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1. One hundred malaria attacks since birth. A longitudinal study of African children and young adults exposed to high malaria transmission

Author

Trape, Jean-François, Diagne, Nafissatou, Diene-Sarr, Fatoumata, Faye, Joseph, Dieye-Ba, Fambaye, Bassène, Hubert, Badiane, Abdoulaye, Bouganali, Charles, Tall, Adama, Ndiaye, Ramatoulaye, Doucouré, Souleymane, Wotodjo, Amélé Nyedzie, Vigan-Womas, Inès, Guillotte-Blisnick, Micheline, Talla, Cheikh, Niang, Makhtar, Touré-Baldé, Aissatou, Perraut, Ronald, Roussilhon, Christian, Druilhe, Pierre, Rogier, Christophe, Mercereau-Puijalon, Odile, Loucoubar, Cheikh, and Sokhna, Cheikh

Published
2024
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2. A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens

Author

Sokhna Cheikh, Poinsignon Anne, Sarr Jean, Tall Adama, Toure-Baldé Aissatou, Remoue Franck, Orlandi-Pradines Eve, Dumoulin Chloé, Ambrosino Elena, Puget Karine, Trape Jean-François, Pascual Aurélie, Druilhe Pierre, Fusai Thierry, and Rogier Christophe

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Assessment exposure and immunity to malaria is an important step in the fight against the disease. Increased malaria infection in non-immune travellers under anti-malarial chemoprophylaxis, as well as the implementation of malaria elimination programmes in endemic countries, raises new issues that pertain to these processes. Notably, monitoring malaria immunity has become more difficult in individuals showing low antibody (Ab) responses or taking medications against the Plasmodium falciparum blood stages. Commonly available techniques in malaria seroepidemiology have limited sensitivity, both against pre-erythrocytic, as against blood stages of the parasite. Thus, the aim of this study was to develop a sensitive tool to assess the exposure to malaria or to bites from the vector Anopheles gambiae, despite anti-malarial prophylactic treatment. Methods Ab responses to 13 pre-erythrocytic P. falciparum-specific peptides derived from the proteins Lsa1, Lsa3, Glurp, Salsa, Trap, Starp, CSP and Pf11.1, and to 2 peptides specific for the Anopheles gambiae saliva protein gSG6 were tested. In this study, 253 individuals from three Senegalese areas with different transmission intensities and 124 European travellers exposed to malaria during a short period of time were included. Results The multiplex assay was optimized for most but not all of the antigens. It was rapid, reproducible and required a small volume of serum. Proportions of Ab-positive individuals, Ab levels and the mean number of antigens (Ags) recognized by each individual increased significantly with increases in the level of malaria exposure. Conclusion The multiplex assay developed here provides a useful tool to evaluate immune responses to multiple Ags in large populations, even when only small amounts of serum are available, or Ab titres are low, as in case of travellers. Finally, the relationship of Ab responses with malaria endemicity levels provides a way to monitor exposure in differentially exposed autochthonous individuals from various endemicity areas, as well as in travellers who are not immune, thus indirectly assessing the parasite transmission and malaria risk in the new eradication era.

Published
2010
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3. Use of HRP-2-based rapid diagnostic test for Plasmodium falciparum malaria: assessing accuracy and cost-effectiveness in the villages of Dielmo and Ndiop, Senegal

Author

Trape Jean-François, Sokhna Cheikh, Touré Aissatou, Rogier Christophe, Faye Joseph, Badiane Abdoulaye, Perry Robert, Baril Laurence, Tall Adama, Ly Alioune, and Michel Rémy

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In 2006, the Senegalese National Malaria Control Programme (NMCP) has recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria and, in 2007, mandated testing for all suspected cases of malaria with a Plasmodium falciparum HRP-2-based rapid diagnostic test for malaria (RDT(Paracheck®). Given the higher cost of ACT compared to earlier anti-malarials, the objectives of the present study were i) to study the accuracy of Paracheck® compared to the thick blood smear (TBS) in two areas with different levels of malaria endemicity and ii) analyse the cost-effectiveness of the strategy of the parasitological confirmation of clinically suspected malaria cases management recommended by the NMCP. Methods A cross-sectional study was undertaken in the villages of Dielmo and Ndiop (Senegal) nested in a cohort study of about 800 inhabitants. For all the individuals consulting between October 2008 and January 2009 with a clinical diagnosis of malaria, a questionnaire was filled and finger-prick blood samples were taken both for microscopic examination and RDT. The estimated costs and cost-effectiveness analysis were made considering five scenarios, the recommendations of the NMCP being the reference scenario. In addition, a sensitivity analysis was performed assuming that all the RDT-positive patients and 50% of RDT-negative patients were treated with ACT. Results A total of 189 consultations for clinically suspected malaria occurred during the study period. The sensitivity, specificity, positive and negative predictive values were respectively 100%, 98.3%, 80.0% and 100%. The estimated cost of the reference scenario was close to 700€ per 1000 episodes of illness, approximately twice as expensive as most of the other scenarios. Nevertheless, it appeared to us cost-effective while ensuring the diagnosis and the treatment of 100% of malaria attacks and an adequate management of 98.4% of episodes of illness. The present study also demonstrated that full compliance of health care providers with RDT results was required in order to avoid severe incremental costs. Conclusions A rational use of ACT requires laboratory testing of all patients presenting with presumed malaria. Use of RDTs inevitably has incremental costs, but the strategy associating RDT use for all clinically suspected malaria and prescribing ACT only to patients tested positive is cost-effective in areas where microscopy is unavailable.

Published
2010
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4. Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting

Author

Trape Jean-François, Ohashi Jun, Patarapotikul Jintana, Bouchier Christiane, Bischoff Emmanuel, Guillotte Micheline, Ekala Marie-Thérèse, Sokhna Cheikh, Tall Adama, Marrama Laurence, Jouin Hélène, Prugnolle Franck, Noranate Nitchakarn, Rogier Christophe, and Mercereau-Puijalon Odile

