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1. Anomalously porous boulders on (162173) Ryugu as primordial materials from its parent body

Author

Sakatani, N., Tanaka, S., Okada, T., Fukuhara, T., Riu, L., Sugita, S., Honda, R., Morota, T., Kameda, S., Yokota, Y., Tatsumi, E., Yumoto, K., Hirata, N., Miura, A., Kouyama, T., Senshu, H., Shimaki, Y., Arai, T., Takita, J., Demura, H., Sekiguchi, T., Müller, T. G., Hagermann, A., Biele, J., Grott, M., Hamm, M., Delbo, M., Neumann, W., Taguchi, M., Ogawa, Y., Matsunaga, T., Wada, T., Hasegawa, S., Helbert, J., Hirata, N., Noguchi, R., Yamada, M., Suzuki, H., Honda, C., Ogawa, K., Hayakawa, M., Yoshioka, K., Matsuoka, M., Cho, Y., Sawada, H., Kitazato, K., Iwata, T., Abe, M., Ohtake, M., Matsuura, S., Matsumoto, K., Noda, H., Ishihara, Y., Yamamoto, K., Higuchi, A., Namiki, N., Ono, G., Saiki, T., Imamura, H., Takagi, Y., Yano, H., Shirai, K., Okamoto, C., Nakazawa, S., Iijima, Y., Arakawa, M., Wada, K., Kadono, T., Ishibashi, K., Terui, F., Kikuchi, S., Yamaguchi, T., Ogawa, N., Mimasu, Y., Yoshikawa, K., Takahashi, T., Takei, Y., Fujii, A., Takeuchi, H., Yamamoto, Y., Hirose, C., Hosoda, S., Mori, O., Shimada, T., Soldini, S., Tsukizaki, R., Ozaki, M., Tachibana, S., Ikeda, H., Ishiguro, M., Yabuta, H., Yoshikawa, M., Watanabe, S., and Tsuda, Y.

Published
2021
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7. Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Author

Van Thillo, Q, De Bie, J, Seneviratne, JA, Demeyer, S, Omari, S, Balachandran, A, Zhai, V, Tam, WL, Sweron, B, Geerdens, E, Gielen, O, Provost, S, Segers, H, Boeckx, N, Marshall, GM, Cheung, BB, Isobe, K, Kato, I, Takita, J, Amos, TG, Deveson, IW, McCalmont, H, Lock, RB, Oxley, EP, Garwood, MM, Dickins, RA, Uyttebroeck, A, Carter, DR, Cools, J, de Bock, CE, Van Thillo, Q, De Bie, J, Seneviratne, JA, Demeyer, S, Omari, S, Balachandran, A, Zhai, V, Tam, WL, Sweron, B, Geerdens, E, Gielen, O, Provost, S, Segers, H, Boeckx, N, Marshall, GM, Cheung, BB, Isobe, K, Kato, I, Takita, J, Amos, TG, Deveson, IW, McCalmont, H, Lock, RB, Oxley, EP, Garwood, MM, Dickins, RA, Uyttebroeck, A, Carter, DR, Cools, J, and de Bock, CE

Abstract

Spi-1 Proto-Oncogene (SPI1) fusion genes are recurrently found in T-cell acute lymphoblastic leukemia (T-ALL) cases but are insufficient to drive leukemogenesis. Here we show that SPI1 fusions in combination with activating NRAS mutations drive an immature T-ALL in vivo using a conditional bone marrow transplant mouse model. Addition of the oncogenic fusion to the NRAS mutation also results in a higher leukemic stem cell frequency. Mechanistically, genetic deletion of the β-catenin binding domain within Transcription factor 7 (TCF7)-SPI1 or use of a TCF/β-catenin interaction antagonist abolishes the oncogenic activity of the fusion. Targeting the TCF7-SPI1 fusion in vivo with a doxycycline-inducible knockdown results in increased differentiation. Moreover, both pharmacological and genetic inhibition lead to down-regulation of SPI1 targets. Together, our results reveal an example where TCF7-SPI1 leukemia is vulnerable to pharmacological targeting of the TCF/β-catenin interaction.

