Search

Your search keyword '"Takebayashi Y"' showing total 481 results
Start Over Author "Takebayashi Y"
481 results on '"Takebayashi Y"'

1. Cognitive Behavioral Therapy Reduces Benzodiazepine Anxiolytics Use in Japanese Patients with Mood and Anxiety Disorders: A Retrospective Observational Study

Author

Nakajima A, Kanie A, Ito M, Hirabayashi N, Imamura F, Takebayashi Y, and Horikoshi M

Subjects
psychiatric diseases, depression, acquired dependency, discontinuation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Aiichiro Nakajima,1 Ayako Kanie,1 Masaya Ito,1 Naotsugu Hirabayashi,2 Fumi Imamura,3 Yoshitake Takebayashi,1,4 Masaru Horikoshi1 1National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Tokyo, Japan; 2Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan; 3Department of Clinical Psychology, National Center of Neurology and Psychiatry, Tokyo, Japan; 4Department of Health Risk Communication, School of Medicine, Fukushima Medical University, Fukushima, JapanCorrespondence: Aiichiro NakajimaNational Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo 187-8551, JapanTel +81-42-341-2711Fax +81-42-346-1944Email aiichiro.nakajima@ncnp.go.jpPurpose: Benzodiazepines (BZDs) are prescribed to treat psychiatric diseases. However, many guidelines recommend limiting the use of BZDs because of side effects and lack of evidence regarding long-term efficacy. Moreover, reducing BZDs’ use is difficult because of dependency and the severity of withdrawal symptoms. The efficacy of cognitive behavioral therapy (CBT) for mood and anxiety disorders has been demonstrated. However, there is scant evidence that CBT has effectively reduced BZDs use, especially in Japan, where the BZDs prescription rate is high. Therefore, we sought to examine the impact of CBT on reducing BZDs use in a Japanese psychiatric setting.Patients and Methods: Participants were outpatients with mood and anxiety disorders who were prescribed BZD anxiolytics. We retrospectively reviewed changes in BZD anxiolytics prescription dosages during CBT (66 patients; mean number of CBT sessions, 14.6) from our hospital record between April 2015 and September 2017. We checked prescriptions at four time points: at first interview for judging adaptation of CBT (baseline), at the first CBT session, at the last CBT session, and 3 months after the last CBT session.Results: A total of 13 of 66 patients discontinued BZD anxiolytics during CBT, and 21 of 66 reduced their prescribed dosage by 50%. The association between discontinuation and dose-reduction and assessment period was modeled simultaneously using Bayesian hierarchical hurdle model. Results from the modeling showed a significant discontinuation at post-CBT and at 3 months post-CBT session compared to baseline (estimated median odds ratio [OR] post-CBT = 9.79 [95% CI: 4.65– 20.45]; OR at 3 months post-CBT = 11.53 [95% CI: 6.06– 22.33]). Moreover, a significant dose reduction was observed post-intervention (estimated median relative risk = 0.845 [95% CI: 0.729– 0.982]), with a median reduction of 1.7 mg (diazepam conversion) in BZD use.Conclusion: Our results suggest that CBT possibly aids in reducing and discontinuing BZD anxiolytics use for Japanese patients.Keywords: psychiatric diseases, depression, acquired dependency, discontinuation

Published
2020

2. Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study

Author

Ohnuma T, Toda A, Kimoto A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N, and Arai H

Subjects
Alzheimer’s disease, medium-chain triglycerides, ketone, cognitive function, apolipoprotein E epsilon 4, Geriatrics, RC952-954.6
Abstract