Subjects
Microbiology, QR1-502
Abstract

Abstract Background Genetic evidence for diversifying selection identified the Merozoite Surface Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against Plasmodium falciparum. The locus displays three family types and one recombinant type, each with multiple allelic forms differing by single nucleotide polymorphism as well as sequence, copy number and arrangement variation of three amino acid repeats. The family-specific antibody responses observed in endemic settings support immune selection operating at the family level. However, the factors contributing to the large intra-family allelic diversity remain unclear. To address this question, population allelic polymorphism and sequence variant-specific antibody responses were studied in a single Senegalese rural community where malaria transmission is intense and perennial. Results Family distribution showed no significant temporal fluctuation over the 10 y period surveyed. Sequencing of 358 PCR fragments identified 126 distinct alleles, including numerous novel alleles in each family and multiple novel alleles of recombinant types. The parasite population consisted in a large number of low frequency alleles, alongside one high-frequency and three intermediate frequency alleles. Population diversity tests supported positive selection at the family level, but showed no significant departure from neutrality when considering intra-family allelic sequence diversity and all families combined. Seroprevalence, analysed using biotinylated peptides displaying numerous sequence variants, was moderate and increased with age. Reactivity profiles were individual-specific, mapped to the family-specific flanking regions and to repeat sequences shared by numerous allelic forms within a family type. Seroreactivity to K1-, Mad20- and R033 families correlated with the relative family genotype distribution within the village. Antibody specificity remained unchanged with cumulated exposure to an increasingly large number of alleles. Conclusion The Pfmsp1 block2 locus presents a very large population sequence diversity. The lack of stable acquisition of novel antibody specificities despite exposure to novel allelic forms is reminiscent of clonal imprinting. The locus appears under antibody-mediated diversifying selection in a variable environment that maintains a balance between the various family types without selecting for sequence variant allelic forms. There is no evidence of positive selection for intra-family sequence diversity, consistent with the observed characteristics of the antibody response.

Published
2009
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5. Longitudinal survey of malaria morbidity over 10 years in Saharevo (Madagascar): further lessons for strengthening malaria control

Author

Ratovonjato Jocelyn, Randremanana Rindra, Rakotomanana Fanja, Ranarivelo Lanto A, Randrianasolo Laurence, Randriamanantena Arthur, Ratsimbasoa Arsène, Raharimalala Lucie A, Randrianarivelojosia Milijaona, Rabarijaona Léon P, Rason Marie-Ange, Duchemin Jean-Bernard, Tall Adama, Robert Vincent, Jambou Ronan, Ariey Frédéric, and Domarle Olivier

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Madagascar has been known for having bio-geo-ecological diversity which is reflected by a complex malaria epidemiology ranging from hyperendemic to malaria-free areas. Malaria-related attacks and infection are frequently recorded both in children and adults living in areas of low malaria transmission. To integrate this variability in the national malaria control policy, extensive epidemiological studies are required to up-date previous records and adjust strategies. Methods A longitudinal malaria survey was conducted from July 1996 to June 2005 among an average cohort of 214 villagers in Saharevo, located at 900 m above the sea. Saharevo is a typical eastern foothill site at the junction between a costal wet tropical area (equatorial malaria pattern) and a drier high-altitude area (low malaria transmission). Results Passive and active malaria detection revealed that malaria transmission in Saharevo follows an abrupt seasonal variation. Interestingly, malaria was confirmed in 45% (1,271/2,794) of malaria-presumed fevers seen at the health centre. All four Plasmodia that infect humans were also found: Plasmodium falciparum; Plasmodium vivax, Plasmodium malariae and Plasmodium ovale. Half of the malaria-presumed fevers could be confirmed over the season with the highest malaria transmission level, although less than a quarter in lower transmission time, highlighting the importance of diagnosis prior to treatment intake. P. falciparum malaria has been predominant (98%). The high prevalence of P. falciparum malaria affects more particularly under 10 years old children in both symptomatic and asymptomatic contexts. Children between two and four years of age experienced an average of 2.6 malaria attacks with P. falciparum per annum. Moreover, estimated incidence of P. falciparum malaria tends to show that half of the attacks (15 attacks) risk to occur during the first 10 years of life for a 60-year-old adult who would have experienced 32 malaria attacks. Conclusion The incidence of malaria decreased slightly with age but remained important among children and adults in Saharevo. These results support that a premunition against malaria is slowly acquired until adolescence. However, this claims for a weak premunition among villagers in Saharevo and by extension in the whole eastern foothill area of Madagascar. While the Malagasy government turns towards malaria elimination plans nowadays, choices and expectations to up-date and adapt malaria control strategies in the foothill areas are discussed in this paper.

Published
2009
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6. Assessment of the relative success of sporozoite inoculations in individuals exposed to moderate seasonal transmission

Author

Spiegel André, Trape Jean-François, Toure Aïssatou, Sarr Fatoumata D, Ly Alioune B, Marrama Laurence, Fontenille Didier, Perraut Ronald, Sokhna Cheikh, Tall Adama, Rogier Christophe, and Druilhe Pierre

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The time necessary for malaria parasite to re-appear in the blood following treatment (re-infection time) is an indirect method for evaluating the immune defences operating against pre-erythrocytic and early erythrocytic malaria stages. Few longitudinal data are available in populations in whom malaria transmission level had also been measured. Methods One hundred and ten individuals from the village of Ndiop (Senegal), aged between one and 72 years, were cured of malaria by quinine (25 mg/day oral Quinimax™ in three equal daily doses, for seven days). Thereafter, thick blood films were examined to detect the reappearance of Plasmodium falciparum every week, for 11 weeks after treatment. Malaria transmission was simultaneously measured weekly by night collection of biting mosquitoes. Results Malaria transmission was on average 15.3 infective bites per person during the 77 days follow up. The median reappearance time for the whole study population was 46.8 days, whereas individuals would have received an average one infective bite every 5 days. At the end of the follow-up, after 77 days, 103 of the 110 individuals (93.6%; CI 95% [89.0–98.2]) had been re-infected with P. falciparum. The median reappearance time ('re-positivation') was longer in subjects with patent parasitaemia at enrolment than in parasitologically-negative individuals (58 days vs. 45.9; p = 0.03) and in adults > 30 years than in younger subjects (58.6 days vs. 42.7; p = 0.0002). In a multivariate Cox PH model controlling for the sickle cell trait, G6PD deficiency and the type of habitat, the presence of parasitaemia at enrolment and age ≥ 30 years were independently predictive of a reduced risk of re-infection (PH = 0.5 [95% CI: 0.3–0.9] and 0.4; [95% CI: 0.2–0.6] respectively). Conclusion Results indicate the existence of a substantial resistance to sporozoites inoculations, but which was ultimately overcome in almost every individual after 2 1/2 months of natural challenges. Such a study design and the results obtained suggest that, despite a small sample size, this approach can contribute to assess the impact of intervention methods, such as the efficacy vector-control measures or of malaria pre-erythrocytic stages vaccines.

