1.35 (95% CI = 1.18–1.55) and 1.23 (95% CI = 1.17–1.29) higher odds of having CRS. Among patients with CRS, non‐smokers reported higher initial QOL than smokers (standardized mean difference [SMD] = 0.23, 95% CI = 0.11–0.35), although post‐FESS QOL was similar (SMD = 0.10, 95% CI = −0.30–0.51). Descriptive analysis found no significant correlations between smoking and post‐FESS olfactory function and endoscopy scores. Conclusions: Cigarette smoking is associated with higher prevalence and odds of CRS. Clinicians should be aware that smoking predisposes to CRS, but does not negatively impact the rhinologic outcomes of FESS. Laryngoscope, 134:2513–2524, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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18. Association Between Hearing Loss and Cardiovascular Disease: A Meta‐analysis.

Author

Tan, Claire Jing‐Wen, Koh, Jia Wen Tricia, Tan, Benjamin Kye Jyn, Woon, Chang Yi, Teo, Yao Hao, Ng, Li Shia, and Loh, Woei Shyang

Abstract

Objective: Hearing loss (HL) has been postulated to be linked to cardiovascular diseases (CVDs) via vascular mechanisms, but epidemiological associations remain unclear. The study aims to clarify the association between HL and stroke, coronary artery disease (CAD), and any CVD. Data Sources: PubMed, Embase, and SCOPUS from inception until April 27, 2022. Review Methods: Three blinded reviewers selected observational studies reporting stroke, CAD, and any CVD in patients with HL, compared to individuals without HL. We extracted data, evaluated study bias using the Newcastle‐Ottawa scale, following Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines and a PROSPERO‐registered protocol (CRD42022348648). We used random‐effects inverse variance meta‐analyses to pool the odds ratios (ORs) for the association of HL with stroke, CAD, and any CVD. Results: We included 4 cohort studies (N = 940,771) and 6 cross‐sectional studies (N = 680,349). Stroke, CAD, and any CVD were all strongly associated with HL. The overall pooled OR of the association between HL and stroke was 1.26 (95% confidence interval [CI] = 1.16‐1.37, I2 = 78%), and was 1.33 (95% CI = 1.12‐1.58) and 1.29 (95% CI = 1.14‐1.45) for low‐ and high‐frequency HL, respectively. Minimal publication bias was observed, with minimal change to pooled effect size following trim and fill. Similarly, the pooled OR of the association between HL and CAD was 1.36 (95% CI = 1.13‐1.64, I2 = 96%), while that between HL and any CVD was 1.38 (95% CI = 1.07‐1.77, I2 = 99%). Conclusion: Our findings suggest that HL and CVD are closely related. Physicians treating patients with HL should be cognizant of this association and view HL in the broader context of general health and aging. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Large language models approach expert-level clinical knowledge and reasoning in ophthalmology: A head-to-head cross-sectional study

Author

Thirunavukarasu, Arun James, primary, Mahmood, Shathar, additional, Malem, Andrew, additional, Foster, William Paul, additional, Sanghera, Rohan, additional, Hassan, Refaat, additional, Zhou, Sean, additional, Wong, Shiao Wei, additional, Wong, Yee Ling, additional, Chong, Yu Jeat, additional, Shakeel, Abdullah, additional, Chang, Yin-Hsi, additional, Tan, Benjamin Kye Jyn, additional, Jain, Nikhil, additional, Tan, Ting Fang, additional, Rauz, Saaeha, additional, Ting, Daniel Shu Wei, additional, and Ting, Darren Shu Jeng, additional

Published
2023
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22. Meta‐analysis of multi‐modality therapies in sinonasal undifferentiated carcinoma—A timely update.

