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15. The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in Vietnamese men

Author

Sun, Xian Liang, primary, Kido, Teruhiko, additional, Honma, Seijiro, additional, Koh, Eitetsu, additional, Okamoto, Rie, additional, Manh, Ho Dung, additional, Maruzeni, Shoko, additional, Nishijo, Muneko, additional, Nakagawa, Hideaki, additional, Nakano, Takeshi, additional, Takasuga, Takumi, additional, Nhu, Dang Duc, additional, Hung, Nguyen Ngoc, additional, and Son, Le Ke, additional

Published
2017
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18. Promotive Excretion of Causative Agents of Yusho by One Year Intake of FBRA in Japanese People

Author

Nagayama, Junya, Takasuga, Takumi, Tsuji, Hiroshi, and Iwasaki, Teruaki

Subjects
PCDFs, PCDDs, FBRA, food and beverages, Promotive Excretion, Agents, Yusho
Abstract

Thirty-six years have passed since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several objective and subjective symptoms. In order to improve or, if possible, to cure the such symptoms, the most important therapeutic treatment is considered to actively excrete the causative agents, that is, polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs) from the bodies of the patients and to reduce their body burdens. In rats, dietary fiber and chlorophyll have been shown to promote the fecal excretion of dioxins and to reduce their levels in rat liver. In this study, we examined whether such kinds of effect were also observed by FBRA, which was the health food and relatively rich with dietary fiber and chlorophyll, in nine married Japanese couples. As a result, concentrations of PCDFs and PCDDs on the lipid weight basis in the blood of the FBRA-intake group in which they took 7.0 to 10.5g of FBRA after each meal and three times a day for one year were more lowered than those in the blood of the nonintake group ; Blood levels of PCDFs and PCDDs in the FBRA-intake group were decreased by 41.0 and 37.2 %, respectively, and those decreases were 33.7 and 29.4 % in the non-intake group. Their total bod y burdens just before and one year after the study were calculated on the assumptions that the body fat was also contaminated with these dioxins at their blood levels on the lipid weight basis and the content of body fat was 20 % of the body weight. Then, we computed the average amounts in excretion of PCDFs and PCDDs from the body in both the FBRA-intake and non-intake groups. Consequently, the amounts of excretion of PCDFs and PCDDs in the FBRA-intake group were 1.81 and 1.74 times, respectively, greater than those in the non-intake group. Therefore, FBRA seemed to promote the fecal excretion of causative agents of Yusho, from the human body. We also expect FBRA to reduce their body burdens of patie nts with Yusho and to improve some objective and subjective symptoms of Yusho patients., カネミ油症中毒事件が発生してから36年が経過したが,今でも油症患者は種々様々な自覚および臨床症状で苦しんでいる.このような症状を改善し治療するには,その主要な原因物質であるポリ塩化ダイベンゾフラン(PCDFs)とポリ塩化ダイベンゾーp一ダイオキシン(PCDDs)を積極的に体外へ排泄し,汚染レベルを低下させることが第一である.この研究では動物実験によりダイオキシン類の体外排泄促進作用が認められている食物繊維と葉緑素を比較的多量に含む栄養補助食品FBRA(発酵玄米栄養補助食品ハイ・ゲンキ,㈱玄米酵素,本社:北海道札幌市)によるカネミ油症原因物質の体外排泄促進を9組の夫婦の協力により調べた.その結果,毎食後7～10.5gのFBRAを1日3回1年間摂取することにより,血液脂質重量当りのPCDFsとPCDDsの濃度が非摂取群よりもそれぞれ6.2%と7.7%低下した.この血液脂質濃度で体脂肪も汚染されており,体脂肪率を体重の20%と仮定し,1人当り1年間の体外排泄量を両化学物質について計算した.そうすると,FBRAを摂取することによりPCDFsとPCDDsの排泄量がそれぞれ1.81倍と1.74倍高まることが示された.以上のような結果より,FBRAは油症原因物質のPCDFsとPCDDsの体外への排泄を促進するので,油症患者の治療にも有効と考えられた.

