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Examines kanji errors in handwriting of Japanese students and Australian learners of Japanese. Finds that Japanese students' phonologically-related kanji writing errors were most numerous, followed by orthographically-related errors and semantically-related errors; while Australian students wrote more non-existing kanji and made orthographically-related mistakes rather than semantically- and phonologically-related errors. Proposes suggestions for methods of teaching kanji writing. (SR)

The present study examined two questions concerning the cognitive processing of Japanese loanwords borrowed from English and written in katakana. The first question was whether “interlexical activation” occurs between Japanese and English. Results from a lexical decision task showed that loanwords phonetically similar to the original English words were judged with the same speed and accuracy as those being phonetically dissimilar to their original English words. The study further examined the cognitive processing of unadopted loanwords (i.e., words unlisted in a Japanese loanword dictionary). Reaction times displayed the shortest mean for non–words, followed by pseudo–loanwords, and finally unadopted loanwords. Thus, the only time the lexical representation of an original English word was possibly activated was when native Japanese speakers had seldom seen the word in katakana. The second question was what creates the “lexical mental boundary” between adopted and unadopted loanwords. A questionnaire showed that native Japanese speakers are likely to use decision–making strategies for determining lexicality of loanwords in Japanese based on their daily experience of exposure to katakana words in print. [ABSTRACT FROM AUTHOR]

CYFRA 21-1 is a fragment of cytokeratin 19 (CK 19). Four patients with large intrahepatic (or peripheral) cholangiocarcinoma (CC) and high serum levels of CYFRA 21-1 (normal, < or = 2 ng/ml) are reported. CYFRA 21-1 levels exceeded 9 ng/ml in all 4 patients. Carcinoembryonic antigen (CEA), was high in 1 (CEA; normal range, < or = 5.0 ng/ml) and carbohydrate antigen 19-9 (CA 19-9) was high in 3 (CA19-9; normal range, < or = 36 U/ml). We also measured serum levels of CYFRA 21-1 in 13 patients with hepatocellular carcinoma (HCC) more than 5 cm in diameter. Levels of CYFRA 21-1 exceeded 2 ng/ml in 9 of the HCC patients and were higher than 9 ng/ml in 2 of the HCC patients. Levels of alpha fetoprotein (AFP) and/or protein induced by vitamin K absence or antagonist II (PIVKA II) were elevated in all HCC patients (AFP, PIVKA II, respectively; normal range, < or = 10.0 ng/ml and < or = 0.1 AU/ml) CYFRA 21-1 levels were measured twice or three times during the clinical course in 2 CC patients and in 6 HCC patients, and increased gradually with tumor growth in the 2 CC patients and in 3 of the 6 HCC patients. Marked increases in serum CYFRA 21-1 levels in patients with large liver cancers, particularly in those with normal levels of AFP and PIVKA II, would suggest the existence of intrahepatic CC rather than HCC. [ABSTRACT FROM AUTHOR]

Abstract Background Understanding ethanol tolerance in microorganisms is important for the improvement of bioethanol production. Hence, we performed parallel-evolution experiments using Escherichia coli cells under ethanol stress to determine the phenotypic changes necessary for ethanol tolerance. Results After cultivation of 1,000 generations under 5% ethanol stress, we obtained 6 ethanol-tolerant strains that showed an approximately 2-fold increase in their specific growth rate in comparison with their ancestor. Expression analysis using microarrays revealed that common expression changes occurred during the adaptive evolution to the ethanol stress environment. Biosynthetic pathways of amino acids, including tryptophan, histidine, and branched-chain amino acids, were commonly up-regulated in the tolerant strains, suggesting that activating these pathways is involved in the development of ethanol tolerance. In support of this hypothesis, supplementation of isoleucine, tryptophan, and histidine to the culture medium increased the specific growth rate under ethanol stress. Furthermore, genes related to iron ion metabolism were commonly up-regulated in the tolerant strains, which suggests the change in intracellular redox state during adaptive evolution. Conclusions The common phenotypic changes in the ethanol-tolerant strains we identified could provide a fundamental basis for designing ethanol-tolerant strains for industrial purposes.

Loeffler's endocarditis, characterized by eosinophilic infiltration leading to thrombus formation and fibrosis in the ventricle, is associated with severe complications, such as embolism and heart failure. While anticoagulation and steroids are standard treatments, surgical thrombectomy is rarely reported. This is a case report of a 74-year-old man presented with an abnormal electrocardiogram. Echocardiography revealed a 38 × 29 mm mass in the left ventricular apex, and blood studies revealed hypereosinophilia, leading to a diagnosis of Loeffler's endocarditis. Despite warfarin treatment, the thrombus persisted. The left ventricular intracardiac thrombus exhibited significant mobility, and we decided to perform a thrombectomy via a trans-left ventricular approach. After the surgery, steroid therapy was initiated. The patient recovered without recurrence of the thrombus or deterioration in cardiac function. Left ventricular thrombectomy for Loeffler's endocarditis is considered a beneficial option to prevent thrombosis., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Kimura et al.)

