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4. A case of hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome with kidney failure and recurrent pancreatitis: Answers

Author

Yoshino, Atsunori, Kawamoto, Shinya, Abe, Toshihiro, Hidaka, Yuji, Muroya, Koji, Tokumoto, Tadahiko, and Takeda, Tetsuro

Subjects
Diagnosis, Tests, problems and exercises, Complications and side effects, Case studies, Hypoparathyroidism -- Case studies -- Tests, problems and exercises -- Diagnosis, Pancreatitis -- Case studies -- Tests, problems and exercises -- Complications and side effects, Kidney failure -- Tests, problems and exercises -- Complications and side effects -- Case studies, Dysplasia -- Case studies -- Tests, problems and exercises -- Diagnosis, Deafness -- Case studies -- Tests, problems and exercises -- Diagnosis
Abstract

Author(s): Atsunori Yoshino [sup.1] [sup.3] , Shinya Kawamoto [sup.1] , Toshihiro Abe [sup.1] , Yuji Hidaka [sup.1] , Koji Muroya [sup.4] , Tadahiko Tokumoto [sup.2] , Tetsuro Takeda [sup.1] Author [...]

Published
2021
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6. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Elbert, Alicia, Vallejos, Augusto, Alvarisqueta, Andres, Maffei, Laura, Juncos, Luis, de Arteaga, Javier, Greloni, Gustavo, Farias, Eduardo, Zucchini, Alfredo, Vogel, Daniel, Cusumano, Ana, Santos, Juan, Fraenkel, Margaret, Gallagher, Martin, Davis, Tim, Acharya, Shamasunder, Cooke, Duncan, Suranyi, Michael, Roger, Simon, Toussaint, Nigel, Pollock, Carol, Chan, Doris, Stranks, Stephen, MacIsaac, Richard, Endre, Zoltan, Schmidt, Alice, Prager, Rudolf, Mayer, Gert, Warling, Xavier, Jadoul, Michel, Hougardy, Jean, Vercammen, Chris, Van Vlem, Bruno, Gillard, Pieter, Costa e Forti, Adriana, Borges, Joao Lindolfo, Santos Canani, Luis, Eliaschewitz, Freddy, Leite, Silmara, Fraige Filho, Fadlo, Paschoalin, Raphael, Moura Neto, Jose Andrade, Deboni, Luciane, de Lourdes Noronha, Irene, Cercato, Cintia, Prompt, Carlos Alberto, Zanella, Maria, Rassi, Nelson, D'Avila, Domingos, Milagres, Rosangela, Felicio, Joao, Pecoits Filho, Roberto, Riella, Miguel Carlos, Salles, Joao, Keitel, Elizete, Draibe, Sergio, Amodeo, Celso, Youmbissi, Joseph, Roy, Louise, Cournoyer, Serge, Jolly, Shivinder, Pichette, Vincent, Nesrallah, Gihad, Bajaj, Harpreet Singh, Khandwala, Hasnain, Aronson, Ronnie, Goluch, Richard, Tam, Paul, Rabbat, Christian, Tobe, Sheldon, Bailey, Gordon, Chow, Stephen, Castillo, Alvaro, Danin Vargas, Alfredo, Gonzalez, Fernando, Munoz, Rodrigo, Gutierrez, Vicente, Godoy, Gonzalo, Zhao, Hongwen, Liu, Zhangsuo, Zhao, Minghui, Guo, Xiaohui, Su, Benli, Fu, Shuxia, Xu, Yan, Yang, Jinkui, Shi, Bingyin, Xiao, Guanqing, Shi, Wei, Hao, Chuanming, Xing, Changying, Hou, Fanfan, Luo, Qun, Li, Yuxiu, Ji, Linong, Zuo, Li, Wang, Song, Ni, Zhaohui, Ding, Guohua, Chen, Nan, Zhao, Jiajun, Jia, Weiping, Yu, Shengqiang, Weng, Jian, Xu, Gang, Fu, Ping, Sun, Shiren, Liu, Bicheng, Ding, Xiaoqiang, Rychlik, Ivan, Oplustilova, Alexandra, Bartaskova, Dagmar, Honova, Vaclava, Chmelickova, Hana, Petr, Martin, Bucek, Petr, Tesar, Vladimir, Zahumensky, Emil, Povlsen, Johan, Egstrup, Kenneth, Oczachowska-Kulik, Anna, Rossing, Peter, Lahtela, Jorma, Strand, Jorma, Kantola, Ilkka, Petit, Catherine, Combe, Christian, Zaoui, Philippe, Esnault, Vincent, Urena Torres, Pablo, Halimi, Jean-Michel, Dussol, Bertrand, Bieler, Tasso, Budde, Klemens, Dellanna, Frank, Segiet, Thomas, Kosch, Christine, Schmidt-Guertler, Hans, Schenkenberger, Isabelle, Vielhauer, Volker, Pistrosch, Frank, Alscher, Mark, Hasslacher, Christoph, Hugo, Christian, Muehlfeld, Anja, Wanner, Christoph, Passadakis, Ploumis, Apostolou, Theofanis, Tentolouris, Nikolaos, Stefanidis, Ioannis, Mavromatidis, Konstantinos, Liakopoulos, Vasilios, Goumenos, Dimitrios, Siamopoulos, Konstantinos, Yeung, Vincent, Ozaki, Risa, Fung, Samuel, Tan, Kathryn, Tang, Sydney, Lui, Sing Leung, Cheung, Siu Fai, Sreenan, Seamus, Eustace, Joseph, O'Shea, Donal, Lavin, Peter, Stack, Austin, Yagil, Yoram, Wainstein, Julio, Knobler, Hilla, Cohen, Josef, Kenis, Irina, Daoud, Deeb, Bar-Dayan, Yosefa, Frajewicki, Victor, Adawi, Faiad, Gesualdo, Loreto, Santoro, Domenico, Marino, Francesco, Galfre, Andrea, Brunati, Chiara, Ruggenenti, Piero, Rombola, Giuseppe, Pugliese, Giuseppe, Ravera, Maura, Malberti, Fabio, Pontoriero, Giuseppe, Rampino, Teresa, De