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1. T cell–mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19

Author

Fernández-Ruiz, Mario, Olea, Beatriz, Almendro-Vázquez, Patricia, Giménez, Estela, Marcacuzco, Alberto, San Juan, Rafael, Justo, Iago, Calvo-Pulido, Jorge, García-Sesma, Álvaro, Manrique, Alejandro, Caso, Oscar, Cambra, Félix, Talayero, Paloma, López-Medrano, Francisco, Remigia, María José, Ruiz-Merlo, Tamara, Parra, Patricia, Paz-Artal, Estela, Jiménez, Carlos, Loinaz, Carmelo, Navarro, David, Laguna-Goya, Rocío, and Aguado, José M.

Published
2021
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6. Preclinical Study of DCD and Normothermic Perfusion for Visceral Transplantation

Author

Serradilla, Javier, primary, Andrés Moreno, Ane Miren, additional, Talayero, Paloma, additional, Burgos, Paula, additional, Machuca, Mariana, additional, Camps Ortega, Onys, additional, Vallejo, María Teresa, additional, Rubio Bolívar, Francisco Javier, additional, Bueno, Alba, additional, Sánchez, Alba, additional, Zambrano, Cristina, additional, De la Torre Ramos, Carlos Andrés, additional, Rodríguez, Olaia, additional, Largo, Carlota, additional, Serrano, Pilar, additional, Prieto Bozano, Gerardo, additional, Ramos, Esther, additional, López Santamaría, Manuel, additional, Stringa, Pablo, additional, and Hernández, Francisco, additional

Published
2023
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7. 46: The fall of a myth: the first three cases of DCD in intestinal transplantation

Author

Serradilla, Javier, primary, Andrés Moreno, Ane Miren, additional, Burgos, Paula Patricia, additional, Galán, Alba Sánchez, additional, Talayero, Paloma, additional, Encinas, Jose Luis, additional, Torre Ramos, Carlos Andrés De La, additional, Stringa, Pablo, additional, Aroca, Ángel, additional, Estébanez, Belen, additional, González, Rocío, additional, Alcolea, Alida, additional, Serrano, Pilar, additional, Ramos, Esther, additional, and Oliveros, Francisco Hernández, additional

Published
2023
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8. 63: DCD in intestinal transplantation: the path to prove its validity in both experimental and clinical models

Author

Serradilla, Javier, primary, Andrés Moreno, Ane Miren, additional, Burgos, Paula, additional, Talayero, Paloma, additional, Encinas, Jose Luis, additional, Galán, Alba Sánchez, additional, De la Torre Ramos, Carlos Andrés, additional, Alcolea, Alida, additional, Sacristán, Rocío González, additional, Serrano, Pilar, additional, Aramburu, Carlota Largo, additional, Boluda, Esther Ramos, additional, Stringa, Pablo, additional, and Oliveros, Francisco Hernández, additional

Published
2023
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11. Antibody-removal therapies for de novo DSA in pediatric intestinal recipients: Why, when, and how? A single-center experience

Author

Lasa-Lázaro, María, primary, Ramos-Boluda, Esther, additional, Mancebo, Esther, additional, Castro-Panete, María José, additional, González-Sacristán, Rocío, additional, Serradilla, Javier, additional, Andrés-Moreno, Ane Miren, additional, Hernández-Oliveros, Francisco, additional, Paz-Artal, Estela, additional, and Talayero, Paloma, additional

Published
2023
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14. Experimental Assessment of Intestinal Damage in Controlled Donation After Circulatory Death for Visceral Transplantation

Author

Stringa, Pablo, primary, Vecchio Dezillio, Leandro Emmanuel, additional, Talayero, Paloma, additional, Serradilla, Javier, additional, Errea, Agustina, additional, Machuca, Mariana, additional, Papa-Gobbi, Rodrigo, additional, Camps Ortega, Onys, additional, Pucci Molineris, Melisa, additional, Lausada, Natalia, additional, Andres Moreno, Ane Miren, additional, Rumbo, Martin, additional, and Hernández Oliveros, Francisco, additional