This study explored sentence processing in two typologically distinct languages: Korean, a verb-final language, and Tongan, a verb-initial language. The first experiment revealed that in Korean, sentences arranged in the scrambled OSV (Object, Subject, Verb) order were processed more slowly than those in the canonical SOV order, highlighting a scrambling effect. It also found that sentences with subject topicalization in the SOV order were processed as swiftly as those in the canonical form, whereas sentences with object topicalization in the OSV order were processed with speeds and accuracy comparable to scrambled sentences. However, since topicalization and scrambling in Korean use the same OSV order, independently distinguishing the effects of topicalization is challenging. In contrast, Tongan allows for a clear separation of word orders for topicalization and scrambling, facilitating an independent evaluation of topicalization effects. The second experiment, employing a maze task, confirmed that Tongan's canonical VSO order was processed more efficiently than the VOS scrambled order, thereby verifying a scrambling effect. The third experiment investigated the effects of both scrambling and topicalization in Tongan, finding that the canonical VSO order was processed most efficiently in terms of speed and accuracy, unlike the VOS scrambled and SVO topicalized orders. Notably, the OVS object-topicalized order was processed as efficiently as the VSO canonical order, while the SVO subject-topicalized order was slower than VSO but faster than VOS. By independently assessing the effects of topicalization apart from scrambling, this study demonstrates that both subject and object topicalization in Tongan facilitate sentence processing, contradicting the predictions based on movement-based anticipation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Tamaoka, Yu, Zhang, Otsuka, Lim, Koizumi and Verdonschot.)

This study is the first to report chronometric evidence on Tongan language production. It has been speculated that the mora plays an important role during Tongan phonological encoding. A mora follows the (C)V form, so /a/ and /ka/ (but not /k/) denote a mora in Tongan. Using a picture-word naming paradigm, Tongan native speakers named pictures containing superimposed non-word distractors. This task has been used before in Japanese, Korean, and Vietnamese to investigate the initially selected unit during phonological encoding (IPU). Compared with control distractors, both onset and mora overlapping distractors resulted in faster naming latencies. Several alternative explanations for the pattern of results-proficiency in English, knowledge of Latin script, and downstream effects-are discussed. However, we conclude that Tongan phonological encoding likely natively uses the phoneme, and not the mora, as the IPU.

The current study explored the role of sentential inference in connecting lexical/grammatical knowledge and overall text comprehension in foreign language learning. Using structural equation modeling (SEM), causal relationships were examined between four latent variables: lexical knowledge, grammatical knowledge, sentential inference, and text comprehension. The study analyzed 281 Chinese university students learning Japanese as a second language and compared two causal models: (1) the partially-mediated model, which suggests that lexical knowledge, grammatical knowledge, and sentential inference concurrently influence text comprehension, and (2) the wholly-mediated model, which posits that both lexical and grammatical knowledge impact sentential inference, which then further affects text comprehension. The SEM comparison analysis supported the wholly-mediated model, showing sequential causal relationships from lexical knowledge to sentential inference and then to text comprehension, without significant contribution from grammatical knowledge. The results indicate that sentential inference serves as a crucial bridge between lexical knowledge and text comprehension., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Tamaoka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

In English, Dutch, and other Germanic languages the initial phonological unit used in word production has been shown to be the phoneme; conversely, others have revealed that in Chinese this is the atonal syllable and in Japanese the mora. The current paper is, to our knowledge, the first to report chronometric data on Vietnamese phonological encoding. Vietnamese, a tonal language, is of interest as, despite its Austroasiatic roots, it has clear similarities with Chinese through extended contact over a prolonged period. Four experiments (i.e., masked priming, phonological Stroop, picture naming with written distractors, picture naming with auditory distractors) have been conducted to investigate Vietnamese phonological encoding. Results show that in all four experiments both onset effects as well as whole syllable effects emerge. This indicates that the fundamental phonological encoding unit during Vietnamese language production is the phoneme despite its apparent similarities to Chinese. This result might have emerged due to tone assignment being a qualitatively different process in Vietnamese compared to Chinese.

The present study investigated the canonical position of instrumental and locative adverbial phrases in both Japanese sentences and noun phrases to determine whether the canonical positions are parallel. A series of sentence/phrase decision tasks were used to compare sentences with different word-orders, including sentences with SAdvOV (S is subject phrase, Adv adverb, O object phrase and V verb), AdvSOV, SAdvOV and SOAdvV word orders. SAdvOV word order was found to be the most quickly processed, for both instrumental adverbial (Experiment 1) and locative adverbial phrases (Experiment 2). Thus, the canonical position for these adverbial phrases is identified as the position immediately preceding the object (Theme argument). This finding was replicated when the same experimental methods were applied to event-denoting noun phrases. Adverbial adjuncts in the initial position (AdvON, N is noun phrase) were processed more quickly and accurately than noun phrases with adverbial phrases in the second position (OAdvN), for both instrumental adverbial (Experiment 3) and locative adverbial phrases (Experiment 4). Therefore, the position immediately preceding the object is the canonical position for both instrumental and locative adverbial phrases in sentences and in noun phrases. In conclusion, this indicates that the base structure of a sentence is shared by its related noun phrase., (© 2022. The Author(s).)