Cosmo, Salvatore, Esposito, Ciro, Nappi, Felice, Abaterusso, Cataldo, Conte, Giuseppe, Panichi, Vincenzo, Lauro, Davide, Capasso, Giovambattista, Russo, Domenico, Anzai, Jiichi, Naka, Motoji, Ato, Keita, Tsujimoto, Tetsuro, Nimura, Toshinori, Nakashima, Eitaro, Takeda, Tetsuro, Fujii, Shinya, Kobayashi, Kunihisa, Iwaoka, Hideaki, Nagayama, Koji, Harada, Hiroyuki, Maeda, Hajime, Kishimoto, Rui, Iitsuka, Tadashi, Itabashi, Naoki, Furuya, Ryuichi, Maeda, Yoshitaka, Yamada, Daishiro, Sasaki, Nobuhiro, Sasaki, Hiromitsu, Ueda, Shinichiro, Kashihara, Naoki, Watanabe, Shuichi, Nakamura, Takehiro, Kanai, Hidetoshi, Makita, Yuichiro, Ono, Keiko, Iehara, Noriyuki, Goto, Daisuke, Kosuge, Keiichiro, Tsuchida, Kenichi, Sato, Toshiaki, Sekikawa, Takashi, Okamoto, Hideki, Tanaka, Tsuyoshi, Ikeda, Naoko, Tadika, Takenobu, Mukasa, Koji, Osonoi, Takeshi, Hirano, Fuminori, Nishimura, Motonobu, Yambe, Yuko, Tanaka, Yukio, Ujihara, Makoto, Sakai, Takashi, Imura, Mitsuo, Umayahara, Yutaka, Makino, Shinya, Nakazawa, Jun, Yamaguchi, Yukinari, Kashine, Susumu, Miyaoka, Hiroaki, Suzuki, Katsunori, Inoue, Toshihiko, Nagai, Sou, Sato, Nobuyuki, Yamamoto, Masahiro, Taya, Noriyasu, Fujita, Akira, Matsutani, Akira, Shibagaki, Yugo, Sato, Yuichi, Yamauchi, Akira, Tsutsui, Masahiro, Ishiko, Tamayo, Kaneko, Shizuka, Azuma, Nobuyuki, Matsuda, Hirofumi, Hashiguchi, Yasuhiro, Onishi, Yukiko, Tokui, Mikiya, Matsuhisa, Munehide, Kiyosue, Arihiro, Shinoda, Junji, Ishikawa, Kazuo, Ahmad, Ghazali, Vijayasingham, Shalini, Aziz, Nor Azizah, Hussein, Zanariah, Fung, Yin Khet, Hassan, Wan Hasnul Halimi Wan, Wong, Hin Seng, Goh, Bak Leong, Ali, Norhaliza Mohd, Merican, Nor Shaffinaz Yusuf Azmi, Vaithilingam, Indralingam, Nik Ahmad, Nik Nur Fatnoon, Adam, Noor, Sukor, Norlela, Vengadasalam, V Paranthaman P, Abdul Kadir, Khalid, Mohamed, Mafauzy, Renoirte Lopez, Karina, Leguizamo-Dimas, Aniceto, Chew Wong, Alfredo, Chevaile-Ramos, Jose, Gonzalez Gonzalez, Jose, Rico Hernandez, Raul, Nino-Cruz, Jose, Sauque Reyna, Leobardo, Gonzalez-Galvez, Guillermo, Madero Rovalo, Magdalena, Bochicchio-Ricardelli, Tomasso, Aldrete, Jorge, Carranza-Madrigal, Jaime, Vogt, Liffert, Smak Gregoor, Peter, Barendregt, JNM, Luik, Peter, Gansevoort, Ronald, Laverman, Gozewijn, Pilmore, Helen, Lunt, Helen, Baker, John, Miller, Steven, Rabindranath, Kannaiyan, Zapata-Rincon, Luis, Vargas-Gonzales, Rolando, Calderon Ticona, Jorge, Dextre Espinoza, Augusto, Burga Nunez, Jose, Zea-Nunez, Carlos Antonio, Herrada Orue, Benjamin, Medina-Santander, Boris, Delgado-Butron, Cesar, Farfan-Aspilcueta, Julio, Mazur, Stanislaw, Necki, Miroslaw, Wruk, Michal, Klodawska, Katarzyna, Popenda, Grazyna, Skokowska, Ewa, Arciszewska, Malgorzata, Wiecek, Andrzej, Ciechanowski, Kazimierz, Nowicki, Michal, Birne, Rita, Cabrita, Antonio, Ramos, Aura, Antunes Ferreira, Manuel Anibal, Matta Fontanet, Evelyn, Alcantara-Gonzalez, Altagracia Aurora, Comulada-Rivera, Angel, Galindo Ramos, Eugenia, Cangiano, Jose, Quesada-Suarez, Luis, Calderon Ortiz, Ricardo, Vazquez-Tanus, Jose, Burgos-Calderon, Rafael, Rosado, Carlos, Hancu, Nicolae, Pintilei, Ella, Mistodie, Cristina, Bako, Gabriel, Ionutiu, Lavinia, Petrica, Ligia, Timar, Romulus, Tuta, Liliana, Duma, Livia, Tutescu, Adriana, Ivanova, Svetlana, Essaian, Ashot, Zrazhevskiy, Konstantin, Tomilina, Natalia, Smolyarchuk, Elena, Kuzin, Anatoly, Lantseva, Olga, Karpova, Irina, Shamkhalova, Minara, Liberanskaya, Natalia, Yavdosyuk, Andrey, Shvarts, Yuri, Bardymova, Tatiana, Blagoveshchenskaya, Olga, Solovev, Oleg, Rechkova, Elena, Pikalova, Natalia, Pavlova, Maria, Kolmakova, Elena, Sayfutdinov, Rustam, Villevalde, Svetlana, Koziolova, Natalya, Martynenko, Vladimir, Marasaev, Vyacheslav, Maksudova, Adelya, Sigitova, Olga, Mordovin, Viktor, Klimontov, Vadim, Samoylova, Yulia, Karonova, Tatiana, Yeoh, Lee Ying, Teo, Boon Wee, Foo, Marjorie Wai Yin, Liew, Adrian, Tkac, Ivan, Oroszova, Aniko, Fekete, Jozef, Rosenberger, Jaroslav, Obetkova, Ida, Fulopova, Alla, Kolesarova, Eva, Raslova, Katarina, Smolko, Peter, Oksa, Adrian, Distiller, Larry, Trokis, Julien, Adams, Luthando, Makan, Hemant, Ramlachan, Padaruth, Mitha, Essack, Coetzee, Kathleen, Punt, Zelda, Bhorat, Qasim, Naiker, Puvenesvari, Ellis, Graham, Van Zyl, Louis, Lee, Kwan Woo, Kim, Min Seon, Yoo, Soon-Jib, Yoon, Kun Ho, Cho, Yong-Wook, Park, Tae-Sun, Kim, Sang Yong, Choi, Moon-Gi, Oh, Tae Keun, Lee, Kang-Wook, Shon, Ho Sang, Suh, Sung Hwan, Kim, Byung-Joon, Doo-Man, Kim, Yi, Joo Hark, Lee, Sang Ah, Cho, Ho Chan, Kim, Sin-Gon, Cha, Dae-Ryong, Seo, Ji A, Choi, Kyung Mook, Woo, Jeong-Taek, Ahn, Kyu Jeung, Lee, Jae Hyuk, Kim, In-Joo, Lee, Moon-Kyu, Jang, Hak Chul, Park, Kyong-Soo, Kim, Beom Seok, Mok, Ji Oh, Shin, Mijung, Yoon, Sun