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3. Practical guide for the diagnosis and management of primary ciliary dyskinesia

Author

Takeuchi, Kazuhiko, Abo, Miki, Date, Hiroshi, Gotoh, Shimpei, Kamijo, Atsushi, Kaneko, Takeshi, Keicho, Naoto, Kodama, Satoru, Koinuma, Goro, Kondo, Mitsuko, Masuda, Sawako, Mori, Eri, Morimoto, Kozo, Nagao, Mizuho, Nakano, Atsuko, Nakatani, Kaname, Nishida, Naoya, Nishikido, Tomoki, Ohara, Hirotatsu, Okinaka, Yosuke, Sakaida, Hiroshi, Shiraishi, Koji, Suzaki, Isao, Tojima, Ichiro, Tsunemi, Yasuhiro, Kainuma, Keigo, Ota, Nobuo, Takeno, Sachio, and Fujieda, Shigeharu

Published
2024
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5. Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors

Author

Yoshikawa, Yuki, Imamura, Michio, Yamauchi, Masami, Hayes, C. Nelson, Aikata, Hiroshi, Okamoto, Wataru, Miyata, Yoshihiro, Okada, Morihito, Hattori, Noboru, Sugiyama, Kazuhiko, Yoshioka, Yukio, Toratani, Shigeaki, Takechi, Masaaki, Ichinohe, Tatsuo, Ueda, Tsutomu, Takeno, Sachio, Kobayashi, Tsuyoshi, Ohdan, Hideki, Teishima, Jun, Hide, Michihiro, Nagata, Yasushi, Kudo, Yoshiki, Iida, Koji, and Chayama, Kazuaki

Published
2022
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9. Severe Type 2 Inflammation Leads to High Platelet-Activating-Factor-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps—A Hierarchical Cluster Analysis Using Bulk RNA Barcoding and Sequencing

Author

Ishino, Takashi, primary, Oda, Takashi, additional, Kawasumi, Tomohiro, additional, Takemoto, Kota, additional, Nishida, Manabu, additional, Horibe, Yuichiro, additional, Chikuie, Nobuyuki, additional, Taruya, Takayuki, additional, Hamamoto, Takao, additional, Ueda, Tsutomu, additional, and Takeno, Sachio, additional

Published
2024
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10. Severe Type 2 Inflammation Leads to High PAF-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): Hierarchal Cluster Analysis Using Bulk RNA Barcoding and Sequencing

Author

Ishino, Takashi, primary, Oda, Takashi, additional, Kawasumi, Tomohiro, additional, Takemoto, Kota, additional, Nishida, Manabu, additional, Horibe, Yuichiro, additional, Chikuie, Nobuyuki, additional, Taruya, Takayuki, additional, Hamamoto, Takao, additional, Ueda, Tsutomu, additional, and Takeno, Sachio, additional

Published
2024
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13. Swallowing Exercise Evaluated Using High-Density Surface Electromyography in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial

Author

Yoshikawa, Kohei, primary, Hamamoto, Takao, additional, Sato, Yuki, additional, Yumii, Kohei, additional, Chikuie, Nobuyuki, additional, Taruya, Takayuki, additional, Ishino, Takashi, additional, Horibe, Yuichiro, additional, Takemoto, Kota, additional, Nishida, Manabu, additional, Kawasumi, Tomohiro, additional, Ueda, Tsutomu, additional, Nishikawa, Yuichi, additional, Mikami, Yukio, additional, and Takeno, Sachio, additional

Published
2023
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14. Exhaled Nitric Oxide and Olfactory Dysfunction in Patients with Asthma: Association with Chronic Rhinosinusitis

Author

Oda, Takashi, primary, Iwamoto, Hiroshi, additional, Takeno, Sachio, additional, Kawasumi, Tomohiro, additional, Takemoto, Kota, additional, Nishida, Manabu, additional, Chikuie, Nobuyuki, additional, Horibe, Yuichiro, additional, Yamaguchi, Kakuhiro, additional, Sakamoto, Shinjiro, additional, Higaki, Naoko, additional, Taruya, Takayuki, additional, Horimasu, Yasushi, additional, Masuda, Takeshi, additional, Hamamoto, Takao, additional, Nakashima, Taku, additional, Ishino, Takashi, additional, Ueda, Tsutomu, additional, Fujitaka, Kazunori, additional, Hamada, Hironobu, additional, and Hattori, Noboru, additional