The present study examined how prosody affects Japanese speakers' processing of the polarity item darenimo 'any/everyone'. Upward (LHHH pitch) and downward (HLLL pitch) prosody for darenimo associates with negative and positive polarity, respectively. In Study 1, a corpus search showed that darenimo is more often associated with negative than positive polarity. In Study 2, subjective acceptability judgments indicated that darenimo is also more likely to be perceived as acceptable by native Japanese speakers when used with negative polarity. In line with Study 2, Study 3 showed that upward prosody with negative polarity was more accurately and quickly processed than was downward prosody with either positive or negative polarity. These three studies showed a one-sided distribution of upward prosody with negative polarity, and further indicated that only upward prosody facilitates listeners' processing of negation. Early heightened pitch of darenimo provides a cue to predict an ending negation - nai in the head-final Japanese language, resulting in faster speed and higher accuracy for the processing of negative sentences (i.e., a facilitation effect) compared to their corresponding affirmative sentences., (© 2022 Katsuo Tamaoka and Yuanyuan Ji, published by De Gruyter, Berlin/Boston.)

The present study aimed to investigate how native Japanese speakers learning Chinese choose preferred positions for temporal adverbs depending on their level of Chinese proficiency. A naturalness judgment task conducted on native Chinese speakers showed that the most natural position for Chinese temporal adverbs was before the subject and that placement after the locative prepositional phrase was incorrect. The same task applied to native Japanese speakers found the most natural position for Japanese temporal adverbs was also before the subject. Further, when they appear at the beginning of a sentence, they provide the time for the entire sentence. Accordingly, temporal topicalization appears to influence naturalness decisions by both native Chinese and Japanese speakers. A point of difference was that in Japanese, a temporal adverb placed after a locative prepositional phrase was judged to be acceptable. When the same task was given to native Japanese speakers learning Chinese divided into three Chinese proficiency level groups, placement before the subject was the most preferred by the higher Chinese proficiency group. In addition, placement after the locative prepositional phrase was unfavored by them while the same position was frequently selected by the lower level group. As Chinese proficiency increases it appears that the preferred temporal adverb position is before the subject and the placement after the locative prepositional is judged to be unnatural. Thus, a sense of suitable temporal adverb positions in Chinese is influenced by the level of Chinese proficiency of native Japanese speakers., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Tamaoka and Zhang.)

Purpose: This retrospective study was conducted to compare the long-term outcomes of single-incision totally extraperitoneal (S-TEP) inguinal hernia repair and conventional multiport totally extraperitoneal (M-TEP) inguinal hernia repair., Methods: The study population included 186 consecutive patients (S-TEP, n = 149; M-TEP, n = 37) who underwent elective surgery for inguinal hernia at Osaka Police Hospital between 2011 and 2013., Results: No significant between-group difference was found in patient or hernia characteristics or in perioperative outcomes, with the exception of age (S-TEP group vs. M-TEP group: median 69 [IQR 60-75] years vs. 64 [55-69] years, respectively; P = 0.019). Furthermore, no significant between-group difference was found in follow-up time (5.5 [3.0-5.8] vs. 5.4 [3.1-5.7] years, P = 0.839), recurrence rate (0.6 vs. 2.4%, P = 0.358), chronic pain (1.2 vs. 0%, P = 1.000), feeling the mesh (2.3 vs. 7.1%, P = 0.142), or movement limitation (0.6 vs. 0%, P = 1.000). All chronic symptoms were "mild but not bothersome." A metachronous contralateral inguinal hernia developed in 8.1% of patients., Conclusion: The long-term outcomes of S-TEP repair were comparable to those of M-TEP, with rates of recurrence, chronic pain, feeling the mesh, and movement limitation falling within acceptable limits., (© 2021. Springer Nature Singapore Pte Ltd.)

Pseudo-entropy is an interesting quantity with a simple gravity dual, which generalizes entanglement entropy such that it depends on both an initial and a final state. Here we reveal the basic properties of pseudo-entropy in quantum field theories by numerically calculating this quantity for a set of two-dimensional free-scalar field theories and the Ising spin chain. We extend the Gaussian method for pseudo-entropy in free-scalar theories with two parameters: mass m and dynamical exponent z. This computation finds two novel properties of pseudo-entropy which we conjecture to be universal in field theories, in addition to an area law behavior. One is a saturation behavior and the other one is nonpositivity of the difference between pseudo-entropy and averaged entanglement entropy. Moreover, our numerical results for the Ising chain imply that pseudo-entropy can play a role as a new quantum order parameter which detects whether two states are in the same quantum phase or not.

A 67-year-old woman presented with bloody stools to a local physician. Lower gastrointestinal endoscopy revealed a type 3 all-circumferential tumor at descending colon. She was diagnosed with descending colon cancer and referred to our hospital for surgery. Preoperative computed tomography(CT)revealed a horseshoe kidney. We performed single-incision laparoscopic colectomy for descending colon cancer(cT3cN0cM0, cStageⅡa)complicated by a horseshoe kidney. The surgery was performed safely without any additional injuries. In patients with horseshoe kidneys, abnormalities have been reported in the running of the blood vascular system and the renal pelvis and ureter systems. Thus, sufficient understanding of the anatomic abnormality by preoperative examinations, such as 3D-CT, is essential for performing surgery safely.