Published
2023
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15. First case report of multivisceral transplant from a deceased cardiac death donor

Author

Andres, Ane M., primary, Encinas, Jose Luis, additional, Sánchez-Galán, Alba, additional, Rodríguez, Javier Serradilla, additional, Estefania, Karla, additional, Sacristan, Rocio Gonzalez, additional, Alcolea, Alida, additional, Serrano, Pilar, additional, Estébanez, Belén, additional, Leon, Iñigo Velasco, additional, Burgos, Paula, additional, Rocafort, Alvaro Gonzalez, additional, Ramchandani, Bunty, additional, Calderón, Belén, additional, Verdú, Cristina, additional, Jimenez, Esperanza, additional, Talayero, Paloma, additional, Stringa, Pablo, additional, Navarro, Itziar de la Peña, additional, Ramos, Esther, additional, and Oliveros, Francisco Hernandez, additional

Published
2023
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18. Delayed introduction of sirolimus in paediatric intestinal transplant recipients: indications and long‐term benefits

Author

Andres, Ane M., primary, Talayero, Paloma, additional, Alcolea Sanchez, Alida, additional, Sanchez Galán, Alba, additional, Serradilla Rodríguez, Javier, additional, Bueno Jimenez, Alba, additional, Gonzalez Sacristan, Rocío, additional, Stringa, Pablo, additional, Papa Gobbi, Rodrigo, additional, Lasa Lazaro, Maria, additional, Díaz Almirón, Mariana, additional, Ramos Boluda, Esther, additional, Lopez Santamaría, Manuel, additional, and Hernández Oliveros, Francisco, additional

Published
2021
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19. Toward Sézary Syndrome immunotherapy

Author

Marin, Ana V., primary, Megino, Rebeca F., additional, Viñuela, Marcos, additional, Popova, Olga, additional, Real-Arevalo, Irene, additional, Sanchez-Majano, Jose L., additional, Ortiz-Romero, Pablo L., additional, Castro-Panete, Maria J., additional, Mancebo, Esther, additional, Talayero, Paloma, additional, Paz-Artal, Estela, additional, Paciello, Maria L., additional, Martinez-Lopez, Joaquin, additional, Subiza, Jose L., additional, Reche, Pedro A., additional, Lopez-Bigas, Nuria, additional, Marcilla, Miguel, additional, Paradela, Alberto, additional, Moral, Manuel Gomez del, additional, Martinez-Naves, Eduardo, additional, Serrano, Alvaro, additional, Marina-Zarate, Ester, additional, Ramiro, Almudena R., additional, Engel, Pablo, additional, Dominguez, Mercedes, additional, Moreno, Inmaculada, additional, Cortegano, Isabel, additional, de Andres, Belen, additional, Gaspar, Maria L., additional, Garcia-Peydro, Marina, additional, Balas, Antonio, additional, Moreno, Miguel A., additional, Alenda, Raquel, additional, Vicario, Jose L., additional, Luescher, Immanuel F., additional, Toribio, Maria L., additional, Alarcon, Balbino, additional, and Regueiro, Jose R., additional

Published
2021
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20. Graft infusion of adipose‐derived mesenchymal stromal cells to prevent rejection in experimental intestinal transplantation: A feasibility study

Author

Andres, Ane M., primary, Stringa, Pablo, additional, Talayero, Paloma, additional, Santamaria, Monica, additional, García‐Arranz, Mariano, additional, García Gómez‐Heras, Soledad, additional, Largo‐Aramburu, Carlota, additional, Aras‐Lopez, Rosa M., additional, Vallejo‐Cremades, Maria Teresa, additional, Guerra Pastrián, Laura, additional, Vega, Luz, additional, Encinas, Jose Luis, additional, Lopez‐Santamaria, Manuel, additional, and Hernández‐Oliveros, Francisco, additional

Published
2021
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21. IL-6–based mortality risk model for hospitalized patients with COVID-19