Published
2005

19. Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men

Author

Sun, Xian Liang, primary, Kido, Teruhiko, additional, Honma, Seijiro, additional, Okamoto, Rie, additional, Manh, Ho Dung, additional, Maruzeni, Shoko, additional, Nishijo, Muneko, additional, Nakagawa, Hideaki, additional, Nakano, Takeshi, additional, Koh, Eitetsu, additional, Takasuga, Takumi, additional, Nhu, Dang Duc, additional, Hung, Nguyen Ngoc, additional, and Son, Le Ke, additional

Published
2016
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20. Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics

Author

Harada, Kouji H., primary, Tanaka, Keiko, additional, Sakamoto, Hiroko, additional, Imanaka, Mie, additional, Niisoe, Tamon, additional, Hitomi, Toshiaki, additional, Kobayashi, Hatasu, additional, Okuda, Hiroko, additional, Inoue, Sumiko, additional, Kusakawa, Koichi, additional, Oshima, Masayo, additional, Watanabe, Kiyohiko, additional, Yasojima, Makoto, additional, Takasuga, Takumi, additional, and Koizumi, Akio, additional

Published
2016
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24. Associations between levels of hydroxylated PCBs and PCBs in serum of pregnant women and blood thyroid hormone levels and body size of neonates

Author

Hisada, Aya, primary, Shimodaira, Kazuhisa, additional, Okai, Takashi, additional, Watanabe, Kiyohiko, additional, Takemori, Hiroaki, additional, Takasuga, Takumi, additional, Koyama, Maiko, additional, Watanabe, Noriko, additional, Suzuki, Emiko, additional, Shirakawa, Miyako, additional, Noda, Yumiko, additional, Komine, Yoko, additional, Ariki, Nagako, additional, Kato, Nobumasa, additional, and Yoshinaga, Jun, additional

Published
2014
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25. Relationship between dioxin and steroid hormones in sera of Vietnamese men

Author

Sun, Xian Liang, primary, Kido, Teruniko, additional, Okamoto, Rie, additional, Manh, Ho Dung, additional, Maruzeni, Shoko, additional, Nishijo, Muneko, additional, Nakagawa, Hideaki, additional, Honma, Seijiro, additional, Nakano, Takeshi, additional, Takasuga, Takumi, additional, Nhu, Dang Duc, additional, Hung, Nguyen Ngoc, additional, and Son, Le Ke, additional

Published
2014
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26. Serum Dioxin Levels in Vietnamese Men more than 40 Years after Herbicide Spraying

Author

Manh, Ho Dung, primary, Kido, Teruhiko, additional, Okamoto, Rie, additional, XianLiang, Sun, additional, Anh, Le Thai, additional, Supratman, Supratman, additional, Maruzeni, Shoko, additional, Nishijo, Muneko, additional, Nakagawa, Hideaki, additional, Honma, Seijiro, additional, Nakano, Takeshi, additional, Takasuga, Takumi, additional, Nhu, Dang Duc, additional, Hung, Nguyen Ngoc, additional, and Son, Le Ke, additional

Published
2014
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27. Active elimination of causative PCDFs/DDs congeners of Yusho by one year intake of FBRA in Japanese people

Author

Nagayama, Junya, Takasuga, Takumi, Tsuji, Hiroshi, Umehara, Motomi, Sada, Takehiko, and Iwasaki, Teruaki

Subjects
Adult, Dietary Fiber, Male, Polychlorinated Dibenzodioxins, Time Factors, PCDFs / DDs, Aspergillus oryzae, FBRA, PenCDF, Food Contamination, Oryza, Middle Aged, Polychlorinated Biphenyls, Japan, HxCDD, Body Burden, Humans, Plant Oils, Female, Food, Organic, Benzofurans
Abstract

