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4. A model of owner controlled, full-provenance, non-persistent, high-availability information sharing

Author

Peisert, S, Bishop, M, and Talbot, E

Abstract

In this paper, we propose principles of information control and sharing that support ORCON (ORiginator COntrolled access control) models while simultaneously improving components of confidentiality, availability, and integrity needed to inherently support, when needed, responsibility to share policies, rapid information dissemination, data provenance, and data redaction. This new paradigm of providing unfettered and unimpeded access to information by authorized users, while at the same time, making access by unauthorized users impossible, contrasts with historical approaches to information sharing that have focused on need to know rather than need to (or responsibility to) share.

Published
2017

5. Nano-composite MOx materials for NVMs

Author

Bonafos, C., primary, Khomenkhova, L., additional, Gourbilleau, F., additional, Talbot, E., additional, Slaoui, A., additional, Carrada, M., additional, Schamm-Chardon, S., additional, Dimitrakis, P., additional, and Normand, P., additional

Published
2022
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6. Contributors

Author

Antonov, I.N., primary, Belov, A.I., additional, Bonafos, C., additional, Brivio, S., additional, Cario, Laurent, additional, Carrada, M., additional, Caussat, Brigitte, additional, Ch. Sirakoulis, Georgios, additional, Christensen, Dennis Valbjørn, additional, Cianci, Elena, additional, Corraze, Benoit, additional, Demin, V.A., additional, Dimitrakis, P., additional, Emelyanov, A.V., additional, Escudero, Manuel, additional, Esposito, Vincenzo, additional, Filatov, D.O., additional, Giannopoulos, Georgios, additional, Gorshkov, O.N., additional, Gourbilleau, F., additional, Gryaznov, E.G., additional, Guseinov, D.V., additional, Hoffmann, Michael, additional, Janod, Etienne, additional, Kaidatzis, Andreas, additional, Khomenkhova, L., additional, Korolev, D.S., additional, Koryazhkina, M.N., additional, Li, Yang, additional, Liu, Qi, additional, Max, Benjamin, additional, Mikhaylov, A.N., additional, Mikolajick, Thomas, additional, Mulaosmanovic, Halid, additional, Niarchos, Dimitris, additional, Nikiruy, K.E., additional, Normand, P., additional, Okulich, E.V., additional, Okulich, V.I., additional, Pavlov, D.A., additional, Pryds, Nini, additional, Ramkumar, Krishnaswamy, additional, Rubio, Antonio, additional, Rylkov, V.V., additional, Sanna, Simone, additional, Schamm-Chardon, S., additional, Schroeder, Uwe, additional, Shenina, M.E., additional, Shuisky, R.A., additional, Sidorenko, K.V., additional, Slaoui, A., additional, Slesazeck, Stefan, additional, Spagnolo, B., additional, Spiga, Sabina, additional, Talbot, E., additional, Tappertzhofen, Stefan, additional, Tetelbaum, D.I., additional, Tikhov, S.V., additional, Tranchant, Julien, additional, Vahlas, Constantin, additional, Vianello, E., additional, Vourkas, Ioannis, additional, and Zhao, Xiaolong, additional

Published
2022
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7. Effect of Mechanical Ventilation Mode on Outcomes by Severity of Hypoxemia: A Secondary Analysis of the Mode of Ventilation During Critical Illness Trial

Author

Krasinski, D.J., primary, Seitz, K.P., additional, Lloyd, B.D., additional, Wang, L., additional, Shotwell, M.S., additional, Qian, E.T., additional, Muhs, A., additional, Richardson, R.K., additional, Rooks, J., additional, Hennings-Williams, V., additional, Sandoval, C.E., additional, Richardson, W., additional, Morgan, T., additional, Thompson, A.N., additional, Hastings, P.G., additional, Ring, T.P., additional, Stollings, J.L., additional, Talbot, E., additional, Decoursey, B., additional, Gibbs, K.W., additional, Self, W.H., additional, Mixon, A.S., additional, Rice, T.W., additional, Semler, M.W., additional, and Casey, J.D., additional

Published
2024
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8. Optimal Mode of Mechanical Ventilation for Adults in Shock: A Secondary Analysis of the Mode of Ventilation During Critical Illness Trial