We define a new information theoretic quantity called odd entanglement entropy (OEE) which enables us to compute the entanglement wedge cross section in holographic conformal field theories (CFTs). The entanglement wedge cross section has been introduced as a minimal cross section of the entanglement wedge, a natural generalization of the Ryu-Takayanagi surface. By using the replica trick, we explicitly compute the OEE for two-dimensional holographic CFT (three-dimensional anti-de Sitter space and planar Bañados-Teitelboim-Zanelli black hole) and see agreement with the entanglement wedge cross section. We conjecture this relation will hold in general dimensions.

We conducted a retrospective comparative study on feasibility of S-1/oxaliplatin(SOX)therapy and S-1/cisplatin therapy with short hydration(SP-SH)for gastric cancer in the outpatient setting. The subjects were patients with gastric cancer aged younger than 75 years who underwent SOX or SP-SH therapy at our hospital. There were 22 patients in the SOX group and 30 patients in the SP-SH group. Both the groups received the first course during hospitalization and then received the subsequent courses in the outpatient section. Evaluation items for each therapy included the treatment rate in the outpatient setting, number of re-hospitalization cases, relative dose intensity(RDI), and adverse events. The treatment rate in the outpatient setting was 100%(22/22)in the SOX group and 96%in the SP-SH group(26/27). Re-hospitalization cases included 1 case of loss of appetite in the SOX group and 1 cases of loss of appetite and 2 cases of febrile neutropenia(FN)in the SP-SH group. The median values of the RDI were 86% with S-1 and 85% with oxaliplatin in the SOX group and 92% with S-1 and 80% with cisplatin in the SP-SH group. The SP-SH group had a higher proportion of neutropenia cases of Grade 3 or higher(SP-SH 33% v. s SOX 5%, p=0.012). The SOX group showed a higher proportion of loss of appetite cases for all the Grades(SOX 86% v. s SP-SH 50%, p=0.007)and peripheral neuropathy cases(SOX 64% v. s SP-SH 23%, p=0.003). It was considered that SOX and SP-SH therapies can be treated in the outpatient section, although the occurrence of loss of appetite and FN must be considered.

BACKGROUND Cholangiocarcinoma is a rare, aggressive biliary tract malignancy. On histopathology, most tumors are adenocarcinomas, while squamous cell carcinoma of the biliary tract is extremely rare. CASE REPORT An 82-year-old male was admitted due to the detection of a space-occupying lesion at S6 of the liver. On abdominal dynamic computed tomography, there was an irregular mass with inhomogeneous density associated with mild delayed enhancement in the tumor's peripheral zone, measuring approximately 22×25 mm, at S6, with secondary dilated biliary ducts of B6. Endoscopic retrograde cholangiopancreatography showed a severe stricture at B6. Brush cytology of B6 was positive for both adenocarcinoma and squamous cell carcinoma. Furthermore, mucous brushing cytology of the papilla of Vater was also positive for adenocarcinoma. Finally, the preoperative diagnosis of primary intrahepatic cholangiocarcinoma, combined with a cancer of the papilla of Vater, was made. The patient underwent both extended right lobectomy and pancreaticoduodenectomy. Histological examination showed that the majority (>99%) of this liver tumor was composed of keratinizing squamous cell carcinoma. CONCLUSIONS Squamous cell carcinoma of the biliary tree is very rare, since the majority of biliary tree tumors are adenocarcinomas. Cholangiocarcinoma containing a squamous cell component has a poor prognosis. To the best of our knowledge, this is the first case report of a primary intrahepatic squamous cell carcinoma that presented as a solid tumor showing clear histological collision between adenocarcinoma and squamous cell carcinoma and was successfully treated with hepatic resection and achieved disease-free survival of more than one year.

[This corrects the article DOI: 10.1371/journal.pone.0178369.].

Previous studies on Korean relative clauses (RC) show that, with respect to processing, object-extracted relative clauses (ORC) are more difficult to process at the head noun than subject-extracted relative clauses within temporarily ambiguous contexts. ORCs, however, are predicted by experience-based processing models to incur a greater processing cost during early processing stages at the RC verb, since it is a likely locus of disambiguation for RCs in Korean, and because ORCs are a less frequent structure. Consequently, the current study investigates whether processing difficulty for ORCs manifests itself at the RC verb using eye-tracking methods, a simple sentence structure and a sentential-decision task. The results revealed significantly increased go-past reading times for ORCs at the RC verb. We believe this is a result of a less frequent structure being more difficult to parse during disambiguation. Accordingly, experience-based models of processing can accurately predict difficulty for ORCs in Korean.

This study addresses the question of whether native Mandarin Chinese speakers process and comprehend subject-extracted relative clauses (SRC) more readily than object-extracted relative clauses (ORC) in Mandarin Chinese. Presently, this has been a hotly debated issue, with various studies producing contrasting results. Using two eye-tracking experiments with ambiguous and unambiguous RCs, this study shows that both ORCs and SRCs have different processing requirements depending on the locus and time course during reading. The results reveal that ORC reading was possibly facilitated by linear/temporal integration and canonicity. On the other hand, similarity-based interference made ORCs more difficult, and expectation-based processing was more prominent for unambiguous ORCs. Overall, RC processing in Mandarin should not be broken down to a single ORC (dis)advantage, but understood as multiple interdependent factors influencing whether ORCs are either more difficult or easier to parse depending on the task and context at hand.