Ae, Nam-Goong, Il-Seong, Chung, Choon Hee, Yu, Tae Yang, Lee, Hyoung Woo, Soto Gonzalez, Alfonso, Almirall, Jaume, Egido, Jesus, Calero Gonzalez, Francesca, Fernandez Fresnedo, Gema, Valera Cortes, Ildefonso, Praga Terente, Manuel, Garcia Mendez, Isabel, Navarro Gonzalez, Juan, Herrero Calvo, Jose, Cigarran Guldris, Secundino, Prieto Velasco, Mario, Minguela Pesquera, Jose Ignacio, Galan, Antonio, Pascual, Julio, Marques Vidas, Maria, Martins Munoz, Judith, Rodriguez-Perez, Jose, Castro-Alonso, Cristina, Bonet Sol, Josep, Seron, Daniel, Fernandez Giraldez, Elvira, Arrieta Lezama, Javier, Montero, Nuria, Hernandez-Jaras, Julio, Santamaria Olmo, Rafael, Molas Coten, Jose Ramon, Hellberg, Olof, Fellstrom, Bengt, Bock, Andreas, Pei, Dee, Lin, Ching-Ling, Tien, Kai-Jen, Chen, Ching-Chu, Huang, Chien-Ning, Jiang, Ju-Ying, Wu, Du-An, Chu, Chih-Hsun, Tseng, Shih-Ting, Chen, Jung-Fu, Bau, Cho-Tsan, Sheu, Wayne, Wu, Mai-Szu, Sari, Ramazan, Sezer, Siren, Yildiz, Alaattin, Satman, Ilhan, Kalender, Betul, Mankovskyy, Borys, Fushtey, Ivan, Stanislavchuk, Mykola, Kolenyk, Mykola, Dudar, Iryna, Zolotaikina, Viktoriia, Abrahamovych, Orest, Kostynenko, Tetyana, Petrosyan, Olena, Kuskalo, Petro, Galushchak, Olga, Legun, Oleg, Topchii, Ivan, Martynyuk, Liliya, Stryzhak, Vasyl, Panina, Svitlana, Tkach, Sergii, Korpachev, Vadym, Maxwell, Peter, Gnudi, Luigi, Kon, Sui Phin, Tindall, Hilary, Kalra, Phillip, Mark, Patrick, Patel, Dipesh, El-Shahawy, Mohamed, Bai, Liqun, Nica, Romanita, Lien, Yeong-Hau, Menefee, Judson, Busch, Robert, Miller, Alan, Ahmed, Azazuddin, Arif, Ahmed, Lee, Joseph, Desai, Sachin, Bansal, Shweta, Bentsianov, Marie, Belledonne, Mario, Jere, Charles, Gaona, Raul, Greenwood, Gregory, Brusco, Osvaldo, Boiskin, Mark, Belo, Diogo, Minasian, Raffi, Atray, Naveen, Lawrence, Mary, Taliercio, John, Pergola, Pablo, Scott, David, Alvarez, German, Marder, Bradley, Powell, Thomas, Bakdash, Wa'el, Stoica, George, McFadden, Christopher, Rendell, Marc, Wise, Jonathan, Jones, Audrey, Jardula, Michael, Madu, Ivy-Joan, Varghese, Freemu, Tulloch, Brian, Ahmed, Ziauddin, Hames, Melanie, Nazeer, Imran, Shahid, Newman, John, Rekha, Montero, Manuel, Fitz-Patrick, David, Phillips, Lawrence, Guasch, Antonio, Christofides, Elena, Gundroo, Aijaz, Amin, Mohammad, Bowman-Stroud, Cynthia, Link, Michael, Mulloy, Laura, Nammour, Michael, Lalwani, Tarik, Hanson, Lenita, Whaley-Connell, Adam, Herman, Lee, Chatha, Rupi, Osama, Sayed, Liss, Kenneth, Kayali, Zeid, Bhargava, Anuj, Israel, Ezra, Peguero-Rivera, Alfredo, Fang, Michael, Slover, Judith, Barengolts, Elena, Flores, Jose, Muoneke, Rosemary, Savin, Virginia, Awua-Larbi, Stella, Levine, Andrew, Newman, George, Golestaneh, Laden, Bohm, Guillermo, Reisin, Efrain, Cruz, Lucita, Weiss, Robert, Zieve, Franklin, Horwitz, Edward, Chuang, Peale, Mersey, James, Manley, John, Graf, Ronald, Bedros, Fadi, Joshi, Sudhir, Frias, Juan, Assefi, Ali, O'Shaughnessy, Andrew, Brantley, Roman, Minga, Todd, Tietjen, David, Kantor, Samuel, Jamal, Aamir, Guadiz, Ramon, Hershon, Kenneth, Bressler, Peter, Kopyt, Nelson, Cathcart, Harold, Bloom, Scott, Reichel, Ronald, Nakhle, Samer, Dulude, Emily, Tarkan, Joshua, Baker, Penelope, Zeig, Steven, Moya Hechevarria, Jaynier, Ropero-Cartier, Armando, De la Calle, Gilda, Doshi, Ankur, Saba, Fadi, Sligh, Teresa, Shaw, Sylvia, Kumar, Jayant, Szerlip, Harold, Bayliss, George, Perlman, Alan, Sakhrani, Lakhi, Gouge, Steven, Argoud, Georges, Acosta, Idalia, Elder, John, Joshi, Sucharit, Sensenbrenner, John, Vicks, Steven, Mangoo-Karim, Roberto, Galphin, Claude, Leon-Forero, Carlos, Gilbert, John, Brown, Eric, Ijaz, Adeel, Butt, Salman, Markell, Mariana, Arauz-Pacheco, Carlos, Sloan, Lance, Alvarado, Odilon, Jabbour, Serge, Simon, Eric, Rastogi, Anjay, James, Sam, Bakris, George, Hall, Karen, Melish, John, Dixon, Brad, Adolphe, Allen, Kovesdy, Csaba, Beddhu, Srinivasan, Solomon, Richard, Fernando, Ronald, Levin, Ellis, Thakar, Charuhas, Robey, Brooks, Goldfarb, David, Fried, Linda, Maddukuri, Geetha, Thomson, Stephen, Annand, Andrew, Kronfli, Saeed, Kalirao, Paramjit, Schmidt, Rebecca, Dahl, Neera, Blumenthal, Samuel, Weinstein, Debra, Ostergaard, Ove, Weinstein, Talia, Ono, Yasuhiro, Yalcin, Murat, Karim, Shahana, Heerspink, Hiddo J L, Parving, Hans-Henrik, Andress, Dennis L, Correa-Rotter, Ricardo, Hou, Fan-Fan, Kitzman, Dalane W, Kohan, Donald, Makino, Hirofumi, McMurray, John J V, Melnick, Joel Z, Miller, Michael G, Pergola, Pablo E, Perkovic, Vlado, Yi, Tingting, Wigderson, Melissa, and de Zeeuw, Dick

