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5. Liposome‐encapsulated hemoglobin rescues hemorrhagic shock heart through anti‐ischemic and anti‐arrhythmogenic effects on myocardium in repetitive 65% bleeding rat model.

Author

Takase, Bonpei, Higashimura, Yuko, Masaki, Nobuyuki, Kinoshita, Manabu, Adachi, Takeshi, and Sakai, Hiromi

Subjects
*LABORATORY rats, *ACTION potentials, *TROPONIN I, *GUNSHOT wounds, *HEMORRHAGIC shock, *ARRHYTHMIA
Abstract

Background Methods Results Conclusions Phase I clinical trial of an artificial oxygen carrier (liposome‐encapsulated hemoglobin vesicles [HbVs]) is safely completed, considering the other clinical application. Herein, we aimed to investigate the resuscitation effects of HbVs in cases of lethal hemorrhage, including the mechanisms involved.Optical mapping analysis (OMP) and electrophysiological studies (EPS), immunostaining pathological examination for hypoxia‐inducible factor‐1α (HIF1‐alpha) in the heart tissue, and blood troponin I (TnI) level measurements were performed in rats that underwent five rounds of spontaneous arterial bleeding with up to 65% hemorrhage.Ten rats in each group were resuscitated by a transvenous infusion of 5% albumin (ALB), washed erythrocytes (wRBC), HbVs (HbV), 50% HbV diluted by 5% albumin (50% HbV), and 66% HbV diluted by 5% albumin (66% HbV). The rats in the ALB and 50% HbV groups died, whereas those in the other groups survived. OMP showed impaired action potential duration dispersion (APDd) in the left ventricle in the ALB and 50% HbV groups, which was attenuated in the other groups. Lethal arrhythmias were provoked by EPS in the ALB and 50% HbV groups but not in the other groups. HIF1‐alpha was positively stained only in the ALB and 50% HbV groups. TnI levels were elevated in the ALB and 50% HbV groups.Acute lethal hemorrhage causes myocardial ischemia with hypoxia and arrhythmias, which may be induced by impaired APDd and myocardial damage, reflected in the increased levels of HIF1‐alpha and TnI. HbVs could be useful for resuscitation and may help save patients with injuries such as gunshot wounds. [ABSTRACT FROM AUTHOR]

Published
2024
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6. JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia.

Author

Takase, Bonpei, Ikeda, Takanori, Shimizu, Wataru, Abe, Haruhiko, Aiba, Takeshi, Chinushi, Masaomi, Koba, Shinji, Kusano, Kengo, Niwano, Shinichi, Takahashi, Naohiko, Takatsuki, Seiji, Tanno, Kaoru, Watanabe, Eiichi, Yoshioka, Koichiro, Amino, Mari, Fujino, Tadashi, Iwasaki, Yu‐ki, Kohno, Ritsuko, Kinoshita, Toshio, and Kurita, Yasuo

Subjects
ATRIAL fibrillation diagnosis, ARRHYTHMIA diagnosis, BRADYCARDIA diagnosis, TACHYCARDIA diagnosis, MYOCARDIAL infarction diagnosis, SARCOIDOSIS diagnosis, BRUGADA syndrome diagnosis, CONGENITAL heart disease diagnosis, ATRIAL fibrillation risk factors, RISK assessment, MEDICAL protocols, PLETHYSMOGRAPHY, MYOCARDIAL ischemia, WOLFF-Parkinson-White syndrome, VENTRICULAR ejection fraction, BUNDLE-branch block, LONG QT syndrome, SICK sinus syndrome, ABLATION techniques, CARDIOMYOPATHIES, EXERCISE, DIFFERENTIAL diagnosis, ARTIFICIAL intelligence, SYNCOPE, AMBULATORY electrocardiography, WEARABLE technology, SEVERITY of illness index, SUPRAVENTRICULAR tachycardia, CARDIAC hypertrophy, DILATED cardiomyopathy, VENTRICULAR fibrillation, FAMILY history (Medicine), MEDICALLY unexplained symptoms, MAGNETIC resonance imaging, ARRHYTHMIA, ELECTROCARDIOGRAPHY, VENTRICULAR tachycardia, DEEP learning, VENTRICULAR arrhythmia, ISCHEMIC stroke, EXERCISE tolerance, IMPLANTABLE cardioverter-defibrillators, CARDIAC arrest, BLOOD pressure testing machines, CARDIAC pacemakers, AUTONOMIC nervous system diseases, ATRIAL flutter, CARDIAC pacing, HEART block, CEREBRAL infarction, CORONARY artery disease, GENETIC testing, ELECTROPHYSIOLOGY, CARDIAC surgery, RADIONUCLIDE imaging, ECHOCARDIOGRAPHY, EVALUATION, DISEASE risk factors
Published
2024
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9. JCS/JHRS2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia

Author

Takase, Bonpei, Ikeda, Takanori, Shimizu, Wataru, Abe, Haruhiko, Aiba, Takeshi, Chinushi, Masaomi, Koba, Shinji, Kusano, Kengo, Niwano, Shinichi, Takahashi, Naohiko, Takatsuki, Seiji, Tanno, Kaoru, Watanabe, Eiichi, Yoshioka, Koichiro, Amino, Mari, Fujino, Tadashi, Iwasaki, Yu‐ki, Kohno, Ritsuko, Kinoshita, Toshio, Kurita, Yasuo, Masaki, Nobuyuki, Murata, Hiroshige, Shinohara, Tetsuji, Yada, Hirotaka, Yodogawa, Kenji, Kimura, Takeshi, Kurita, Takashi, Nogami, Akihiko, and Sumitomo, Naokata

