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856 results on '"Takkar, Brijesh"'

9. Characterization of retinal hemorrhages delimited by the internal limiting membrane

Author

Brar, Anand, Ramachandran, Sivaranjan, Takkar, Brijesh, Narayanan, Raja, Mandal, Sohini, and Padhy, Srikanta

Subjects
Blood banks, Health
Abstract

Byline: Anand. Brar, Sivaranjan. Ramachandran, Brijesh. Takkar, Raja. Narayanan, Sohini. Mandal, Srikanta. Padhy Clinically, hemorrhages at the vitreoretinal interface have been termed as 'pre-retinal' in location. However, there is a [...]

Published
2024

10. Bardet-Biedl syndrome with chorioretinal coloboma: a case series and review of literature.

Author

Chattannavar, Goura, Ger, Marina, Balasubramanian, Jeyapoorani, Mandal, Sohini, Jalali, Subhadra, Takkar, Brijesh, Pisuchpen, Phattrawan, de Guimaraes, Thales A. C., Capasso, Jenina E., Kumar Padhy, Srikanta, and Levin, Alex V

Abstract

Introduction: Bardet-Biedl Syndrome (BBS) is a ciliopathy causing developmental defects and progressive retinal dystrophy, whereas choroidal coloboma is a developmental defect causing structural deficiency in the posterior retina. Both are rarely reported together. Methods: Here, we describe the phenotype and genotype of three unrelated patients with co-occurrence of Bardet-Biedl Syndrome and chorioretinal coloboma and review the pertinent literature. Results: We describe three unrelated patients, with variable clinical features of Bardet Biedl syndrome. None had family history of BBS or coloboma. Each carried biallelic variants in BBS1, BBS9 and TTC8 gene, respectively. Two had unilateral chorioretinal coloboma, while one had bilateral chorioretinal coloboma. Discussion: Although there may be other explanatory factors yet to be revealed, our data suggests that chorioretinal coloboma may be associated with BBS. The Hedgehog (Hh) signaling pathway, an intercellular communicator for development of the eye, is dependent on the primary cilia and plays a crucial role in the closure of the optic fissure. Both disorders therefore involve disruption of primary cilia function which may explain their association. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Central retinal artery occlusion following pediatric blunt ocular trauma

Author

Ramachandran, Sivaranjan, Chavan, Kasturi, Padhi, Tapas, Takkar, Brijesh, Karande, Sayali, Kelgaonkar, Anup, Panda, Krushna, and Padhy, Srikanta

Subjects
Pediatrics -- Research, Retinal diseases -- Research -- Diagnosis, Health
Abstract

Byline: Sivaranjan. Ramachandran, Kasturi. Chavan, Tapas. Padhi, Brijesh. Takkar, Sayali. Karande, Anup. Kelgaonkar, Krushna. Panda, Srikanta. Padhy Background: To analyze the clinical profile, presentation, possible pathophysiology, and outcomes of central [...]

Published
2023

12. Clinical profile and demographic distribution of Stargardt disease phenotypes: An Electronic medical record-driven big data analytics from a multitier eye care network

Author

Das, Anthony, Venugopal, Ragukumar, Takkar, Brijesh, Sharma, Sumant, Balakrishnan, Neelima, Narayanan, Raja, Parameswarappa, Deepika, and Padhy, Srikanta

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Medical records -- Health aspects, Big data -- Health aspects, Ophthalmology -- Health aspects, Electronic records -- Health aspects, Hospital patients -- Health aspects, Health
Abstract

Byline: Anthony. Das, Ragukumar. Venugopal, Brijesh. Takkar, Sumant. Sharma, Neelima. Balakrishnan, Raja. Narayanan, Deepika. Parameswarappa, Srikanta. Padhy Purpose: To describe the demographics and clinical profile of Stargardt disease in patients [...]

Published
2023

17. Clinical presentation and outcomes of trivial trauma-associated giant macular holes in children with Best vitelliform macular dystrophy

Author

Ramachandran, Sivaranjan, Parameswarappa, Deepika, Takkar, Brijesh, Jalali, Subhadra, and Padhy, Srikanta

Subjects
Vision disorders in children -- Diagnosis -- Care and treatment -- Genetic aspects, Patient education -- Methods, Health
Abstract

Byline: Sivaranjan. Ramachandran, Deepika. Parameswarappa, Brijesh. Takkar, Subhadra. Jalali, Srikanta. Padhy We present three cases of children with giant macular holes in relation to trivial trauma. These children had brittle [...]

