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Wound or injury can be defined as partial or complete separation of the skin, while the healing of the wounds is defined as the sequences of processes by which the skin heals and returns to its normal appearance. This study aims to evaluate the efficacy of Laurus nobilis leaf extracts on the healing of open wounds in rabbits. Twenty‐four healthy rabbits were used, divided randomly into control and treated groups, each consisting of 12 rabbits. The rabbits were caused to experience circular wound defects (2.5 cm) in diameter. All animals in the control (C) group were left without treatment while those in the Laurus nobilis leaf extract group were treated with drops of the aqueous extract of Laurus nobilis in a dose of 200 mg/kg per day for 20 days. The results of macroscopic observation revealed that all animals in both groups showed equitable viability and good appetite, no mortality occurred, and no signs of infection. In the group with the Laurus nobilis extract, we noticed a significant improvement in wound‐healing activity and a reduction in the wound area at p ≤ 0.05 compared with the C group. Histopathological results at the end of the study show that the thick epidermal layer covers a mass of granulation with congested blood vessels and the dermis transforms into a denser layer gradually due to the improvements of the cellularity in the C group and also revealed a well‐formed skin appearance, widespread of collagen, and fibrosis within the dermis with an appearance near the normal dermis in the group treated with Laurus nobilis leaf extract. In conclusion, the results confirmed that using Laurus nobilis methanolic extract solution in a daily dose of 200 mg/kg promotes healing of open wounds in rabbits. [ABSTRACT FROM AUTHOR]

The object of this study were to evaluate the toxic effect of celecoxib and ibuprofen with regard toxicopathological changes in mature male albino mice. Non- steroidal anti-inflammatory drugs (NSAIDs) must be prescribed with carefulness as courses of just a few days, even at amounts within prescribing recommendations, can be related with serious adverse effects in some patients. The cyclo-oxygenase-1 and 2 (COX-1 and COX-2) enzymes produce prostaglandins (PGs) after the metabolism of omega-6 polyunsaturated fatty acid (arachidonic acid). PGs are chemical messengers that mediate inflammation, fever and the sensation of pain. The analgesic and anti-inflammatory effects of NSAIDs are produced by the prevention of PGs production by prevention of COX activity. Clinical effects and the risk profiles of the different NSAIDs are main factors to select which one are the best to achieve its function and by their variance ability to inhibit the COX-1 and/or COX-2 enzymes and their half-lives. [ABSTRACT FROM AUTHOR]