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269 results on '"Takeda, Atsunobu"'

7. Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis

Author

Yamada, Kazuhisa, Tazaki, Akira, Ushio-Watanabe, Nanako, Usui, Yoshihiko, Takeda, Atsunobu, Matsunaga, Masaaki, Suzumura, Ayana, Shimizu, Hideyuki, Zheng, Hao, Ariefta, Nanang R., Yamamoto, Masahiro, Hara, Hideaki, Goto, Hiroshi, Sonoda, Koh-Hei, Nishiguchi, Koji M., Kato, Masashi, Nishikawa, Yoshifumi, Toyokuni, Shinya, and Kaneko, Hiroki

Published
2023
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15. Functions of mucosal associated invariant T cells in eye diseases

Author

Fukui, Chihiro, primary, Yamana, Satoshi, additional, Xue, Yanqi, additional, Shirane, Mariko, additional, Tsutsui, Hiroki, additional, Asahara, Kenichiro, additional, Yoshitomi, Keiko, additional, Ito, Takako, additional, Lestari, Tantri, additional, Hasegawa, Eiichi, additional, Yawata, Nobuyo, additional, Takeda, Atsunobu, additional, Sonoda, Koh-Hei, additional, and Shibata, Kensuke, additional

Published
2024
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19. Successful Treatment of Hemi-Retinal Vein Occlusion with Macular Edema following Spinal Surgery Using Intravitreal Aflibercept and Retinal Photocoagulation: A Case Report.

Author

Nakatake, Shunji, Sato, Yoshiki, Itotani, Maho, Kimoto, Kenichi, Kubota, Toshiaki, and Takeda, Atsunobu

Subjects
RETINAL vein occlusion, RETINAL surgery, LASER photocoagulation, SPINAL surgery, MACULAR edema, TREATMENT effectiveness, AFLIBERCEPT, LIGHT coagulation
Abstract

Introduction: Perioperative visual loss (POVL) owing to hemi-retinal vein occlusion (HRVO) following prone positioning during spinal surgery is rare. Here, we report a case of HRVO with macular edema (ME) after spinal surgery that was successfully treated with intravitreal aflibercept (IVA) injections and retinal photocoagulation (RP). Case Presentation: A 63-year-old Japanese man underwent spinal surgery for lumbar spinal canal stenosis. Surgery was performed with the patient in the prone position under general anesthesia; the operation time was 305 min. No complications were associated with intraoperative anesthesia. On postoperative day 4, the patient noticed decreased visual acuity in his left eye and visited the Department of Ophthalmology on postoperative day 9. The best-corrected visual acuity (BCVA) in the left eye was 0.1. Fundus and optical coherence tomography revealed HRVO and ME in the left eye. IVA injections and RP were performed in the eye, which substantially decreased the ME and improved the patient's BCVA to 0.8. Conclusions: HRVO can cause POVL after prone positioning during spinal surgery. This is the first case of HRVO with ME after spinal surgery, which was successfully treated with IVA injections and RP. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Clinical Features of Pediatric Uveitis at a Tertiary Referral Center in the Western Region of Japan.

Author

Fukuda, Yosuke, Yawata, Nobuyo, Hasegawa, Eiichi, Yamana, Satoshi, Shirane, Mariko, Ito, Takako, Takeda, Atsunobu, Sonoda, Motoshi, Eguchi, Katsuhide, Ishimura, Masataka, Ohga, Shouichi, and Sonoda, Koh-Hei

Subjects
IRIDOCYCLITIS, BEHCET'S disease, UVEITIS, JUVENILE idiopathic arthritis, SUMMATIVE tests, VISUAL acuity
Abstract