Author

Laguna-Goya, Rocio, primary, Utrero-Rico, Alberto, additional, Talayero, Paloma, additional, Lasa-Lazaro, Maria, additional, Ramirez-Fernandez, Angel, additional, Naranjo, Laura, additional, Segura-Tudela, Alejandro, additional, Cabrera-Marante, Oscar, additional, Rodriguez de Frias, Edgar, additional, Garcia-Garcia, Rocio, additional, Fernández-Ruiz, Mario, additional, Aguado, Jose Maria, additional, Martinez-Lopez, Joaquin, additional, Lopez, Elena Ana, additional, Catalan, Mercedes, additional, Serrano, Antonio, additional, and Paz-Artal, Estela, additional

Published
2020
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22. Novel coronavirus (SARS‐CoV‐2) infection in a patient with multivisceral transplant

Author

Papa‐Gobbi, Rodrigo, primary, Bueno, Alba, additional, Serradilla, Javier, additional, Talayero, Paloma, additional, Stringa, Pablo, additional, Pascual‐Miguel, Bárbara, additional, Alcolea‐Sánchez, Alida, additional, González‐Sacristan, Rocío, additional, Andrés, Ane M., additional, López‐Santamaría, Manuel, additional, Rumbo, Martín, additional, Ramos‐Boluda, Esther, additional, and Hernández‐Oliveros, Francisco, additional

Published
2020
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23. Donor helper innate lymphoid cells are replaced earlier than lineage positive cells and persist long‐term in human intestinal grafts – a descriptive study

Author

Gómez‐Massa, Elena, primary, Lasa‐Lázaro, María, additional, Gil‐Etayo, Francisco Javier, additional, Ulloa‐Márquez, Esperanza, additional, Justo, Iago, additional, Loinaz, Carmelo, additional, Calvo‐Pulido, Jorge, additional, Paz‐Artal, Estela, additional, and Talayero, Paloma, additional

Published
2020
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24. Number and function of circulatory helper innate lymphoid cells are unaffected by immunosuppressive drugs used in solid organ recipients – a single centre cohort study

Author

Gómez‐Massa, Elena, primary, Talayero, Paloma, additional, Utrero‐Rico, Alberto, additional, Laguna‐Goya, Rocío, additional, Andrés, Amado, additional, Mancebo, Esther, additional, Leivas, Alejandra, additional, Polanco‐Fernández, Natalia, additional, Justo, Iago, additional, Jimenez‐Romero, Carlos, additional, Pleguezuelo, Daniel, additional, and Paz‐Artal, Estela, additional

Published
2020
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25. P4.46: PEDIATRIC INTESTINAL RETRANSPLANTATION: OUTCOMES IN A REFERAL CENTER

Author

Bueno, Alba, primary, Serradilla, Javier, additional, Andrés, Ane Miren, additional, Boluda, Esther Ramos, additional, Alcolea, Alida, additional, López-Santamaría, Manuel, additional, Talayero, Paloma, additional, Mancebo, Esther, additional, José Castro, María, additional, Paz, Estela, additional, and Hernández, Francisco, additional

Published
2019
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27. Donor‐Specific Antibodies in Pediatric Intestinal and Multivisceral Transplantation: The Role of Liver and Human Leukocyte Antigen Mismatching

Author

Talayero, Paloma, primary, Ramos Boluda, Esther, additional, Gómez Massa, Elena, additional, Castro Panete, María José, additional, Prieto Bozano, Gerardo, additional, Hernández Oliveros, Francisco, additional, López Santamaría, Manuel, additional, Calvo Pulido, Jorge, additional, Paz‐Artal, Estela, additional, and Mancebo, Esther, additional

Published
2018
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28. Novel coronavirus (SARS‐CoV‐2) infection in a patient with multivisceral transplant.

