1. Feeding during Blood Transfusions and the Association with Necrotizing Enterocolitis
- Author
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Julie Farr, Megan M. Doty, Tala Nasr, Vanessa Celleri Gomezcoello, Gregory Martin, and Christine Wade
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Blood transfusion ,Neonatal intensive care unit ,medicine.medical_treatment ,Gestational Age ,Infant, Premature, Diseases ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Enterocolitis, Necrotizing ,030225 pediatrics ,Intensive Care Units, Neonatal ,medicine ,Humans ,Infant, Very Low Birth Weight ,030212 general & internal medicine ,Fisher's exact test ,Retrospective Studies ,Enterocolitis ,business.industry ,Incidence (epidemiology) ,Incidence ,Arizona ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,Infant ,Retrospective cohort study ,Feeding Behavior ,medicine.disease ,digestive system diseases ,Logistic Models ,Pediatrics, Perinatology and Child Health ,Necrotizing enterocolitis ,Multivariate Analysis ,symbols ,Female ,medicine.symptom ,business ,Erythrocyte Transfusion - Abstract
Objective The aim of this study was to determine whether very low-birth-weight (VLBW) infants who had feedings withheld during all blood transfusions had a lower incidence of necrotizing enterocolitis (NEC) compared with infants who were fed during transfusions. Study Design A retrospective chart review over a 3-year period in a level-3 neonatal intensive care unit was conducted. A total of 108 inborn VLBW infants (weight range: 500–1,500 g) who had received a transfusion before 36 weeks were reviewed. Diagnosis of NEC (≥ Bell stage II), demographics, feeds, transfusions, outcomes, and variables associated with NEC were collected. Results The percentage of NEC cases was lower in infants who had feeds withheld during transfusions: 5/64 (7.8%) compared with 16/116 (13.8%) infants who were fed during transfusions. While potentially clinically important (6% absolute difference), this difference was not statistically significant ( p = 0.33 by two-tailed Fisher exact test). Conclusions No significant decrease in the incidence of NEC was found when feeds were withheld during blood transfusions. Holding feeds during transfusions is not without consequences such as the need for intravenous access, additional fluids, and the disruption of optimum nutrition. Further studies are needed to establish the relationship between blood transfusions, feeds, and NEC.
- Published
- 2016