Published
2019
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9. The adaptor protein ARH escorts megalin to and through endosomes

Author

Nagai, Masaaki, Meerloo, Timo, Takeda, Tetsuro, and Farquhar, Marilyn Gist

Abstract

Megalin is an endocytic receptor that binds multiple ligands and is essential for many physiological processes such as brain development and uptake of proteins by the kidney tubule, yolk sac, and thyroid. The cytoplasmic tail of megalin contains two FXNPXY motifs. Autosomal recessive hypercholesterolemia (ARH) is an adaptor protein that binds to the FXNPXY motif of the low-density lipoprotein receptor as well as clathrin and AP-2. We found that ARH also binds to the first FXNPXY motif of megalin in two-hybrid, pull-down and coimmunoprecipitation assays. ARH colocalizes with megalin in clathrin coated pits and in recycling endosomes in the Golgi region. When cells are treated with nocodazole, the recycling endosomes containing megalin and ARH disperse. On internalization of megalin, ARH and megalin are first seen in clathrin coated pits followed by sequential localization in early endosomes and tubular recycling endosomes in the pericentriolar region followed by their reappearance at the cell surface. Expression of ARH in Madin-Darby canine kidney cells expressing megalin mini-receptors enhances megalin-mediated uptake of I-125-lactoferrin, a megalin ligand. These results show that ARH facilitates endocytosis of megalin, escorts megalin along its endocytic route and raise the possibility that transport through the endosomal system is selective and requires interaction with specific adaptor proteins.

Published
2003

10. Preservation of Renal Function in Predialysis Patients before Dialysis Initiation with Nephrology Care: A Single-center Retrospective Study

Author

Kawamoto, Shinya, Nagahori, Katsuhiro, Yasu, Takanori, Takeda, Tetsuro, Kawamoto, Shinya, Nagahori, Katsuhiro, Yasu, Takanori, and Takeda, Tetsuro

Abstract

Background: Progressive chronic kidney disease, which necessitates dialysis, results in inability to maintain renal homeostasis. Although drugs are available, maintenance of residual renal function is challenging, and the estimated glomerular filtration rate (eGFR) declines rapidly. Age, sex, primary disease of renal failure, blood pressure, urinary protein, anemia, and access preparation for dialysis affect the decline in eGFR during this period. Methods: We investigated 428 incident dialysis patients who received nephrology care for >6 months before dialysis initiation. We retrospectively compared age, primary disease (diabetic vs. non-diabetic kidney disease), blood pressure, serum hemoglobin levels, urinary protein levels, renin-angiotensin system (RAS) inhibitor, diuretics, vitamin D use and preparation of access at initiation to determine their association with the decline in eGFR over 6 months before dialysis initiation. Result: The decline in eGFR was significantly associated with age (<60 years), sex (male), without access preparation, hypertension (6 months before and at initiation), renin-angiotensin system inhibitor use (6 months prior), nephrotic-range proteinuria, and vitamin D use. We observed no significant differences in the primary disease (diabetic vs. non-diabetic kidney disease), RAS inhibitor use and hemoglobin levels at initiation. RAS inhibitors are also effective in CKDG1 to G4, whereas they are not effective in CKD with advanced G5. Multivariate analysis showed that eGFR decline was significantly correlated with sex, vascular access preparation, and urinary protein levels. Conclusion: Renal function preservation is challenging in patients with progressive chronic kidney disease accompanied by increased urinary protein levels. Regardless of renin-angiotensin system inhibitor use, renal function was better preserved in women with strict blood pressure control and vascular access preparation before dialysis initiation.

Published
2023

17. Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

Author

Sugiyama, Hitoshi, Yokoyama, Hitoshi, Sato, Hiroshi, Saito, Takao, Kohda, Yukimasa, Nishi, Shinichi, Tsuruya, Kazuhiko, Kiyomoto, Hideyasu, Iida, Hiroyuki, Sasaki, Tamaki, Higuchi, Makoto, Hattori, Motoshi, Oka, Kazumasa, Kagami, Shoji, Kawamura, Tetsuya, Takeda, Tetsuro, Hataya, Hiroshi, Fukasawa, Yuichiro, Fukatsu, Atsushi, Morozumi, Kunio, Yoshikawa, Norishige, Shimizu, Akira, Kitamura, Hiroshi, Yuzawa, Yukio, Matsuo, Seiichi, Kiyohara, Yutaka, Joh, Kensuke, Nagata, Michio, Taguchi, Takashi, Makino, Hirofumi, and Committee for Standardization of Renal Pathological Diagnosis and Committee for Kidney Disease Registry, Japanese Society of Nephrology, Japan

Published
2013
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22. Identification of an apical sorting determinant in the cytoplasmic tail of megalin

Author

Takeda, Tetsuro, Yamazaki, Hajime, and Farquhar, Marilyn G.