Author

Papa‐Gobbi, Rodrigo, Bueno, Alba, Serradilla, Javier, Talayero, Paloma, Stringa, Pablo, Pascual‐Miguel, Bárbara, Alcolea‐Sánchez, Alida, González‐Sacristan, Rocío, Andrés, Ane M., López‐Santamaría, Manuel, Rumbo, Martín, Ramos‐Boluda, Esther, and Hernández‐Oliveros, Francisco

Subjects
SARS-CoV-2, VISCERAL pain, COVID-19, INFECTION
Abstract

More experience needs to be accumulated in order to conclude whether transplanted patients represent or not a group of risk for SARS-CoV-2 infection and determine the best way to handle immunosuppression treatment. Novel coronavirus (SARS-CoV-2) infection in a patient with multivisceral transplant To the Editor, Coronavirus disease 2019 (COVID-19) pandemic has become one of the most challenging episodes in the history of modern public health, with particular emphasis in high-risk population.1 However, the evidence regarding their response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for COVID-19 is scant.2 Herein, we present the clinical and therapeutic course of a SARS-CoV-2 infection in a patient with multivisceral transplant and a recent tuberculosis infection. [Extracted from the article]

Published
2021
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29. 5-gene differential expression predicts stability of human intestinal allografts

Author

Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Talayero, Paloma, Alonso, Lola, Padilla, Guillermo, Artaza-Álvarez, Haydeé, García de Lacoba, Mario, Paz-Artal, Estela, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Talayero, Paloma, Alonso, Lola, Padilla, Guillermo, Artaza-Álvarez, Haydeé, García de Lacoba, Mario, and Paz-Artal, Estela

Abstract

In intestinal allografts, endoscopy and histology detect the injury once changes in the bowel wall architecture have occurred. We aimed to identify a molecular signature that could predict early deterioration, within histologically indistinguishable biopsies with "minimal changes" (MC) pathology. Sixty biopsies from 12 adult recipients were longitudinally taken during 8years post-transplant. They were classified as either stable (STA) or non-stable (NSTA) according to the prospectively recorded number, frequency and severity of rejection events of the allograft. In a discovery set of MC samples analyzed by RNA-Seq, 816 genes were differentially expressed in STA vs NSTA biopsies. A group of 5 genes (ADH1C, SLC39A4, CYP4F2, OPTN and PDZK1) correctly classified all NSTA biopsies in the discovery set and all STA biopsies from an independent set. These results were validated by qPCR in a new group of MC biopsies. Based on a logistic regression model, a cutoff of 0.28 predicted the probability of being a NSTA biopsy with 85% sensitivity and 69% specificity. In conclusion, by analyzing MC samples early after transplantation, the expression of a 5-gene set may predict the evolution of the bowel allograft. This prognostic biomarker may be of help to personalize care of the intestinal transplant recipient.

Published
2017

30. High proportion of CD95+ and CD38+ in cultured CD8+ T cells predicts acute rejection and infection, respectively, in kidney recipients

Author

Mancebo, Esther, primary, Castro, María José, additional, Allende, Luís M., additional, Talayero, Paloma, additional, Brunet, Mercè, additional, Millán, Olga, additional, Guirado, Luís, additional, López-Hoyos, Marcos, additional, San Segundo, David, additional, Rodrigo, Emilio, additional, Muñoz, Pedro, additional, Boix Giner, Francisco, additional, Llorente Viñas, Santiago, additional, Muro-Amador, Manuel, additional, and Paz-Artal, Estela, additional

Published
2016
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31. Early renal graft function deterioration in recipients with preformed anti-MICA antibodies: partial contribution of complement-dependent cytotoxicity

Author

Sánchez-Zapardiel, Elena, primary, Castro-Panete, María José, additional, Mancebo, Esther, additional, Morales, Pablo, additional, Laguna-Goya, Rocío, additional, Morales, José María, additional, Apaza, Jacqueline, additional, de Andrés, Amado, additional, Talayero, Paloma, additional, and Paz-Artal, Estela, additional

Published
2015
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32. High Proportion of Pretransplantation Activated Regulatory T cells (CD4+CD25highCD62L+CD45RO+) Predicts Acute Rejection in Kidney Transplantation

Author

San Segundo, David, primary, Millán, Olga, additional, Muñoz-Cacho, Pedro, additional, Boix, Francisco, additional, Paz-Artal, Estela, additional, Talayero, Paloma, additional, Morales, José María, additional, Muro, Manuel, additional, De Cos, María Ángeles, additional, Guirado, Lluis, additional, Llorente, Santiago, additional, Pascual, Julio, additional, Arias, Manuel, additional, Brunet, Mercè, additional, and López-Hoyos, Marcos, additional

