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Your search keyword '"Tamminen, Kirsi"' showing total 34 results
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34 results on '"Tamminen, Kirsi"'

5. A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine

Author

Leroux-Roels, Isabel, primary, Maes, Cathy, additional, Joye, Jasper, additional, Jacobs, Bart, additional, Jarczowski, Franziska, additional, Diessner, André, additional, Janssens, Yorick, additional, Waerlop, Gwenn, additional, Tamminen, Kirsi, additional, Heinimäki, Suvi, additional, Blazevic, Vesna, additional, Leroux-Roels, Geert, additional, Klimyuk, Victor, additional, Adachi, Hiroshi, additional, Hiruta, Kazuyuki, additional, and Thieme, Frank, additional

Published
2022
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17. Early life exposure to common virus infections did not differ between coeliac disease patients and controls

Author

Simre, Kärt, Uibo, Oivi, Peet, Aleksandr, Puustinen, Leena, Oikarinen, Sami, Tamminen, Kirsi, Blazevic, Vesna, Tillmann, Vallo, Hämäläinen, Anu-Maaria, Härkönen, Taina, Siljander, Heli, Virtanen, Suvi M., Ilonen, Jorma, Hyöty, Heikki, Knip, Mikael, Uibo, Raivo, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, and Tampere University

Subjects
Coeliac disease, Rhinovirus, Viral infection, Biolääketieteet - Biomedicine, Sisätaudit - Internal medicine, Childhood infections, Enterovirus
Published
2019

33. Early-life exposure to common virus infections did not differ between coeliac disease patients and controls.

Author

Simre K, Uibo O, Peet A, Puustinen L, Oikarainen S, Tamminen K, Blazevic V, Tillmann V, Hämäläinen AM, Härkönen T, Siljander H, Virtanen SM, Ilonen J, Hyöty H, Knip M, and Uibo R

Subjects
Antibodies, Viral blood, Case-Control Studies, Celiac Disease immunology, Child, Preschool, Cohort Studies, Feces virology, Humans, Nose virology, Celiac Disease virology, Virus Diseases complications
Abstract

Aim: Our aim was to compare the presence of various common viruses (rhinovirus, enterovirus, adenovirus, Epstein-Barr virus, cytomegalovirus, norovirus, parechovirus) in stool and nasal swab samples as well as virus-specific antibodies in serum samples between children who developed coeliac disease and controls., Methods: A case-control study was established based on the DIABIMMUNE Study cohorts. During the study, eight Estonian children and 21 Finnish children aged 1.5 years to five years developed coeliac disease and each was matched with a disease-free control. Nasal swabs and stool samples were taken at the age of three to six months and the serum samples at the time of diagnosis., Results: Rhinovirus ribonucleic acid was detected in the nasal swabs from five coeliac disease children, but none of the control children (p = 0.05). There were no statistically significant differences in the level of viral antibodies between cases and controls. Enterovirus immunoglobulin G class antibodies were found more frequently in the Estonian than in the Finnish children (63% versus 23%, p = 0.02)., Conclusion: This study did not find any marked overall differences in laboratory-confirmed common viral infections between the children who developed coeliac disease and the controls. However, rhinovirus infections were detected slightly more often in those patients who developed coeliac disease., (©2019 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)

Published
2019
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34. Pre-existing immunity to norovirus GII-4 virus-like particles does not impair de novo immune responses to norovirus GII-12 genotype.

Author

Tamminen K, Huhti L, Vesikari T, and Blazevic V

Subjects
Animals, Female, Genotype, Mice, Mice, Inbred BALB C, Norovirus classification, Norovirus genetics, Vaccines, Virus-Like Particle administration & dosage, Viral Vaccines administration & dosage, Caliciviridae Infections immunology, Caliciviridae Infections virology, Cross Reactions, Immune Tolerance, Norovirus immunology, Vaccines, Virus-Like Particle immunology, Viral Vaccines immunology
Abstract

Noroviruses (NoVs) are one of the leading causes of acute nonbacterial gastroenteritis in humans of all ages. In the 1990s, NoV genotype GII-4 became responsible for the majority of NoV sporadic gastroenteritis cases and outbreaks worldwide. Vaccine development against NoV GII-4 is underway. At the same time, there is concern of new emerging NoV genotypes, such as GII-12, which has been recently associated with increasing numbers of NoV outbreaks worldwide. The specific question is whether type-specific pre-existing immunity to NoV GII-4 might impair cognate immune response induced by new viral infections or vaccines. Using GII-4 and GII-12 virus-like particles, we tested the impact of the immunity generated against NoV GII-4 on de novo antibody responses to GII-12 in mice. We found that pre-existing immunity to NoV GII-4 did not impair de novo immune response to the novel antigen, therefore suggesting lack of original antigenic sin (OAS).

Published
2013
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