Published
2009
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7. Seroprevalence of anti-SARS-CoV-2 antibodies in Senegal: a national population-based cross-sectional survey, between October and November 2020

Author

Talla, Cheikh, Loucoubar, Cheikh, Roka, Jerlie Loko, Barry, Mamadou A., Ndiaye, Seynabou, Diarra, Maryam, Thiam, Mareme Seye, Faye, Oumar, Dia, Moussa, Diop, Mamadou, Ndiaye, Oumar, Tall, Adama, Faye, Rokhaya, Mbow, Adji Astou, Diouf, Babacar, Diallo, Jean Pierre, Keita, Ibrahima Mamby, Ndiaye, Mamadou, Woudenberg, Tom, White, Michael, Ting, Jim, Diagne, Cheikh Tidiane, Pasi, Omer, Diop, Boly, Sall, Amadou A., Vigan-Womas, Inès, and Faye, Ousmane

Published
2022
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9. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Band, Gavin, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Clarke, Geraldine, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, deVries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hubbart, Christina, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jeffreys, Anna, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Le, Si, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Ly, Alioune, Macharia, Alexander, MacInnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Kevin, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, McCreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Peshu, Norbert, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Rowlands, Kate, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, SanJoaquin, Miguel, Sepúlveda, Nuno, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Uyoga, Sophie, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, Ndila, Carolyne M, Macharia, Alexander W, Nyutu, Gideon, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Clark, Taane G, Kariuki, Silvia, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, and Williams, Thomas N

Published
2018
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10. Correction to: Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Dieye, Yakou, Hainsworth, Michael, Tall, Adama, Cissé, Badara, Faye, Farba, Sy, Mame Demba, Ba, Amadou, Sene, Doudou, Ba, Souleymane, Doucouré, Elhadji, Thiam, Tidiane, Diop, Moussa, Schneider, Kammerle, Cissé, Moustapha, Ba, Mady, Scott, Callie A., Kumar, Ritu, Asfaw, Elias, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Published
2020
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12. Analysis of contact tracing data showed contribution of asymptomatic and non-severe infections to the maintenance of SARS-CoV-2 transmission in Senegal

Author

Diarra, Maryam, primary, Ndiaye, Ramatoulaye, additional, Barry, Aliou, additional, Talla, Cheikh, additional, Diagne, Moussa Moise, additional, Dia, Ndongo, additional, Faye, Joseph, additional, Sarr, Fatoumata Diene, additional, Gaye, Aboubacry, additional, Diallo, Amadou, additional, Cisse, Mamadou, additional, Dieng, Idrissa, additional, Fall, Gamou, additional, Tall, Adama, additional, Faye, Oumar, additional, Faye, Ousmane, additional, Sall, Amadou A., additional, and Loucoubar, Cheikh, additional

Published
2023
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13. Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study

Author

Marks, Florian, von Kalckreuth, Vera, Aaby, Peter, Adu-Sarkodie, Yaw, El Tayeb, Muna Ahmed, Ali, Mohammad, Aseffa, Abraham, Baker, Stephen, Biggs, Holly M, Bjerregaard-Andersen, Morten, Breiman, Robert F, Campbell, James I, Cosmas, Leonard, Crump, John A, Espinoza, Ligia Maria Cruz, Deerin, Jessica Fung, Dekker, Denise Myriam, Fields, Barry S, Gasmelseed, Nagla, Hertz, Julian T, Van Minh Hoang, Nguyen, Im, Justin, Jaeger, Anna, Jeon, Hyon Jin, Kabore, Leon Parfait, Keddy, Karen H, Konings, Frank, Krumkamp, Ralf, Ley, Benedikt, Løfberg, Sandra Valborg, May, Jürgen, Meyer, Christian G, Mintz, Eric D, Montgomery, Joel M, Niang, Aissatou Ahmet, Nichols, Chelsea, Olack, Beatrice, Pak, Gi Deok, Panzner, Ursula, Park, Jin Kyung, Park, Se Eun, Rabezanahary, Henintsoa, Rakotozandrindrainy, Raphaël, Raminosoa, Tiana Mirana, Razafindrabe, Tsiriniaina Jean Luco, Sampo, Emmanuel, Schütt-Gerowitt, Heidi, Sow, Amy Gassama, Sarpong, Nimako, Seo, Hye Jin, Sooka, Arvinda, Soura, Abdramane Bassiahi, Tall, Adama, Teferi, Mekonnen, Thriemer, Kamala, Warren, Michelle R, Yeshitela, Biruk, Clemens, John D, and Wierzba, Thomas F

Published
2017
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14. Prevalence of Salmonella Excretion in Stool: A Community Survey in 2 Sites, Guinea-Bissau and Senegal

Author

Im, Justin, Nichols, Chelsea, Bjerregaard-Andersen, Morten, Sow, Amy Gassama, Løfberg, Sandra, Tall, Adama, Pak, Gi Deok, Aaby, Peter, Baker, Stephen, Clemens, John D., Espinoza, Ligia Maria Cruz, Konings, Frank, May, Jürgen, Monteiro, Mario, Niang, Aissatou, Panzner, Ursula, Park, Se Eun, Schütt-Gerowitt, Heidi, Wierzba, Thomas F., Marks, Florian, and von Kalckreuth, Vera

Published
2016

15. A Multicountry Molecular Analysis of Salmonella enterica Serovar Typhi With Reduced Susceptibility to Ciprofloxacin in Sub-Saharan Africa

Author

Al-Emran, Hassan M., Eibach, Daniel, Krumkamp, Ralf, Ali, Mohammad, Baker, Stephen, Biggs, Holly M., Bjerregaard-Andersen, Morten, Breiman, Robert F., Clements, John D., Crump, John A., Espinoza, Ligia Maria Cruz, Deerin, Jessica, Dekker, Denise Myriam, Sow, Amy Gassama, Hertz, Julian T., Im, Justin, Ibrango, Samuel, von Kalckreuth, Vera, Kabore, Leon Parfait, Konings, Frank, Lefberg, Sandra Valborg, Meyer, Christian G., Mintz, Eric D., Montgomery, Joel M., Olack, Beatrice, Pak, Gi Deok, Panzner, Ursula, Park, Se Eun, Razafindrabe, Jean Luco Tsiriniaina, Rabezanahary, Henintsoa, Rakotondrainiarivelo, Jean Philibert, Rakotozandrindrainy, Raphaël, Raminosoa, Tiana Mirana, Schütt-Gerowitt, Heidi, Sampo, Emmanuel, Soura, Abdramane Bassiahi, Tall, Adama, Warren, Michelle, Wierzba, Thomas F., May, Jürgen, and Marks, Florian

