13 results on '"Takeshi Uenaka"'
Search Results
2. Endocytosis in the axon initial segment maintains neuronal polarity
- Author
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Kelsie Eichel, Takeshi Uenaka, Vivek Belapurkar, Rui Lu, Shouqiang Cheng, Joseph S. Pak, Caitlin A. Taylor, Thomas C. Südhof, Robert Malenka, Marius Wernig, Engin Özkan, David Perrais, and Kang Shen
- Subjects
Multidisciplinary ,Cell Membrane ,Cell Polarity ,Receptors, Cell Surface ,Dendrites ,Endosomes ,Endocytosis ,Rats ,Diffusion ,Mice ,Protein Transport ,Proteolysis ,Animals ,Humans ,Caenorhabditis elegans ,Axon Initial Segment - Abstract
Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly1. The axon initial segment (AIS) is a specialized domain that separates a neuron’s morphologically, biochemically and functionally distinct axon and dendrite compartments2,3. How the AIS maintains polarity between these compartments is not fully understood. Here we find that in Caenorhabditis elegans, mouse, rat and human neurons, dendritically and axonally polarized transmembrane proteins are recognized by endocytic machinery in the AIS, robustly endocytosed and targeted to late endosomes for degradation. Forcing receptor interaction with the AIS master organizer, ankyrinG, antagonizes receptor endocytosis in the AIS, causes receptor accumulation in the AIS, and leads to polarity deficits with subsequent morphological and behavioural defects. Therefore, endocytic removal of polarized receptors that diffuse into the AIS serves as a membrane-clearance mechanism that is likely to work in conjunction with the known AIS diffusion-barrier mechanism to maintain neuronal polarity on the plasma membrane. Our results reveal a conserved endocytic clearance mechanism in the AIS to maintain neuronal polarity by reinforcing axonal and dendritic compartment membrane boundaries.
- Published
- 2021
3. In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease
- Author
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Motoi Kanagawa, Wataru Satake, Yukinori Okada, Pei-Chieng Cha, Takeshi Uenaka, Hideki Hayakawa, Hideki Mochizuki, Shiying Jiang, Tatsushi Toda, Kousuke Baba, and Kazuhiro Kobayashi
- Subjects
0301 basic medicine ,Drug ,MAPK/ERK pathway ,Proto-Oncogene Proteins B-raf ,mice ,MAP Kinase Signaling System ,media_common.quotation_subject ,In silico ,Drug Evaluation, Preclinical ,Genome-wide association study ,Antineoplastic Agents ,Apoptosis ,Pharmacology ,Biology ,03 medical and health sciences ,parkinson disease ,Oximes ,Genetics ,medicine ,melanoma ,Animals ,Humans ,Computer Simulation ,Protein Interaction Maps ,drug screening ,dabrafenib ,Association Studies Article ,Molecular Biology ,Drug Approval ,Protein Kinase Inhibitors ,Genetics (clinical) ,media_common ,Monomeric GTP-Binding Proteins ,genome-wide association study ,Kinase ,phosphorylation ,Melanoma ,Dopaminergic Neurons ,Neurotoxicity ,Imidazoles ,JNK Mitogen-Activated Protein Kinases ,Dabrafenib ,General Medicine ,medicine.disease ,030104 developmental biology ,Neuroprotective Agents ,Cytoprotection ,Databases, Chemical ,medicine.drug - Abstract
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss. At present, there are no drugs that stop the progression of PD. As with other multifactorial genetic disorders, genome-wide association studies (GWASs) found multiple risk loci for PD, although their clinical significance remains uncertain. Here, we report the identification of candidate drugs for PD by a method using GWAS data and in silico databases. We identified 57 Food and Drug Administration-approved drug families as candidate neuroprotective drugs for PD. Among them, dabrafenib, which is known as a B-Raf kinase inhibitor and is approved for the treatment of malignant melanoma, showed remarkable cytoprotective effects in neurotoxin-treated SH-SY5Y cells and mice. Dabrafenib was found to inhibit apoptosis, and to enhance the phosphorylation of extracellular signal-regulated kinase (ERK), and inhibit the phosphorylation of c-Jun NH2-terminal kinase. Dabrafenib targets B-Raf, and we confirmed a protein–protein interaction between B-Raf and Rit2, which is coded by RIT2, a PD risk gene in Asians and Caucasians. In RIT2-knockout cells, the phosphorylation of ERK was reduced, and dabrafenib treatment improved the ERK phosphorylation. These data indicated that dabrafenib exerts protective effects against neurotoxicity associated with PD. By using animal model, we confirmed the effectiveness of this in silico screening method. Furthermore, our results suggest that this in silico drug screening system is useful in not only neurodegenerative diseases but also other common diseases such as diabetes mellitus and hypertension.