Tohru Ohnuma, Aiko Toda, Ayako Kimoto, Yuto Takebayashi, Ryoko Higashiyama, Yuko Tagata, Masanobu Ito, Tsuneyoshi Ota, Nobuto Shibata, Heii Arai Department of Psychiatry, Juntendo University Alzheimer’s Disease Project, Faculty of Medicine, Juntendo University, Tokyo, Japan Objectives: This is the first clinical trial of this type in Japan, designed to analyze two important aspects of Alzheimer’s disease (AD) management using medium-chain triglycerides. Axona was administered for 3 months (40 g of powder containing 20 g of caprylic triglycerides). We used an indurating, four-step dose-titration method (from 10 to 40 g per day) for 7 days before the trial, and examined the tolerance and adverse effects of this intervention. We also investigated its effect on cognitive function in mild-to-moderate AD patients.Patients and methods: This was a clinical intervention in 22 Japanese patients with sporadic AD at a mild-to-moderate stage (ten females, 12 males), mean age (± standard deviation) 63.9 (±8.5) years, Mini-Mental State Examination (MMSE) score, 10–25, seven patients were ApoE4-positive. During Axona administration, we examined changes in cognitive function by obtaining MMSE and AD assessment-scale scores. Intolerance and serum ketone concentrations were also examined.Results: The tolerance of Axona was good, without severe gastrointestinal adverse effects. Axona did not improve cognitive function in our sample of AD patients, even in those patients without the ApoE4 allele. However, some ApoE4-negative patients with baseline MMSE score ≥14 showed improvement in their cognitive functions.Conclusion: The modified dose-titration method, starting with a low dose of Axona, decreased gastrointestinal adverse effects in Japanese patients. Axona might be effective for some relatively mildly affected patients with AD (with cognitive function MMSE score of ≥14 and lacking the ApoE4 allele). Keywords: Alzheimer’s disease, medium-chain triglycerides, ketone, cognitive function, apolipoprotein E epsilon 4

Published
2016

4. Classifying patients with depressive and anxiety disorders according to symptom network structures: A Gaussian graphical mixture model-based clustering

Author

Li, Z, Kashihara, J, Takebayashi, Y, Kunisato, Y, Ito, M, Li, Z, Kashihara, J, Takebayashi, Y, Kunisato, Y, and Ito, M

Abstract

Patients with mental disorders often suffer from comorbidity. Transdiagnostic understandings of mental disorders are expected to provide more accurate and detailed descriptions of psychopathology and be helpful in developing efficient treatments. Although conventional clustering techniques, such as latent profile analysis, are useful for the taxonomy of psychopathology, they provide little implications for targeting specific symptoms in each cluster. To overcome these limitations, we introduced Gaussian graphical mixture model (GGMM)-based clustering, a method developed in mathematical statistics to integrate clustering and network statistical approaches. To illustrate the technical details and clinical utility of the analysis, we applied GGMM-based clustering to a Japanese sample of 1,521 patients (Mage = 42.42 years), who had diagnostic labels of major depressive disorder (MDD; n = 406), panic disorder (PD; n = 198), social anxiety disorder (SAD; n = 116), obsessive-compulsive disorder (OCD; n = 66), comorbid MDD and any anxiety disorder (n = 636), or comorbid anxiety disorders (n = 99). As a result, we identified the following four transdiagnostic clusters characterized by i) strong OCD and PD symptoms, and moderate MDD and SAD symptoms; ii) moderate MDD, PD, and SAD symptoms, and weak OCD symptoms; iii) weak symptoms of all four disorders; and iv) strong symptoms of all four disorders. Simultaneously, a covariance symptom network within each cluster was visualized. The discussion highlighted that the GGMM-based clusters help us generate clinical hypotheses for transdiagnostic clusters by enabling further investigations of each symptom network, such as the calculation of centrality indexes.

Published
2021

5. Theoretical screening of candidate materials for DRAM capacitors and experimental demonstration of a cubic-hafnia MIM capacitor

Author

Mise, N., Ogawa, A., Tonomura, O., Sekiguchi, T., Horii, S., Itatani, H., Saito, T., Sakai, M., Takebayashi, Y., Yamazaki, H., and Torii, K.

Subjects
Random access memory -- Usage, Capacitors -- Innovations, Tunneling (Physics) -- Analysis, Distribution (Probability theory) -- Usage, Electrodes -- Usage, RAM, Business, Electronics, Electronics and electrical industries
Published
2010

6. The relationship between geographical region and perceptions of radiation risk after the Fukushima accident: The mediational role of knowledge

Author

Kashiwazaki, Y., Takebayashi, Y., Murakami, M., Kashiwazaki, Y., Takebayashi, Y., and Murakami, M.

Abstract

Since the Fukushima accident, radiation risk perception has been of public concern. Factors related to regional differences in radiation risk perception and the role that knowledge of radiation effects plays are still not clearly understood. Here, we first assessed the validity of the Lindell radiation risk perception scale by comparing it with the mortality rate of traffic accidents. We then investigated the relationship between the perceptions and both the geographical regions and the knowledge of genetic effects and, further, verified the mediating role of knowledge in the perception. The sample comprised of 832 participants who responded to an online questionnaire in August 2018 from Tokyo and Fukushima. There was a significant association between the Lindell scale and the perceived magnitude of genetic risk relative to traffic accident mortality. Knowledge of genetic effects, after the atomic bombs, was associated with perceptions of lower genetic risks. The relationship between geographical region and risk perception was mediated by knowledge. However, approximately 40% of those who had knowledge still perceived a high risk, indicating that perception is not governed by knowledge alone. In addition to efforts to share knowledge, it is important to interactively communicate regarding risk to alleviate the anxiety felt by individuals.