Published
2016

16. Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program

Author

Panzner, Ursula, Pak, Gi Deok, Aaby, Peter, Adu-Sarkodie, Yaw, Ali, Mohammad, Aseffa, Abraham, Baker, Stephen, Bjerregaard-Andersen, Morten, Crump, John A., Deerin, Jessica, Espinoza, Ligia Maria Cruz, Gasmelseed, Nagla, Heriniaina, Jean Noël, Hertz, Julian T., Im, Justin, von Kalckreuth, Vera, Keddy, Karen H., Lankoande, Bruno, Løfberg, Sandra, Meyer, Christian G., Oresto, Michael Munishi, Park, Jin Kyung, Park, Se Eun, Rakotozandrindrainy, Raphaël, Sarpong, Nimako, Soura, Abdramane Bassiahi, Sow, Amy Gassama, Tall, Adama, Teferi, Mekonnen, Worku, Alemayehu, Yeshitela, Biruk, Wierzba, Thomas F., and Marks, Florian

Published
2016

17. Validation and Identification of Invasive Salmonella Serotypes in Sub-Saharan Africa by Multiplex Polymerase Chain Reaction

Author

Al-Emran, Hassan M., Krumkamp, Ralf, Dekker, Denise Myriam, Eibach, Daniel, Aaby, Peter, Adu-Sarkodie, Yaw, Ali, Mohammad, Rubach, Mathew P., Bjerregaard-Andersen, Morten, Crump, John A., Espinoza, Ligia Maria Cruz, Lefberg, Sandra Valborg, Sow, Amy Gassama, Hertz, Julian T., Im, Justin, Jaeger, Anna, Kabore, Leon Parfait, Konings, Frank, Meyer, Christian G., Niang, Aissatou, Pak, Gi Deok, Panzner, Ursula, Park, Se Eun, Rabezanahary, Henintsoa, Rakotozandrindrainy, Raphaël, Raminosoa, Tiana Mirana, Razafindrabe, Tsiriniaina Jean Luco, Sampo, Emmanuel, Schütt-Gerowitt, Heidi, Sarpong, Nimako, Soura, Abdramane Bassiahi, Tall, Adama, von Kalckreuth, Vera, Wierzba, Thomas F., May, Jürgen, and Marks, Florian

Published
2016

18. The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa

Author

Park, Se Eun, Pak, Gi Deok, Aaby, Peter, Adu-Sarkodie, Yaw, Ali, Mohammad, Aseffa, Abraham, Biggs, Holly M., Bjerregaard-Andersen, Morten, Breiman, Robert F., Crump, John A., Espinoza, Ligia Maria Cruz, Eltayeb, Muna Ahmed, Gasmelseed, Nagla, Hertz, Julian T., Im, Justin, Jaeger, Anna, Kabore, Leon Parfait, von Kalckreuth, Vera, Keddy, Karen H., Konings, Frank, Krumkamp, Ralf, MacLennan, Calman A., Meyer, Christian G., Montgomery, Joel M., Niang, Aissatou Ahmet, Nichols, Chelsea, Olack, Beatrice, Panzner, Ursula, Park, Jin Kyung, Rabezanahary, Henintsoa, Rakotozandrindrainy, Raphaël, Sampo, Emmanuel, Schütt-Gerowitt, Heidi, Sooka, Arvinda, Soura, Abdramane Bassiahi, Sow, Amy Gassama, Tall, Adama, Teferi, Mekonnen, Yeshitela, Biruk, May, Jürgen, Wierzba, Thomas F., Clemens, John D., Baker, Stephen, and Marks, Florian

Published
2016

19. Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa

Author

Nichols, Chelsea, Espinoza, Ligia Maria Cruz, von Kalckreuth, Vera, Aaby, Peter, El Tayeb, Muna Ahmed, Ali, Mohammad, Aseffa, Abraham, Bjerregaard-Andersen, Morten, Breiman, Robert F., Cosmas, Leonard, Crump, John A., Dekker, Denise Myriam, Sow, Amy Gassama, Gasmelseed, Nagla, Hertz, Julian T., Im, Justin, Kabore, Leon Parfait, Keddy, Karen H., Konings, Frank, Løfberg, Sandra Valborg, Meyer, Christian G., Montgomery, Joel M., Niang, Aissatou, Njariharinjakamampionona, Andriamampionona, Olack, Beatrice, Pak, Gi Deok, Panzner, Ursula, Park, Jin Kyung, Park, Se Eun, Rabezanahary, Henintsoa, Rakotondrainiarivelo, Jean Philibert, Rakotozandrindrainy, Raphaël, Raminosoa, Tiana Mirana, Rubach, Matthew P., Teferi, Mekonnen, Seo, Hye Jin, Sooka, Arvinda, Soura, Abdramane, Tall, Adama, Toy, Trevor, Yeshitela, Biruk, Clemens, John D., Wierzba, Thomas F., Baker, Stephen, and Marks, Florian

Published
2015

20. The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

Author

Park, Se Eun, Pham, Duy Thanh, Boinett, Christine, Wong, Vanessa K., Pak, Gi Deok, Panzner, Ursula, Espinoza, Ligia Maria Cruz, von Kalckreuth, Vera, Im, Justin, Schütt-Gerowitt, Heidi, Crump, John A., Breiman, Robert F., Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, Rakotozandrindrainy, Raphaël, Soura, Abdramane Bassiahi, Aseffa, Abraham, Gasmelseed, Nagla, Keddy, Karen H., May, Jürgen, Sow, Amy Gassama, Aaby, Peter, Biggs, Holly M., Hertz, Julian T., Montgomery, Joel M., Cosmas, Leonard, Olack, Beatrice, Fields, Barry, Sarpong, Nimako, Razafindrabe, Tsiriniaina Jean Luco, Raminosoa, Tiana Mirana, Kabore, Leon Parfait, Sampo, Emmanuel, Teferi, Mekonnen, Yeshitela, Biruk, El Tayeb, Muna Ahmed, Sooka, Arvinda, Meyer, Christian G., Krumkamp, Ralf, Dekker, Denise Myriam, Jaeger, Anna, Poppert, Sven, Tall, Adama, Niang, Aissatou, Bjerregaard-Andersen, Morten, Løfberg, Sandra Valborg, Seo, Hye Jin, Jeon, Hyon Jin, Deerin, Jessica Fung, Park, Jinkyung, Konings, Frank, Ali, Mohammad, Clemens, John D., Hughes, Peter, Sendagala, Juliet Nsimire, Vudriko, Tobias, Downing, Robert, Ikumapayi, Usman N., Mackenzie, Grant A., Obaro, Stephen, Argimon, Silvia, Aanensen, David M., Page, Andrew, Keane, Jacqueline A., Duchene, Sebastian, Dyson, Zoe, Holt, Kathryn E., Dougan, Gordon, Marks, Florian, and Baker, Stephen