Author

See, Alicia Su Yun, Chu, Clarisse, Lim, Isis Claire Zhen Yu, Tan, Benjamin Kye Jyn, Ang, Sheryl Xiu Qi, Xu, Shuhui, Teo, Neville Wei Yang, and Charn, Tze Choong

Subjects
CARCINOMA, PARANASAL sinuses, OVERALL survival, SURVIVAL rate, DESCRIPTIVE statistics
Abstract

Objectives: Sinonasal undifferentiated carcinoma (SNUC) is a rare but aggressive tumour with very poor prognosis. There are currently no well‐established clinical trials to guide therapy and the impact of various treatment modalities on survival is not well defined. We aim to provide an updated systematic review on current treatment modalities on survival outcomes. Design and Setting: Individual patient data were extracted, and survival data pooled in a one‐stage meta‐analysis. Descriptive statistics were analysed using the Kaplan–Meier method. Patient‐level comparisons stratified by treatment modalities, adjusted for demographics, were conducted using shared‐frailty Cox regression. Participants and Main outcome measures: Participants include all patients diagnosed with SNUC based on histological evidence. We looked at the overall cumulative survival outcome for different treatment modalities and overall survival by treatment modality in low versus high stage SNUC patients. Results and Conclusion: Seventeen studies were identified, comprising 208 patients from 1993 to 2020. There was no significant difference in cumulative overall survival in low versus high stage patients, and no significant difference in outcomes by treatment modality. The overall cumulative survival of SNUC is 30% at 95 months. Among patients treated with various combinations of treatment modalities, patients with chemoradiotherapy had the highest cumulative survival of 42% at 40 months. Definitive chemoradiotherapy was associated with improved disease survival rate. Regardless of tumour stage, patients should be treated early and aggressively, with no superiority of one treatment regimen over another. Trimodality treatment does not confer survival advantage over bimodality treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Neutralising antibody titers and COVID outcomes in cancer patients

Author

Lee, Matilda Xinwei, primary, Peng, Siyu, additional, Lee, Ainsley Ryan Yan Bin, additional, Tay, Ryan Yong Kiat, additional, Li, Jiaqi, additional, Wong, Shi Yin, additional, Tariq, Areeba, additional, Goh, Claire Xin Yi, additional, Tan, Ying Kiat, additional, Tan, Benjamin Kye Jyn, additional, Teo, Chong Boon, additional, Chan, Esther, additional, Ooi, Melissa, additional, Chng, Wee Joo, additional, Chee, Cheng Ean, additional, Ho, Carol LF., additional, Walsh, Robert John, additional, Sethi, Sunil Kumar, additional, Tan, Shaun Shi Yan, additional, Chan, Yiong Huak, additional, Tan, Kelvin Bryan, additional, Lee, Soo-Chin, additional, Chai, Louis Yi Ann, additional, and Sundar, Raghav, additional

Published
2023
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26. Clinical efficacy and long-term immunogenicity of an early triple dose regimen of SARS-CoV-2 mRNA vaccination in cancer patients

Author

Lee, Matilda Xinwei, primary, Peng, Siyu, additional, Lee, Ainsley Ryan Yan Bin, additional, Wong, Shi Yin, additional, Tay, Ryan Yong Kiat, additional, Li, Jiaqi, additional, Tariq, Areeba, additional, Goh, Claire Xin Yi, additional, Tan, Ying Kiat, additional, Tan, Benjamin Kye Jyn, additional, Teo, Chong Boon, additional, Chan, Esther, additional, Ooi, Melissa, additional, Chng, Wee Joo, additional, Chee, Cheng Ean, additional, Ho, Carol LF, additional, Walsh, Robert John, additional, Wong, Maggie, additional, Su, Yan, additional, Alexander, Lezhava, additional, Sethi, Sunil Kumar, additional, Tan, Shaun Shi Yan, additional, Chan, Yiong Huak, additional, Tan, Kelvin Bryan, additional, Lee, Soo-Chin, additional, Chai, Louis Yi Ann, additional, and Sundar, Raghav, additional

Published
2023
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27. Obstructive sleep apnea and the incidence and mortality of gastrointestinal cancers: a systematic review and meta-analysis of 5,120,837 participants