Published
2023
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17. A multicenter study to investigate the positive rate of SARS-CoV-2 in middle ear and mastoid specimens from otologic surgery patients

Author

Yamazaki, Hiroshi, primary, Yamamoto, Norio, additional, Sonoyama, Toru, additional, Maruoka, Hayato, additional, Nasu, Seiko, additional, Makino, Akiko, additional, Tomonaga, Keizo, additional, Shigemoto, Norifumi, additional, Ohge, Hiroki, additional, Fujiwara, Keizo, additional, Shinohara, Shogo, additional, Takeno, Sachio, additional, Omori, Koichi, additional, and Naito, Yasushi, additional

Published
2023
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18. An Evaluation of the Caudal End Deviation of the Nasal Septum Using the Quantitative Analysis of Computed Tomography.

Author

Hirai, Tomohisa, Ueda, Tsutomu, Ishino, Takashi, and Takeno, Sachio

Subjects
NASAL septum, COMPUTED tomography, QUANTITATIVE research, SURGICAL indications, CONVEX surfaces, NASAL surgery
Abstract

Objectives: This study was designed to determine objective surgical indications of correcting caudal end deviation of the nasal septum. Methods: We employed quantitative computed tomographic (CT) analysis and assessed the validity by comparing this with anterior rhinoscopic findings (AR findings). The study population consisted of 300 patients. The archived CT data were transferred to a workstation, and 3D CT volume-rendered images were generated using computer graphics tools. In the plane of the nostril entrance, we calculated ratios of the cross-sectional area of the convex side (narrower side) and the concave side (wider side), which is abbreviated as the N/W ratio. We also examined the presence of laterality between the right and the left cross-sectional area of the nasal valve based on the AR findings. Surgical procedures for whether to expose the caudal end were planned based on the AR findings and the N/W ratio. Results: A significant correlation was found between the AR findings and the N/W ratio. After surgery, the average N/W ratio improved from 0.53 ± 0.15 to 0.81 ± 0.15, and the average values of VAS scaling for nasal obstruction improved from 8.1 ± 0.2 to 1.0 ± 0.1. Conclusions: The quantitative CT analysis proposed in the study is a useful modality to objectively determine the surgical indications of managing the caudal end of the nasal septum. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Determining Invasion Depth in Superficial Pharyngeal Carcinoma by Transoral Ultrasonography.

Author

Yumii, Kouhei, Ueda, Tsutomu, Urabe, Yuji, Fukuhara, Motomitsu, Chikuie, Nobuyuki, Taruya, Takayuki, Kono, Takashi, Hamamoto, Takao, Hattori, Minoru, Takumida, Masaya, Ishino, Takashi, and Takeno, Sachio

Abstract

Objectives: To examine the clinical usefulness of transoral ultrasonography (US) in determining the invasion depth of superficial pharyngeal carcinoma (SPC). Determining the invasion depth of SPC is crucial for transoral surgery including determining treatment strategy. This study aimed to examine the usefulness of transoral US in determining the invasion depth of SPC. Methods: Forty‐six patients with 51 lesions who underwent both magnifying endoscopy with narrow‐band imaging (ME‐NBI) and transoral US were included. The primary outcomes were the sensitivity, specificity, positive (PPV), and negative predictive values (NPV) of ME‐NBI and transoral US findings for pathological tumor depth in SPCs. Results: The accuracy (82.4%), sensitivity (85.2%), PPV (82.1%), and NPV (82.6%) rates of US for subepithelial propria (SEP) were higher than those of ME‐NBI and macroscopic classification, indicating that transoral US is superior to ME‐NBI in determining the invasion depth. All cases where the SEP was clearly invaded (SEP deep) could be diagnosed as SEP by transoral US. Conclusions: Transoral US may be useful in determining the invasion depth of SPCs. Level of Evidence: 3 Laryngoscope, 133:2192–2197, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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20. A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor

Author

Kono, Takashi, Monden, Nobuya, Chikuie, Nobuyuki, Taruya, Takayuki, Hamamoto, Takao, Ishino, Takashi, Ueda, Tsutomu, and Takeno, Sachio

Subjects
head and neck osteosarcomas, tumor suppressor p16
Abstract

We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy.