Published
2018
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25. Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study

Author

Trape, Jean-François, Tall, Adama, Diagne, Nafissatou, Ndiath, Ousmane, Ly, Alioune B, Faye, Joseph, Dieye-Ba, Fambaye, Roucher, Clémentine, Bouganali, Charles, Badiane, Abdoulaye, Sarr, Fatoumata Diene, Mazenot, Catherine, Touré-Baldé, Aïssatou, Raoult, Didier, Druilhe, Pierre, Mercereau-Puijalon, Odile, Rogier, Christophe, and Sokhna, Cheikh

Published
2011
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27. Common epidemiology of Rickettsia felis infection and malaria, Africa

Author

Mediannikov, Oleg, Socolovschi, Cristina, Edouard, Sophie, Fenollar, Florence, Mouffok, Nadjet, Bassene, Hubert, Diatta, Georges, Tall, Adama, Niangaly, Hamidou, Doumbo, Ogobara, Lekana-Douki, Jean Bernard, Znazen, Abir, Sarih, M'hammed, Ratmanov, Pavel, Richet, Herve, Ndiath, Mamadou O., Sokhna, Cheikh, Parola, Philippe, and Raoult, Didier

Subjects
Infection -- Health aspects -- Analysis, Malaria -- Health aspects -- Analysis, Epidemiology -- Health aspects -- Analysis, Health
Abstract

Investigations examining the etiologic spectrum of fever of unknown origin in Africa rapidly progressed during 2008-2011 (1-3), providing increased knowledge about bacterial infections. Bacterial agents that have been most frequently [...]

Published
2013
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30. The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries

Author

Park, Se Eun, primary, Pham, Duy Thanh, additional, Pak, Gi Deok, additional, Panzner, Ursula, additional, Maria Cruz Espinoza, Ligia, additional, von Kalckreuth, Vera, additional, Im, Justin, additional, Mogeni, Ondari D., additional, Schütt-Gerowitt, Heidi, additional, Crump, John A, additional, Breiman, Robert F, additional, Adu-Sarkodie, Yaw, additional, Owusu-Dabo, Ellis, additional, Rakotozandrindrainy, Raphaël, additional, Bassiahi Soura, Abdramane, additional, Aseffa, Abraham, additional, Gasmelseed, Nagla, additional, Sooka, Arvinda, additional, Keddy, Karen H, additional, May, Jürgen, additional, Aaby, Peter, additional, Biggs, Holly M, additional, Hertz, Julian T, additional, Montgomery, Joel M, additional, Cosmas, Leonard, additional, Olack, Beatrice, additional, Fields, Barry, additional, Sarpong, Nimako, additional, Razafindrabe, Tsiriniaina Jean Luco, additional, Raminosoa, Tiana Mirana, additional, Kabore, Leon Parfait, additional, Sampo, Emmanuel, additional, Teferi, Mekonnen, additional, Yeshitela, Biruk, additional, El Tayeb, Muna Ahmed, additional, Krumkamp, Ralf, additional, Dekker, Denise Myriam, additional, Jaeger, Anna, additional, Tall, Adama, additional, Gassama, Amy, additional, Niang, Aissatou, additional, Bjerregaard-Andersen, Morten, additional, Løfberg, Sandra Valborg, additional, Deerin, Jessica Fung, additional, Park, Jin Kyung, additional, Konings, Frank, additional, Carey, Megan E, additional, Van Puyvelde, Sandra, additional, Ali, Mohammad, additional, Clemens, John, additional, Dougan, Gordon, additional, Baker, Stephen, additional, and Marks, Florian, additional

Published
2021
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31. The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries

Author

Park, Se Eun, Pak, Gi Deok, Panzner, Ursula, Espinoza, Ligia Maria Cruz, von Kalckreuth, Vera, Im, Justin, Mogeni, Ondari D., Schutt-Gerowitt, Heidi, Crump, John A., Breiman, Robert F., Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, Rakotozandrindrainy, Raphael, Soura, Abdramane Bassiahi, Aseffa, Abraham, Gasmelseed, Nagla, Sooka, Arvinda, Keddy, Karen H., May, Jurgen, Aaby, Peter, Biggs, Holly M., Hertz, Julian T., Montgomery, Joel M., Cosmas, Leonard, Olack, Beatrice, Fields, Barry, Sarpong, Nimako, Razafindrabe, Tsiriniaina Jean Luco, Raminosoa, Tiana Mirana, Kabore, Leon Parfait, Sampo, Emmanuel, Teferi, Mekonnen, Yeshitela, Biruk, El Tayeb, Muna Ahmed, Krumkamp, Ralf, Dekker, Denise Myriam, Jaeger, Anna, Tall, Adama, Gassama, Amy, Niang, Aissatou, Bjerregaard-Andersen, Morten, Lofberg, Sandra Valborg, Deerin, Jessica Fung, Park, Jin Kyung, Konings, Frank, Carey, Megan E., Van Puyvelde, Sandra, Ali, Mohammad, Clemens, John, Dougan, Gordon, Baker, Stephen, Marks, Florian, Park, Se Eun, Pak, Gi Deok, Panzner, Ursula, Espinoza, Ligia Maria Cruz, von Kalckreuth, Vera, Im, Justin, Mogeni, Ondari D., Schutt-Gerowitt, Heidi, Crump, John A., Breiman, Robert F., Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, Rakotozandrindrainy, Raphael, Soura, Abdramane Bassiahi, Aseffa, Abraham, Gasmelseed, Nagla, Sooka, Arvinda, Keddy, Karen H., May, Jurgen, Aaby, Peter, Biggs, Holly M., Hertz, Julian T., Montgomery, Joel M., Cosmas, Leonard, Olack, Beatrice, Fields, Barry, Sarpong, Nimako, Razafindrabe, Tsiriniaina Jean Luco, Raminosoa, Tiana Mirana, Kabore, Leon Parfait, Sampo, Emmanuel, Teferi, Mekonnen, Yeshitela, Biruk, El Tayeb, Muna Ahmed, Krumkamp, Ralf, Dekker, Denise Myriam, Jaeger, Anna, Tall, Adama, Gassama, Amy, Niang, Aissatou, Bjerregaard-Andersen, Morten, Lofberg, Sandra Valborg, Deerin, Jessica Fung, Park, Jin Kyung, Konings, Frank, Carey, Megan E., Van Puyvelde, Sandra, Ali, Mohammad, Clemens, John, Dougan, Gordon, Baker, Stephen, and Marks, Florian