Published
2014
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33. Harmful Effect of Preformed Anti-MICA Antibodies on Renal Allograft Evolution in Early Posttransplantation Period

Author

Sánchez-Zapardiel, Elena, primary, Castro-Panete, María J., additional, Castillo-Rama, Marcela, additional, Morales, Pablo, additional, Lora-Pablos, David, additional, Valero-Hervás, Diana, additional, Ruiz-García, Raquel, additional, Apaza, Jacqueline, additional, Talayero, Paloma, additional, Andrés, Amado, additional, Morales, José M., additional, and Paz-Artal, Estela, additional

Published
2013
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35. Perforin gene variant A91V in young patients with severe COVID-19.

Author

Cabrera-Marante O, Rodríguez de Frías E, Pleguezuelo DE, Allende LM, Serrano A, Laguna-Goya R, Mancebo ME, Talayero P, Álvarez-Vallina L, Morales P, Castro-Panete MJ, and Paz-Artal E

Subjects
COVID-19 genetics, COVID-19 virology, Female, Humans, Lymphohistiocytosis, Hemophagocytic genetics, Lymphohistiocytosis, Hemophagocytic virology, Male, Middle Aged, Prognosis, Severity of Illness Index, COVID-19 immunology, Cytotoxicity, Immunologic immunology, Lymphohistiocytosis, Hemophagocytic immunology, Mutation, Perforin genetics, SARS-CoV-2 immunology
Published
2020
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36. Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency.

Author

Bernardo I, Mancebo E, Aguiló I, Anel A, Allende LM, Guerra-Vales JM, Ruiz-Contreras J, Serrano A, Talayero P, de la Calle O, Gonzalez-Santesteban C, and Paz-Artal E

Subjects
Adolescent, Adult, CD8 Antigens genetics, CD8-Positive T-Lymphocytes immunology, Cytoplasm metabolism, Cytotoxicity, Immunologic, Female, Flow Cytometry, Gene Expression Regulation immunology, Humans, Immunophenotyping, Mutation genetics, Receptors, Antigen, T-Cell immunology, Receptors, Antigen, T-Cell metabolism, T-Lymphocyte Subsets metabolism, CD8 Antigens metabolism, Phenotype, T-Lymphocyte Subsets immunology
Abstract

Background: Human CD8 immunodeficiency is characterized by undetectable CD8(+) lymphocytes and an increased population of CD4(-)CD8(-) (double negative) T lymphocytes., Design and Methods: We hypothesized that the double negative subset corresponds to the cellular population that should express CD8 and is committed to the cytotoxic T lymphocyte lineage. To assess this, we determined the phenotype and function of peripheral blood mononuclear cells and/or magnetically isolated double negative T lymphocytes from two CD8-deficient patients. To analyze the expression and co-localization with different organelles, 293T cells were transfected with plasmids bearing wild-type or mutated CD8α., Results: CD8α mutated protein was retained in the cytoplasm of transfected cells. The percentages of double negative cells in patients were lower than the percentages of CD8(+) T cells in healthy controls. Double negative cells mostly had an effector or effector memory phenotype whereas naïve T cells were under-represented. A low concentration of T-cell receptor excision circles together with a skewed T-cell receptor-V repertoire were observed in the double negative population. These data suggest that, in the absence of CD8 co-receptor, the thymic positive selection functions suboptimally and a limited number of mature T-cell clones would emerge from the thymus. In vitro, the double negative cells showed a mild defect in cytotoxic function and decreased proliferative capacity., Conclusions: It is possible that the double negative cells are major histocompatibility complex class-I restricted T cells with cytolytic function. These results show for the first time in humans that the presence of the CD8 co-receptor is dispensable for cytotoxic ability, but that it affects the generation of thymic precursors committed to the cytotoxic T lymphocyte lineage and the proliferation of mature cytotoxic T cells.

Published
2011
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