Most experimental research making use of the Japanese language has involved the 1945 officially standardized kanji (Japanese logographic characters) in the Jōyō kanji list (originally announced by the Japanese government in 1981). However, this list was extensively modified in 2010: five kanji were removed and 196 kanji were added; the latest revision of the list now has a total of 2136 kanji. Using an up-to-date corpus consisting of 11 years' worth of articles printed in the Mainichi Newspaper (2000-2010), we have constructed two novel databases that can be used in psychological research using the Japanese language: (1) a database containing a wide variety of properties on the latest 2136 Jōyō kanji, and (2) a novel database containing 27,950 two-kanji compound words (or jukugo). Based on these two databases, we have created an interactive website ( www.kanjidatabase.com ) to retrieve and store linguistic information to be used in psychological and linguistic experiments. The present paper reports the most important characteristics for the new databases, as well as their value for experimental psychological and linguistic research.

Using the eye-tracking method, the present study depicted pre- and post-head processing for simple scrambled sentences of head-final languages. Three versions of simple Japanese active sentences with ditransitive verbs were used: namely, (1) SO₁O₂V canonical, (2) SO₂O₁V single-scrambled, and (3) O₁O₂SV double-scrambled order. First pass reading times indicated that the third noun phrase just before the verb in both single- and double-scrambled sentences required longer reading times compared to canonical sentences. Re-reading times (the sum of all fixations minus the first pass reading) showed that all noun phrases including the crucial phrase before the verb in double-scrambled sentences required longer re-reading times than those required for single-scrambled sentences; single-scrambled sentences had no difference from canonical ones. Therefore, a single filler-gap dependency can be resolved in pre-head anticipatory processing whereas two filler-gap dependencies require much greater cognitive loading than a single case. These two dependencies can be resolved in post-head processing using verb agreement information.

An essential step to create phonology according to the language production model by Levelt, Roelofs and Meyer is to assemble phonemes into a metrical frame. However, recently, it has been proposed that different languages may rely on different grain sizes of phonological units to construct phonology. For instance, it has been proposed that, instead of phonemes, Mandarin Chinese uses syllables and Japanese uses moras to fill the metrical frame. In this study, we used a masked priming-naming task to investigate how bilinguals assemble their phonology for each language when the two languages differ in grain size. Highly proficient Mandarin Chinese-English bilinguals showed a significant masked onset priming effect in English (L2), and a significant masked syllabic priming effect in Mandarin Chinese (L1). These results suggest that their proximate unit is phonemic in L2 (English), and that bilinguals may use different phonological units depending on the language that is being processed. Additionally, under some conditions, a significant sub-syllabic priming effect was observed even in Mandarin Chinese, which indicates that L2 phonology exerts influences on L1 target processing as a consequence of having a good command of English.

English words with an inconsistent grapheme-to-phoneme conversion or with more than one pronunciation ("homographic heterophones"; e.g., "lead"-/lεd/, /lid/) are read aloud more slowly than matched controls, presumably due to competition processes. In Japanese kanji, the majority of the characters have multiple readings for the same orthographic unit: the native Japanese reading (KUN) and the derived Chinese reading (ON). This leads to the question of whether reading these characters also shows processing costs. Studies examining this issue have provided mixed evidence. The current study addressed the question of whether processing of these kanji characters leads to the simultaneous activation of their KUN and ON reading, This was measured in a direct way in a masked priming paradigm. In addition, we assessed whether the relative frequencies of the KUN and ON pronunciations ("dominance ratio", measured in compound words) affect the amount of priming. The results of two experiments showed that: (a) a single kanji, presented as a masked prime, facilitates the reading of the (katakana transcriptions of) their KUN and ON pronunciations; however, (b) this was most consistently found when the dominance ratio was around 50% (no strong dominance towards either pronunciation) and when the dominance was towards the ON reading (high-ON group). When the dominance was towards the KUN reading (high-KUN group), no significant priming for the ON reading was observed. Implications for models of kanji processing are discussed.

This study reports the factor structure of a Korean version of the 16-item Wong and Law Emotional Intelligence Scale (WLEIS) for a sample of 161 Korean university students. Confirmatory factor analysis supported the four-factor model of the WLEIS: (1) self-emotional appraisal, (2) others' emotional appraisal, (3) use of emotion, and (4) regulation of emotion. However, improvement of the model fit after removing three items suggests the need for future research on the cross-cultural measurement invariance of the WLEIS.

Theories of language production generally describe the segment as the basic unit in phonological encoding (e.g., Dell, 1988; Levelt, Roelofs, & Meyer, 1999). However, there is also evidence that such a unit might be language specific. Chen, Chen, and Dell (2002), for instance, found no effect of single segments when using a preparation paradigm. To shed more light on the functional unit of phonological encoding in Japanese, a language often described as being mora based, we report the results of 4 experiments using word reading tasks and masked priming. Experiment 1 demonstrated using Japanese kana script that primes, which overlapped in the whole mora with target words, sped up word reading latencies but not when just the onset overlapped. Experiments 2 and 3 investigated a possible role of script by using combinations of romaji (Romanized Japanese) and hiragana; again, facilitation effects were found only when the whole mora and not the onset segment overlapped. Experiment 4 distinguished mora priming from syllable priming and revealed that the mora priming effects obtained in the first 3 experiments are also obtained when a mora is part of a syllable. Again, no priming effect was found for single segments. Our findings suggest that the mora and not the segment (phoneme) is the basic functional phonological unit in Japanese language production planning.

