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27 results on '"Takashima, Toshinobu"'

21. Risk Factors of Atherosclerosis and Aortic Pulse Wave Velocity.

Author

Keizo Ohmori, Sei Emura, and Takashima, Toshinobu

Subjects
ATHEROSCLEROSIS, AORTIC valve, HEART valves, DISEASE risk factors, PULSE (Heart beat), BLOOD circulation
Abstract

Aortic pulse wave velocity (PWV) is a noninvasive technique that can estimate aortic stiffness or organic change quantitatively. The authors examined the correlation between age and the PWV value in 113 subjects and also examined the relationship between atherosclerotic associated diseases and PWV. A positive correlation was observed between age and the PWV value. No significant difference was found in the PWV value between groups with and without risk factors of atherosclerosis. No significant difference was observed in the PWV value between groups with and without a history of atherosclerotic disease. [ABSTRACT FROM AUTHOR]

Published
2000

23. Regions necessary for pH-dependent assembly of gizzard myosin rod.

Author

Kumon, Akira, Kuba, Masako, Murakami, Noriko, Yasuda, Seiji, Takashima, Toshinobu, Matsumura, Seuo, and Suezaki, Yukio

Subjects
MYOSIN, GLOBULINS, GEL permeation chromatography, GIZZARD, HYDROGEN-ion concentration
Abstract

Aggregated and disaggregated forms of gizzard myosin rod and its fragments in various concentrations of NaCl (0-0.30 M) at various pH (7.4-8.6) were distinguished from each other by their permeability through a Sepharose 4B column. 1. The rod existed in three forms, namely: large aggregates impermeable to the column, small aggregates eluted at the void volume of the column and a disaggregated monomer which penetrated the column. The relative proportions of the three forms varied depending on the salt concentration and pH. The monomeric rod was detected in NaCl solutions above 0.20 M and its relative proportion at 0.25 M NaCl was larger than those of the small and large aggregates. The small aggregates of the rod were predominant at below 0.05 M NaCl and. upon decrease in pH from 8.6 to 7.4, these small aggregates in NaCl solutions between 0.10 M and 0.15 M were replaced by the large aggregates. 2. Light meromyosin, which corresponded to the C-terminal two-thirds of the rod, existed exclusively as large aggregates in NaCl solutions below 0.15 M; increase of NaCl concentration to above 0.20 M resulted in the formation of its monomer, instead of the large aggregates. In contrast to the rod, no small aggregated form of the light meromyosin was detected. 3. Truncated light meromyosin which had lost a small segment from either the C-terminal or N-terminal of light meromyosin was eluted only as a monomer in any NaCl concentration at any pH. 4. It may be deduced from the above results that a small segment in the light meromyosin is requisite for the assembly of both rod and light meromyosin in the NaCl solutions below 0.15 M and that the relative proportion of small and large aggregates of the rod is determined in a pH-dependent manner by the subfragment 2 segment, the N-terminal third of the rod. [ABSTRACT FROM AUTHOR]

Published
1986
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27. Lipid Deposition in Aorta of Cholesterol-Fed Rabbits

Author

TAKASHIMA, Toshinobu, primary, KATO, Hiroyuki, additional, OHTA, Yhukou, additional, KURIYAMA, Kazumichi, additional, OHGUSHI, Kazuhisa, additional, EMURA, Sei, additional, HIGUCHI, Naoaki, additional, YOSHIHARA, Masahiro, additional, ONOHARA, Shingo, additional, OHMORI, Keizo, additional, MATSUI, Yukio, additional, and SUNAGA, Toshiaki, additional

Published
1988
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