Author

Talbot, E., primary, Lloyd, B., additional, Wang, L., additional, Shotwell, M., additional, Qian, E.T., additional, Muhs, A., additional, Richardson, R.K., additional, Rooks, J.C., additional, Hennings-Williams, V., additional, Sandoval, C.E., additional, Richardson, W.D., additional, Morgan, T., additional, Thompson, A.N., additional, Hastings, P.G., additional, Ring, T.P., additional, Stollings, J.L., additional, Krasinski, D.J., additional, Decoursey, B., additional, Gibbs, K., additional, Self, W., additional, Mixon, A.S., additional, Rice, T.W., additional, Casey, J.D., additional, Semler, M.W., additional, and Seitz, K.P., additional

Published
2024
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13. Widespread deoxygenation of temperate lakes

Author

Jane, S, Hansen, G, Kraemer, B, Leavitt, P, Mincer, J, North, R, Pilla, R, Stetler, J, Williamson, C, Woolway, R, Arvola, L, Chandra, S, Degasperi, C, Diemer, L, Dunalska, J, Erina, O, Flaim, G, Grossart, H, Hambright, K, Hein, C, Hejzlar, J, Janus, L, Jenny, J, Jones, J, Knoll, L, Leoni, B, Mackay, E, Matsuzaki, S, Mcbride, C, Muller-Navarra, D, Paterson, A, Pierson, D, Rogora, M, Rusak, J, Sadro, S, Saulnier-Talbot, E, Schmid, M, Sommaruga, R, Thiery, W, Verburg, P, Weathers, K, Weyhenmeyer, G, Yokota, K, Rose, K, Jane S. F., Hansen G. J. A., Kraemer B. M., Leavitt P. R., Mincer J. L., North R. L., Pilla R. M., Stetler J. T., Williamson C. E., Woolway R. I., Arvola L., Chandra S., DeGasperi C. L., Diemer L., Dunalska J., Erina O., Flaim G., Grossart H. -P., Hambright K. D., Hein C., Hejzlar J., Janus L. L., Jenny J. -P., Jones J. R., Knoll L. B., Leoni B., Mackay E., Matsuzaki S. -I. S., McBride C., Muller-Navarra D. C., Paterson A. M., Pierson D., Rogora M., Rusak J. A., Sadro S., Saulnier-Talbot E., Schmid M., Sommaruga R., Thiery W., Verburg P., Weathers K. C., Weyhenmeyer G. A., Yokota K., Rose K. C., Jane, S, Hansen, G, Kraemer, B, Leavitt, P, Mincer, J, North, R, Pilla, R, Stetler, J, Williamson, C, Woolway, R, Arvola, L, Chandra, S, Degasperi, C, Diemer, L, Dunalska, J, Erina, O, Flaim, G, Grossart, H, Hambright, K, Hein, C, Hejzlar, J, Janus, L, Jenny, J, Jones, J, Knoll, L, Leoni, B, Mackay, E, Matsuzaki, S, Mcbride, C, Muller-Navarra, D, Paterson, A, Pierson, D, Rogora, M, Rusak, J, Sadro, S, Saulnier-Talbot, E, Schmid, M, Sommaruga, R, Thiery, W, Verburg, P, Weathers, K, Weyhenmeyer, G, Yokota, K, Rose, K, Jane S. F., Hansen G. J. A., Kraemer B. M., Leavitt P. R., Mincer J. L., North R. L., Pilla R. M., Stetler J. T., Williamson C. E., Woolway R. I., Arvola L., Chandra S., DeGasperi C. L., Diemer L., Dunalska J., Erina O., Flaim G., Grossart H. -P., Hambright K. D., Hein C., Hejzlar J., Janus L. L., Jenny J. -P., Jones J. R., Knoll L. B., Leoni B., Mackay E., Matsuzaki S. -I. S., McBride C., Muller-Navarra D. C., Paterson A. M., Pierson D., Rogora M., Rusak J. A., Sadro S., Saulnier-Talbot E., Schmid M., Sommaruga R., Thiery W., Verburg P., Weathers K. C., Weyhenmeyer G. A., Yokota K., and Rose K. C.

