1. Microsatellite Instability-high Intrahepatic Cholangiocarcinoma with Portal Vein Tumor Thrombosis Successfully Treated with Pembrolizumab
- Author
-
Tatsuma Murakami, Yoshizumi Kitamoto, Sanae Uehara, Tetsushi Ogawa, Atsushi Naganuma, Hiroshi Ishihara, Takayoshi Sakuda, Kosuke Aihara, Hidetoshi Yasuoka, Erina Shibasaki, Tomohiro Kudo, Tomoyuki Masuda, Yuhei Suzuki, Akira Ogawa, Yuta Watanuki, and Takashi Hoshino
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Immune checkpoint inhibitors ,immune checkpoint inhibitor ,Case Report ,Pembrolizumab ,030204 cardiovascular system & hematology ,Antibodies, Monoclonal, Humanized ,Gastroenterology ,Cholangiocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Antineoplastic Agents, Immunological ,intrahepatic cholangiocarcinoma ,Internal medicine ,Internal Medicine ,Medicine ,Humans ,microsatellite instability-high ,Adverse effect ,Intrahepatic Cholangiocarcinoma ,Venous Thrombosis ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Portal Vein ,Microsatellite instability ,General Medicine ,portal vein tumor thrombosis ,Middle Aged ,medicine.disease ,Thrombosis ,digestive system diseases ,Bile Duct Neoplasms ,Liver biopsy ,030211 gastroenterology & hepatology ,Microsatellite Instability ,pembrolizumab ,Neoplasm Recurrence, Local ,business - Abstract
A 60-year-old man presented with postoperative recurrence of intrahepatic cholangiocarcinoma with right portal vein tumor thrombosis (PVTT). After failure of standard chemotherapy, a liver biopsy showed that his microsatellite instability (MSI) status was high. Treatment with the immune checkpoint inhibitor (ICI) pembrolizumab was commenced, which resulted in a partial response and resolution of the PVTT. There were no significant immune-related adverse events. According to recently published reports, the frequency of MSI-high biliary tract cancer (BTC) is about 0%-2.1%, which is extremely rare. However, ICIs may be effective in patients with MSI-high BTC, such as the present patient.
- Published
- 2020