Published
2022

26. Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy.

Author

Hamamoto, Takao, Sato, Yuki, Yumii, Kohei, Chikuie, Nobuyuki, Taruya, Takayuki, Horibe, Yuichiro, Ishino, Takashi, Ueda, Tsutomu, Takeno, Sachio, and Yoshimura, Kenichi

Subjects
SENSORY stimulation, NEURAL stimulation, HEAD & neck cancer, HEALTH facilities, CHEMORADIOTHERAPY, NECK, MEDICAL rehabilitation, TIBIAL nerve
Abstract

Chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer; however, CRT may cause post-treatment dysphagia. Transcutaneous electrical sensory stimulation (TESS), developed in recent years for swallowing rehabilitation, is used at many medical facilities. Although TESS has been used for dysphagia in several fields, its safety and efficacy in patients with head and neck cancer remain to be clarified. Therefore, this study evaluated the safety of TESS in ten patients with head and neck cancers undergoing CRT. Swallowing rehabilitation intervention and TESS implementation were performed for all patients during CRT. Non-blood-toxicity adverse events (AEs), such as dermatitis and mucositis, occurred during CRT; however, the severity was less than grade 3. No patient experienced pain due to TESS. As survival time analysis using the Kaplan–Meier method for interferential current device implementation rates revealed a feasibility of 100% for up to 60 Gy and a feasibility of 78% for up to 70 Gy, TESS may be feasible until 70 Gy. This study confirmed the feasibility and safety of TESS in the head and neck region during CRT. Although the precise mechanism of TESS on dysphagia remains unclear, its continued use has great potential for improving sensory disturbance. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps

Author

Sonoyama, Toru, primary, Ishino, Takashi, additional, Takemoto, Kota, additional, Yamato, Kensuke, additional, Oda, Takashi, additional, Nishida, Manabu, additional, Horibe, Yuichiro, additional, Chikuie, Nobuyuki, additional, Kono, Takashi, additional, Taruya, Takayuki, additional, Hamamoto, Takao, additional, Ueda, Tsutomu, additional, and Takeno, Sachio, additional

Published
2022
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32. Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era

Author

Oda, Takashi, primary, Maeda, Fumiaki, additional, Takeno, Sachio, additional, Tsuru, Yuri, additional, Ishikawa, Chie, additional, Ishino, Takashi, additional, Takemoto, Kota, additional, Hamamoto, Takao, additional, Ueda, Tsutomu, additional, Kawasumi, Tomohiro, additional, Iwamoto, Hiroshi, additional, Kubota, Kazunori, additional, Nakao, Yoshio, additional, and Kunimoto, Masaru, additional

Published
2022
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34. Distinct Gene Set Enrichment Profiles in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Bulk RNA Barcoding and Sequencing

Author

Ishino, Takashi, primary, Takeno, Sachio, additional, Takemoto, Kota, additional, Yamato, Kensuke, additional, Oda, Takashi, additional, Nishida, Manabu, additional, Horibe, Yuichiro, additional, Chikuie, Nobuyuki, additional, Kono, Takashi, additional, Taruya, Takayuki, additional, Hamamoto, Takao, additional, and Ueda, Tsutomu, additional

Published
2022
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35. sj-pdf-1-ajr-10.1177_19458924211009429 - Supplemental material for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis

Author

Takabayashi, Tetsuji, Asaka, Daiya, Okamoto, Yoshitaka, Himi, Tetsuo, Haruna, Shinichi, Yoshida, Naohiro, Kondo, Kenji, Yoshikawa, Mamoru, Sakuma, Yasunori, Shibata, Kunihiko, Suzuki, Motohiko, Kobayashi, Masayoshi, Kawata, Ryo, Tsuzuki, Kenzo, Okano, Mitsuhiro, Higaki, Takaya, Takeno, Sachio, Kodama, Satoru, Yonekura, Syuji, Saito, Hiromi, Nozaki, Akiyo, Otori, Nobuyoshi, and Fujieda, Shigeharu

