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In 2014 school year, four female teachers of Nazareth Kindergarten decided to resign (DRT) due to workplace stress caused by human relationships between themselves. Our preliminary interview investigation revealed there was a stressor (STR), a certain elder female teacher and her less polite words and attitude. Using small and wearable ECG and acceleration measuring device, we measured 24 hour's autonomic nervous system's activity (ASNA) and sleep behavior of the STR and surrounding teachers, and tried to evaluate their stress objectively and to understand the reason of STR's less polite behaviors. For comparison, we also measured female Mind-Body Medicine (MBM) patients suffering adjustment disorder and clinical depression.

To prevent kindergarten teacher’s resignation due to workplace stress, and to maintain better education, we established the stress evaluation method based on the measurement of the autonomic nervous system’s activity (ANSA) by M-BIT, and we applied it to evaluate and decrease workplace stress. We proposed the method of detecting the subject with large stress and remains stress by the distribution of epoch values of sympathetic nervous system’s activity (SNSA) during awake and sleep, respectively. We also proposed the method to evaluate the degree of chronic unhealthy of ANSA, normal, incoordination of ANSA or depressed state based on epoch values of coefficients of variation of RR intervals (CVRR) during awake, and co-use of Self-Rating Scale increases the accuracy of evaluation. Furthermore, we proposed that status of ANSA, normal, incoordination of ANSA and depressed state can be evaluated by the CVRR and SNSA values measured by 120 seconds stress application measurement. We found that the chronic continuation of large SNSA does not always lead to chronic unhealthy state of ANSA. Hence, we proposed two dimensional evaluation of SNSA with CVRR, and separation of stress to passive stress and active stress.

The purpose of this study was to verify the relationship of the occurrence of low body temperature at rising time and intraday body temperature changes, rising time, going-to-bed time, exercise hours, heart rate at rising time, and intrinsic motivation for attending school at rising time. The subjects, 452 healthy junior and senior high school male students, were divided into two groups, namely, Average group (AG) with an axillary temperature above 36.0 and below 37.0 at rising time and Low group (LG) with an axillary temperature below 36.0. The temperature was taken on a weekday without physical exercise classes in school in June 1999 and in the same month in 2001. The level of intraday body temperature of LG was lower than that of AG. The body temperature of AG reached its peak around noon, but that of LG peaked around 4 o'clock in the afternoon. The body temperature at going-to-bed time of LG did not get lower to the level at rising time. The heart rate of LG (66.6±9.0 beat · min-1) was significantly lower than that of AG (70.9±10.7 beat · min-1). The intrinsic motivation for attending school of LG (3.0±1.1 points) was significantly lower than that of AG (3.6±1.2 points). Those with the above motivation in LG (36.6%) were significantly smaller in number than those in AG (54.4%). The students with an axillary temperature below 36.0 at rising time were found to have characteristically lower level of intraday body temperature, showing the highest at around 4 o'clock in the afternoon. Also their going-to-bed time temperature did not go lower to the level of rising time. Furthermore, their heart rate was low at rising time and they were low in the intrinsic motivation for attending school at rising time.

We have developed wearable (size: 40×39×8mm, weight: 14g) acceleration and ECG measuring device which can measure physical activity (PA) during awake and sleep behavior continuously 25 hours even for very young children.

We have developed a sleep measuring system which can measure any subject at any pace. This system is consisted with wearable (size: 40×39×8mm, weight: 14g) acceleration and ECG measuring device and data analyzing software which able to output times in bed, sleep duration, NREM sleep proportion, sleep posture distribution and changing times, measures of autonomic system's activity, frequency of respiration and its variation, and results of sleep apnea detection. In this paper, we had measured 4 y.o. children and analyzed their sleep at home.

This research, conducted in 1998 and 2008, uses go/no-go data to investigate the fundamentals of cognitive functioning in the inhibitory control ability of Japanese children. 844 subjects from kindergarten to junior high school participated in go/no-go task experiments. Performance of go/no-go tasks, which are frequently used to investigate response inhibition, measures a variety of cognitive components besides response inhibition. With normal brain development, the ability to inhibit responses improves substantially in adolescence. An increase over time in the error rate during the go/no-go tasks of subjects of the same age indicates that these processes are not functioning properly. Comparisons between the 1998 and 2008 data revealed several differences in error rates. In 2008, there were increases in the number of errors in groups from each age range. The comparison also revealed that overall error rates peaked at later ages in the 2008 subjects. Taken together, these results show changing conditions in the inhibitory function of the prefrontal cortex. However, the reason for these changing conditions remains unclear. While a lifestyle questionnaire revealed several differences in factors such as bedtimes and hours spent watching TV, analysis did not reveal a significant correlation., Article, BioPsychoSocial Medicine.8(1):14(2014)

1) Nucleotid in cat's blood cells is adenine-nucleotid, but it is transformed into inosine-nucleotid when it is released from blood cells upon intravenous injection of colloid. The deamination is performed either in the blood immediately after releasing, or in some organs, e.g. in liver, on circulation. This is the reason why we could not find adenine-nucleotid in the plasma even during colloid shock. 2) Ultraviolet absorption curve of the active principle which appeared in the plasma on recovering from colloid shock corresponded with that of epinephrine. This suggests that the rise in blood pressure which appears on recovering from colloid shock is due to the excretion of epinephrine.

It was often seen that after the administration of quinine the lowering of blood pressure induced by intravenous injection of colloid was remarkably diminished and that a secondary rise in blood pressure occasionally occurred. This phenomenon is probably due to the fact that the hypertensive action of epinephrine, which is excreted from adrenal glands compensatorily for the hypotensive effect of nucleotid released. from blood cells, is significantly potentiated by quinine.

Publisher Summary This chapter examines the effect of bovine brain hydrate on mentally retarded children. The biological effect of the administration of brain and spinal cord tissues has been extensively investigated. The electroencephalography was recorded by routine frontal, temporal, parietal and occipital mono-polar leads of both sides at rest, under hyperventilation and under photic stimulations with frequencies of 3-20/s. Miki's Social Ability Test was used for testing social adaptability. This test consists of various inquiries about working abilities, autonomy and other abilities in everyday life. In five out of seven items, nearly or exactly the same pattern of average development is seen, and the average of P subjects equals or dominates that of C subjects at the end of drug administration. This tendency was maintained after the administration of the drug was discontinued. Other two items are lower limb length and height of spina iliaca anterior superior, both of which are related to the length of legs. It is found that C subjects made a poor development in body weight, biacromial breadth and the ratio of body weight to stature, which is the index of breadth development of the whole body.