Subjects
Epithelial cells -- Physiological aspects, Kidneys -- Physiological aspects, Biological sciences
Abstract

Megalin is the main endocytic receptor of the proximal tubule and is responsible for reabsorption of many filtered proteins. In contrast to other members of the low-density lipoprotein (LDL) receptor gene family, it is expressed on the apical plasma membrane (PM) of polarized epithelial cells. To identify megalin's apical sorting signal, we generated deletion mutants and chimeric minireceptors composed of complementary regions of megalin and LDL receptor-related protein (LRP) and assessed the distribution of the mutants in Madin-Darby canine kidney (MDCK) cells by immunofiuorescence and cell surface biotinylation. Megalin and LRP minireceptors are correctly targeted to the apical and basolateral PM, respectively, of MDCK cells. We found that the information that directs apical sorting is present in the cytoplasmic tail (CT) of megalin, which contains three NPXY motifs, YXXO, SH3, and dileucine motifs, and a PDZ-binding motif at its COOH terminus. Deletion analysis established that amino acids 107-136 of the megalin-CT containing the second NPXY-like motif are critical for apical sorting and targeting, whereas the regions containing the first and third NPXY motifs are required for efficient endocytosis. We conclude that the megalin-CT contains a novel apical sorting determinant and that cytoplasmic sorting machinery exists in MDCK cells for some apical transmembrane proteins. Madin-Darby canine kidney cells; low-density lipoprotein receptor-related protein; chimeric minireceptors; NPXY sorting signals; endocytosis