- Published
- 2018
4. Japanese <scp>WDR</scp> 45 de novo mutation diagnosed by exome analysis: A case report
- Author
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Hironobu Endo, Tatsushi Toda, Hisatomo Kowa, Wataru Satake, Kenji Sekiguchi, Taniguchi‐Ikeda Mariko, Takehiro Ueda, Yutaka Suzuki, Norio Chihara, Takeshi Uenaka, Fumio Kanda, and Hisatsugu Tachibana
- Subjects
0301 basic medicine ,autophagy ,Pathology ,medicine.medical_specialty ,beta‐propeller protein‐associated neurodegeneration ,Neurodegeneration with brain iron accumulation ,Nonsense mutation ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,WDR45 ,Medicine ,Exome ,parkinsonism ,Sanger sequencing ,business.industry ,Parkinsonism ,medicine.disease ,030104 developmental biology ,Globus pallidus ,Neurology ,iron accumulation ,basal ganglia ,Mutation (genetic algorithm) ,symbols ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
A 40‐year‐old Japanese woman presented with slowly progressing parkinsonism in adulthood. She had a history of epilepsy with intellectual disability in childhood. In a head magnetic resonance scan, T2‐weighted imaging showed low signal intensity areas in the globus pallidus and the substantia nigra; T1‐weighted imaging showed a halo in the nigra. Because the patient's symptoms and history were similar to those of patients with neurodegeneration with brain iron accumulation, we ran an exome analysis to investigate neurodegeneration with brain iron accumulation‐associated genes. We identified a c.700 C>T (p.Arg 234*) mutation in exon 9 of the WDR45 gene, which had not been reported in Japanese patients with beta‐propeller protein‐associated neurodegeneration (a neurodegeneration with brain iron accumulation subtype). Sanger sequencing confirmed a heterozygous mutation in this patient that was absent in both her parents, so it was judged to be a de novo nonsense mutation.
- Published
- 2017
5. Less Limb Muscle Involvement in Myositis Patients with Anti-Mitochondrial Antibodies
- Author
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Yoshihisa Ohtsuka, Kenji Sekiguchi, Tsuneyoshi Seki, Hisatomo Kowa, Takeshi Uenaka, Fumio Kanda, and Tatsushi Toda
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Polymyositis ,Mitochondrial Proteins ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,medicine ,Humans ,Muscle, Skeletal ,Myositis ,Autoantibodies ,Retrospective Studies ,Muscle biopsy ,Muscle Weakness ,medicine.diagnostic_test ,business.industry ,Autoantibody ,Middle Aged ,medicine.disease ,Muscle atrophy ,Neurology ,Biomarker (medicine) ,Female ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Biomarkers ,Anti-mitochondrial antibody - Abstract
Recent studies have revealed the clinical, histological, and pathophysiological characteristics in a group of inflammatory myopathies with selected autoantibodies. We retrospectively compared the clinical manifestations and histological features between 8 anti-mitochondrial (anti-M2) antibody-positive and 33 antibody-negative patients. Patients with anti-M2 antibodies have been previously reported to have delayed diagnostic confirmation and frequent cardiopulmonary complications in comparison to those without the antibodies. In our study, clinical characteristics in patients with the antibodies were as follows: lesser degree of limb muscle weakness and atrophy as well as lymphocytic infiltration in muscle biopsy specimens, and frequent paravertebral muscle atrophy. Anti-M2 antibody appeared to be a biomarker related to not only cardiopulmonary complications, but also characteristic distributions of affected muscles.