Published
2022
Full Text
View/download PDF

9. Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study

Author

Jinnin R, Okamoto Y, Takagaki K, Nishiyama Y, Yamamura T, Miyake Y, Takebayashi Y, Tanaka K, Sugiura Y, Shimoda H, Kawakami N, Furukawa TA, and Yamawaki S

Subjects
Subthreshold depression, University student, Major depressive episode, cohort study, Neurosciences. Biological psychiatry. Neuropsychiatry, Neurology. Diseases of the nervous system, RC346-429, Adolescence, RC321-571
Abstract

Ran Jinnin,1 Yasumasa Okamoto,1 Koki Takagaki,1 Yoshiko Nishiyama,1 Takanao Yamamura,1 Yuri Okamoto,2 Yoshie Miyake,2 Yoshitake Takebayashi,3 Keisuke Tanaka,4 Yoshinori Sugiura,5 Haruki Shimoda,6 Norito Kawakami,6 Toshi A Furukawa,7 Shigeto Yamawaki1 1Department of Psychiatry and Neurosciences, 2Health Service Center, Hiroshima University, Hiroshima, Japan; 3Risk Analysis Research Center, The Institute of Statistical Mathematics, Tokyo, Japan; 4Graduated School of Education, Joetsu University of Education, Niigata, Japan; 5Graduated School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan; 6Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 7Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan Purpose: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year.Patients and methods: One hundred and seventy-two participants

Published
2016

11. Cognitive behavioral therapy for depression in Japanese Parkinson's disease patients: a pilot study

Author

Shinmei I, Kobayashi K, Oe Y, Takagishi Y, Kanie A, Ito M, Takebayashi Y, Murata M, Horikoshi M, and Dobkin RD

Subjects
Japan, Parkinson's disease, depression, pilot study, Neurosciences. Biological psychiatry. Neuropsychiatry, Neurology. Diseases of the nervous system, RC346-429, cognitive behavioral therapy, RC321-571
Abstract

Issei Shinmei,1,2 Kei Kobayashi,3 Yuki Oe,1 Yuriko Takagishi,1,4 Ayako Kanie,1 Masaya Ito,1 Yoshitake Takebayashi,1,5 Miho Murata,3 Masaru Horikoshi,1 Roseanne D Dobkin6 1National Center for Cognitive Behavioral Therapy and Research, National Center of Neurology and Psychiatry, Tokyo, Japan; 2Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan; 3Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan; 4Department of Psychology, Surugadai University, Saitama, Japan; 5Risk Analysis Research Center, The Institute of Statistical Mathematics, Tokyo, Japan; 6Department of Psychiatry, Rutgers-Robert Wood Johnson Medical school, NJ, USA Objectives: This study evaluated the feasibility of cognitive behavioral therapy (CBT) for Japanese Parkinson’s disease (PD) patients with depression. To increase cultural acceptability, we developed the CBT program using manga, a type of Japanese comic novel.Methods: Participants included 19 non-demented PD patients who had depressive symptoms (GRID-Hamilton Rating Scale for Depression score ≥8). A CBT program comprising six sessions was individually administered. We evaluated the feasibility and safety of the CBT program in terms of the dropout rate and occurrence of adverse events. The primary outcome was depressive symptom reduction in the GRID-Hamilton Rating Scale for Depression upon completion of CBT. Secondary outcomes included changes in the self-report measures of depression (Beck Depression Inventory-II, Hospital Anxiety and Depression Scale-Depression), anxiety (Hospital Anxiety and Depression Scale-Anxiety, State and Trait Anxiety Inventory, Overall Anxiety Severity and Impairment Scale), functional impairment, and quality of life (Medical Outcomes Study 36-Item Short-Form Health Survey).Results: Of the 19 participants (mean age =63.8years, standard deviation [SD] =9.9 years; mean Hohen–Yahr score =1.7, SD =0.8), one patient (5%) withdrew. No severe adverse event was observed. The patients reported significant improvements in depression (Hedges’ g =-1.02, 95% confidence interval =-1.62 to -0.39). The effects were maintained over a 3-month follow-up period. Most of the secondary outcome measurements showed a small-to-moderate but nonsignificant effect size from baseline to post-intervention.Conclusion: This study provides preliminary evidence that CBT is feasible among Japanese PD patients with depression. Similar approaches may be effective for people with PD from other cultural backgrounds. The results warrant replication in a randomized controlled trial. Keywords: CBT, anxiety, Japan, dPD, comorbidity

Published
2016

15. Study of polar dumbbell fluids from the gaseous to the liquid densities by the reference interaction site model-1 and -2 integral equations.