Published
2003

35. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Heerspink, Hiddo J L, primary, Parving, Hans-Henrik, additional, Andress, Dennis L, additional, Bakris, George, additional, Correa-Rotter, Ricardo, additional, Hou, Fan-Fan, additional, Kitzman, Dalane W, additional, Kohan, Donald, additional, Makino, Hirofumi, additional, McMurray, John J V, additional, Melnick, Joel Z, additional, Miller, Michael G, additional, Pergola, Pablo E, additional, Perkovic, Vlado, additional, Tobe, Sheldon, additional, Yi, Tingting, additional, Wigderson, Melissa, additional, de Zeeuw, Dick, additional, Elbert, Alicia, additional, Vallejos, Augusto, additional, Alvarisqueta, Andres, additional, Maffei, Laura, additional, Juncos, Luis, additional, de Arteaga, Javier, additional, Greloni, Gustavo, additional, Farias, Eduardo, additional, Zucchini, Alfredo, additional, Vogel, Daniel, additional, Cusumano, Ana, additional, Santos, Juan, additional, Fraenkel, Margaret, additional, Gallagher, Martin, additional, Davis, Tim, additional, Acharya, Shamasunder, additional, Cooke, Duncan, additional, Suranyi, Michael, additional, Roger, Simon, additional, Toussaint, Nigel, additional, Pollock, Carol, additional, Chan, Doris, additional, Stranks, Stephen, additional, MacIsaac, Richard, additional, Endre, Zoltan, additional, Schmidt, Alice, additional, Prager, Rudolf, additional, Mayer, Gert, additional, Warling, Xavier, additional, Jadoul, Michel, additional, Hougardy, Jean, additional, Vercammen, Chris, additional, Van Vlem, Bruno, additional, Gillard, Pieter, additional, Costa e Forti, Adriana, additional, Borges, Joao Lindolfo, additional, Santos Canani, Luis, additional, Eliaschewitz, Freddy, additional, Leite, Silmara, additional, Fraige Filho, Fadlo, additional, Paschoalin, Raphael, additional, Moura Neto, Jose Andrade, additional, Deboni, Luciane, additional, de Lourdes Noronha, Irene, additional, Cercato, Cintia, additional, Prompt, Carlos Alberto, additional, Zanella, Maria, additional, Rassi, Nelson, additional, D'Avila, Domingos, additional, Milagres, Rosangela, additional, Felicio, Joao, additional, Pecoits Filho, Roberto, additional, Riella, Miguel Carlos, additional, Salles, Joao, additional, Keitel, Elizete, additional, Draibe, Sergio, additional, Amodeo, Celso, additional, Youmbissi, Joseph, additional, Roy, Louise, additional, Cournoyer, Serge, additional, Jolly, Shivinder, additional, Pichette, Vincent, additional, Nesrallah, Gihad, additional, Bajaj, Harpreet Singh, additional, Khandwala, Hasnain, additional, Aronson, Ronnie, additional, Goluch, Richard, additional, Tam, Paul, additional, Rabbat, Christian, additional, Bailey, Gordon, additional, Chow, Stephen, additional, Castillo, Alvaro, additional, Danin Vargas, Alfredo, additional, Gonzalez, Fernando, additional, Munoz, Rodrigo, additional, Gutierrez, Vicente, additional, Godoy, Gonzalo, additional, Zhao, Hongwen, additional, Liu, Zhangsuo, additional, Zhao, Minghui, additional, Guo, Xiaohui, additional, Su, Benli, additional, Fu, Shuxia, additional, Xu, Yan, additional, Yang, Jinkui, additional, Shi, Bingyin, additional, Xiao, Guanqing, additional, Shi, Wei, additional, Hao, Chuanming, additional, Xing, Changying, additional, Hou, Fanfan, additional, Luo, Qun, additional, Li, Yuxiu, additional, Ji, Linong, additional, Zuo, Li, additional, Wang, Song, additional, Ni, Zhaohui, additional, Ding, Guohua, additional, Chen, Nan, additional, Zhao, Jiajun, additional, Jia, Weiping, additional, Yu, Shengqiang, additional, Weng, Jian, additional, Xu, Gang, additional, Fu, Ping, additional, Sun, Shiren, additional, Liu, Bicheng, additional, Ding, Xiaoqiang, additional, Rychlik, Ivan, additional, Oplustilova, Alexandra, additional, Bartaskova, Dagmar, additional, Honova, Vaclava, additional, Chmelickova, Hana, additional, Petr, Martin, additional, Bucek, Petr, additional, Tesar, Vladimir, additional, Zahumensky, Emil, additional, Povlsen, Johan, additional, Egstrup, Kenneth, additional, Oczachowska-Kulik, Anna, additional, Rossing, Peter, additional, Lahtela, Jorma, additional, Strand, Jorma, additional, Kantola, Ilkka, additional, Petit, Catherine, additional, Combe, Christian, additional, Zaoui, Philippe, additional, Esnault, Vincent, additional, Urena Torres, Pablo, additional, Halimi, Jean-Michel, additional, Dussol, Bertrand, additional, Bieler, Tasso, additional, Budde, Klemens, additional, Dellanna, Frank, additional, Segiet, Thomas, additional, Kosch, Christine, additional, Schmidt-Guertler, Hans, additional, Schenkenberger, Isabelle, additional, Vielhauer, Volker, additional, Pistrosch, Frank, additional, Alscher, Mark, additional, Hasslacher, Christoph, additional, Hugo, Christian, additional, Muehlfeld, Anja, additional, Wanner, Christoph, additional, Passadakis, Ploumis, additional, Apostolou, Theofanis, additional, Tentolouris, Nikolaos, additional, Stefanidis, Ioannis, additional, Mavromatidis, Konstantinos, additional, Liakopoulos, Vasilios, additional, Goumenos, Dimitrios, additional, Siamopoulos, Konstantinos, additional, Yeung, Vincent, additional, Ozaki, Risa, additional, Fung, Samuel, additional, Tan, Kathryn, additional, Tang, Sydney, additional, Lui, Sing Leung, additional, Cheung, Siu Fai, additional, Sreenan, Seamus, additional, Eustace, Joseph, additional, O'Shea, Donal, additional, Lavin, Peter, additional, Stack, Austin, additional, Yagil, Yoram, additional, Wainstein, Julio, additional, Knobler, Hilla, additional, Cohen, Josef, additional, Kenis, Irina, additional, Daoud, Deeb, additional, Bar-Dayan, Yosefa, additional, Frajewicki, Victor, additional, Adawi, Faiad, additional, Gesualdo, Loreto, additional, Santoro, Domenico, additional, Marino, Francesco, additional, Galfre, Andrea, additional, Brunati, Chiara, additional, Ruggenenti, Piero, additional, Rombola, Giuseppe, additional, Pugliese, Giuseppe, additional, Ravera, Maura, additional, Malberti, Fabio, additional, Pontoriero, Giuseppe, additional, Rampino, Teresa, additional, De Cosmo, Salvatore, additional, Esposito, Ciro, additional, Nappi, Felice, additional, Abaterusso, Cataldo, additional, Conte, Giuseppe, additional, Panichi, Vincenzo, additional, Lauro, Davide, additional, Capasso, Giovambattista, additional, Russo, Domenico, additional, Anzai, Jiichi, additional, Naka, Motoji, additional, Ato, Keita, additional, Tsujimoto, Tetsuro, additional, Nimura, Toshinori, additional, Nakashima, Eitaro, additional, Takeda, Tetsuro, additional, Fujii, Shinya, additional, Kobayashi, Kunihisa, additional, Iwaoka, Hideaki, additional, Nagayama, Koji, additional, Harada, Hiroyuki, additional, Maeda, Hajime, additional, Kishimoto, Rui, additional, Iitsuka, Tadashi, additional, Itabashi, Naoki, additional, Furuya, Ryuichi, additional, Maeda, Yoshitaka, additional, Yamada, Daishiro, additional, Sasaki, Nobuhiro, additional, Sasaki, Hiromitsu, additional, Ueda, Shinichiro, additional, Kashihara, Naoki, additional, Watanabe, Shuichi, additional, Nakamura, Takehiro, additional, Kanai, Hidetoshi, additional, Makita, Yuichiro, additional, Ono, Keiko, additional, Iehara, Noriyuki, additional, Goto, Daisuke, additional, Kosuge, Keiichiro, additional, Tsuchida, Kenichi, additional, Sato, Toshiaki, additional, Sekikawa, Takashi, additional, Okamoto, Hideki, additional, Tanaka, Tsuyoshi, additional, Ikeda, Naoko, additional, Tadika, Takenobu, additional, Mukasa, Koji, additional, Osonoi, Takeshi, additional, Hirano, Fuminori, additional, Nishimura, Motonobu, additional, Yambe, Yuko, additional, Tanaka, Yukio, additional, Ujihara, Makoto, additional, Sakai, Takashi, additional, Imura, Mitsuo, additional, Umayahara, Yutaka, additional, Makino, Shinya, additional, Nakazawa, Jun, additional, Yamaguchi, Yukinari, additional, Kashine, Susumu, additional, Miyaoka, Hiroaki, additional, Suzuki, Katsunori, additional, Inoue, Toshihiko, additional, Nagai, Sou, additional, Sato, Nobuyuki, additional, Yamamoto, Masahiro, additional, Taya, Noriyasu, additional, Fujita, Akira, additional, Matsutani, Akira, additional, Shibagaki, Yugo, additional, Sato, Yuichi, additional, Yamauchi, Akira, additional, Tsutsui, Masahiro, additional, Ishiko, Tamayo, additional, Kaneko, Shizuka, additional, Azuma, Nobuyuki, additional, Matsuda, Hirofumi, additional, Hashiguchi, Yasuhiro, additional, Onishi, Yukiko, additional, Tokui, Mikiya, additional, Matsuhisa, Munehide, additional, Kiyosue, Arihiro, additional, Shinoda, Junji, additional, Ishikawa, Kazuo, additional, Ahmad, Ghazali, additional, Vijayasingham, Shalini, additional, Aziz, Nor Azizah, additional, Hussein, Zanariah, additional, Fung, Yin Khet, additional, Hassan, Wan Hasnul Halimi Wan, additional, Wong, Hin Seng, additional, Goh, Bak Leong, additional, Ali, Norhaliza Mohd, additional, Merican, Nor Shaffinaz Yusuf Azmi, additional, Vaithilingam, Indralingam, additional, Nik Ahmad, Nik Nur Fatnoon, additional, Adam, Noor, additional, Sukor, Norlela, additional, Vengadasalam, V Paranthaman P, additional, Abdul Kadir, Khalid, additional, Mohamed, Mafauzy, additional, Renoirte Lopez, Karina, additional, Leguizamo-Dimas, Aniceto, additional, Chew Wong, Alfredo, additional, Chevaile-Ramos, Jose, additional, Gonzalez Gonzalez, Jose, additional, Rico Hernandez, Raul, additional, Nino-Cruz, Jose, additional, Sauque Reyna, Leobardo, additional, Gonzalez-Galvez, Guillermo, additional, Madero Rovalo, Magdalena, additional, Bochicchio-Ricardelli, Tomasso, additional, Aldrete, Jorge, additional, Carranza-Madrigal, Jaime, additional, Vogt, Liffert, additional, Smak Gregoor, Peter, additional, Barendregt, JNM, additional, Luik, Peter, additional, Gansevoort, Ronald, additional, Laverman, Gozewijn, additional, Pilmore, Helen, additional, Lunt, Helen, additional, Baker, John, additional, Miller, Steven, additional, Rabindranath, Kannaiyan, additional, Zapata-Rincon, Luis, additional, Vargas-Gonzales, Rolando, additional, Calderon Ticona, Jorge, additional, Dextre Espinoza, Augusto, additional, Burga Nunez, Jose, additional, Zea-Nunez, Carlos Antonio, additional, Herrada Orue, Benjamin, additional, Medina-Santander, Boris, additional, Delgado-Butron, Cesar, additional, Farfan-Aspilcueta, Julio, additional, Mazur, Stanislaw, additional, Necki, Miroslaw, additional, Wruk, Michal, additional, Klodawska, Katarzyna, additional, Popenda, Grazyna, additional, Skokowska, Ewa, additional, Arciszewska, Malgorzata, additional, Wiecek, Andrzej, additional, Ciechanowski, Kazimierz, additional, Nowicki, Michal, additional, Birne, Rita, additional, Cabrita, Antonio, additional, Ramos, Aura, additional, Antunes Ferreira, Manuel Anibal, additional, Matta Fontanet, Evelyn, additional, Alcantara-Gonzalez, Altagracia Aurora, additional, Comulada-Rivera, Angel, additional, Galindo Ramos, Eugenia, additional, Cangiano, Jose, additional, Quesada-Suarez, Luis, additional, Calderon Ortiz, Ricardo, additional, Vazquez-Tanus, Jose, additional, Burgos-Calderon, Rafael, additional, Rosado, Carlos, additional, Hancu, Nicolae, additional, Pintilei, Ella, additional, Mistodie, Cristina, additional, Bako, Gabriel, additional, Ionutiu, Lavinia, additional, Petrica, Ligia, additional, Timar, Romulus, additional, Tuta, Liliana, additional, Duma, Livia, additional, Tutescu, Adriana, additional, Ivanova, Svetlana, additional, Essaian, Ashot, additional, Zrazhevskiy, Konstantin, additional, Tomilina, Natalia, additional, Smolyarchuk, Elena, additional, Kuzin, Anatoly, additional, Lantseva, Olga, additional, Karpova, Irina, additional, Shamkhalova, Minara, additional, Liberanskaya, Natalia, additional, Yavdosyuk, Andrey, additional, Shvarts, Yuri, additional, Bardymova, Tatiana, additional, Blagoveshchenskaya, Olga, additional, Solovev, Oleg, additional, Rechkova, Elena, additional, Pikalova, Natalia, additional, Pavlova, Maria, additional, Kolmakova, Elena, additional, Sayfutdinov, Rustam, additional, Villevalde, Svetlana, additional, Koziolova, Natalya, additional, Martynenko, Vladimir, additional, Marasaev, Vyacheslav, additional, Maksudova, Adelya, additional, Sigitova, Olga, additional, Mordovin, Viktor, additional, Klimontov, Vadim, additional, Samoylova, Yulia, additional, Karonova, Tatiana, additional, Yeoh, Lee Ying, additional, Teo, Boon Wee, additional, Foo, Marjorie Wai Yin, additional, Liew, Adrian, additional, Tkac, Ivan, additional, Oroszova, Aniko, additional, Fekete, Jozef, additional, Rosenberger, Jaroslav, additional, Obetkova, Ida, additional, Fulopova, Alla, additional, Kolesarova, Eva, additional, Raslova, Katarina, additional, Smolko, Peter, additional, Oksa, Adrian, additional, Distiller, Larry, additional, Trokis, Julien, additional, Adams, Luthando, additional, Makan, Hemant, additional, Ramlachan, Padaruth, additional, Mitha, Essack, additional, Coetzee, Kathleen, additional, Punt, Zelda, additional, Bhorat, Qasim, additional, Naiker, Puvenesvari, additional, Ellis, Graham, additional, Van Zyl, Louis, additional, Lee, Kwan Woo, additional, Kim, Min Seon, additional, Yoo, Soon-Jib, additional, Yoon, Kun Ho, additional, Cho, Yong-Wook, additional, Park, Tae-Sun, additional, Kim, Sang Yong, additional, Choi, Moon-Gi, additional, Oh, Tae Keun, additional, Lee, Kang-Wook, additional, Shon, Ho Sang, additional, Suh, Sung Hwan, additional, Kim, Byung-Joon, additional, Doo-Man, Kim, additional, Yi, Joo Hark, additional, Lee, Sang Ah, additional, Cho, Ho Chan, additional, Kim, Sin-Gon, additional, Cha, Dae-Ryong, additional, Seo, Ji A, additional, Choi, Kyung Mook, additional, Woo, Jeong-Taek, additional, Ahn, Kyu Jeung, additional, Lee, Jae Hyuk, additional, Kim, In-Joo, additional, Lee, Moon-Kyu, additional, Jang, Hak Chul, additional, Park, Kyong-Soo, additional, Kim, Beom Seok, additional, Mok, Ji Oh, additional, Shin, Mijung, additional, Yoon, Sun Ae, additional, Nam-Goong, Il-Seong, additional, Chung, Choon Hee, additional, Yu, Tae Yang, additional, Lee, Hyoung Woo, additional, Soto Gonzalez, Alfonso, additional, Almirall, Jaume, additional, Egido, Jesus, additional, Calero Gonzalez, Francesca, additional, Fernandez Fresnedo, Gema, additional, Valera Cortes, Ildefonso, additional, Praga Terente, Manuel, additional, Garcia Mendez, Isabel, additional, Navarro Gonzalez, Juan, additional, Herrero Calvo, Jose, additional, Cigarran Guldris, Secundino, additional, Prieto Velasco, Mario, additional, Minguela Pesquera, Jose Ignacio, additional, Galan, Antonio, additional, Pascual, Julio, additional, Marques