- Published
- 2017
6. Japanese
- Author
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Hironobu, Endo, Takeshi, Uenaka, Wataru, Satake, Yutaka, Suzuki, Hisatsugu, Tachibana, Norio, Chihara, Takehiro, Ueda, Kenji, Sekiguchi, Taniguchi-Ikeda, Mariko, Hisatomo, Kowa, Fumio, Kanda, and Tatsushi, Toda
- Subjects
autophagy ,beta‐propeller protein‐associated neurodegeneration ,iron accumulation ,basal ganglia ,Case Report ,Case Reports ,parkinsonism - Abstract
A 40‐year‐old Japanese woman presented with slowly progressing parkinsonism in adulthood. She had a history of epilepsy with intellectual disability in childhood. In a head magnetic resonance scan, T2‐weighted imaging showed low signal intensity areas in the globus pallidus and the substantia nigra; T1‐weighted imaging showed a halo in the nigra. Because the patient's symptoms and history were similar to those of patients with neurodegeneration with brain iron accumulation, we ran an exome analysis to investigate neurodegeneration with brain iron accumulation‐associated genes. We identified a c.700 C>T (p.Arg 234*) mutation in exon 9 of the WDR45 gene, which had not been reported in Japanese patients with beta‐propeller protein‐associated neurodegeneration (a neurodegeneration with brain iron accumulation subtype). Sanger sequencing confirmed a heterozygous mutation in this patient that was absent in both her parents, so it was judged to be a de novo nonsense mutation.
- Published
- 2017
7. [Medial longitudinal fasciculus (MLF) syndrome in a patient with giant cell arteritis]
- Author
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Hisatomo Kowa, Kenji Sekiguchi, Hirotoshi Hamaguchi, Tatsushi Toda, Takeshi Uenaka, and Fumio Kanda
- Subjects
medicine.medical_specialty ,Prednisolone ,Giant Cell Arteritis ,Administration, Oral ,Pontine Tegmentum ,Mesencephalon ,medicine.artery ,medicine ,Diplopia ,Humans ,Arteritis ,Aged ,Cerebral infarction ,business.industry ,Cerebral Infarction ,Syndrome ,Intermittent Claudication ,medicine.disease ,Superficial temporal artery ,Medial longitudinal fasciculus ,Intermittent claudication ,Temporal Arteries ,Giant cell arteritis ,Diffusion Magnetic Resonance Imaging ,Treatment Outcome ,Female ,Neurology (clinical) ,Radiology ,medicine.symptom ,Claudication ,business - Abstract
A 76-year-old female was referred to our department because of diplopia for two months and intermittent claudication for five months. She showed medial longitudinal fasciculus (MLF) syndrome. Brain MRI (T2WI) showed multiple infarctions in the right pontine tegmentum and left paramedian midbrain. A biopsy of superficial temporal artery showed the characteristic findings of glanulomatous inflammation indicative of giant cell arteritis. We thought the mechanism of this cerebral infarction as artery to artery embolization or intracranial arteritis. Treatment with oral prednisolone (1 mg/kg/day) improved her limb claudication and normalized serum C-reactive protein level.