Abstract

The concentration of dissolved oxygen in aquatic systems helps to regulate biodiversity1,2, nutrient biogeochemistry3, greenhouse gas emissions4, and the quality of drinking water5. The long-term declines in dissolved oxygen concentrations in coastal and ocean waters have been linked to climate warming and human activity6,7, but little is known about the changes in dissolved oxygen concentrations in lakes. Although the solubility of dissolved oxygen decreases with increasing water temperatures, long-term lake trajectories are difficult to predict. Oxygen losses in warming lakes may be amplified by enhanced decomposition and stronger thermal stratification8,9 or oxygen may increase as a result of enhanced primary production10. Here we analyse a combined total of 45,148 dissolved oxygen and temperature profiles and calculate trends for 393 temperate lakes that span 1941 to 2017. We find that a decline in dissolved oxygen is widespread in surface and deep-water habitats. The decline in surface waters is primarily associated with reduced solubility under warmer water temperatures, although dissolved oxygen in surface waters increased in a subset of highly productive warming lakes, probably owing to increasing production of phytoplankton. By contrast, the decline in deep waters is associated with stronger thermal stratification and loss of water clarity, but not with changes in gas solubility. Our results suggest that climate change and declining water clarity have altered the physical and chemical environment of lakes. Declines in dissolved oxygen in freshwater are 2.75 to 9.3 times greater than observed in the world’s oceans6,7 and could threaten essential lake ecosystem services2,3,5,11.