Vidas, Maria, additional, Martins Munoz, Judith, additional, Rodriguez-Perez, Jose, additional, Castro-Alonso, Cristina, additional, Bonet Sol, Josep, additional, Seron, Daniel, additional, Fernandez Giraldez, Elvira, additional, Arrieta Lezama, Javier, additional, Montero, Nuria, additional, Hernandez-Jaras, Julio, additional, Santamaria Olmo, Rafael, additional, Molas Coten, Jose Ramon, additional, Hellberg, Olof, additional, Fellstrom, Bengt, additional, Bock, Andreas, additional, Pei, Dee, additional, Lin, Ching-Ling, additional, Tien, Kai-Jen, additional, Chen, Ching-Chu, additional, Huang, Chien-Ning, additional, Jiang, Ju-Ying, additional, Wu, Du-An, additional, Chu, Chih-Hsun, additional, Tseng, Shih-Ting, additional, Chen, Jung-Fu, additional, Bau, Cho-Tsan, additional, Sheu, Wayne, additional, Wu, Mai-Szu, additional, Sari, Ramazan, additional, Sezer, Siren, additional, Yildiz, Alaattin, additional, Satman, Ilhan, additional, Kalender, Betul, additional, Mankovskyy, Borys, additional, Fushtey, Ivan, additional, Stanislavchuk, Mykola, additional, Kolenyk, Mykola, additional, Dudar, Iryna, additional, Zolotaikina, Viktoriia, additional, Abrahamovych, Orest, additional, Kostynenko, Tetyana, additional, Petrosyan, Olena, additional, Kuskalo, Petro, additional, Galushchak, Olga, additional, Legun, Oleg, additional, Topchii, Ivan, additional, Martynyuk, Liliya, additional, Stryzhak, Vasyl, additional, Panina, Svitlana, additional, Tkach, Sergii, additional, Korpachev, Vadym, additional, Maxwell, Peter, additional, Gnudi, Luigi, additional, Kon, Sui Phin, additional, Tindall, Hilary, additional, Kalra, Phillip, additional, Mark, Patrick, additional, Patel, Dipesh, additional, El-Shahawy, Mohamed, additional, Bai, Liqun, additional, Nica, Romanita, additional, Lien, Yeong-Hau, additional, Menefee, Judson, additional, Busch, Robert, additional, Miller, Alan, additional, Ahmed, Azazuddin, additional, Arif, Ahmed, additional, Lee, Joseph, additional, Desai, Sachin, additional, Bansal, Shweta, additional, Bentsianov, Marie, additional, Belledonne, Mario, additional, Jere, Charles, additional, Gaona, Raul, additional, Greenwood, Gregory, additional, Brusco, Osvaldo, additional, Boiskin, Mark, additional, Belo, Diogo, additional, Minasian, Raffi, additional, Atray, Naveen, additional, Lawrence, Mary, additional, Taliercio, John, additional, Pergola, Pablo, additional, Scott, David, additional, Alvarez, German, additional, Marder, Bradley, additional, Powell, Thomas, additional, Bakdash, Wa'el, additional, Stoica, George, additional, McFadden, Christopher, additional, Rendell, Marc, additional, Wise, Jonathan, additional, Jones, Audrey, additional, Jardula, Michael, additional, Madu, Ivy-Joan, additional, Varghese, Freemu, additional, Tulloch, Brian, additional, Ahmed, Ziauddin, additional, Hames, Melanie, additional, Nazeer, Imran, additional, Shahid, Newman, additional, John, Rekha, additional, Montero, Manuel, additional, Fitz-Patrick, David, additional, Phillips, Lawrence, additional, Guasch, Antonio, additional, Christofides, Elena, additional, Gundroo, Aijaz, additional, Amin, Mohammad, additional, Bowman-Stroud, Cynthia, additional, Link, Michael, additional, Mulloy, Laura, additional, Nammour, Michael, additional, Lalwani, Tarik, additional, Hanson, Lenita, additional, Whaley-Connell, Adam, additional, Herman, Lee, additional, Chatha, Rupi, additional, Osama, Sayed, additional, Liss, Kenneth, additional, Kayali, Zeid, additional, Bhargava, Anuj, additional, Israel, Ezra, additional, Peguero-Rivera, Alfredo, additional, Fang, Michael, additional, Slover, Judith, additional, Barengolts, Elena, additional, Flores, Jose, additional, Muoneke, Rosemary, additional, Savin, Virginia, additional, Awua-Larbi, Stella, additional, Levine, Andrew, additional, Newman, George, additional, Golestaneh, Laden, additional, Bohm, Guillermo, additional, Reisin, Efrain, additional, Cruz, Lucita, additional, Weiss, Robert, additional, Zieve, Franklin, additional, Horwitz, Edward, additional, Chuang, Peale, additional, Mersey, James, additional, Manley, John, additional, Graf, Ronald, additional, Bedros, Fadi, additional, Joshi, Sudhir, additional, Frias, Juan, additional, Assefi, Ali, additional, O'Shaughnessy, Andrew, additional, Brantley, Roman, additional, Minga, Todd, additional, Tietjen, David, additional, Kantor, Samuel, additional, Jamal, Aamir, additional, Guadiz, Ramon, additional, Hershon, Kenneth, additional, Bressler, Peter, additional, Kopyt, Nelson, additional, Cathcart, Harold, additional, Bloom, Scott, additional, Reichel, Ronald, additional, Nakhle, Samer, additional, Dulude, Emily, additional, Tarkan, Joshua, additional, Baker, Penelope, additional, Zeig, Steven, additional, Moya Hechevarria, Jaynier, additional, Ropero-Cartier, Armando, additional, De la Calle, Gilda, additional, Doshi, Ankur, additional, Saba, Fadi, additional, Sligh, Teresa, additional, Shaw, Sylvia, additional, Kumar, Jayant, additional, Szerlip, Harold, additional, Bayliss, George, additional, Perlman, Alan, additional, Sakhrani, Lakhi, additional, Gouge, Steven, additional, Argoud, Georges, additional, Acosta, Idalia, additional, Elder, John, additional, Joshi, Sucharit, additional, Sensenbrenner, John, additional, Vicks, Steven, additional, Mangoo-Karim, Roberto, additional, Galphin, Claude, additional, Leon-Forero, Carlos, additional, Gilbert, John, additional, Brown, Eric, additional, Ijaz, Adeel, additional, Butt, Salman, additional, Markell, Mariana, additional, Arauz-Pacheco, Carlos, additional, Sloan, Lance, additional, Alvarado, Odilon, additional, Jabbour, Serge, additional, Simon, Eric, additional, Rastogi, Anjay, additional, James, Sam, additional, Hall, Karen, additional, Melish, John, additional, Dixon, Brad, additional, Adolphe, Allen, additional, Kovesdy, Csaba, additional, Beddhu, Srinivasan, additional, Solomon, Richard, additional, Fernando, Ronald, additional, Levin, Ellis, additional, Thakar, Charuhas, additional, Robey, Brooks, additional, Goldfarb, David, additional, Fried, Linda, additional, Maddukuri, Geetha, additional, Thomson, Stephen, additional, Annand, Andrew, additional, Kronfli, Saeed, additional, Kalirao, Paramjit, additional, Schmidt, Rebecca, additional, Dahl, Neera, additional, Blumenthal, Samuel, additional, Weinstein, Debra, additional, Ostergaard, Ove, additional, Weinstein, Talia, additional, Ono, Yasuhiro, additional, Yalcin, Murat, additional, and Karim, Shahana, additional

Published
2019
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41. Efficacy and safety of adding mizoribine to standard treatment in patients with immunoglobulin A nephropathy: A randomized controlled trial

Author

Hirai, Keiji, primary, Ookawara, Susumu, additional, Kitano, Taisuke, additional, Miyazawa, Haruhisa, additional, Ito, Kiyonori, additional, Ueda, Yuichirou, additional, Kaku, Yoshio, additional, Hoshino, Taro, additional, Mori, Honami, additional, Yoshida, Izumi, additional, Kubota, Kenji, additional, Yamaji, Yasuyoshi, additional, Takeda, Tetsuro, additional, Nakamura, Yoshikazu, additional, Tabei, Kaoru, additional, and Morishita, Yoshiyuki, additional

Published
2017
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