Background: Understanding ethanol tolerance in microorganisms is important for the improvement of bioethanol production. Hence, we performed parallel-evolution experiments using Escherichia coli cells under ethanol stress to determine the phenotypic changes necessary for ethanol tolerance., Results: After cultivation of 1,000 generations under 5% ethanol stress, we obtained 6 ethanol-tolerant strains that showed an approximately 2-fold increase in their specific growth rate in comparison with their ancestor. Expression analysis using microarrays revealed that common expression changes occurred during the adaptive evolution to the ethanol stress environment. Biosynthetic pathways of amino acids, including tryptophan, histidine, and branched-chain amino acids, were commonly up-regulated in the tolerant strains, suggesting that activating these pathways is involved in the development of ethanol tolerance. In support of this hypothesis, supplementation of isoleucine, tryptophan, and histidine to the culture medium increased the specific growth rate under ethanol stress. Furthermore, genes related to iron ion metabolism were commonly up-regulated in the tolerant strains, which suggests the change in intracellular redox state during adaptive evolution., Conclusions: The common phenotypic changes in the ethanol-tolerant strains we identified could provide a fundamental basis for designing ethanol-tolerant strains for industrial purposes.

The present study investigated the existence of a Japanese mental syllabary and units stored therein for speech production. Experiment 1 compared naming latencies between high and low initial mora frequencies using CVCVCV nonwords, indicating that nonwords with a high initial mora frequency were named faster than those with a low frequency initial mora. Experiments 2 and 3 clarified the possibility of CV light and CVN/CVR heavy syllables as being units implicated in speech production. CVNCV nonwords in Experiment 2 and CVRCV nonwords in Experiment 3 displayed shorter naming latencies and lower error rates than their baseline (same bi-mora frequencies) of CVCVCV-structured nonwords. Since bi-mora frequencies between CVN/CVR and CVCV were the same, heavy syllables comprised of CVN and CVR units may contribute to ready-made motor-programs stored in the Japanese mental syllabary as variations of the 100 core light syllables (300 units in total). Experiment 4 further tested the effects of bi-mora frequency on the naming of nonwords, and found that CVCVCV-structured nonwords with high bi-mora frequencies were named more quickly and accurately than those with low bi-mora frequencies, although some bi-mora combinations seem to exhibit nonconforming tendencies (i.e., null significance in item analysis). Experiment 5 demonstrated that the naming of real words with high word frequency was quicker than for other real word conditions with low word frequencies (i.e., word frequency effects), with little effect of bi-mora frequencies. Unlike the nonword condition of Experiment 4, bi-mora frequency had only a minor influence on the naming of real words. Based on these findings, the present study proposes a possible model of the Japanese mental syllabary accompanied by a discussion of bi-mora and word frequency effects.

In an examination of the time course of activation of phonological and semantic information in processing kanji script, two lexical decision experiments were conducted with native readers of Japanese. Kanji targets were preceded at short (85-msec) and long (150-msec) intervals by homophonic, semantically related, or unrelated primes presented in kanji (Experiment 1) or by hiragana transcriptions of the kanji primes (Experiment 2). When primes were in kanji, semantic relatedness facilitated kanji target recognition at both intervals but homophonic relatedness did not. When primes were in hiragana, kanji target recognition was facilitated by homophonic relatedness at both intervals and by semantic relatedness only at the longer interval. The absence of homophonic priming of kanji targets by kanji primes challenges the universal phonology principle's claim that phonology is central to accessing meaning from print. The stimuli used in the present study may be downloaded from www.psychonomic.org/archive.

The present study investigated scrambling effects on the processing of Japanese sentences and priority information used among thematic roles, case particles and grammatical functions. Reaction times for correct sentence decisions were significantly prolonged for scrambled active sentences with transitive verbs in the first experiment and with ditransitive verbs in the second experiment. Errors were made with scrambled sentences more than canonical sentences in both experiments, which suggested that scrambling effects were apparent in active sentences. Passive sentences in the third experiment indicated that canonical order defined based on case particles, not thematic roles, was more quickly and accurately identified than scrambled order. Potential sentences in the fourth experiment and causative sentences in the fifth experiment indicated that the processing of scrambled sentences based on grammatical functions, but not on case particles, required longer reaction times and resulted in higher error rates than canonical sentences. Consequently, scrambling effects in the present study indicated that neither thematic roles nor case particles can provide fully-satisfactory information for canonical phrase order, and that only grammatical functions offer satisfactory information in all types of sentences.

