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351 results on '"Takasu M"'

22. Genetic diversity and relationships among native Japanese horse breeds, the Japanese Thoroughbred and horses outside of Japan using genome‐wide SNP data

Author

Tozaki, T., primary, Kikuchi, M., additional, Kakoi, H., additional, Hirota, K., additional, Nagata, S., additional, Yamashita, D., additional, Ohnuma, T., additional, Takasu, M., additional, Kobayashi, I., additional, Hobo, S., additional, Manglai, D., additional, and Petersen, J. L., additional

Published
2019
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31. Mutual Positional Preference of IPMDH Proteins for Binding Studied by Coarse-grained Molecular Dynamics Simulation.

Author

Ishioka, T., Yamada, H., Miyakawa, T., Morikawa, R., Akanuma, S., Yamagishi, A., and Takasu, M.

Subjects
PROTEIN binding, MOLECULAR dynamics, NANOTECHNOLOGY, THERMAL stability, AMINO acid residues
Abstract

Proteins, which incorporate charged and hydrophobic amino acid residues, are useful as a material of nanotechnology. Among these proteins, IPMDH (3-isopropylmalate dehydrogenase), which has thermal stability, has potential as a material of nanofiber. In this study, we performed coarse-grained molecular dynamics simulation of IPMDH using MARTINI force fields, and we investigated the orientation for the binding of IPMDH. In simulation, we analyzed wild type of IPMDH and the mutated IPMDH proteins, where 13, 20, 27, 332, 335 and 338th amino acid residues are replaced by lysine residues which have positive charge and by glutamic acid residues which have negative charge. Since the binding of mutated IPMDH is advantageous compared with the binding of wild type for one orientation, we suggest that the Coulomb interaction for the binding of IPMDH is important. [ABSTRACT FROM AUTHOR]

Published
2016
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32. A rare case of fetal extensive intracranial hemorrhage and whole-cerebral hypoplasia due to latent maternal vitamin K deficiency.

Author

Goto, T., Kakita, H., Takasu, M., Takeshita, S., Ueda, H., Muto, D., Kondo, T., Kurahashi, H., Okumura, A., and Yamada, Y.

Subjects
VITAMIN K, VITAMIN deficiency, PREGNANCY complications
Abstract

We present here a late preterm infant with extensive brain lesions resulting from vitamin K deficiency. A female infant was born after 35 weeks of gestation by emergent cesarean section because of non-reassuring fetal status. Her mother had severe eating disorder and recurrent vomiting since early pregnancy. She was immediately intubated and ventilated because she was extremely pale, hypotonic, and non-reactive. Cerebral magnetic resonance imaging immediately after birth showed intraparenchymal hemorrhage in the left frontal lobe and cerebellum, marked cerebral edema, and cerebellar hypoplasia. Coagulation studies of the infant showed hepaplastin test <5%, prolonged PT and APTT, and a marked elevation of protein induced by vitamin K absence or antagonist-II. This case highlighted a potential risk of intracranial bleeding due to maternal vitamin K deficiency and difficulty in its prediction before delivery. Vitamin K supplementation to high risk mothers might be indispensable for preventing severe fetal vitamin K deficiency. Even when coagulation studies in mothers is normal, it is imperative to provide vitamin K supplementation for total protection. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Structure Analysis of Jungle-gym-type gels by Brownian Dynamics Simulation(Poster session 1, New Frontiers in Colloidal Physics : A Bridge between Micro- and Macroscopic Concepts in Soft Matter)

Author

Takasu, M., Ohta, N., Ono, K., and Furukawa, H.

Abstract

化学ゲルの角度ポテンシャルの違う2つのモデルに関して、動径分布関数、構造因子およびループの分布を計算して、構造やダイナミクスを議論した。, この論文は国立情報学研究所の電子図書館事業により電子化されました。

Published
2007

46. Rapid evolution of major histocompatibility complex Class I genes in primates generates new disease alleles in humans via hitchhiking diversity

Author

Shiina, T., Ota, M., Shimizu, S., Katsuyama, Y., Hashimoto, N., Takasu, M., Anzai, T., Kulski, J., Kikkawa, E., Naruse, T., Kimura, N., Yanagiya, K., Watanabe, A., Hosomichi, K., Kohara, S., Iwamoto, C., Umehara, Y., Meyer, A., Wanner, V., Sano, K., Macquin, C., Ikeo, K., Tokunaga, K., Gojobori, T., Inoko, H., Bahram, S., Shiina, T., Ota, M., Shimizu, S., Katsuyama, Y., Hashimoto, N., Takasu, M., Anzai, T., Kulski, J., Kikkawa, E., Naruse, T., Kimura, N., Yanagiya, K., Watanabe, A., Hosomichi, K., Kohara, S., Iwamoto, C., Umehara, Y., Meyer, A., Wanner, V., Sano, K., Macquin, C., Ikeo, K., Tokunaga, K., Gojobori, T., Inoko, H., and Bahram, S.

Abstract

A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was rather concentrated within two gene-rich clusters. These were each centered, but importantly not limited to, the antigen-presenting HLA-A and HLA-B/-C loci. Rapid evolution of MHC-I alleles, as evidenced by an unusually high number of haplotype-specific (hs) and hypervariable (hv) (which could not be traced to a single species or haplotype) SNVs within the classical MHC-I, seems to have not only hitchhiked alleles within nearby genes, but also hitchhiked deleterious mutations in these same unrelated loci. The overrepresentation of a fraction of these hvSNV (hv1SNV) along with hsSNV, as compared to those that appear to have been maintained throughout primate evolution (trans-species diversity; tsSNV; included within hv2SNV) tends to establish that the majority of the MHC polymorphism is de novo (species specific). This is most likely reminiscent of the fact that these hsSNV and hv1SNV have been selected in adaptation to the constantly evolving microbial antigenic repertoire.

Published
2006

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