Published
2021

10. Unveiling Highly-Porous Nature of Primitive Asteroid 162173 Ryugu by Thermal Imager on Hayabusa2

Author

Okada, T., Fukuhara, T., Tanaka, S., Taguchi, M., Arai, T., Sakatani, N., Shimaki, Y., Senshu, H., Ogawa, Y., Demura, H., Suko, K., Kitazato, K., Kouyama, T., Sekiguchi, T., Takita, J., Hasegawa, S., Matsunaga, T., Wada, T., Imamura, T., Helbert, Jörn, Mueller, T. G., Hagermann, A., Biele, Jens, Grott, Matthias, Hamm, Maximilian, Delbo, M, Yamamoto, Y., Hirata, N., Terui, F., Saiki, T., Nakazawa, S., Yoshikawa, M., Watanabe, S, and Tsuda, T.

Subjects
Planetenphysik, Planetare Labore, Ryugu, Hayabusa, Nutzerzentrum für Weltraumexperimente (MUSC), Asteroiden
Published
2020

11. Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL

Author

Watanabe, A., Miyake, K., Nordlund, Jessica, Syvänen, Ann-Christine, van der Weyden, L., Honda, H., Yamasaki, N., Nagamachi, A., Inaba, T., Ikawa, T., Urayama, K. Y., Kiyokawa, N., Ohara, A., Kimura, S., Kubota, Y., Takita, J., Goto, H., Sakaguchi, K., Minegishi, M., Iwamoto, S., Shinohara, T., Kagami, K., Abe, M., Akahane, K., Goi, K., Sugita, K., Inukai, T., Watanabe, A., Miyake, K., Nordlund, Jessica, Syvänen, Ann-Christine, van der Weyden, L., Honda, H., Yamasaki, N., Nagamachi, A., Inaba, T., Ikawa, T., Urayama, K. Y., Kiyokawa, N., Ohara, A., Kimura, S., Kubota, Y., Takita, J., Goto, H., Sakaguchi, K., Minegishi, M., Iwamoto, S., Shinohara, T., Kagami, K., Abe, M., Akahane, K., Goi, K., Sugita, K., and Inukai, T.

Abstract

Karyotype is an important prognostic factor in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), but the underlying pharmacogenomics remain unknown. Asparaginase is an integral component in current chemotherapy for childhood BCP-ALL. Asparaginase therapy depletes serum asparagine. Normal hematopoietic cells can produce asparagine by asparagine synthetase (ASNS) activity, but ALL cells are unable to synthesize adequate amounts of asparagine. The ASNS gene has a typical CpG island in its promoter. Thus, methylation of the ASNS CpG island could be one of the epigenetic mechanisms for ASNS gene silencing in BCP-ALL. To gain deep insights into the pharmacogenomics of asparaginase therapy, we investigated the association of ASNS methylation status with asparaginase sensitivity. The ASNS CpG island is largely unmethylated in normal hematopoietic cells, but it is allele-specifically methylated in BCP-ALL cells. The ASNS gene is located at 7q21, an evolutionally conserved imprinted gene cluster. ASNS methylation in childhood BCP-ALL is associated with an aberrant methylation of the imprinted gene cluster at 7q21. Aberrant methylation of mouse Asns and a syntenic imprinted gene cluster is also confirmed in leukemic spleen samples from ETV6-RUNX1 knockin mice. In 3 childhood BCP-ALL cohorts, ASNS is highly methylated in BCP-ALL patients with favorable karyotypes but is mostly unmethylated in BCP-ALL patients with poor prognostic karyotypes. Higher ASNS methylation is associated with higher L-asparaginase sensitivity in BCP-ALL through lower ASNS gene and protein expression levels. These observations demonstrate that silencing of the ASNS gene as a result of aberrant imprinting is a pharmacogenetic mechanism for the leukemia-specific activity of asparaginase therapy in BCP-ALL.