This study aimed to assess the clinical features of pediatric uveitis at a tertiary referral center in Western Japan. One hundred forty eyes of 80 patients aged <20 years at the time of uveitis onset, who visited Kyushu University Hospital between January 2010 and December 2019 were included in this study. Clinical records were retrospectively reviewed. Demographics, clinical findings, treatments, and visual prognoses were compared between the disease groups. Of 80 patients, 32 were males and 48 were females. The average age of onset was 12.5 ± 4.8 (0–19) years. Tubulointerstitial nephritis and uveitis (TINU) and juvenile idiopathic arthritis (JIA) were the most frequent causes, accounting for 11.3% and 10% of cases, respectively, followed by sarcoidosis (5%), Behçet's disease, acute anterior uveitis, Vogt-Koyanagi-Harada disease, and juvenile chronic iridocyclitis (3.8% each). Infectious uveitis accounted for 7.6% of the cases: cytomegalovirus was the most frequent agent. Of these cases, 43.8% were unclassified. Systemic therapies were administered to 87.5% of the patients with JIA, 33.3% of those with TINU, and 28.6% of the other diagnostic groups. In the unclassified group, 80% of the patients were followed up with only topical corticosteroids. LogMAR visual acuity of 0 or less accounted for more than 80% in the final examination. TINU and JIA were the most common causes of pediatric uveitis. Although each required systemic therapy, most unclassified cases of pediatric uveitis were managed by topical corticosteroids alone with good visual prognosis. Accurate diagnosis is important for pediatric uveitis management. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Corrigendum: Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance

Author

Shirane, Mariko, primary, Yawata, Nobuyo, additional, Motooka, Daisuke, additional, Shibata, Kensuke, additional, Khor, Seik-Soon, additional, Omae, Yosuke, additional, Kaburaki, Toshikatsu, additional, Yanai, Ryoji, additional, Mashimo, Hisashi, additional, Yamana, Satoshi, additional, Ito, Takako, additional, Hayashida, Akira, additional, Mori, Yasuo, additional, Numata, Akihiko, additional, Murakami, Yusuke, additional, Fujiwara, Kohta, additional, Ohguro, Nobuyuki, additional, Hosogai, Mayumi, additional, Akiyama, Masato, additional, Hasegawa, Eiichi, additional, Paley, Michael, additional, Takeda, Atsunobu, additional, Maenaka, Katsumi, additional, Akashi, Koichi, additional, Yokoyama, Wayne M., additional, Tokunaga, Katsushi, additional, Yawata, Makoto, additional, and Sonoda, Koh-Hei, additional

Published
2023
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24. Factors associated with low prevalence of Fuchs' uveitis syndrome in Japan

Author

Yoneda, Yu, Usui, Yoshihiko, Tanaka, Rie, Hase, Keitaro, Namba, Kenichi, Kamoi, Koju, Takase, Hiroshi, Takeuchi, Masaki, Matsumiya, Wataru, Kusuhara, Sentaro, Takeda, Atsunobu, Yawata, Nobuyo, Yanai, Ryoji, Hiyama, Tomona, Harada, Yosuke, Hashida, Noriyasu, Maruyama, Kazuichi, Nakai, Kei, Taguchi, Ryo, Kaburaki, Toshikatsu, Mizuki, Nobuhisa, Goto, Hiroshi, Fujino, Yujiro, and Takeuchi, Masaru

Subjects
General Medicine
Abstract

AimTo investigate the causes of low prevalence of Fuchs' uveitis syndrome (FUS) in Japan.MethodsMedical records of 160 patients diagnosed with FUS at 14 uveitis specialty facilities in Japan were reviewed retrospectively.ResultsIn 160 FUS patients, mean follow-up period before referral to our uveitis facilities was 31.6 ± 50.9 months. The most common reason for referral was idiopathic uveitis (61.9%), followed by cataract (25.0%), high intraocular pressure (IOP) including glaucoma (16.3%), and FUS (14.4%). Unilateral involvement was 96.9%. The most frequent ocular finding of FUS was anterior inflammation (91.9%), followed by stellate-shaped keratic precipitates (88.1%), cataract/pseudophakia (88.1%), diffuse iris atrophy (84.4%), vitreous opacity (62.5%), heterochromia (53.1%) and high IOP including glaucoma (36.3%). As treatments of these ocular findings, cataract surgery was performed in 52.5%, glaucoma surgery in 10.6%, and vitrectomy in 13.8%. Mean logMAR VA was 0.28 ± 0.59 at the initial visit, and decreased significantly to 0.04 ± 0.32 at the last visit. Proportions of FUS patients with BCVA ConclusionsOcular findings of FUS in Japanese FUS patients were consistent with the characteristic features. The low prevalence of FUS in Japan may be a result of being overlooked and misdiagnosed as mild idiopathic uveitis, cataract, and/or glaucoma.