Author

Teo, Yao Hao, primary, Tan, Benjamin Kye Jyn, additional, Tan, Nicole Kye Wen, additional, Yap, Dominic Wei Ting, additional, Chai, Yi Xuen, additional, Teo, Yao Neng, additional, Sia, Ching-Hui, additional, Sundar, Raghav, additional, Tan, Emile, additional, See, Anna, additional, and Toh, Song Tar, additional

Published
2022
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29. Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves

Author

Tan, Benjamin Kye Jyn, primary, Han, Ruobing, additional, Zhao, Joseph J, additional, Tan, Nicole Kye Wen, additional, Quah, Emrick Sen Hui, additional, Tan, Claire Jing-Wen, additional, Chan, Yiong Huak, additional, Teo, Neville Wei Yang, additional, Charn, Tze Choong, additional, See, Anna, additional, Xu, Shuhui, additional, Chapurin, Nikita, additional, Chandra, Rakesh K, additional, Chowdhury, Naweed, additional, Butowt, Rafal, additional, von Bartheld, Christopher S, additional, Kumar, B Nirmal, additional, Hopkins, Claire, additional, and Toh, Song Tar, additional

Published
2022
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30. Choice of PD-L1 immunohistochemistry assay influences clinical eligibility for gastric cancer immunotherapy.

Author

Tay, Ryan Yong Kiat, primary, Yeong, Joe Poh Sheng, additional, Lum, Jeffrey, additional, Teo, Chong Boon, additional, Tan, Benjamin Kye Jyn, additional, Chan, Yiong Huak, additional, Choo, Joan RE, additional, Jeyasekhran, Anand, additional, Miow, Qing Hao, additional, Loo, Lit-Hsin, additional, Yong, Wei-Peng, additional, and Sundar, Raghav, additional

Published
2022
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31. PRECISE CURATE.AI: A prospective feasibility trial to dynamically modulate personalized chemotherapy dose with artificial intelligence.

Author

Blasiak, Agata, primary, Truong, Anh, additional, Tan, Wen Jeit, Lester, additional, Kumar, Kirthika Senthil, additional, Tan, Shi Bei, additional, Teo, Chong Boon, additional, Tan, Benjamin Kye Jyn, additional, Tadeo, Xavier, additional, Tan, Hon Lyn, additional, Chee, Cheng Ean, additional, Yong, Wei-Peng, additional, Ho, Dean, additional, and Sundar, Raghav, additional

Published
2022
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33. Association of Olfactory Impairment With All-Cause Mortality

Author

Pang, Natalie Yan-Lin, primary, Song, Harris Jun Jie Muhammad Danial, additional, Tan, Benjamin Kye Jyn, additional, Tan, Jun Xiang, additional, Chen, Ashley Si Ru, additional, See, Anna, additional, Xu, Shuhui, additional, Charn, Tze Choong, additional, and Teo, Neville Wei Yang, additional

Published
2022
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35. Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis

Author

Lee, Ainsley Ryan Yan Bin, primary, Wong, Shi Yin, additional, Chai, Louis Yi Ann, additional, Lee, Soo Chin, additional, Lee, Matilda Xinwei, additional, Muthiah, Mark Dhinesh, additional, Tay, Sen Hee, additional, Teo, Chong Boon, additional, Tan, Benjamin Kye Jyn, additional, Chan, Yiong Huak, additional, Sundar, Raghav, additional, and Soon, Yu Yang, additional

Published
2022
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44. Relationship between vision impairment and employment

Author

Chai, Yi Xuen, primary, Gan, Alfred Tau Liang, additional, Fenwick, Eva K, additional, Sui, Abraham Y, additional, Tan, Benjamin Kye Jyn, additional, Quek, Debra Q Y, additional, Qian, Chaoxu, additional, Wong, Tien Yin, additional, Cheng, Ching-Yu, additional, Lamoureux, Ecosse Luc, additional, and Man, Ryan Eyn Kidd, additional

Published
2021
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45. Efficacy of COVID-19 vaccines in immunocompromised patients: A systematic review and meta-analysis

