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4 results on '"Talebinasab Fereshteh"'

1. Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer

Author

Babaei Kosar, Khaksar Roya, Zeinali Tahereh, Hemmati Hossein, Bandegi Ahmadreza, Samidoust Pirouz, Ashoobi Mohammad Taghi, Hashemian Hooman, Delpasand Kourosh, Talebinasab Fereshteh, Naebi Hoora, Mirpour Seyed Hossein, Keymoradzadeh Arman, and Norollahi Seyedeh Elham

Subjects
epigenetics, fluctuations, tumorigenesis, carcinogenesis, Medicine
Abstract

Colorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive ability in order to be used in CRC targeted therapy. Meaningly, DNA methylation is identified as one of most important epigenetic regulators in gene expression and is considered as a notable potential driver in tumorigenesis and carcinogenesis through gene-silencing of tumor suppressors genes. Abnormal methylation situation, even in the level of promoter regions, does not essentially change the gene expression levels, particularly if the gene was become silenced, leaving the mechanisms of methylation without any response. According to the methylation situation which has a strong eagerness to be highly altered on CpG islands in carcinogenesis and tumorigenesis, considering its epigenetic fluctuations in finding new biomarkers is of great importance. Modifications in DNA methylation pattern and also enrichment of methylated histone signs in the promoter regions of some certain genes like MUTYH, KLF4/6 and WNT1 in different signaling pathways could be a notable key contributors to the upregulation of tumor initiation in CRC. These epigenetic alterations could be employed as a practical diagnostic biomarkers for colorectal cancer. In this review, we will be discuss these fluctuations of MUTYH, KLF4/6 and WNT1 genes in CRC.

Published
2019
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3. Performance of KLF4 and Wnt1 genes expression fluctuations in tumoral and margin tissues of colorectal cancer in an Iranian population

Author

Talebinasab, Fereshteh, primary, Bandegi, Ahmadreza, additional, Naebi, Hoora, additional, Hemmati, Hossein, additional, Samidoust, Pirouz, additional, Delshad, Mohammad Sadegh Esmaeili, additional, Norollahi, Seyedeh Elham, additional, Vahidi, Sogand, additional, Karimian, Paridokht, additional, Najafzadeh, Akram, additional, and Samadani, Ali Akbar, additional

Published
2022
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4. MUTYHand KLF6gene expression fluctuations in tumor tissue and tumor margins tissues of colorectal cancer

Author

Naebi, Hoora, Bandegi, Ahmadreza, Talebinasab, Fereshteh, Samidoust, Pirouz, Norollahi, Seyedeh Elham, Vahidi, Sogand, and Samadani, Ali Akbar

Abstract

Background: Colorectal cancer (CRC) is one of the most important cancers in the world, and its prevalence varies depending on the geographical area. Genetically, tumor regeneration in CRC as a multi-step process involves activating mutations in protocogenes and losing the function of tumor suppressor genes as well as DNA repair and recovery genes. Occur in this way, our goal was to investigate the expression of KLF6genes as a tumor suppressor and MUTYHinvolved in the DNA repair process in colorectal cancer. Methods: This research was conducted during the years 2019–2018 in Razi Hospital, Rasht. The subjects included 30 tumoral and 30 non-tumoral tissues of colorectal cancer and 20 healthy controls. The real-time PCR method was used to investigate the gene expression. For data analysis by SPSS, parametric statistical tests ANOVA and Ttest and regression analysis were used and pvalue values less than 0.05 were considered significant. Results: The expression of KLF6gene in tumoral tissues showed a significant decrease compared to non-tumoral tissues (P= 0.04). Also, the expression of MUTYHgene in tumor tissue showed a significant decrease compared to non-tumoral (P= 0.02) and this decrease in MUTYHgene expression had a significant relationship with increasing tumor stage (P= 0.01). Conclusion: These findings suggest that decreased expression of KLF6and MUTYHgenes in the study population has a significant relationship with colorectal cancer and can be considered as tumor marker in diagnostic purpose.

Published
2022
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