Abstract

Background Invasive non-typhoidal Salmonella (iNTS) is one of the leading causes of bacteraemia in sub-Saharan Africa. We aimed to provide a better understanding of the genetic characteristics and transmission patterns associated with multi-drug resistant (MDR) iNTS serovars across the continent. Methods A total of 166 iNTS isolates collected from a multi-centre surveillance in 10 African countries (2010-2014) and a fever study in Ghana (2007-2009) were genome sequenced to investigate the geographical distribution, antimicrobial genetic determinants and population structure of iNTS serotypes-genotypes. Phylogenetic analyses were conducted in the context of the existing genomic frameworks for various iNTS serovars. Population-based incidence of MDR-iNTS disease was estimated in each study site. Results Salmonella Typhimurium sequence-type (ST) 313 and Salmonella Enteritidis ST11 were predominant, and both exhibited high frequencies of MDR; Salmonella Dublin ST10 was identified in West Africa only. Mutations in the gyrA gene (fluoroquinolone resistance) were identified in S. Enteritidis and S. Typhimurium in Ghana; an ST313 isolate carrying bla(CTX-M-15) was found in Kenya. International transmission of MDR ST313 (lineage II) and MDR ST11 (West African clade) was observed between Ghana and neighbouring West African countries. The incidence of MDR-iNTS disease exceeded 100/100 000 person-years-of-observation in children aged Conclusions We identified the circulation of multiple MDR iNTS serovar STs in the sampled sub-Saharan African countries. Investment in the development and deployment of iNTS vaccines coupled with intensified antimicrobial resistance surveillance are essential to limit the impact of these pathogens in Africa.

Published
2021

32. Additional file 5 of Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Yakou Dieye, Hainsworth, Michael, Tall, Adama, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Diop, Moussa, Kammerle Schneider, Moustapha Cissé, Ba, Mady, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Subjects
parasitic diseases
Abstract

Additional file 5. Incident malaria cases over high malaria transmission seasons (Sept. to January) of 2012–2013*, 2013–2014 and 2014–2015 in intervention vs comparison group to assess parallel trends assumption in the difference-in-difference analysis.

Published
2020
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33. Additional file 3 of Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Yakou Dieye, Hainsworth, Michael, Tall, Adama, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Diop, Moussa, Kammerle Schneider, Moustapha Cissé, Ba, Mady, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Abstract

Additional file 3. PECADOM++ profile.

Published
2020
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34. Additional file 6 of Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Yakou Dieye, Hainsworth, Michael, Tall, Adama, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Diop, Moussa, Kammerle Schneider, Moustapha Cissé, Ba, Mady, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Subjects
Data_FILES
Abstract

Additional file 6. MTAT costs

Published
2020
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35. Additional file 1 of Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Yakou Dieye, Hainsworth, Michael, Tall, Adama, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Diop, Moussa, Kammerle Schneider, Moustapha Cissé, Ba, Mady, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Abstract

Additional file 1. Distribution of independent and dependent variables.

Published
2020
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36. Additional file 7 of Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Yakou Dieye, Hainsworth, Michael, Tall, Adama, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Diop, Moussa, Kammerle Schneider, Moustapha Cissé, Ba, Mady, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Subjects
Data_FILES
Abstract

Additional file 7. PECADOM++ costs.

Published
2020
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37. Additional file 2 of Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., Yakou Dieye, Hainsworth, Michael, Tall, Adama, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Diop, Moussa, Kammerle Schneider, Moustapha Cissé, Ba, Mady, Earle, Duncan, Guinot, Philippe, Steketee, Richard W., and Guinovart, Caterina

Subjects
parasitic diseases
Abstract

Additional file 2. Weekly incident malaria cases per 1000 population during the high transmission seasons (Sept. to January) in a) intervention and b) comparison health facility catchment areas*.

Published
2020
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38. Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3

Author

Roussilhon, Christian, Oeuvray, Claude, Muller-Graf, Christine, Tall, Adama, Rogier, Christophe, Trape, Jean-Francois, Theisen, Michael, Balde, Aissatou, Perignon, Jean-Louis, and Druilhe, Pierre

Abstract

Background Surrogate markers of protective immunity to malaria in humans are needed to rationalize malaria vaccine discovery and development. In an effort to identify such markers, and thereby provide a clue to the complex equation malaria vaccine development is facing, we investigated the relationship between protection acquired through exposure in the field with naturally occurring immune responses (i.e., induced by the parasite) to molecules that are considered as valuable vaccine candidates. Methods and Findings We analyzed, under comparative conditions, the antibody responses of each of six isotypes to five leading malaria vaccine candidates in relation to protection acquired by exposure to natural challenges in 217 of the 247 inhabitants of the African village of Dielmo, Senegal (96 children and 121 older adolescents and adults). The status of susceptibility or resistance to malaria was determined by active case detection performed daily by medical doctors over 6 y from a unique follow-up study of this village. Of the 30 immune responses measured, only one, antibodies of the IgG3 isotype directed to merozoite surface protein 3 (MSP3), was strongly associated with clinical protection against malaria in all age groups, i.e., independently of age. This immunological parameter had a higher statistical significance than the sickle cell trait, the strongest factor of protection known against Plasmodium falciparum. A single determination of antibody was significantly associated with the clinical outcome over six consecutive years in children submitted to massive natural parasite challenges by mosquitoes (over three parasite inoculations per week). Finally, the target epitopes of these antibodies were found to be fully conserved. Conclusions Since anti-MSP3 IgG3 antibodies can naturally develop along with protection against P. falciparum infection in young children, our results provide the encouraging indication that these antibodies should be possible to elicit by vaccination early in life. Since these antibodies have been found to achieve parasite killing under in vitro and in vivo conditions, and since they can be readily elicited by immunisation in naive volunteers, our immunoepidemiological findings support the further development of MSP3-based vaccine formulations., Introduction A malaria vaccine is urgently needed [1,2]; however, the rational development of such a vaccine has suffered from a lack of knowledge of the relevance of experimental models [3]. [...]