Published
2022

25. Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance

Author

Shirane, Mariko, primary, Yawata, Nobuyo, additional, Motooka, Daisuke, additional, Shibata, Kensuke, additional, Khor, Seik-Soon, additional, Omae, Yosuke, additional, Kaburaki, Toshikatsu, additional, Yanai, Ryoji, additional, Mashimo, Hisashi, additional, Yamana, Satoshi, additional, Ito, Takako, additional, Hayashida, Akira, additional, Mori, Yasuo, additional, Numata, Akihiko, additional, Murakami, Yusuke, additional, Fujiwara, Kohta, additional, Ohguro, Nobuyuki, additional, Hosogai, Mayumi, additional, Akiyama, Masato, additional, Hasegawa, Eiichi, additional, Paley, Michael, additional, Takeda, Atsunobu, additional, Maenaka, Katsumi, additional, Akashi, Koichi, additional, Yokoyama, Wayne M., additional, Tokunaga, Katsushi, additional, Yawata, Makoto, additional, and Sonoda, Koh-Hei, additional

Published
2022
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26. Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography

Author

Wada, Iori, primary, Nakao, Shintaro, additional, Arima, Mitsuru, additional, Ishikawa, Keijiro, additional, Yamaguchi, Muneo, additional, Kaizu, Yoshihiro, additional, Sekiryu, Haruka, additional, Mori, Kenichiro, additional, Kiyohara, Kohei, additional, Takeda, Atsunobu, additional, Ishibashi, Tatsuro, additional, Sadda, SriniVas R., additional, and Sonoda, Koh-Hei, additional

Published
2022
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28. Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia

Author

Takeda, Atsunobu, primary, Sakoda, Teppei, additional, Yawata, Nobuyo, additional, Kato, Koji, additional, Hasegawa, Eiichi, additional, Shima, Takahiro, additional, Hikita, Shinichi, additional, Yoshitomi, Keiko, additional, Takenaka, Katsuto, additional, Oda, Yoshinao, additional, Akashi, Koichi, additional, and Sonoda, Koh-Hei, additional

Published
2022
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32. Circulating inflammatory monocytes oppose microglia and contribute to cone cell death in retinitis pigmentosa

Author

Funatsu, Jun, primary, Murakami, Yusuke, additional, Shimokawa, Shotaro, additional, Nakatake, Shunji, additional, Fujiwara, Kohta, additional, Okita, Ayako, additional, Fukushima, Masatoshi, additional, Shibata, Kensuke, additional, Yoshida, Noriko, additional, Koyanagi, Yoshito, additional, Akiyama, Masato, additional, Notomi, Shoji, additional, Nakao, Shintaro, additional, Hisatomi, Toshio, additional, Takeda, Atsunobu, additional, Paschalis, Eleftherios I, additional, Vavvas, Demetrios G, additional, Ikeda, Yasuhiro, additional, and Sonoda, Koh-Hei, additional

Published
2022
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37. Surgical Outcomes of Contrast Sensitivity and Visual Acuity in Uveitis-Associated Cataract

Author

Takeda,Atsunobu, Hasegawa,Eiichi, Notomi,Shoji, Ishikawa,Keijiro, Arima,Mitsuru, Murakami,Yusuke, Nakao,Shintaro, Hisatomi,Toshio, Sonoda,Koh-Hei, Takeda,Atsunobu, Hasegawa,Eiichi, Notomi,Shoji, Ishikawa,Keijiro, Arima,Mitsuru, Murakami,Yusuke, Nakao,Shintaro, Hisatomi,Toshio, and Sonoda,Koh-Hei