Published
2021

14. Global data set of long-term summertime vertical temperature profiles in 153 lakes

Author

Pilla, R, Mette, E, Williamson, C, Adamovich, B, Adrian, R, Anneville, O, Balseiro, E, Ban, S, Chandra, S, Colom-Montero, W, Devlin, S, Dix, M, Dokulil, M, Feldsine, N, Feuchtmayr, H, Fogarty, N, Gaiser, E, Girdner, S, Gonzalez, M, Hambright, K, Hamilton, D, Havens, K, Hessen, D, Hetzenauer, H, Higgins, S, Huttula, T, Huuskonen, H, Isles, P, Joehnk, K, Keller, W, Klug, J, Knoll, L, Korhonen, J, Korovchinsky, N, Koster, O, Kraemer, B, Leavitt, P, Leoni, B, Lepori, F, Lepskaya, E, Lottig, N, Luger, M, Maberly, S, Macintyre, S, Mcbride, C, Mcintyre, P, Melles, S, Modenutti, B, Muller-Navarra, D, Pacholski, L, Paterson, A, Pierson, D, Pislegina, H, Plisnier, P, Richardson, D, Rimmer, A, Rogora, M, Rogozin, D, Rusak, J, Rusanovskaya, O, Sadro, S, Salmaso, N, Saros, J, Sarvala, J, Saulnier-Talbot, E, Schindler, D, Shimaraeva, S, Silow, E, Sitoki, L, Sommaruga, R, Straile, D, Strock, K, Swain, H, Tallant, J, Thiery, W, Timofeyev, M, Tolomeev, A, Tominaga, K, Vanni, M, Verburg, P, Vinebrooke, R, Wanzenbock, J, Weathers, K, Weyhenmeyer, G, Zadereev, E, Zhukova, T, Pilla R. M., Mette E. M., Williamson C. E., Adamovich B. V., Adrian R., Anneville O., Balseiro E., Ban S., Chandra S., Colom-Montero W., Devlin S. P., Dix M. A., Dokulil M. T., Feldsine N. A., Feuchtmayr H., Fogarty N. K., Gaiser E. E., Girdner S. F., Gonzalez M. J., Hambright K. D., Hamilton D. P., Havens K., Hessen D. O., Hetzenauer H., Higgins S. N., Huttula T. H., Huuskonen H., Isles P. D. F., Joehnk K. D., Keller W. B., Klug J., Knoll L. B., Korhonen J., Korovchinsky N. M., Koster O., Kraemer B. M., Leavitt P. R., Leoni B., Lepori F., Lepskaya E. V., Lottig N. R., Luger M. S., Maberly S. C., MacIntyre S., McBride C., McIntyre P., Melles S. J., Modenutti B., Muller-Navarra D. C., Pacholski L., Paterson A. M., Pierson D. C., Pislegina H. V., Plisnier P. -D., Richardson D. C., Rimmer A., Rogora M., Rogozin D. Y., Rusak J. A., Rusanovskaya O. O., Sadro S., Salmaso N., Saros J. E., Sarvala J., Saulnier-Talbot E., Schindler D. E., Shimaraeva S. V., Silow E. A., Sitoki L. M., Sommaruga R., Straile D., Strock K. E., Swain H., Tallant J. M., Thiery W., Timofeyev M. A., Tolomeev A. P., Tominaga K., Vanni M. J., Verburg P., Vinebrooke R. D., Wanzenbock J., Weathers K., Weyhenmeyer G. A., Zadereev E. S., Zhukova T. V., Pilla, R, Mette, E, Williamson, C, Adamovich, B, Adrian, R, Anneville, O, Balseiro, E, Ban, S, Chandra, S, Colom-Montero, W, Devlin, S, Dix, M, Dokulil, M, Feldsine, N, Feuchtmayr, H, Fogarty, N, Gaiser, E, Girdner, S, Gonzalez, M, Hambright, K, Hamilton, D, Havens, K, Hessen, D, Hetzenauer, H, Higgins, S, Huttula, T, Huuskonen, H, Isles, P, Joehnk, K, Keller, W, Klug, J, Knoll, L, Korhonen, J, Korovchinsky, N, Koster, O, Kraemer, B, Leavitt, P, Leoni, B, Lepori, F, Lepskaya, E, Lottig, N, Luger, M, Maberly, S, Macintyre, S, Mcbride, C, Mcintyre, P, Melles, S, Modenutti, B, Muller-Navarra, D, Pacholski, L, Paterson, A, Pierson, D, Pislegina, H, Plisnier, P, Richardson, D, Rimmer, A, Rogora, M, Rogozin, D, Rusak, J, Rusanovskaya, O, Sadro, S, Salmaso, N, Saros, J, Sarvala, J, Saulnier-Talbot, E, Schindler, D, Shimaraeva, S, Silow, E, Sitoki, L, Sommaruga, R, Straile, D, Strock, K, Swain, H, Tallant, J, Thiery, W, Timofeyev, M, Tolomeev, A, Tominaga, K, Vanni, M, Verburg, P, Vinebrooke, R, Wanzenbock, J, Weathers, K, Weyhenmeyer, G, Zadereev, E, Zhukova, T, Pilla R. M., Mette E. M., Williamson C. E., Adamovich B. V., Adrian R., Anneville O., Balseiro E., Ban S., Chandra S., Colom-Montero W., Devlin S. P., Dix M. A., Dokulil M. T., Feldsine N. A., Feuchtmayr H., Fogarty N. K., Gaiser E. E., Girdner S. F., Gonzalez M. J., Hambright K. D., Hamilton D. P., Havens K., Hessen D. O., Hetzenauer H., Higgins S. N., Huttula T. H., Huuskonen H., Isles P. D. F., Joehnk K. D., Keller W. B., Klug J., Knoll L. B., Korhonen J., Korovchinsky N. M., Koster O., Kraemer B. M., Leavitt P. R., Leoni B., Lepori F., Lepskaya E. V., Lottig N. R., Luger M. S., Maberly S. C., MacIntyre S., McBride C., McIntyre P., Melles S. J., Modenutti B., Muller-Navarra D. C., Pacholski L., Paterson A. M., Pierson D. C., Pislegina H. V., Plisnier P. -D., Richardson D. C., Rimmer A., Rogora M., Rogozin D. Y., Rusak J. A., Rusanovskaya O. O., Sadro S., Salmaso N., Saros J. E., Sarvala J., Saulnier-Talbot E., Schindler D. E., Shimaraeva S. V., Silow E. A., Sitoki L. M., Sommaruga R., Straile D., Strock K. E., Swain H., Tallant J. M., Thiery W., Timofeyev M. A., Tolomeev A. P., Tominaga K., Vanni M. J., Verburg P., Vinebrooke R. D., Wanzenbock J., Weathers K., Weyhenmeyer G. A., Zadereev E. S., and Zhukova T. V.