Thirty-five years have been passing since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several objective and subjective symptoms. In order to improve or, if possible, to cure the such symptoms, the most important therapeutic treatment is considered to actively excrete the most toxic causative PCDFs/DDs congeners, that is, 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) and 1,2,3,6,7,8-hexachlorodibenzo- p-dioxin (HxCDD) from the bodies of the patients and to reduce their body burdens. In rats, dietary fiber and chlorophyll have been shown to promote the fecal excretion of dioxins and to reduce their levels in rat liver. In this study, we examined whether such kinds of effect were also observed by FBRA, which was the health food and relatively rich with dietary fiber and chlorophyll in nine married Japanese couples. As a result, concentrations of PenCDF and HxCDD on the lip id weight basis in the blood of the FBRA-intake group in which they took 7.0 to 10.5g of FBRA after each meal and three times a day for one year were more lowered than those in the blood of the nonintake group ; Blood levels of PenCDF and HxCDD in the FBRA-intake group were decreased by 30.5 and 33.9%, respectively, and those decreases were 22.0 and 24.5% in the non-intake group. Their total body burdens just before and one year after the study were calculated on the assumptions that the body fat was also contaminated with these congeners at their blood levels on the lipid weight basis and the content of body fat was 20% of the body weight. Then, we computed the average amounts in excretion of PenCDF and HxCDD from the body in both the FBRA-intake and non-intake groups. Consequently, the amounts of excretion of PenCDF and HxCDD in the FBRA-intake group were 2.1 and 1.9 times, respectively, greater than those in the non-intake group. Therefore, FBRA seemed to promote the fecal excretion of PenCDF and HxCDD, the main causative PCDFs/DDs congeners of Yusho, from the human body. We also expect FBRA to reduce th eir body burdens of patients with Yusho and to improve some objective and subjective symptoms of Yusho patients., カネミ油症中毒事件が発生してから35年が経過しようとしているが, 今でも油症患者は種々様々な自覚および他覚症状で苦しんでいる. このような症状を改善し治療するには, その主要な原因物質である2,3,4,7,8一五塩化ダイベンゾフラン(PenCDF)と1,2,3,6,7,8一六塩化ダイオキシン(HxCDD)を積極的に体外へ排泄し, 汚染レベルを低下させることが第一である. この研究では動物実験によりダイオキシン類の体外排泄促進作用の認められている食物繊維と葉緑素を比較的多量に含む栄養補助食品FBRAによるカネミ油症原因物質の体外排泄促進を9組の夫婦の協力により調べた. その結果, 毎食後7～10.5gのFBRAを1日3回1年間摂取することにより, 血液脂質重量当りのPenCDFとHxCDDの濃度が非摂取群よりもそれぞれ8.5%と9.4%低下した. この血液脂質濃度で体脂肪も汚染されており, 体脂肪率を体重の20%と仮定し, 1人当り1年間の体外排泄量を両化学物質について計算した. そうすると, FBRAを摂取することによりPenCDFとHxCDDの排泄量がそれぞれ2.1倍と1.9倍高まることが示された. 以上のような結果より, FBRAは油症原因物質のPenCDFとHxCDDの体外への排泄を促進するので, 油症患者の治療にも有効と考えられた.

Published
2003

28. Relationship between dietary exposure and serum perfluorochemical (PFC) levels-A case study

Author

Kärrman, Anna, Harada, Kouji H., Inoue, Kayoko, Takasuga, Takumi, Ohi, Etsumasa, Koizumi, Akio, Kärrman, Anna, Harada, Kouji H., Inoue, Kayoko, Takasuga, Takumi, Ohi, Etsumasa, and Koizumi, Akio

Abstract

Daily dietary intake of perfluorinated chemicals (PFCs) in relation to serum levels was assessed by determination of nine PFCs including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in matched daily diet duplicates and serum samples. Diet and serum were collected in year 2004 from 20 women in Osaka and Miyagi, Japan. Only PFOS and PFOA were detected in the diet samples and no significant difference between cities was seen. After adjusted by water content, diet concentration of PFOA was significantly higher in Osaka. The median daily intake calculated using the measured diet concentrations was 1.47 ng PFOS/kg b.w. and 1.28 ng PFOA/kg b.w. for Osaka, and 1.08 ng PFOS/kg b.w. and 0.72 ng PFOA/kg b.w. for Miyagi. A significant difference between cities was seen for the serum concentrations with median of 31 ng/mL PFOS and PFOA in Osaka, compared to 14 ng/mL PFOS and 4.6 ng/mL PFOA in Miyagi. Carboxylates such as perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUnDA) were also detected in serum at median levels 6.9 ng/mL and 3.2 ng/mL (Osaka), and 2.8 ng/mL and 5.1 ng/mL (Miyagi). Based on one-compartment model under steady state, dietary intake of PFOS and PFOA accounted for only 22.4% and 23.7% of serum levels in Osaka females, and in contrast 92.5% and 110.6% in Miyagi females, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

Published
2009
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36. Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994–2008 and Vietnam in 2007–2008

Author

Harada, Kouji H., primary, Yang, Hye-Ran, additional, Moon, Chan-Seok, additional, Hung, Nguyen Ngoc, additional, Hitomi, Toshiaki, additional, Inoue, Kayoko, additional, Niisoe, Tamon, additional, Watanabe, Takao, additional, Kamiyama, Shigetoshi, additional, Takenaka, Katsunobu, additional, Kim, Min-Young, additional, Watanabe, Kiyohiko, additional, Takasuga, Takumi, additional, and Koizumi, Akio, additional

Published
2010
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