Abstract

Atsunobu Takeda,1,2 Eiichi Hasegawa,1 Shoji Notomi,1,2 Keijiro Ishikawa,1 Mitsuru Arima,1,2 Yusuke Murakami,1 Shintaro Nakao,1 Toshio Hisatomi,3 Koh-Hei Sonoda1,4 1Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 2Department of Ophthalmology, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan; 3Department of Ophthalmology, Chikushi Hospital, Fukuoka University, Fukuoka, Japan; 4Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanCorrespondence: Atsunobu TakedaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, JapanTel +81-92-642-5648Fax +81-92-642-5663Email takeda.atsunobu.248@m.kyushu-u.ac.jpPurpose: To evaluate the pre- and post-operative outcomes of phacoemulsification in patients with uveitis-associated cataract in remission, such as conventional visual acuity (VA), photopic and mesopic contrast visual acuity (CVA), and flares in the anterior chamber objectively assessed as intraocular inflammation.Patients and Methods: This prospective study included 26 eyes of 19 patients with uveitis and 45 eyes of 26 controls who underwent cataract surgery at the Kyushu University Hospital and Kyushu Medical Center in Fukuoka, Japan, from October 2016 to December 2018. Conventional VA and flare values in the anterior chamber were evaluated preoperatively and 1 and 3 months postoperatively. Photopic and mesopic CVAs were assessed preoperatively and 3 months postoperatively.Results: The best-corrected VA (BCVA) was improved significantly from baseline to 1 and 3 months postoperatively in both groups (P < 0.01 in both groups). The mean preoperative 100% and 10% CVAs under the photopic condition were significantly lower in the uveitis group than in the control group (P < 0.05 for both CVA), whereas the mean preoperative 100% C

Published
2021

40. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

Author

Albuquerque, Romulo J.C., Hayashi, Takahiko, Cho, Won Gil, Kleinman, Mark E., Dridi, Sami, Takeda, Atsunobu, Baffi, Judit Z., Yamada, Kiyoshi, Kaneko, Hiroki, Green, Martha G., Chappell, Joe, Wilting, Jorg, Weich, Herbert A., Yamagami, Satoru, Amano, Shiro, Mizuki, Nobuhisa, Alexander, Jonathan S., Peterson, Martha L., Brekken, Rolf A., Hirashima, Masanori, Capoor, Seema, Usui, Tomohiko, Ambati, Balamurali K., and Ambati, Jayakrishna

Subjects
Company growth, United States. Food and Drug Administration -- Powers and duties, Vascular endothelial growth factor -- Physiological aspects, Vascular endothelial growth factor -- Research
Abstract

Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not to our knowledge been previously described. We report the existence of a splice variant of the gene encoding vascular endothelial growth factor receptor-2 (Vegfr-2) that encodes a secreted form of the protein, designated soluble Vegfr-2 (sVegfr-2), that inhibits developmental and reparative lymphangiogenesis by blocking Vegf-c function. Tissue-specific loss of sVegfr-2 in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea and hyperplasia of skin lymphatics without affecting blood vasculature. Administration of sVegfr-2 inhibited lymphangiogenesis but not hemangiogenesis induced by corneal suture injury or transplantation, enhanced corneal allograft survival and suppressed lymphangioma cellular proliferation. Naturally occurring sVegfr-2 thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of sVegfr-2 might have therapeutic effects in treating lymphatic vascular malformations, transplantation rejection and, potentially, tumor lymphangiogenesis and lymphedema., The blood and lymphatic vessel networks are jointly essential for development, wound healing and immune surveillance and activation. Pathological responses of these parallel circulatory systems can lead to diseases as [...]

Published
2009

41. CCR3 is a target for age-related macular degeneration diagnosis and therapy

Author

Takeda, Atsunobu, Baffi, Judit Z., Kleinman, Mark E., Cho, Won Gil, Nozaki, Miho, Yamada, Kiyoshi, Kaneko, Hiroki, Albuquerque, Romulo J.C., Dridi, Sami, Saito, Kuniharu, Raisler, Brian J., Budd, Steven J., Geisen, Pete, Munitz, Ariel, Ambati, Balamurali K., Green, Martha G., Ishibashi, Tatsuro, Wright, John D., Humbles, Alison A., Gerard, Craig J., Ogura, Yuichiro, Pan, Yuzhen, Smith, Justine R., Grisanti, Salvatore, Hartnett, M. Elizabeth, Rothenberg, Marc E., and Ambati, Jayakrishna

Subjects
Chemokine receptors -- Physiological aspects -- Genetic aspects, Macular degeneration -- Physiological aspects -- Genetic aspects -- Care and treatment, Environmental issues, Science and technology, Zoology and wildlife conservation, Care and treatment, Physiological aspects, Genetic aspects
Abstract

Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expressed in choroidal neovascular endothelial cells in humans with AMD, and that despite the expression of its ligands eotaxin-1, -2 and -3, neither eosinophils nor mast cells are present in human CNV. Genetic or pharmacological targeting of CCR3 or eotaxins inhibited injury-induced CNV in mice. CNV suppression by CCR3 blockade was due to direct inhibition of endothelial cell proliferation, and was uncoupled from inflammation because it occurred in mice lacking eosinophils or mast cells, and was independent of macrophage and neutrophil recruitment. CCR3 blockade was more effective at reducing CNV than vascular endothelial growth factor A (VEGF-A) neutralization, which is in clinical use at present, and, unlike VEGF-A blockade, is not toxic to the mouse retina. In vivo imaging with CCR3-targeting quantum dots located spontaneous CNV invisible to standard fluorescein angiography in mice before retinal invasion. CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition., AMD affects 30-50 million people globally, with approximately 90% of severe vision loss attributed to CNV (1). The worldwide prevalence of CNV is expected to double in the next decade [...]

Published
2009

42. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

Author

Kleinman, Mark E., Yamada, Kiyoshi, Takeda, Atsunobu, Chandrasekaran, Vasu, Nozaki, Miho, Baffi, Judit Z., Albuquerque, Romulo J.C., Yamasaki, Satoshi, Itaya, Masahiro, Pan, Yuzhen, Appukuttan, Binoy, Gibbs, Daniel, Yang, Zhenglin, Kariko, Katalin, Ambati, Balamurali K., Wilgus, Traci A., DiPietro, Luisa A., Sakurai, Eiji, Zhang, Kang, Smith, Justine R., Taylor, Ethan W., and Ambati, Jayakrishna

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from age-related macular [...]

Published
2008

45. Changes of Serum Inflammatory Molecules and Their Relationships with Visual Function in Retinitis Pigmentosa

Author

Okita, Ayako, primary, Murakami, Yusuke, additional, Shimokawa, Shotaro, additional, Funatsu, Jun, additional, Fujiwara, Kohta, additional, Nakatake, Shunji, additional, Koyanagi, Yoshito, additional, Akiyama, Masato, additional, Takeda, Atsunobu, additional, Hisatomi, Toshio, additional, Ikeda, Yasuhiro, additional, and Sonoda, Koh-Hei, additional

Published
2020
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47. Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population

Author

Sakono, Takuto, primary, Meguro, Akira, additional, Takeuchi, Masaki, additional, Yamane, Takahiro, additional, Teshigawara, Takeshi, additional, Kitaichi, Nobuyoshi, additional, Horie, Yukihiro, additional, Namba, Kenichi, additional, Ohno, Shigeaki, additional, Nakao, Kumiko, additional, Sakamoto, Taiji, additional, Sakai, Tsutomu, additional, Nakano, Tadashi, additional, Keino, Hiroshi, additional, Okada, Annabelle A., additional, Takeda, Atsunobu, additional, Ito, Takako, additional, Mashimo, Hisashi, additional, Ohguro, Nobuyuki, additional, Oono, Shinichirou, additional, Enaida, Hiroshi, additional, Okinami, Satoshi, additional, Horita, Nobuyuki, additional, Ota, Masao, additional, and Mizuki, Nobuhisa, additional

Published
2020
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49. Corneal avascularity is due to soluble VEGF receptor-1

Author

Ambati, Balamurali K., Nozaki, Miho, Singh, Nirbhai, Takeda, Atsunobu, Jani, Pooja D., Suthar, Tushar, Albuquerque, Romulo J. C., Richter, Elizabeth, Sakurai, Eiji, Newcomb, Michael T., Kleinman, Mark E., Caldwell, Ruth B., Lin, Qing, Ogura, Yuichiro, Orecchia, Angela, Samuelson, Don A., Agnew, Dalen W., St. Leger, Judy, Green, W. Richard, Mahasreshti, Parameshwar J., Curiel, David T., Kwan, Donna, Marsh, Helene, Ikeda, Sakae, Leiper, Lucy J., Collinson, J. Martin, Bogdanovich, Sasha, Khurana, Tejvir S., Shibuya, Masabumi, Baldwin, Megan E., Ferrara, Napoleone, Gerber, Hans-Peter, De Falco, Sandro, Witta, Jassir, Baffi, Judit Z., Raisler, Brian J., and Ambati, Jayakrishna

Published
2006

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