- Published
- 2015
8. Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy
- Author
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Masahiro Maeyama, Hiroaki Nagashima, Hidehito Kimura, Noriaki Minami, Kazuhiro Tanaka, Takanori Hirose, Tomoo Itoh, Takashi Sasayama, Satoshi Nakamizo, Takeshi Uenaka, Katsu Mizukawa, Hiroaki Sekiya, Tatsuya Mori, and Eiji Kohmura
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Radiography ,Clinical Neurology ,Cranial nerve palsy ,Case Report ,T2 star-weighted image ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Basal ganglia ,medicine ,Humans ,Cerebellar Neoplasms ,Occult germinoma ,Susceptibility-weighted image ,Unusual case ,Hypointensity ,Germinoma ,business.industry ,General Medicine ,medicine.disease ,Occult ,Magnetic Resonance Imaging ,Cranial Nerve Diseases ,Progressive ataxia ,Cerebellar germinoma ,Ataxia ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Although the usefulness of susceptibility-weighted imaging (SWI) for detecting basal ganglia germinoma has been reported, the technique is not widely used. We recently encountered an unusual case of primary cerebellar germinoma, presenting with progressive ataxia and cranial nerve palsy, characterized by gradually enlarging low-intensity lesions visible with both T2*-weighted imaging (T2*WI), which were the key to the diagnosis. Case presentation A 30-year-old man was referred to our hospital because of slowly progressive dizziness and mild ataxia. Magnetic resonance imaging (MRI) revealed a small, low-intensity spot in the left cerebellar peduncle on the T2*WI and SWI without enhancement. Cerebral angiography revealed no vascular abnormality. The serum α-fetoprotein value was normal. A steroid-pulse was administered as a therapeutic and diagnostic trial, but the symptoms improved little. The patient was discharged from the hospital but soon developed brainstem dysfunction, characterized by dyspnea or hiccups, and he was readmitted. T2*WI imaging revealed expanded and extended spotty lesions in the cerebellum and brainstem, which had not enhanced with contrast agent previously. Targeted stereotactic biopsy of the newly enhanced cerebellar lesion was performed; histopathological examination of the tissue revealed pure germinoma. Serum and cerebral spinal fluid values of beta-human chorionic gonadotropin were not significantly elevated. Chemotherapy with carboplatin and etoposide was initiated. The enhanced lesion disappeared promptly, but the patient continued to require assisted automatic ventilation because of paralysis of respiratory muscles. Conclusions We conclude that enlarging low-intensity lesions on T2*WI and SWI may be a reliable clue to the diagnosis of germinomas, irrespective of their location, even without enhancement. Biopsy of the tumor at an early stage is the only way to make the diagnosis conclusively and enable prompt start of treatment. Electronic supplementary material The online version of this article (doi:10.1186/s12883-015-0516-9) contains supplementary material, which is available to authorized users.
- Published
- 2015
9. Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy
- Author
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Takeshi Uenaka, Fumio Kanda, Hisatomo Kowa, Yoshihisa Ohtsuka, Kakuya Nagata, Tatsushi Toda, and Kenji Sekiguchi
- Subjects
Pathology ,medicine.medical_specialty ,Muscle biopsy ,medicine.diagnostic_test ,Physiology ,business.industry ,Autoantibody ,medicine.disease ,Polymyositis ,Biceps ,Cellular and Molecular Neuroscience ,Primary biliary cirrhosis ,Physiology (medical) ,Biopsy ,medicine ,Neurology (clinical) ,skin and connective tissue diseases ,business ,Rectus abdominis muscle ,Myositis - Abstract
Introduction Antimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (PBC) patients. Some PBC cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles. Methods Our aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a PBC patient. Results A 48-year-old woman with a 5-year history of atrial fibrillation and chronic heart failure was evaluated for elevated serum creatine kinase level. Antimitochondrial M2 antibodies were detected, and PBC was diagnosed. A biceps brachii biopsy specimen showed mild, non-specific myogenic changes; a second biopsy was performed on the rectus abdominis muscle, which showed typical inflammatory changes. Myositis with antimitochondrial M2 antibodies was confirmed. Conclusions In myositis patients with antimitochondrial M2 antibodies, muscles of the extremities are involved to a lesser extent. Radiological and histological examination focusing on truncal muscles, including a biopsy, is important. Muscle Nerve 47: 766–768, 2013
- Published
- 2013
10. [Reversible cerebral vasoconstriction syndrome in a stroke patient with systemic lupus erythematosus and antiphospholipid antibody]
- Author
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Takeshi, Uenaka, Hirotoshi, Hamaguchi, Kenji, Sekiguchi, Hisatomo, Kowa, Fumio, Kanda, and Tatsushi, Toda
