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9 results on '"Takeuchi, Genji"'

2. CXC Chemokine Receptor 3 and CC Chemokine Receptor 4 Expression in T-Cell and NK-Cell Lymphomas with Special Reference to Clinicopathological Significance for Peripheral T-Cell Lymphoma, Unspecified

Author

Ishida, Takashi, primary, Inagaki, Hiroshi, additional, Utsunomiya, Atae, additional, Takatsuka, Yoshifusa, additional, Komatsu, Hirokazu, additional, Iida, Shinsuke, additional, Takeuchi, Genji, additional, Eimoto, Tadaaki, additional, Nakamura, Shigeo, additional, and Ueda, Ryuzo, additional

Published
2004
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3. Frequent occurrence of CCND1 deregulation in patients with early stages of plasma cell dyscrasia

Author

Miura, Kazuhisa, primary, lida, Shinsuke, additional, Hanamura, Ichiro, additional, Kato, Miyuki, additional, Banno, Shogo, additional, Ishida, Takashi, additional, Kusumoto, Shigeru, additional, Takeuchi, Genji, additional, Miwa, Hiroshi, additional, Nitta, Masakazu, additional, Inagaki, Hiroshi, additional, Eimoto, Tadaaki, additional, Nomura, Kenichi, additional, Taniwaki, Masafumi, additional, and Ueda, Ryuzo, additional

Published
2003
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6. A Novel Cell Line (NCU-L-1) from a Patient with Acute Lymphoblastic Leukemia, FAB, L3, Burkitt's Type

Author

Nitta, Masakazu, primary, Iwaki, Osamu, additional, Wakita, Atsushi, additional, Kodama, Hiroyuki, additional, Takeuchi, Genji, additional, Takada, Katsutoshi, additional, Mitomo, Yasuharu, additional, Yamamoto, Masahiko, additional, Amano, Masao, additional, Murate, Takashi, additional, Koike, Koichi, additional, Osada, Hirotaka, additional, Ueda, Ryuzo, additional, and Shamoto, Mikihiro, additional

Published
1990
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7. Frequent occurrence of CCND1deregulation in patients with early stages of plasma cell dyscrasia

Author

Miura, Kazuhisa, Lida, Shinsuke, Hanamura, Ichiro, Kato, Miyuki, Banno, Shogo, Ishida, Takashi, Kusumoto, Shigeru, Takeuchi, Genji, Miwa, Hiroshi, Nitta, Masakazu, Inagaki, Hiroshi, Eimoto, Tadaaki, Nomura, Kenichi, Taniwaki, Masafumi, and Ueda, Ryuzo

Abstract

Chromosomal translocations involving the immunoglobulin heavy chain gene (IgH) and nonrandom protooncogene loci are the hallmark of genetic alterations found not only in multiple myeloma (MM), but also in premalignant stages of MM, including monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM). We studied the frequency of IgH(14q32) rearrangements and their partner chromosomes in 16 Japanese patients with MGUS (13 cases), and SMM (3 cases) by means of interphase double‐color fluorescence in situhybridization (DCFISH) applied to purified plasma cells and using CD138‐bead selection. IgHrearrangement was recognized in nine of the patients (56.3%). Protooncogene loci juxtaposed to IgHwere identified in seven cases including CCND1(11q13) in six cases and FGFR3(4p16) in one. Four out of the six t(11;14)‐positive cases showed nuclear staining of the cyclin D1 protein, whereas none of the seven t(11;14)‐negative cases did. Moreover, neither MUM1(6p25)‐IgHnor MAFB(20q11)‐IgHfusion signals were observed. This suggests to us that cyclin D1 deregulation due to the presence of t(11;14) is involved in the early development of plasma cell neoplasms, and that this event alone is not enough for the development of symptomatic myeloma. (Cancer Sci 2003; 94: 350‐354)

Published
2003
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9. Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome.

Author

Ishida T, Utsunomiya A, Iida S, Inagaki H, Takatsuka Y, Kusumoto S, Takeuchi G, Shimizu S, Ito M, Komatsu H, Wakita A, Eimoto T, Matsushima K, and Ueda R

Subjects
Adult, Aged, Aged, 80 and over, Cell Line, Tumor, Chemokine CCL17, Chemokines, CC biosynthesis, Female, Flow Cytometry, Humans, Leukemia, T-Cell mortality, Ligands, Lymph Nodes pathology, Lymphoma, T-Cell mortality, Male, Middle Aged, Multivariate Analysis, Phenotype, Prognosis, RNA, Messenger metabolism, Receptors, CCR4, Receptors, CXCR3, Receptors, Chemokine metabolism, Reverse Transcriptase Polymerase Chain Reaction, Skin metabolism, Skin pathology, Time Factors, Treatment Outcome, Leukemia, T-Cell metabolism, Lymphoma, T-Cell metabolism, Receptors, Chemokine biosynthesis, Skin Neoplasms secondary
Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a distinct clinical entity among mature T-cell neoplasms, and its causative agent has been confirmed to be long-term infection by human T-lymphotropic virus type 1. A recent study demonstrated frequent expression of a chemokine receptor, CC chemokine receptor (CCR)4, which is known as a Th2 marker but not CXC chemokine receptor (CXCR)3, which is known as a Th1 marker, among both ATLL- and human T-lymphotropic virus type 1-immortalized T cells. In this study, immunostaining analysis for CCR4 and CXCR3 expression in ATLL cells obtained from 103 patients with ATLL was performed, and the clinical parameters and overall survival of the CCR4-positive and -negative cases were compared. Ninety-one (88.3%) of the 103 cases were positive for CCR4 staining, whereas only 5 (4.9%) were positive for CXCR3 staining. Positivity for CCR4 was significantly associated with skin involvement (P < 0.05), although there were no significant differences in clinical characteristics between the CCR4-positive and -negative cases at the time of initial diagnosis. CCR4(+) ATLL cells may accumulate in the skin because of the expression of a CCR4 ligand, thymus and activation-regulated chemokine (TARC), on normal and inflamed cutaneous endothelia. As for survival analysis, positivity for CCR4 expression was extracted as an unfavorable prognostic factor as well as other factors, including the presence of B symptoms and extranodal involvement of more than one site. Multivariate analysis confirmed that CCR4 expression was an independent and significant prognostic factor (P < 0.05). Thus, our finding may provide a novel insight into not only the biological but also the clinical features of ATLL.

Published
2003

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