Published
2023

19. Diabetes, Diabetic Retinopathy, and Inflammatory Disorders.

Author

Sheemar, Abhishek, Goel, Pallavi, Thakur, Pratima Singh, Takkar, Brijesh, Kaur, Inderjeet, Rani, Padmaja K., Tyagi, Mudit, Basu, Soumyava, and Venkatesh, Pradeep

Subjects
EYE inflammation, ANTI-inflammatory agents, DIABETES, INSULIN resistance, RHEUMATOID arthritis, DIABETIC retinopathy
Abstract

This review summarizes the impact of systemic and ocular inflammatory disorders on diabetes mellitus (DM) and diabetic retinopathy (DR). Local inflammation is a key pathology in diabetic retinopathy (DR) and is also an evolving target for clinical therapy. The legacy effects of local inflammation at the intracellular level make DR a persistent self-driven vicious process. Ocular inflammation is accompanied as well as incited by systemic inflammation due to diabetes mellitus (DM) itself. Over the years, a multitude of studies have evaluated the impact of systemic inflammatory disorders (SIDs, like rheumatoid arthritis, lupus, psoriasis, etc.) and anti-inflammatory drugs prescribed for managing them on manifestations of DM. Recent studies have indicated increased insulin resistance to be a result of chronic inflammation, and the anti-inflammatory drugs to have a protective effect towards DM. Very few studies have evaluated the impact of SIDs on DR. Furthermore, the evidence from these studies is conflicting, and while local anti-inflammatory therapy has shown a lot of clinical potential for use in DR, the results of systemic anti-inflammatory therapies have been inconsistent. The impact of local ocular inflammation due to uveitis on DR is a crucial aspect that has not been evaluated well at present. Initial pre-clinical studies and small-sized clinical reports have shown a strong and positive relationship between the presence of uveitis and the severity of DR as well as its progression, while larger cross-sectional patient surveys have refuted the same. The long term impact of ocular inflammation due to uveitis on DR needs to be studied while adjusting for confounders. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Objectively measuring anterior segment alterations in the eyes of mucopolysaccharidoses: Its utility in early diagnosis of glaucoma

Author

Achanta, Divya Ramya, Mohamed, Ashik, Chaurasia, Sunita, Senthil, Sirisha, Mandal, Anil, Takkar, Brijesh, Mishra, Dilip, Edward, Deepak, and Ramappa, Muralidhar

Subjects
Mucopolysaccharidosis -- Diagnosis -- Complications and side effects, Glaucoma -- Risk factors -- Diagnosis, Health
Abstract

Byline: Divya. Ramya Achanta, Ashik. Mohamed, Sunita. Chaurasia, Sirisha. Senthil, Anil. Mandal, Brijesh. Takkar, Dilip. Mishra, Deepak. Edward, Muralidhar. Ramappa Purpose: Our study aimed to evaluate the utility of the [...]

Published
2022

34. Normative data of retinal arteriolar and venular calibre measurements determined using confocal scanning laser ophthalmoscopy system - Importance and implications for study of cardiometabolic disorders

Author

Garg, Gaurav, Venkatesh, Pradeep, Chawla, Rohan, Takkar, Brijesh, Temkar, Shreyas, and Damodaran, Sourav

Subjects
Laser scanning microscopy -- Usage, Ophthalmoscope and ophthalmoscopy -- Usage, Metabolic diseases -- Diagnosis, Cardiovascular diseases -- Diagnosis, Retina -- Blood-vessels, Health
Abstract

Byline: Gaurav. Garg, Pradeep. Venkatesh, Rohan. Chawla, Brijesh. Takkar, Shreyas. Temkar, Sourav. Damodaran Purpose: To determine and validate retinal vascular caliber measurements by using the confocal scanning laser ophthalmoscopy system. [...]