- Subjects
Adult ,medicine.medical_specialty ,Cerebral arteries ,Infarction ,Fluid-attenuated inversion recovery ,Antiphospholipid syndrome ,Internal medicine ,medicine ,Humans ,Lupus Erythematosus, Systemic ,cardiovascular diseases ,Thunderclap headaches ,Cerebral infarction ,business.industry ,Amaurosis fugax ,medicine.disease ,Stroke ,Stenosis ,Cerebrovascular Disorders ,Vasoconstriction ,Cardiology ,Antibodies, Antiphospholipid ,Female ,Neurology (clinical) ,medicine.symptom ,business - Abstract
A 36-year-old female with systemic lupus erythematosus and antiphospholipid syndrome was referred to our department because of mild weakness of left arm and an episode of right amaurosis fugax for twenty days. Brain MRI showed right ACA/MCA/PCA border zone infarction on DWI/T2WI/FLAIR and MR angiography (MRA) showed multiple segmental stenosis in right internal carotid artery, right and left middle cerebral artery, and bilateral posterior cerebral arteries. Treatment with oral aspirin (100 mg/day) and continuous infusion of heparin kept her neurological symptoms and signs stable. MRA on 28 days revealed complete recovery of multiple stenotic lesions, thus, diagnosis of reversible cerebral vasoconstriction (RCVS) was made. RCVS should be considered as a cause of neurological deficit in patients with SLE regardless of thunderclap headache.
- Published
- 2013
11. Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy
- Author
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Takeshi, Uenaka, Hisatomo, Kowa, Kenji, Sekiguchi, Kakuya, Nagata, Yoshihisa, Ohtsuka, Fumio, Kanda, and Tatsushi, Toda
- Subjects
Myositis ,Liver Cirrhosis, Biliary ,Humans ,Female ,Middle Aged ,Muscle, Skeletal ,Autoantibodies ,Mitochondria - Abstract
Antimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (PBC) patients. Some PBC cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles.Our aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a PBC patient.A 48-year-old woman with a 5-year history of atrial fibrillation and chronic heart failure was evaluated for elevated serum creatine kinase level. Antimitochondrial M2 antibodies were detected, and PBC was diagnosed. A biceps brachii biopsy specimen showed mild, non-specific myogenic changes; a second biopsy was performed on the rectus abdominis muscle, which showed typical inflammatory changes. Myositis with antimitochondrial M2 antibodies was confirmed.In myositis patients with antimitochondrial M2 antibodies, muscles of the extremities are involved to a lesser extent. Radiological and histological examination focusing on truncal muscles, including a biopsy, is important.
- Published
- 2012
12. Brain imaging modality before systemic thrombolysis for ischemic stroke within three hours
- Author
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Haruo Yamashita, Shinji Yamamoto, Yukihiro Yoneda, Takeshi Uenaka, and Yoshie Hara
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Tomography Scanners, X-Ray Computed ,medicine.medical_treatment ,Ischemia ,Tissue plasminogen activator ,Magnetic resonance angiography ,Statistics, Nonparametric ,Neuroimaging ,medicine ,Humans ,Thrombolytic Therapy ,Stroke ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Retrospective cohort study ,Thrombolysis ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Logistic Models ,Neurology ,Tissue Plasminogen Activator ,Injections, Intravenous ,Female ,Neurology (clinical) ,Radiology ,business ,Magnetic Resonance Angiography ,medicine.drug - Abstract
Objective: In Japan, MRI-based thrombolysis after CT screening is the most common imaging strategy prior to intravenous thrombolysis (IVT) with tissue plasminogen activator (tPA) within 3 h after ischemic stroke. A choice of MRI with MR angiography (MRA) provides a higher diagnostic accuracy, but may delay an initiation of thrombolysis. Methods: In our neuro-unit, brain CT is the first screening image for suspected stroke. We retrospectively examined a delay to thrombolysis, imaging modality, diagnostic accuracy, and clinical outcomes at 3 months by the modified Rankin Scale in patients receiving IVT within 3 h. Results: Among 67 patients receiving IVT with tPA, brain imaging prior to IVT was solely CT in 10 (15%) patients and CT + MRI/MRA in 57 (85%) patients. Final diagnosis of brain ischemia was 100%. Patients receiving CT + MRI had significantly shorter pre-hospital delay (mean 54 vs. 83 min; p = 0.012), but longer door-to-needle time (mean 90 vs. 57 min; p = 0.019) than those receiving CT only. Finally, time from onset to thrombolysis was not different between the two groups and clinical outcomes were also comparable. The earlier patients arrived, the longer door-to-needle times were (p < 0.001). Conclusions: The imaging strategy of initial CT screening with optional MRI/MRA scans prior to IVT was feasible. However, it resulted in an additional 30 min in-hospital delay of tPA administration, which may affect clinical outcomes.