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract

Supplemental material, sj-pdf-1-ajr-10.1177_19458924211009429 for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis by Tetsuji Takabayashi MD, Daiya Asaka MD, Yoshitaka Okamoto MD, Tetsuo Himi MD, Shinichi Haruna MD, Naohiro Yoshida MD, Kenji Kondo MD, Mamoru Yoshikawa MD, Yasunori Sakuma MD, Kunihiko Shibata MD, Motohiko Suzuki MD, Masayoshi Kobayashi MD, Ryo Kawata MD, Kenzo Tsuzuki MD, Mitsuhiro Okano MD, Takaya Higaki MD, Sachio Takeno MD, Satoru Kodama MD, Syuji Yonekura MD, Hiromi Saito MS, Akiyo Nozaki BS, Nobuyoshi Otori MD, Shigeharu Fujieda MD in American Journal of Rhinology & Allergy

Published
2022
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36. sj-pdf-2-ajr-10.1177_19458924211009429 - Supplemental material for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis

Author

Takabayashi, Tetsuji, Asaka, Daiya, Okamoto, Yoshitaka, Himi, Tetsuo, Haruna, Shinichi, Yoshida, Naohiro, Kondo, Kenji, Yoshikawa, Mamoru, Sakuma, Yasunori, Shibata, Kunihiko, Suzuki, Motohiko, Kobayashi, Masayoshi, Kawata, Ryo, Tsuzuki, Kenzo, Okano, Mitsuhiro, Higaki, Takaya, Takeno, Sachio, Kodama, Satoru, Yonekura, Syuji, Saito, Hiromi, Nozaki, Akiyo, Otori, Nobuyoshi, and Fujieda, Shigeharu

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract

Supplemental material, sj-pdf-2-ajr-10.1177_19458924211009429 for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis by Tetsuji Takabayashi MD, Daiya Asaka MD, Yoshitaka Okamoto MD, Tetsuo Himi MD, Shinichi Haruna MD, Naohiro Yoshida MD, Kenji Kondo MD, Mamoru Yoshikawa MD, Yasunori Sakuma MD, Kunihiko Shibata MD, Motohiko Suzuki MD, Masayoshi Kobayashi MD, Ryo Kawata MD, Kenzo Tsuzuki MD, Mitsuhiro Okano MD, Takaya Higaki MD, Sachio Takeno MD, Satoru Kodama MD, Syuji Yonekura MD, Hiromi Saito MS, Akiyo Nozaki BS, Nobuyoshi Otori MD, Shigeharu Fujieda MD in American Journal of Rhinology & Allergy

Published
2022
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38. Questionnaire Survey of Nebulizer Therapy for Managing Rhinosinusitis During the COVID-19 Pandemic

Author

Hyo, Yukiyoshi, primary, Kurono, Yuichi, additional, Shimizu, Takeshi, additional, Takeuchi, Kazuhiko, additional, Morishita, Hiroyuki, additional, Takahata, Junko, additional, Takeno, Sachio, additional, Hashiguchi, Kazuhiro, additional, Hirano, Kojiro, additional, Mori, Shigehito, additional, Ohki, Motofumi, additional, Yoshiyama, Yuji, additional, Takano, Hiroshi, additional, and Harabuchi, Yasuaki, additional

Published
2022
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48. Ganglioneuroma in The Neck Region: A Case Report

Author

Chikuie, Nobuyuki, Hamamoto, Takao, Ishino, Takashi, Ueda, Tsutomu, Nagasawa, Akira, Kuniyasu, Hiroki, Tani, RIna, and Takeno, Sachio

Subjects
ganglioneuroma, head and neck, diagnosis, neurogenic
Abstract

Ganglioneuroma, which rarely occurs in the neck region, is a well-differentiated benign tumor of the sympathetic nervous system. A 39-year-old man presented with neck swelling for a year. A giant tumor was located on the left side of the neck. Schwannoma was suspected on preoperative cytology and core needle biopsy, and the postoperative diagnosis on pathological examination was ganglioneuroma. The origin of the tumor was considered to be the sympathetic nervous system based on the postoperative appearance of Horner’s syndrome. The treatment choice for ganglioneuromas is complete surgical resection, contrary to the nerve-sparing resection of schwannomas. Therefore, making the definitive diagnosis before surgical resection could be important. In this report, we focus on the differential diagnosis obtained with radiological findings and the treatment strategy for the tumor with a literature review.

Published
2019

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