Abstract

Climate change and other anthropogenic stressors have led to long-term changes in the thermal structure, including surface temperatures, deepwater temperatures, and vertical thermal gradients, in many lakes around the world. Though many studies highlight warming of surface water temperatures in lakes worldwide, less is known about long-term trends in full vertical thermal structure and deepwater temperatures, which have been changing less consistently in both direction and magnitude. Here, we present a globally-expansive data set of summertime in-situ vertical temperature profiles from 153 lakes, with one time series beginning as early as 1894. We also compiled lake geographic, morphometric, and water quality variables that can influence vertical thermal structure through a variety of potential mechanisms in these lakes. These long-term time series of vertical temperature profiles and corresponding lake characteristics serve as valuable data to help understand changes and drivers of lake thermal structure in a time of rapid global and ecological change.

Published
2021

17. Returning to education after childhood acquired brain injury: Learning from lived parental experience.

Author

Bennett, E., Fletcher, A., Talbot, E., and Robinson, L.

Subjects
PARENT attitudes, NEUROLOGICAL disorders, RE-entry students, MEDICAL care, QUESTIONNAIRES, DESCRIPTIVE statistics, BRAIN injuries, THEMATIC analysis, PARENTS, DISEASE complications, CHILDREN
Abstract

BACKGROUND: Returning to education (RtE) after an acquired brain injury (ABI) can be stressful for children/young people (CYP) and families. While much can be done to support RtE, there has been limited exploration of the lived experience of parents/carers about what can both help and hinder the process. OBJECTIVE: The aim was to understand more about RtE from parents' perspectives to inform best practice and facilitate improvements in service delivery. METHODS: A service evaluation explored parent/carer views about the RtE process and the support received from healthcare professionals at a regional centre in the UK. Questionnaires (n = 59) were sent to parents of patients treated for an ABI in the last two years. RESULTS: 31 parents (response rate = 51%) completed the survey. Results highlight the many challenges of RtE. Thematic analysis of responses revealed six key themes: Parental mindset and growth; What do they need now?; Specialist support and information; Talk and share; Challenges of new and hidden needs; and Don't forget them! CONCLUSION: Parents offer crucial insight into the challenges of the RtE process. Their feedback highlights important factors for service development and reminds professionals of the key components of an effective return. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Persistent DNA damage promotes microglial dysfunction in Ataxia-telangiectasia

Author

Bourseguin J, Hardy L, Cheng W, Khoronenkova Sv, and Talbot E

Subjects
Genome instability, medicine.anatomical_structure, Microglia, Kinase, DNA damage, RELB, Multiple sclerosis, Ataxia-telangiectasia, Neurodegeneration, medicine, Biology, medicine.disease, Cell biology
Abstract

The autosomal recessive genome instability disorder Ataxia-telangiectasia, caused by mutations in ATM kinase, is characterised by the progressive loss of cerebellar neurons. We find that DNA damage associated with ATM loss results in dysfunctional behaviour of human microglia, immune cells of the central nervous system. Microglial dysfunction is mediated by the pro-inflammatory RELB/p52 non-canonical NF-κB transcriptional pathway and leads to excessive phagocytic clearance of neurites. Pathological phagocytosis of neuronal processes by microglia has also been observed in multiple sclerosis, Alzheimer’s and progranulin deficiency, suggesting a common mechanism that promotes neuronal damage. Activation of the RELB/p52 pathway in ATM-deficient microglia is driven by persistent DNA damage and is dependent on the NIK kinase. These results provide insights into the underlying mechanisms of aberrant microglial behaviour in Ataxia-telangiectasia, potentially contributing to neurodegeneration.