Published
2020
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17. Fine-grained region with low thermal inertia in craters on Ryugu

Author

Sakatani, N., Tanaka, S., Okada, T., Senshu, H., Arai, T., Demura, H., Suko, K., Shimaki, Y., Sekiguchi, Tomohiko, Takita, J., Fuhuhara, T., Tagucchi, M., Müller, T., Hagermann, A., Biele, Jens, Grott, Matthias, Hamm, Maximilian, Delbo, M, Sugita, Seiji, Honda, R., Morota, T., Yamada, M., Kameda, S., Tatsumi, E., Yokota, Y., Kouyama, Toru, Suzuki, H., Honda, C., Ogawa, Kazunori, Hayakawa, M., Yoshioka, K., Matsuoka, A., Cho, Yuichiro, Sawada, H., and Miuara, A.

Subjects
Planetenphysik, Hayabusa2 Ryugu, Nutzerzentrum für Weltraumexperimente (MUSC)
Abstract

Introduction: The Hayabusa2 spacecraft is surveying asteroid Ryugu from June 2018. Global observation by thermal infrared imager TIR revealed low thermal inertia around 200-300J m-2 K-1 s-0.5 [1]. The expected grain size from this thermal inertia was several centimeters [2]. However, the surface of Ryugu is globally filled with larger boulders [3]. These observational results indicate highly porous nature of the surface boulders with low thermal inertia, unexpectedly different from the carbonaceous meteorites we have. Local observations by MARA radiometer onboard MASCOT lander supported it [4, 5]. In addition to the global observation, close-up imaging by TIR during descending operations, including MINERVA and MASCOT releases, touch-down operations and their rehearsals, were conducted. The high resolution TIR images revealed local temperature anomaly related to the boulders [6] and craters, which showed local variation in thermophysical properties.In this study, we show survey of thermally-unusual craters on Ryugu using these close-up images. The unique feature were found as hot spot around the center of some small craters.

Published
2019

18. Surface physical condition of asteroid Ryugu using close-up optical and thermal images

Author

Sakatani, N., Sugita, S., Honda, R., Morota, T., Yamada, M., Kameda, Shingo, Tatsumi, E., Yokota, S., Kouyama, T., Suzuki, H., Honda, C., Hayakawa, M., Yoshioka, K., Matsuoko, Moe, Cho, Y., Sawada, H., Ogawa, N., Miura, A., Okada, T., Tanaka, S., Senshu, H., Arai, T., Demura, Hirohide, Suko, K., Shimaki, Y., Sekigucchi, T., Takita, J., Fuhuhara, T., Tagutchi, M., Müller, T., Hagermann, A., Biele, Jens, Grott, Matthias, and Delbo, M.

Subjects
Hayabusa 2, Planetenphysik, Ryugu, Nutzerzentrum für Weltraumexperimente (MUSC)
Abstract

In 2018, the Hayabusa2 spacecraft [1] successfully conducted some descend operations toward Ryugu’s surface. They included MINERVA rover release in September, MASCOT lander release and two touchdown rehearsals in October. During these operations, we acquired high-resolved optical and thermal images from altitudes below 100 m, us- ing Optical Navigation Camera (ONC-T) and Ther- mal Infrared Imager (TIR), respectively. Close-up optical images by ONC-T show detailed physical conditions of the surface materials, such as particle size distribution of pebbles, surface morphol- ogy of small boulders and craters. Moreover, close-up thermal images by TIR indicate thermophysical prop- erties of the surface materials and its regional differ- ence, which cannot be resolved by higher altitude observations (e.g., home-position observations from 20 km altitude). Combination between optical and thermal observations is of great importance to under- stand the nature of the asteroid surface materials. In this study, we investigate the surface particle size from close-up ONC images. Thermophysical property of the surface component materials inferred from TIR images is also discussed, especially for the range observed for the thermal inertia of boulders.

Published
2019

19. Thermal Imaging of C-Type Near Earth Asteroid 162173 Ryugu by Thermal Imfrared Imager TIR on Hayabusa2

Author

Okada, T., Fukuhara, T., Tanaka, S., Taguchi, M., Arai, T., Sakatani, N., Shimaki, Y., Senshu, H., Ogawa, Y., Demura, H., Suko, K., Kitazato, K., Kouyama, T., Sekiguchi, T., Takita, J., Hasegawa, S., Matsunaga, T., Wada, T., Imamura, T., Helbert, Jörn, Mueller, T. G., Hagermann, A., Biele, Jens, Grott, Matthias, Hamm, Maximilian, Delbo, Marco, Yamamoto, Y., Hirata, N., Saiki, T., Terui, F., Nakazawa, S., Yoshikawa, M., Watanabe, S, and Tsuda, Y.