Author

Lee, Ainsley Ryan Yan Bin, primary, Wong, Shi Yin, additional, Chai, Louis Yi Ann, additional, Lee, Soo Chin, additional, Lee, Matilda, additional, Muthiah, Mark Dhinesh, additional, Tay, Sen Hee, additional, Teo, Chong Boon, additional, Tan, Benjamin Kye Jyn, additional, Chan, Yiong Huak, additional, Sundar, Raghav, additional, and Soon, Yu Yang, additional

Published
2021
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47. Abstract CT211: Personalized, rational, efficacy-driven chemotherapy dosing via an artificial intelligence system (PRECISE): A protocol for the PRECISE CURATE.AI pilot clinical trial

Author

Teo, Chong Boon, primary, Tan, Benjamin Kye Jyn, additional, Tadeo, Xavier, additional, Peng, Siyu, additional, Soh, Hazel Pei Lin, additional, Du, Sherry De Xuan, additional, Luo, Vilianty Wen Ya, additional, Bandla, Aishwarya, additional, Sundar, Raghav, additional, Ho, Dean, additional, Kee, Theodore, additional, and Blasiak, Agata, additional

Published
2021
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48. Erratum to: Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis

Author

Tan, Benjamin Kye Jyn, primary, Eyn Kidd Man, Ryan, additional, Tau Liang Gan, Alfred, additional, Fenwick, Eva K, additional, Varadaraj, Varshini, additional, Swenor, Bonnielin K, additional, Gupta, Preeti, additional, Wong, Tien Yin, additional, Trevisan, Caterina, additional, Lorenzo-López, Laura, additional, Maseda, Ana, additional, Millán-Calenti, José Carlos, additional, Schwanke, Carla Helena Augustin, additional, Liljas, Ann, additional, Al Snih, Soham, additional, Tokuda, Yasuharu, additional, and Lamoureux, Ecosse Luc, additional

Published
2021
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49. Relationship between vision impairment and employment

Author

Chai, Yi Xuen, Gan, Alfred Tau Liang, Fenwick, Eva K, Sui, Abraham Y, Tan, Benjamin Kye Jyn, Quek, Debra Q Y, Qian, Chaoxu, Wong, Tien Yin, Cheng, Ching-Yu, Lamoureux, Ecosse Luc, and Man, Ryan Eyn Kidd

Abstract

AimsTo examine the relationship between vision impairment (VI) and employment outcomes in a multiethnic Asian population.MethodsWe included 7608 Asian individuals aged ≥40 years (mean (SD) age: 58.4 (10.3) years; 64.8% male) from the Singapore Epidemiology Eye Disease Study (response rate: 78.8%), a population-based cohort study (mean follow-up period: 6.2 years). Presenting visual acuity (VA) was assessed using a logarithm of the minimum angle of resolution (logMAR) chart, with VI defined as mild (VA >0.3 to <0.6 logMAR) and moderate to severe (VA ≥0.6 logMAR). Self-reported employment statuses at both baseline and follow-up were used as outcomes. Underemployment was defined as a decline in occupational skill level, categorised by International Standard Classification of Occupations, at follow-up compared with baseline. Multinomial logistic regression models were used to determine independent associations between VI and various employment outcomes, adjusted for variables that were found to significantly differ across employment statuses.ResultsPresenting VI was prevalent in 20.2% (N=1536) of participants. Compared with those without VI, participants with mild and moderate to severe VI were more likely to be unemployed at baseline (OR 1.47, 95% CI 1.15 to 1.87, p=0.002 and 2.74, 95% CI 1.94 to 3.89, p<0.001, respectively). At follow-up, participants with any VI at baseline were more likely to be underemployed (OR 1.46, 95% CI 1.03 to 2.05, p=0.033).ConclusionVI, even when mild, is associated with unemployment and underemployment. Future studies should investigate whether visual interventions could be used as part of a multipronged strategy to improve employment outcomes for the population.

Published
2023
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