Published
2021
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27. Paleoclimatic reconstructions based on the assemblage composition and oxygen isotope ratios of sedimentary diatoms

Author

Narancic, Biljana, Saulnier-Talbot, E., Meyer, Hanno, and Pienitz, Reinhard

Abstract

Sedimentary diatoms have been used to quantitatively reconstruct climate-related variables, such as temperature at different timescales. Even though temperature is often less of a key driver of diatom ecology than other environmental parameters (water chemistry), diatom inference models have been shown to be reliable in deducing past temperature trends. In addition, the oxygen isotope composition (δ18Odiatom) preserved in buried diatom frustules has demonstrated its potential to reflect climatic and hydrological conditions at the time of frustule formation. This study combines results from both diatom-based climate proxies to reconstruct summer water and mean annual air temperatures, and hydrological trends in Nettilling Lake, Baffin Island, from ca. 5000 to 500 cal a bp. Diatom-inferred temperatures revealed an overall ca. 2 °C cooling throughout the Late-Holocene. The δ18Odiatom values showed an increasing trend up to ca. 1900 cal a bp, where they reached their highest values (+24.8‰ at 15 cm) and thereafter decreased to their lowest values (+21.4‰ at 4 cm). These trends were linked to meltwater inflows associated with Penny Ice Cap thaw rate that was in turn controlled by regional climatic conditions which went from intensified cooling during the Neoglacial period to slight warming thereafter. Our results suggest that diatom- and diatom-isotope-based temperature and hydrological reconstructions can identify trends related to the natural climate system variability. The diatom oxygen isotopes are useful for paleoenvironmental studies of terrestrial aquatic ecosystems, but not for all hydrological systems are the ideal temperature proxy. Hence, the combination of proxies helps to disentangle temperature and hydrological effects for paleoclimatic reconstructions and may support future studies of postglacial environmental change in northern lakes.

Published
2021

34. Oxidative β-C–H sulfonylation of cyclic amines† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04900e

Author

Griffiths, R. J., Kong, W. C., Richards, S. A., Burley, G. A., Willis, M. C., and Talbot, E. P. A.

Subjects
Chemistry
Abstract

A new and efficient process to access β-functionalisation of cyclic amines via a mild oxidative β-sulfonylation., A transition metal-free strategy for the dehydrogenative β-sulfonylation of tertiary cyclic amines is described. N-Iodosuccinimide facilitates regioselective oxidative sulfonylation at C–H bonds positioned β to the nitrogen atom of tertiary amines, installing enaminyl sulfone functionality in cyclic systems. Mild reaction conditions, broad functional group tolerance and a wide substrate scope are demonstrated. The nucleophilic character of the enaminyl sulfone is harnessed, demonstrating potential application for scaffold diversification.

Published
2018

35. Structural and optical study of Ce segregation in Ce-doped SiO1.5 thin films.

Author

Beainy, G., Weimmerskirch-Aubatin, J., Stoffel, M., Vergnat, M., Rinnert, H., Castro, C., Pareige, P., and Talbot, E.

Subjects
CERIUM, THIN films, NANOCRYSTALS, ATOM-probe tomography, PHOTOLUMINESCENCE
Abstract

Cerium doped SiO1.5 thin films fabricated by evaporation and containing silicon nanocrystals were investigated by atom probe tomography. The effect of post-growth annealing treatment has been systematically studied to correlate the structural properties obtained by atom probe tomography to the optical properties measured by photoluminescence spectroscopy. The atom probe results demonstrated the formation of Ce-Si rich clusters upon annealing at 900 °C which leads to a drastic decrease of the Ce-related luminescence. At 1100 °C, pure Si nanocrystals and optically active cerium silicate compounds are formed. Consequently, the Ce-related luminescence is found to re-appear at this temperature while no Si-nanocrystal related luminescence is observed for films containing more than 3% Ce. [ABSTRACT FROM AUTHOR]

Published
2015
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36. State of the Arctic Freshwater Biodiversity

Author

Lento, J., Goedkoop, W., Culp, J., Christoffersen, K.S., Lárusson, Kári Fannar, Fefilova, E., Guðbergsson, G., Liljaniemi, P., Ólafsson, J.S., Sandøy, S., Zimmerman, C., Christensen, T., Chambers, P., Heino, J., Hellsten, S., Kahlert, M., Keck, F., Laske, S., Lau, Danny C. P., Lavoie, I., Levenstein, B., Mariash, H., Rühland, K., Saulnier-Talbot, E., Schartau, A.K., and Svenning, M.