Author

Takebayashi, Y., Kimura, Y., Hirota, N., and Ohba, M.

Subjects
*FLUIDS, *THERMODYNAMICS, *INTEGRAL equations
Abstract

The structures and the thermodynamic properties of a fluid composed of a nonpolar or a polar dumbbell molecule have been studied from the gaslike to the liquidlike density regions based on two types of the reference interaction site model (RISM) integral equation theories (RISM-1 and RISM-2). This is the first application of the RISM-2 theory to a polar dumbbell fluid. We have proven that the RISM-2 theory with the hypernetted-chain (HNC) approximation has an inconsistency with respect to the zeroth-order relation between site–site total correlation functions and site–site direct correlation functions in the Fourier space. An hypothetical bridge function is introduced to remedy this inconsistency, which works well to give good information on the structure and the dielectric constant in the lower-density region. On the other hand, the RISM-1 theory works well in the higher-density region, but not well in the lower-density region. Complemental application of these theories, that is, the RISM-1 theory for the high-density region and the RISM-2 theory for the low-density region, allows us to understand the properties of fluid over wide density regions. © 1996 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
1996
Full Text
View/download PDF

16. Effect of the solvent density and species on the back-electron transfer rate in the....

Author

Kimura, Y. and Takebayashi, Y.

Subjects
*CHARGE exchange, *ELECTRON donor-acceptor complexes
Abstract

Examines the back-electron transfer (b-ET) process in the charge transfer complex of hexamethylbenzene/tetracyanoethylene. Use of the transient absorption spectroscopy; Determination of the b-ET rate; Analysis of the decay rate of the excited state absorption; Estimation of the reaction free energy and the solvent reorganization energy.

Published
1998
Full Text
View/download PDF

17. A plant U-box protein, PUB4, regulates asymmetric cell division and cell proliferation in the root meristem

Author

Kinoshita, A., ten Hove, C.A., Tabata, R., Yamada, M., Shimizu, N., Ishida, T., Yamaguchi, K., Shigenobu, S., Takebayashi, Y., Luchies, J., Kobayashi, M., Kurata, T., Wada, T., Seo, M., Hasebe, M., Blilou, I., Fukuda, H., Scheres, B., Heidstra, R., Kamiya, Y., Sawa, S., Kinoshita, A., ten Hove, C.A., Tabata, R., Yamada, M., Shimizu, N., Ishida, T., Yamaguchi, K., Shigenobu, S., Takebayashi, Y., Luchies, J., Kobayashi, M., Kurata, T., Wada, T., Seo, M., Hasebe, M., Blilou, I., Fukuda, H., Scheres, B., Heidstra, R., Kamiya, Y., and Sawa, S.

Abstract

The root meristem (RM) is a fundamental structure that is responsible for postembryonic root growth. The RM contains the quiescent center (QC), stem cells and frequently dividing meristematic cells, in which the timing and the frequency of cell division are tightly regulated. In Arabidopsis thaliana, several gain-of-function analyses have demonstrated that peptide ligands of the CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION-RELATED (CLE) family are important for maintaining RM size. Here, we demonstrate that a plant U-box E3 ubiquitin ligase, PUB4, is a novel downstream component of CLV3/CLE signaling in the RM. Mutations in PUB4 reduced the inhibitory effect of exogenous CLV3/CLE peptide on root cell proliferation and columella stem cell maintenance. Moreover, pub4 mutants grown without exogenous CLV3/CLE peptide exhibited characteristic phenotypes in the RM, such as enhanced root growth, increased number of cortex/endodermis stem cells and decreased number of columella layers. Our phenotypic and gene expression analyses indicated that PUB4 promotes expression of a cell cycle regulatory gene, CYCD6;1, and regulates formative periclinal asymmetric cell divisions in endodermis and cortex/endodermis initial daughters. These data suggest that PUB4 functions as a global regulator of cell proliferation and the timing of asymmetric cell division that are important for final root architecture.