Subjects
TIR, Planetenphysik, Thermal, Leitungsbereich PF, Ryugu, C-Type Asteroid, Thermal Imaging, NEO, Infrared Imager, Nutzerzentrum für Weltraumexperimente (MUSC), Hayabusa2
Published
2019

23. Thermal-Infrared Imager TIR on Hayabusa2 and Its In-Flight Performance and Calibration Using Earth and Moon Thermal Images

Author

Okada, T., Fukuhara, T., Tanaka, S., Taguchi, M., Imamura, T., Arai, T., Senshu, H., Ogawa, Y., Demura, H., Kitazato, K., Nakamura, R., Kouyama, T., Sekiguchi, T., Hasegawa, S., Matsunaga, T., Wada, T., Takita, J., Sakatani, N., Horikawa, Y., Endo, K., Helbert, J., Mueller, T.G., and Hagermann, A.

Subjects
Hayabusa 2, Leitungsbereich PF, Asteroiden
Published
2016

24. Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children

Author

Kato, M, primary, Ishimaru, S, additional, Seki, M, additional, Yoshida, K, additional, Shiraishi, Y, additional, Chiba, K, additional, Kakiuchi, N, additional, Sato, Y, additional, Ueno, H, additional, Tanaka, H, additional, Inukai, T, additional, Tomizawa, D, additional, Hasegawa, D, additional, Osumi, T, additional, Arakawa, Y, additional, Aoki, T, additional, Okuya, M, additional, Kaizu, K, additional, Kato, K, additional, Taneyama, Y, additional, Goto, H, additional, Taki, T, additional, Takagi, M, additional, Sanada, M, additional, Koh, K, additional, Takita, J, additional, Miyano, S, additional, Ogawa, S, additional, Ohara, A, additional, Tsuchida, M, additional, and Manabe, A, additional

Published
2016
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25. Lost Apollo heat flow data suggest a different lunar bulk composition

Author

Saito, Y., Tanaka, S., Takita, J., Horai, K., and Hagermann, A.

Abstract

Lunar surface heat flow values were measured on the Apollo missions between 1971 and 1977. However, the late-term data have been lost. We succeeded in archiving the data after March 1, 1976. We will introduce the new set of archived data.

Published
2007

27. Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia

Author

Koh, K, primary, Tomizawa, D, additional, Moriya Saito, A, additional, Watanabe, T, additional, Miyamura, T, additional, Hirayama, M, additional, Takahashi, Y, additional, Ogawa, A, additional, Kato, K, additional, Sugita, K, additional, Sato, T, additional, Deguchi, T, additional, Hayashi, Y, additional, Takita, J, additional, Takeshita, Y, additional, Tsurusawa, M, additional, Horibe, K, additional, Mizutani, S, additional, and Ishii, E, additional

Published
2014
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28. ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus

Author

Shinohara, M., primary, Saitoh, M., additional, Nishizawa, D., additional, Ikeda, K., additional, Hirose, S., additional, Takanashi, J.-i., additional, Takita, J., additional, Kikuchi, K., additional, Kubota, M., additional, Yamanaka, G., additional, Shiihara, T., additional, Kumakura, A., additional, Kikuchi, M., additional, Toyoshima, M., additional, Goto, T., additional, Yamanouchi, H., additional, and Mizuguchi, M., additional

Published
2013
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33. ALKR1275Qperturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN

Author

Ueda, T, Nakata, Y, Yamasaki, N, Oda, H, Sentani, K, Kanai, A, Onishi, N, Ikeda, K, Sera, Y, Honda, Z-i, Tanaka, K, Sata, M, Ogawa, S, Yasui, W, Saya, H, Takita, J, and Honda, H