Published
2022

41. Diabetes, Diabetic Retinopathy, and Inflammatory Disorders

Author

Sheemar, Abhishek, primary, Goel, Pallavi, additional, Thakur, Pratima Singh, additional, Takkar, Brijesh, additional, Kaur, Inderjeet, additional, Rani, Padmaja K., additional, Tyagi, Mudit, additional, Basu, Soumyava, additional, and Venkatesh, Pradeep, additional

Published
2023
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43. Correlation of vitreous chamber depth with ocular biometry in high axial myopia

Author

Paritala, Anusha, Takkar, Brijesh, Gaur, Nripen, Soni, Deepak, Ali, Mohammad, and Rathi, Anubha

Subjects
Vitreous body -- Physiological aspects -- Measurement, Biometry -- Research, Myopia -- Diagnosis -- Risk factors -- Physiological aspects, Health
Abstract

Byline: Anusha. Paritala, Brijesh. Takkar, Nripen. Gaur, Deepak. Soni, Mohammad. Ali, Anubha. Rathi Purpose: The proportion of axial length (AL) occupied by vitreous chamber depth (VCD), or VCD:AL, consistently correlates [...]

Published
2022

44. Jet stream related iatrogenic retinal breaks during vitreo-retinal surgery

Author

Belenje, Akash, Takkar, Brijesh, Agarwal, Komal, Tyagi, Mudit, Aggarwal, Vinod, Padhi, Tapas, and Narayanan, Raja

Subjects
Surgical errors -- Causes of, Iatrogenic diseases -- Risk factors -- Causes of, Jets -- Health aspects, Retinal diseases -- Risk factors -- Causes of, Eye -- Injuries -- Surgery, Health
Abstract

Byline: Akash. Belenje, Brijesh. Takkar, Komal. Agarwal, Mudit. Tyagi, Vinod. Aggarwal, Tapas. Padhi, Raja. Narayanan Purpose: To evaluate the causes of jet stream injury (JSI)-related iatrogenic retinal breaks (IRBs) during [...]

Published
2022

45. Sight-threatening intraocular infection in patients with COVID-19 in India

Author

Nayak, Sameera, Das, Taraprasad, Parameswarappa, Deepika, Sharma, Savitri, Jakati, Saumya, Jalali, Subhadra, Narayanan, Raja, Basu, Soumyava, Tyagi, Mudit, Dave, Vivek, Pappuru, Rajeev, Pathengay, Avinash, Kaza, Hrishikesh, Rani, Padmaja, Behera, Shashwat, Sahoo, Niroj, Kapoor, Aditya, Agrawal, Hitesh, Agarwal, Komal, Takkar, Brijesh, and Raval, Vishal

Subjects
Eye infections -- Case studies -- Risk factors -- Care and treatment, Health
Abstract

Byline: Sameera. Nayak, Taraprasad. Das, Deepika. Parameswarappa, Savitri. Sharma, Saumya. Jakati, Subhadra. Jalali, Raja. Narayanan, Soumyava. Basu, Mudit. Tyagi, Vivek. Dave, Rajeev. Pappuru, Avinash. Pathengay, Hrishikesh. Kaza, Padmaja. Rani, Shashwat. [...]

Published
2021

48. Experimental evaluation of safety and efficacy of plasma-treated poly-[epsilon]-caprolactone membrane as a substitute for human amniotic membrane in treating corneal epithelial defects in rabbit eyes

Author

Ravani, Raghav, Yadav, Saumya, Takkar, Brijesh, Sen, Seema, Kashyap, Seema, Gupta, Deepika, Jassal, Manjeet, Agrawal, Ashwini, Mohanty, Sujata, and Tandon, Radhika

Subjects
Corneal diseases -- Models -- Care and treatment, Amnion -- Testing -- Comparative analysis, Amniotic sac -- Testing -- Comparative analysis, Membranes (Technology) -- Testing -- Comparative analysis, Polymers in medicine -- Testing -- Comparative analysis, Health
Abstract

Byline: Raghav. Ravani, Saumya. Yadav, Brijesh. Takkar, Seema. Sen, Seema. Kashyap, Deepika. Gupta, Manjeet. Jassal, Ashwini. Agrawal, Sujata. Mohanty, Radhika. Tandon Purpose: To evaluate biocompatibility and safety of plasma-treated poly-[epsilon]-caprolactone [...]

Published
2021

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