On the basis of the lexical corpus created by Amano and Kondo (2000), using the Asahi newspaper, the present study provides frequencies of occurrence for units of Japanese phonemes, morae, and syllables. Among the five vowels, /a/ (23.42%), /i/ (21.54%), /u/ (23.47%), and /o/ (20.63%) showed similar frequency rates, whereas /e/ (10.94%) was less frequent. Among the 12 consonants, /k/ (17.24%), /t/ (15.53%), and /r/ (13.11%) were used often, whereas /p/ (0.60%) and /b/ (2.43%) appeared far less frequently. Among the contracted sounds, /sj/ (36.44%) showed the highest frequency, whereas /mj/ (0.27%) rarely appeared. Among the five long vowels, /aR/ (34.4%) was used most frequently, whereas /uR/ (12.11%) was not used so often. The special sound /N/ appeared very frequently in Japanese. The syllable combination /k/+V+/N/ (19.91%) appeared most frequently among syllabic combinations with the nasal /N/. The geminate (or voiceless obstruent) /Q/, when placed before the four consonants /p/, /t/, /k/, and /s/, appeared 98.87% of the time, but the remaining 1.13% did not follow the definition. The special sounds /R/, /N/, and /Q/ seem to appear very frequently in Japanese, suggesting that they are not special in terms of frequency counts. The present study further calculated frequencies for the 33 newly and officially listed morae/syllables, which are used particularly for describing alphabetic loanwords. In addition, the top 20 bi-mora frequency combinations are reported. Files of frequency indexes may be downloaded from the Psychonomic Society Web archive at http://www.psychonomic.org/archive/.

On the basis of calculations using the latest lexical database produced by Amano and Kondo (2000), the fourth edition of a Web-accessible database of characteristics of the 1,945 basic Japanese kanji was produced by including the mathematical concepts of entropy, redundancy, and symmetry and by replacing selected indexes found in previous editions (Tamaoka, Kirsner, Yanase, Miyaoka, & Kawakami, 2002). The kanji database in the fourth edition introduces seven new figures for kanji characteristics: (1) printed frequency, (2) lexical productivity, (3) accumulative lexical productivity, (4) symmetry for lexical productivity, (5) entropy, (6) redundancy, and (7) numbers of meanings for On-readings and Kun-readings. The file of the fourth edition of the kanji database may be downloaded from the Psychonomic Society Web archive, http://www.psychonomics.org/archive/.

This study makes explicit the limitations and possibilities of voice-key naming latency research on single hiragana symbols (a Japanese syllabic script) by examining three sets of voice-key naming data against Sakuma, Fushimi, and Tatsumi's 1997 speech-analyzer voice-waveform data. Analysis showed that voice-key measurement errors can be substantial in standard procedures as they may conceal the true effects of significant variables involved in hiragana-naming behavior. While one can avoid voice-key measurement errors to some extent by applying Sakuma, et al.'s deltas and by excluding initial phonemes which induce measurement errors, such errors may be ignored when test items are words and other higher-level linguistic materials.

The present study investigated the effects of phrase length and scrambling in the processing of Japanese sentences. Reading times of short phrases, long phrases, verbs, and whole sentences, measured by the method of self-paced reading, did not differ in terms of phrase-length order and scrambling. In addition, four types of sentences constructed on the basis of phrase-length order and scrambling did not affect duration times of correctness decision-making for sentences. However, error rates differed between canonical and scrambled sentences regardless of phrase-length order. This result implies that scrambled sentences were harder to judge as correct sentences than canonical sentences. Thus, scrambling affects the appropriate integration of information, whereas phrase-length order is simply an indication of preference and not of cognitive processing. To explain the present result, the authors propose the "configurational structure without movement," which predicts no difference in speed between the processing of canonical and scrambled sentences, apart from error rates.

We report two cases in which weekly paclitaxel (TXL) administration and concurrent radiation was effective for metastatic breast cancer. TXL (80 mg/m2) was infused over 1 hour after short premedication. Case 1: A 50-year-old woman was found to have atelectasis of the middle lobe after treatment for brain metastasis. She was diagnosed with hilar, mediastinal and supraclavicular lymph nodes metastases. She received weekly TXL administration and concurrent radiation to the mediastinum and supraclavicular fossa. The metastatic lymph nodes had disappeared one month after the treatment. Case 2: A 31-year-old woman was diagnosed with advanced breast cancer with lung, pleural, bone and orbital metastases. She received weekly TXL administration and concurrent radiation to the orbit. The lung and pleural metastases had disappeared and the orbital metastasis was decreased by 75% one month after the treatment, and the case was assessed as a partial response. Leukopenia and other major adverse effects were not observed in either of the two cases.

This study examined how skilled Japanese readers activate semantic information when reading kanji compound words at both the lexical and sentence levels. Experiment 1 used a lexical decision task for two-kanji compound words and nonwords. When nonwords were composed of kanji that were semantically similar to the kanji of real words, reaction times were longer and error rates were higher than when nonwords had kanji that were not semantically similar. Experiment 2 used a proofreading task (detection of kanji miscombinations) for the same two-kanji compound words and nonwords at the sentence level. In this task, semantically similar nonwords were detected faster than dissimilar nonwords, but error rates were much higher for the semantically similar nonwords. Experiment 3 used a semantic decision task for sentences with the same two-kanji compound words and nonwords. It took longer to detect semantically similar nonwords than dissimilar nonwords. This indicates that semantic involvement in the processing of Japanese kanji produces different effects, depending on whether this processing is done at the lexical or sentence level, which in turn is related to where the reader's attention lies.