Abstract

Overexpression of MYCN is a hallmark of neuroblastoma (NB). ALKR1275Q, an activating mutation of ALK (anaplastic lymphoma kinase), has been found in sporadic and familial NB patients. In this report, we demonstrated that ALKR1275Qknock-in, MYCN transgenic compound mice developed NB with complete penetrance. Transcriptome analysis revealed that ALKR1275Qglobally downregulated the expression of extracellular matrix (ECM)- and basement membrane (BM)-associated genes in both primary neuronal cells and NB tumors. Accordingly, ALKR1275Q/MYCN tumors exhibited reduced expression of ECM/BM-related proteins as compared with MYCN tumors. In addition, on MYCN transduction, ALKR1275Q-expressing neuronal cells exhibited increased migratory and invasive activities. Consistently, enhanced invasion and metastasis were demonstrated in ALKR1275Q/MYCN mice. These results collectively indicate that ALKR1275Qconfers a malignant potential on neuronal cells that overexpress MYCN by impairing normal ECM/BM integrity and enhancing tumor growth and dissemination. Moreover, we found that crizotinib, an ALK inhibitor, almost completely inhibited the growth of ALKR1275Q/MYCN tumors in an allograft model. Our findings provided insights into the cooperative mechanism of the mutated ALK and overexpressed MYCN in the pathogenesis of NB and demonstrated the effectiveness of crizotinib on ALKR1275Q-positive tumors.

Published
2016
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40. FINE-GRAINED REGION WITH LOW THERMAL INERTIA IN CRATERS ON RYUGU.

Author

Sakatani, N., Tanaka, S., Okada, T., Senshu, H., Arai, T., Demura, H., Suko, K., Shimaki, Y., Sekiguchi, T., Takita, J., Fuhuhara, T., Taguchi, M., Müller, T., Hagermann, A., Biele, J., Grott, M., Hamm, M., Delbo, M., Sugita, S., and Honda, R.

Subjects
GRANTS in aid (Public finance), LUNAR craters, LUNAR soil, HIGH resolution imaging
Published
2021

41. POLE REGION OBSERVATION CAMPAIGN ON RYUGU.

Author

Tatsumi, E., Sakatani, N., Kameda, S., Kitazato, K., Kouyama, T., Yokota, Y., Honda, R., Yamada, M., Morota, T., Cho, Y., Honda, C., Matsuoka, M., Hayakawa, M., Suzuki, H., Tanaka, S., Takita, J., Nakamura, T., Yabuta, H., Hiroi, T., and Vilas, F.

Subjects
NEAR-earth asteroids, DIFFRACTION patterns, SOLAR heating, PLANETARY exploration, CHARGE-transfer transitions
Published
2021

43. THERMOPHYSICAL PROPERTIES OF ASTEROID 162173 RYUGU REVEALED BY HIGH-RESOLVED THERMAL IMAGING - A LINK TO POROUS ASTEROID FORMATION.

Author

Okada, T., Fukuhara, T., Tanaka, S., Taguchi, M., Arai, T., Sakatani, N., Shimaki, Y., Senshu, H., Ogawa, Y., Demura, H., Suko, K., Kitazato, K., Kouyama, T., Sekiguchi, T., Takita, J., Hasegawa, S., Matsunaga, T., Wada, T., Imamura, T., and Helbert, J.

Subjects
THERMOGRAPHY, THERMOPHYSICAL properties, NEAR-earth asteroids, ASTEROIDS, PLANETARY science, INFRARED imaging
Published
2021

49. Lost Apollo heat flow data suggest a different lunar bulk composition

Author

Saito, Y., Tanaka, S., Takita, J., Horai, K., Hagermann, A., Saito, Y., Tanaka, S., Takita, J., Horai, K., and Hagermann, A.

Abstract

Lunar surface heat flow values were measured on the Apollo missions between 1971 and 1977. However, the late-term data have been lost. We succeeded in archiving the data after March 1, 1976. We will introduce the new set of archived data.

50. Lost Apollo heat flow data suggest a different lunar bulk composition

Author

Saito, Y., Tanaka, S., Takita, J., Horai, K., Hagermann, A., Saito, Y., Tanaka, S., Takita, J., Horai, K., and Hagermann, A.

Abstract

Lunar surface heat flow values were measured on the Apollo missions between 1971 and 1977. However, the late-term data have been lost. We succeeded in archiving the data after March 1, 1976. We will introduce the new set of archived data.

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