Published
2007

39. Incidence of tick-borne relapsing fever in west Africa: longitudinal study

Author

Vial, Laurence, Diatta, Georges, Tall, Adama, Ba, El Hadj, Bouganali, Hilaire, Durand, Patrick, Sokhna, Cheikh, Rogier, Christophe, Renaud, Francois, and Trape, Jean-Francois

Subjects
Jarisch-Herxheimer reaction -- Research, Jarisch-Herxheimer reaction -- Care and treatment, Jarisch-Herxheimer reaction -- Analysis
Published
2006

40. Seroprevalence of Anti-SARS-CoV-2 Antibodies in Senegal: A National Population-Based Cross-Sectional Survey, between October and November 2020

Author

Talla, Cheikh, primary, Loucoubar, Cheikh, additional, Roka, Jerlie Loko, additional, Barry, Aliou, additional, Ndiaye, Seynabou, additional, Diarra, Maryam, additional, Faye, Oumar, additional, Dia, Moussa, additional, Tall, Adama, additional, Ndiaye, Oumar, additional, Faye, Rokhaya, additional, Mbow, Adji Astou, additional, Diouf, Babacar, additional, Diallo, Jean Pierre, additional, Ndiaye, Mamadou, additional, Woudenberg, Tom, additional, White, Michael, additional, Ting, Jim Y., additional, Diagne, Cheikh Tidiane, additional, Pasi, Omer, additional, Diop, Boly, additional, Sall, Amadou, additional, Vigan-Womas, Inès, additional, and Faye, Ousmane, additional

Published
2021
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41. The genomic epidemiology of multi-drug resistant nontyphoidal Salmonella causing invasive disease in sub-Saharan Africa

Author

Park, Se Eun, primary, Pham, Duy Thanh, additional, Pak, Gi Deok, additional, Panzner, Ursula, additional, Espinoza, Ligia Maria Cruz, additional, von Kalckreuth, Vera, additional, Im, Justin, additional, Mogeni, Ondari D., additional, Schütt-Gerowitt, Heidi, additional, Crump, John A., additional, Breiman, Robert F., additional, Adu-Sarkodie, Yaw, additional, Owusu-Dabo, Ellis, additional, Rakotozandrindrainy, Raphaёl, additional, Soura, Abdramane Bassiahi, additional, Aseffa, Abraham, additional, Gasmelseed, Nagla, additional, Sooka, Arvinda, additional, Keddy, Karen H., additional, May, Jürgen, additional, Aaby, Peter, additional, Biggs, Holly M., additional, Hertz, Julian T., additional, Montgomery, Joel M., additional, Cosmas, Leonard, additional, Olack, Beatrice, additional, Fields, Barry, additional, Sarpong, Nimako, additional, Razafindrabe, Tsiriniaina Jean Luco, additional, Raminosoa, Tiana Mirana, additional, Kabore, Leon Parfait, additional, Sampo, Emmanuel, additional, Teferi, Mekonnen, additional, Yeshitela, Biruk, additional, Tayeb, Muna Ahmed El, additional, Krumkamp, Ralf, additional, Dekker, Denise Myriam, additional, Jaeger, Anna, additional, Tall, Adama, additional, Niang, Aissatou, additional, Bjerregaard-Andersen, Morten, additional, Løfberg, Sandra Valborg, additional, Deerin, Jessica Fung, additional, Park, Jin Kyung, additional, Konings, Frank, additional, Van Puyvelde, Sandra, additional, Ali, Mohammad, additional, Clemens, John D., additional, Dougan, Gordon, additional, Baker, Stephen, additional, and Marks, Florian, additional

Published
2020
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42. Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

Author

Conner, Ruben O., primary, Dieye, Yakou, additional, Hainsworth, Michael, additional, Tall, Adama, additional, Cissé, Badara, additional, Faye, Farba, additional, Sy, Mame Demba, additional, Ba, Amadou, additional, Sene, Doudou, additional, Ba, Souleymane, additional, Doucouré, Elhadji, additional, Thiam, Tidiane, additional, Diop, Moussa, additional, Schneider, Kammerle, additional, Cissé, Moustapha, additional, Ba, Mady, additional, Earle, Duncan, additional, Guinot, Philippe, additional, Steketee, Richard W., additional, and Guinovart, Caterina, additional

Published
2020
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43. Increased susceptibility to malaria during the early postpartum period

Author

Diagne, Nafissatou, Rogier, Christophe, Sokhna, Cheikh S., Tall, Adama, Fontenille, Didier, Roussilhon, Christian, Spiegel, Andre, and Trape, Jean-Francois

Subjects
Malaria -- Demographic aspects, Pregnant women -- Health aspects, Puerperal fever -- Analysis, Plasmodium falciparum
Abstract

Women may be more susceptible to malaria during late pregnancy and in the early postpartum period. Susceptibility was investigated in 38 pregnant women followed from preconception to one year after delivery in areas of high disease prevalence. The incidence of malaria was 2-3 times as high during the second and third trimester, and 4 times as high in the first two months postpartum, compared to preconception and the first trimester.

Published
2000

45. A global network for investigating the genomic epidemiology of malaria

Author

Achidi, Eric Akum, Agbenyega, Tsiri, Allen, Stephen, Amodu, Olukemi, Bojang, Kalifa, Conway, David, Corran, Patrick, Deloukas, Panos, Djimde, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Drakeley, Chris, Duffy, Patrick, Dunstan, Sarah, Evans, Jennifer, Farrar, Jeremy, Fernando, Deepika, Hien, Tran Tinh, Horstmann, Rolf, Ibrahim, Muntaser, Karunaweera, Nadira, Kokwaro, Gilbert, Koram, Kojo, Kwiatkowski, Dominic, Lemnge, Martha, Makani, Julie, Marsh, Kevin, Michon, Pascal, Modiano, David, Molyneux, Malcolm E., Mueller, Ivo, Mutabingwa, Theonest, Peshu, Norbert, Plowe, Chris, Puijalon, Odile, Ragoussis, Jiannis, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Rogers, Jane, Sakuntabhai, Anavaj, Singhasivanon, Pratap, Sirima, Sodiomon, Sirugo, Giorgio, Tall, Adama, Taylor, Terrie, Thera, Mahamadou, Troye-Blomberg, Marita, Williams, Tom, Wilson, Michael, Amenga-Etego, Lucas, Apinjoh, Tobias O., Bougouma, Edith, Dewasurendra, Rajika, Diakite, Mahamadou, Enimil, Anthony, Hussein, Ayman, Ishengoma, Deus, Jallow, Muminatou, Lin, Enmoore, Ly, Alioune, Mangano, Valentina D., Manjurano, Alphaxard, Manning, Laurens, Ndila, Carolyne M., Nyirongo, Vysaul, Oluoch, Tom, Quyen, Nguyen T. N., Suriyaphol, Prapat, Toure, Ousman, Kwiatkowski, Dominic, Alcock, Daniel, Auburn, Sarah, Barnwell, David, Bull, Susan, Campino, Susana, deVries, Jantina, Elzein, Abier, Evans, Julie, Fitzpatrick, Kathryn, Ghansah, Anita, Green, Angie, Hart, Lee, Hilton, Eliza, Hubbart, Christina, Hughes, Catherine, Jeffreys, Anna E., Kivinen, Katja, MacInnis, Bronwyn, Manske, Magnus, Maslen, Gareth, McCreight, Marilyn, Mendy, Alieu, Moyes, Catherine, Nyika, Aceme, Potter, Claire, Risley, Paul, Rowlands, Kate, SanJoaquin, Miguel, Small, Kerrin, Somaskantharajah, Elilan, Stevens, Marryat, Teo, YikYing, Watson, Renee, Carucci, Dan, Cook, Katharine, Doyle, Alan, Duombo, Ogobara, Gottlieb, Michael, Kwiatkowski, Dominic, Rockett, Kirk A., Vanderwal, Aaron, Clark, Taane, Parker, Michael, and Wrigley, Rebecca