In 1981, the Japanese government published a list of the 1,945 basic Japanese kanji (Jooyoo Kanji-hyo), including specifications of pronunciation. This list was established as the standard for kanji usage in print. The database for 1,945 basic Japanese kanji provides 30 cells that explain in detail the various characteristics of kanji. Means, standard deviations, distributions, and information related to previous research concerning these kanji are provided in this paper. The database is saved as a Microsoft Excel 2000 file for Windows. This kanji database is accessible on the Web site of the Oxford Text Archive, Oxford University (http://ota.ahds.ac.uk). Using this database, researchers and educators will be able to conduct planned experiments and organize classroom instruction on the basis of the known characteristics of selected kanji.

The methionine adenosyltransferase A1 (MATA1) gene encodes the hepatic forms of the enzyme MAT I and III. To determine the molecular mechanisms that regulate MATA1 gene expression, we characterized promoters and the 5'-flanking sequence of MATA1. Transient expression assays demonstrated the presence of two promoters for the MATA1 gene. The p1 promoter is contained in the -57 to -2 nucleotide region, and gives rise to the P1 transcript initiated at +1. The p2 promoter is contained in the -248 to -146 nucleotide region. The -229 to -213 nucleotide region of the MATA1 gene, which contains an Ets-binding-site sequence, was necessary for p2 promoter activity. Sequence analysis of 5'-RACE products indicated that there was a transcript (P2) initiated at -156. The -107 to +145 nucleotide region is missing from the mature P2 transcript, which suggests that the -107 to +145 nucleotide sequence is an intron of the P2 transcript. The p2 promoter may give rise to the P2 transcript. The p1 promoter activity was increased by glucocorticoids, but the p2 promoter activity was not affected by glucocorticoids.

Insulin, guanosine 5'-[gamma-thio]triphosphate (GTP[S] and phorbol 12-myristate 13-acetate (PMA) trigger the translocation of Gl UT4 (type 4 glucose transporter; insulin-sensitive glucose transporter) from an intracellular pool to the cell surface. We have developed a highly sensitive and quantitative method to detect GLUT4 immunologically on the surface of intact 3T3-L1 adipocytes and Chinese hamster ovary (CHO) cells, using c-myc epitope-tagged GLUT4 (GLUT4myc). We examined the roles of insulin, GTP[S] and PMA in the signalling pathways of GLUT4 translocation in the CHO cell system. Among small molecular GTP-binding proteins, ras, rab3D, rad and rho seem to be candidates as signal transmitters of insulin-stimulated GLUT4 translocation. Overexpression of wild-type H-ras and the dominant negative mutant H-rass17N in our cell system respectively enhanced and blocked insulin-stimulated activation of mitogen-activated protein kinase, but did not affect insulin-stimulated GLUT4 translocation. Overexpression of rab3D or rad in the cells did not affect GLUT4 translocation triggered by insulin, GTP[S] or PMA. Treatment with Botulinum C3 exoenzyme, a specific inhibitor of rho, had no effect on GLUT4 translocation induced by insulin, GTP[S] or PMA. Therefore these small molecular GTP-binding proteins are not likely to be involved in GLUT4 translocation. In addition, insulin, GTP[S] and PMA apparently stimulate GLUT4 translocation through independent pathways.

Intra-arterial digital subtraction portography (IA-DSP) with a blood-isotonic, non-ionic, dimeric contrast medium was carried out in 27 patients with hepatocellular carcinoma. It was possible to obtain images of excellent or good quality of the portal vein and its bilateral main branches in all patients. The third-order branches of the portal vein in the right lobe could be identified in all patients, and images of excellent or good quality were obtained in a mean of 80.2% of patients. Images of third-order branches in the left lobe were of lower quality than those of third-order branches in the right lobe; in particular, images obtained were of poor quality for 27.3% of the medial branches of the left lobe. It was impossible to identify the caudal branches in almost all patients. The side effects of IA-DSP, pain and sensations of heat were very mild: only one patient complained of mild pain, while 18 patients (69.2%) complained of no sensations of heat whatsoever.

Images of computed tomography (CT), ultrasonography (US), angiography and radionuclide imaging were analyzed in six cases of multifocal fatty infiltration of the liver. Histologic confirmation of fatty infiltration was obtained in one patient by percutaneous biopsy. In the remaining patients, presumptive confirmation of the diagnosis was based on the CT number in one patient and partial or complete resolution of the lesions on repeat CT scans or US in 4 patients. CT and US were performed in all six patients. CT scans demonstrated multiple round areas of low attenuation within both lobes of the liver in all cases. US studies showed hyperechoic foci in three cases and diffuse inhomogeneous hyperechogenicity in three cases. Hepatic arteriograms in five cases and liver scintigrams in four cases showed no evidence of space-occupying lesions. In all cases, the lesions completely or partially resolved in follow-up CT and US, and in four cases the lesions disappeared within two months, so follow-up examinations within about 2 months are necessary to differentiate these from liver neoplasms.