Published
2015

19. Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line

Author

Urasaki, Y., Laco, G. S., Philippe Pourquier, Takebayashi, Y., Kohlhagen, G., Gioffre, C., Zhang, H., Chatterjee, D., Pantazis, P., Pommier, Y., Pourquier, Philippe, IDvet [Grabels], Institute of Theoretical and Computational Chemistry, and Nanjing University (NJU)

Subjects
Male, Base Sequence, Sequence Homology, Amino Acid, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Prostatic Neoplasms, Simian virus 40, Antineoplastic Agents, Phytogenic, Catalysis, Recombinant Proteins, [SDV] Life Sciences [q-bio], DNA Topoisomerases, Type I, Drug Resistance, Neoplasm, DNA, Viral, Mutation, Tumor Cells, Cultured, Humans, Camptothecin, Amino Acid Sequence, Enzyme Inhibitors, Topoisomerase I Inhibitors
Abstract

International audience; In this study, we characterized the structure and function of topoisomerase I (top1) protein in the camptothecin (CPT)-resistant prostate cancer cell lines, DU-145/RC0.1 and DU-145/RC1 (RC0.1 and RC1, respectively). Both of the cell lines were previously selected by continuous exposure to 9-nitro-CPT. The RC0.1 and RC1 cells have high cross-resistance to CPT derivatives including SN-38 and topotecan, but are not cross-resistant to the non-top1 inhibitors etoposide, doxorubicin, and vincristine. Although the top1 protein levels were not decreased in the resistant cells compared with the parental cells, CPT-induced DNA cleavage was markedly reduced in the RC0.1 and RC1 nuclear extracts. The resistant-cell-line nuclear extracts also demonstrated top1 catalytic activity and resistance to CPT, in in vitro assays. Reverse transcription-PCR products from the resistant cell lines were sequenced, and revealed a point mutation resulting in a R364H mutation in the top1 of both RC0.1 and RC1. No wild-type top1 RNA or genomic DNA was detected in the resistant cell lines. Using a purified recombinant R364H top1, we found that the R364H mutant top1 was CPT resistant and fully active. In the published top1 crystal structure, the R364H mutation is close to the catalytic tyrosine and other well-known mutations leading to CPT resistance.

Published
2001

33. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma.

Author

Takebayashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, Murata F, Aikou T, Takebayashi, Y, Akiyama, S, Akiba, S, Yamada, K, Miyadera, K, Sumizawa, T, Yamada, Y, Murata, F, and Aikou, T

Abstract

Background: Platelet-derived endothelial cell growth factor (PD-ECGF) is known to promote the development of new blood vessels, which are fundamental to tumor growth and metastasis. We previously found that thymidine phosphorylase (dThdPase) and PD-ECGF are the same protein.Purpose: We retrospectively examined the expression of dThdPase in primary colorectal carcinomas, its association with angiogenesis and clinicopathologic findings, and its prognostic value.Methods: Tissues were obtained from the tumors of 163 patients whose colorectal carcinomas were completely removed by surgery. Microvessels assessed by immunostaining endothelial cells for factor VIII were counted on a 400x field in the most active areas of neovascularization within the tumor. We purified the monoclonal antibody against dThdPase and studied the expression of dThdPase in the same serial sections used for the detection of factor VIII. Those who carried out microvessel counting and dThdPase expression assessment had no knowledge of clinicopathologic findings. The significance of dThdPase in the prognosis of patients with colorectal carcinomas was also examined in the survival analysis of mortality follow-up data covering the period between 1984 through 1991. Reported P values are from two-sided tests of statistical significance.Results: The mean microvessel count (+/- standard deviation) in dThdPase-positive colorectal carcinoma specimens (17.5 +/- 7.2) was higher (P < .001) than that in dThdPase-negative carcinoma specimens (9.3 +/- 5.5). The dThdPase positivity was in accordance with the microvessel count. dThdPase positivity showed highly significant statistical associations with tumor size, extent of invasion, lymph node metastasis, lymphatic invasion, and venous invasion. Cox regression analysis revealed that dThdPase expression was prognostic for poor disease outcome after adjustment for Dukes' stage and microvessel count.Conclusions: These findings suggest that higher levels of dThdPase expression in colorectal carcinomas are associated with more extensive angiogenesis, poor clinical and laboratory findings, and unfavorable clinical outcome.Implications: Inhibition of dThdPase in human colorectal carcinomas might improve prognosis for some patients. [ABSTRACT FROM AUTHOR]

Published
1996
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results