Published
2008
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47. Tick-borne relapsing fever borreliosis, rural Senegal

Author

Parola, Philippe, Diatta, Georges, Socolovschi, Cristina, Mediannikov, Oleg, Tall, Adama, Bassene, Hubert, Trape, Jean Frangois, and Raoult, Didier

Subjects
Relapsing fever -- Health aspects, Infection -- Health aspects, Disease transmission -- Health aspects, Health
Abstract

Tick-borne relapsing fever (TBRF), caused by several species of Borrelia spirochetes, is transmitted to humans through the bites of soft ticks of the genus Ornithodoros (through infected saliva or entry [...]

Published
2011
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50. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Ndila, Carolyne M, Uyoga, Sophie, Macharia, Alexander W, Nyutu, Gideon, Peshu, Norbert, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Sepúlveda, Nuno, Clark, Taane G, Band, Gavin, Clarke, Geraldine, Rowlands, Kate, Hubbart, Christina, Jeffreys, Anna, Kariuki, Silvia, Marsh, Kevin, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, Williams, Thomas N, Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, Devries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Si, Le, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Alioune, Ly, Macharia, Alexander, Macinnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, Mccreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, Sanjoaquin, Miguel, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford, London School of Hygiene and Tropical Medicine (LSHTM), The Wellcome Trust Sanger Institute [Cambridge], St Mary's Hospital, Imperial College, TNW and MM are funded through awards from the Wellcome Trust (grants 091758 and 202800 [to TNW] and grant 088634 [to MM]) and DPK and TGC receive support from the Medical Research Council (grant G19/9 [to DPK] and grants MR/K000551/1, MR/M01360X/1, MR/N010469/1, and MC_PC_15103 [to TGC]). The research leading to these results received funding from the European Community's Seventh Framework Programme (FP7/2007-2013, under grant agreement 242095) and from the Medical Research Council (grant G0600718). MalariaGEN is supported by the Wellcome Trust (WT077383/Z/05/Z) and by the Foundation for the National Institutes of Health (grant 566) as part of the Bill & Melinda Gates' Grand Challenges in Global Health Initiative. The Resource Centre for Genomic Epidemiology of Malaria is supported by the Wellcome Trust (grant 090770/Z/09/Z). Support was also provided by the Medical Research Council (grant G0600718). The Wellcome Trust also provides core awards to the Wellcome Trust Centre for Human Genetics (grant 090532/Z/09/Z) and to the Wellcome Trust Sanger Institute (grant 098051). This work forms part of a larger collaboration with the MalariaGEN Consortium, whose members are listed at http://www.malariagen.net/projects/host/consortium-members. This paper is published with permission from the Director of the Kenya Medical Research Institute (KEMRI)., MalariaGEN Consortium (Anavaj Sakuntabhai), and European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009)

Subjects
Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Kenya, Malaria, Male, Polymorphism, Genetic, Hematology, macromolecular substances, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Article, Genetic, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, parasitic diseases, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Polymorphism, Preschool
Abstract

Summary Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress. Methods We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malaria and its specific phenotypes. We used a permutation approach to account for multiple comparisons between polymorphisms and severe malaria. We judged p values less than 0·005 significant for the primary analysis of the association between candidate genes and severe malaria. Findings Between June 11, 1995, and June 12, 2008, 2244 children with severe malaria were recruited to the study, and 3949 infants were included as controls. Overall, 263 (12%) of 2244 children with severe malaria died in hospital, including 196 (16%) of 1233 with cerebral malaria. We investigated 121 polymorphisms in 70 candidate severe malaria-associated genes. We found significant associations between risk for severe malaria overall and polymorphisms in 15 genes or locations, of which most were related to red blood cells: ABO, ATP2B4, ARL14, CD40LG, FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, RPS6KL1, CAND1, and GNAS. Combined, these genetic associations accounted for 5·2% of the variance in risk for developing severe malaria among individuals in the general population. We confirmed established associations between severe malaria and sickle-cell trait (odds ratio [OR] 0·15, 95% CI 0·11–0·20; p=2·61 × 10−58), blood group O (0·74, 0·66–0·82; p=6·26 × 10−8), and –α3·7-thalassaemia (0·83, 0·76–0·90; p=2·06 × 10−6). We also found strong associations between overall risk of severe malaria and polymorphisms in both ATP2B4 (OR 0·76, 95% CI 0·63–0·92; p=0·001) and FREM3 (0·64, 0·53–0·79; p=3·18 × 10−14). The association with FREM3 could be accounted for by linkage disequilibrium with a complex structural mutation within the glycophorin gene region (comprising GYPA, GYPB, and GYPE) that encodes for the rare Dantu blood group antigen. Heterozygosity for Dantu was associated with risk for severe malaria (OR 0·57, 95% CI 0·49–0·68; p=3·22 × 10−11), as was homozygosity (0·26, 0·11–0·62; p=0·002). Interpretation Both ATP2B4 and the Dantu blood group antigen are associated with the structure and function of red blood cells. ATP2B4 codes for plasma membrane calcium-transporting ATPase 4 (the major calcium pump on red blood cells) and the glycophorins are ligands for parasites to invade red blood cells. Future work should aim at uncovering the mechanisms by which these polymorphisms can result in severe malaria protection and investigate the implications of these associations for wider health. Funding Wellcome Trust, UK Medical Research Council, European Union, and Foundation for the National Institutes of Health as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative.

Published
2018

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