- Published
- 2010
13. Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy.
- Author
-
Noriaki Minami, Kazuhiro Tanaka, Hidehito Kimura, Takanori Hirose, Tatsuya Mori, Masahiro Maeyama, Hiroaki Sekiya, Takeshi Uenaka, Satoshi Nakamizo, Hiroaki Nagashima, Katsu Mizukawa, Tomoo Itoh, Takashi Sasayama, Eiji Kohmura, Minami, Noriaki, Tanaka, Kazuhiro, Kimura, Hidehito, Hirose, Takanori, Mori, Tatsuya, and Maeyama, Masahiro
- Subjects
GERMINOMA ,ATAXIA ,CRANIAL nerves ,CEREBRAL palsy ,ALPHA fetoproteins ,SYMPTOMS ,BRAIN stem ,DYSPNEA ,BRAIN tumor diagnosis ,BRAIN tumors ,MAGNETIC resonance imaging ,CRANIAL nerve diseases ,DISEASE complications ,DIAGNOSIS - Abstract
Background: Although the usefulness of susceptibility-weighted imaging (SWI) for detecting basal ganglia germinoma has been reported, the technique is not widely used. We recently encountered an unusual case of primary cerebellar germinoma, presenting with progressive ataxia and cranial nerve palsy, characterized by gradually enlarging low-intensity lesions visible with both T2*-weighted imaging (T2*WI), which were the key to the diagnosis.Case Presentation: A 30-year-old man was referred to our hospital because of slowly progressive dizziness and mild ataxia. Magnetic resonance imaging (MRI) revealed a small, low-intensity spot in the left cerebellar peduncle on the T2*WI and SWI without enhancement. Cerebral angiography revealed no vascular abnormality. The serum α-fetoprotein value was normal. A steroid-pulse was administered as a therapeutic and diagnostic trial, but the symptoms improved little. The patient was discharged from the hospital but soon developed brainstem dysfunction, characterized by dyspnea or hiccups, and he was readmitted. T2*WI imaging revealed expanded and extended spotty lesions in the cerebellum and brainstem, which had not enhanced with contrast agent previously. Targeted stereotactic biopsy of the newly enhanced cerebellar lesion was performed; histopathological examination of the tissue revealed pure germinoma. Serum and cerebral spinal fluid values of beta-human chorionic gonadotropin were not significantly elevated. Chemotherapy with carboplatin and etoposide was initiated. The enhanced lesion disappeared promptly, but the patient continued to require assisted automatic ventilation because of paralysis of respiratory muscles.Conclusions: We conclude that enlarging low-intensity lesions on T2*WI and SWI may be a reliable clue to the diagnosis of germinomas, irrespective of their location, even without enhancement. Biopsy of the tumor at an early stage is the only way to make the diagnosis conclusively and enable prompt start of treatment. [ABSTRACT FROM AUTHOR]- Published
- 2016
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