Subjects
Geovetenskap och miljövetenskap, Earth and Related Environmental Sciences
Published
2019

44. The early stage of formation of self-organized nanocolumns in thin films: Monte Carlo simulations versus atomic-scale observations in Ge-Mn.

Author

Mouton, I., Talbot, E., Pareige, C., Larde, R., and Blavette, D.

Subjects
*THIN film research, *EPITAXY, *MONTE Carlo method, *DYNAMICS, *MATHEMATICAL models, *NANOSTRUCTURES
Abstract

Formation kinetics of self-organized nanocolumns during epitaxial growth of a thin film composed of immiscible elements (A,B) has been investigated using Kinetic Monte Carlo simulations. Simulated nanostructures show a good agreement with those observed in Ge-Mn using Atom Probe Tomography and Transmission Electron Microscopy. Self organisation is observed although the rigid lattice simulations used do not account for misfit elastic strain. Simulations reveal that the final nanostructure, in term of number density and diameter of nanocolumns, is controlled by the early stages of growth of the film. The influence of both growth temperature and solute concentration on the nanostructure features is discussed in details. [ABSTRACT FROM AUTHOR]

Published
2014
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45. Influence of the supersaturation on Si diffusion and growth of Si nanoparticles in silicon-rich silica.

Author

Roussel, M., Talbot, E., Pareige, P., and Gourbilleau, F.

Subjects
*SILICON oxide, *SILICA, *MAGNETRON sputtering, *NANOPARTICLES, *SILICON, *ANNEALING of crystals
Abstract

SiOX/SiO2 multilayers have been prepared using magnetron sputtering and annealed in order to induce the growth of Si nanoparticles in Si-rich sublayers. This sample has undergone several successive annealing treatments and has been analyzed using a laser-assisted tomographic atom probe. This allows the phase separation between Si and SiO2 and the growth process to be studied at the atomic scale as a function of annealing temperature. Si diffusion coefficient is estimated from the accurate measurement of matrix composition and Si particle size. We demonstrate that the diffusion coefficient in SiOX is supersaturation dependent, leading to a decrease in silicon particle growth kinetics during annealing. In addition, we use our measurements to predict the critical thickness for efficient SiO2 diffusion barriers. [ABSTRACT FROM AUTHOR]

Published
2013
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46. Common Waiting Lists

Author

Shipman, J. J., Giles, K. W., Talbot, E. C. S., Armour, R. H., Millner, W. F., Lancaster, J. M., Essigman, W. K., and Jackson, B. H.

Published
1977

50. Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol

Author

Khalifa, Najat, Talbot, E., Schneider, Justine M., Walker, D.M., Bates, P., Bird, Y., Davies, D., Brookes, C., and Hall, J.

Abstract

Introduction: People with involvement in forensic psychiatric services face many obstacles to employment, arising from their offending, as well as their mental health problems. This study aims to assess the feasibility of conducting a randomised controlled trial (RCT) to evaluate the effectiveness of individual placement and support (IPS), in improving employment rates and associated psychosocial outcomes in forensic psychiatric populations. IPS has been found consistently to achieve employment rates above 50% in psychiatric patients without a history of involvement in criminal justice services.Methods/design: This is a single-centre feasibility cluster RCT. Clusters will be defined according to clinical services in the community forensic services of Nottinghamshire Healthcare NHS Foundation Trust (NHCT). IPS will be implemented into 2 of the randomly assigned intervention clusters in the community forensic services of NHCT. A feasibility cluster RCT will estimate the parameters required to design a full RCT. The primary outcome is the proportion of people in open employment at 12- month follow-up. Secondary outcome measures will include employment, educational activities, psychosocial and economic outcomes, as well as reoffending rates. Outcome measures will be recorded at baseline, 6 months and 12 months. In accordance with the UK Medical Research Council guidelines on the evaluation of complex interventions, a process evaluation will be carried out; qualitative interviews with patients and staff will explore general views of IPS as well as barriers and facilitators to implementation. Fidelity reviews will assess the extent to which the services follow the principles of IPS prior, during and at the end of the trial.

Published
2016

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