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The bacterial isolate MSB-6 collected from Visakhapatnam coast of Bay of Bengal, Andhra Pradesh, India has shown considerable activity against Proteus vulgaris MTCC1771, Bacillus subtilis MTCC441 and Escherichia coli MTCC443. So the culture conditions for the production of bioactive compounds by MSB-6 are optimized by using these pathogens as standard. Galactose and Peptone are the best carbon and nitrogen sources respectively for the optimum growth of the bacterial isolate. The metabolite production is initiated after 24 h of incubation and reached its maximum after 48 h and decreased gradually thereafter. The fermentation yield is high at 35°C and pH 7.0. [ABSTRACT FROM AUTHOR]