Published
2024
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12. Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension

Author

Tomiyama, Hirofumi, Vlachopoulos, Charalambos, Xaplanteris, Panagiotis, Nakano, Hiroki, Shiina, Kazuki, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Tanaka, Atsushi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ohkuma, Toshiaki, Ninomiya, Toshiharu, Chikamori, Taishiro, Yamashina, Akira, and Ueda, Shin-ichiro

Published
2020
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13. Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension

Author

Tanaka, Atsushi, Kawaguchi, Atsushi, Tomiyama, Hirofumi, Ishizu, Tomoko, Matsumoto, Chisa, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Yamashina, Akira, and Node, Koichi

Published
2018
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14. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study

Author

Masaki, Nobuyuki, primary, Adachi, Takeshi, additional, Tomiyama, Hirofumi, additional, Kohro, Takahide, additional, Suzuki, Toru, additional, Ishizu, Tomoko, additional, Ueda, Shinichiro, additional, Yamazaki, Tsutomu, additional, Furumoto, Tomoo, additional, Kario, Kazuomi, additional, Inoue, Teruo, additional, Koba, Shinji, additional, Takemoto, Yasuhiko, additional, Hano, Takuzo, additional, Sata, Masataka, additional, Ishibashi, Yutaka, additional, Node, Koichi, additional, Maemura, Koji, additional, Ohya, Yusuke, additional, Furukawa, Taiji, additional, Ito, Hiroshi, additional, Higashi, Yukihito, additional, Yamashina, Akira, additional, and Takase, Bonpei, additional

Published
2023
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15. Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension

Author

Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Matsumoto, Chisa, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, and Yamashina, Akira

Published
2018
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16. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2018
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17. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study

Author

Oda, Nozomu, Kajikawa, Masato, Maruhashi, Tatsuya, Iwamoto, Yumiko, Kishimoto, Shinji, Matsui, Shogo, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Goto, Chikara, Aibara, Yoshiki, Nakashima, Ayumu, Noma, Kensuke, Tomiyama, Hirofumi, Takase, Bonpei, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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18. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements : The FMD-J B study

Author

Masaki, Nobuyuki, Adachi, Takeshi, Tomiyama, Hirofumi, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Higashi, Yukihito, Yamashina, Akira, Takase, Bonpei, Masaki, Nobuyuki, Adachi, Takeshi, Tomiyama, Hirofumi, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Higashi, Yukihito, Yamashina, Akira, and Takase, Bonpei

Abstract

Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non-T2DM]; women, n = 107 [T2DM] and n = 313 [non-T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5-year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age-adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia.

Published
2023

21. PS-BPC01-6: BRACHIAL-ANKLE PULSE WAVE VELOCITY IS USEFUL FOR CARDIOVASCULAR RISK ASSESSMENT IN WELL-TREATED HYPERTENSIVE PATIENTS WITH CORONARY HEART DISEASE

Author

Maruhashi, Tatsuya, primary, Kajikawa, Masato, additional, Kishimoto, Shinji, additional, Harada, Takahiro, additional, Hashimoto, Yu, additional, Yusoff, Farina Mohamad, additional, Nakano, Yukiko, additional, Nakashima, Ayumu, additional, Takase, Bonpei, additional, Tomiyama, Hirofumi, additional, Yamashina, Akira, additional, and Higashi, Yukihito, additional

Published
2023
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22. A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality

Author

Ishinoda, Yuki, primary, Masaki, Nobuyuki, additional, Hitomi, Yasuhiro, additional, Taruoka, Akira, additional, Kawai, Akane, additional, Iwashita, Midori, additional, Yumita, Yusuke, additional, Kagami, Kazuki, additional, Yasuda, Risako, additional, Ido, Yasuo, additional, Toya, Takumi, additional, Ikegami, Yukinori, additional, Namba, Takayuki, additional, Nagatomo, Yuji, additional, Miyazaki, Koji, additional, Takase, Bonpei, additional, and Adachi, Takeshi, additional

Published
2023
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23. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese

Author

Tomiyama, Hirofumi, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, and Yamashina, Akira

Published
2015
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24. Association of serum nitric oxide metabolite level with mortality in patients undergoing coronary angiography

Author

Namba, Takayuki, primary, Masaki, Nobuyuki, additional, Hitomi, Yasuhiro, additional, Ishinoda, Yuki, additional, Iwashita, Midori, additional, Yumita, Yusuke, additional, Kagami, Kazuki, additional, Yasuda, Risako, additional, Ikegami, Yukinori, additional, Toya, Takumi, additional, Nagatomo, Yuji, additional, Takase, Bonpei, additional, Soejima, Kyoko, additional, and Adachi, Takeshi, additional

Published
2022
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25. Effects of pitavastatin on walking capacity and CD34+/133+ cell number in patients with peripheral artery disease

Author

Arao, Kenshiro, Yasu, Takanori, Endo, Yasuhiro, Funazaki, Toshikazu, Ota, Yoshimi, Shimada, Kazunori, Tokutake, Eiichi, Naito, Naoki, Takase, Bonpei, Wake, Minoru, Ikeda, Nahoko, Horie, Yasuto, Sugimura, Hiroyuki, Momomura, Shin-ichi, Kawakami, Masanobu, and Investigators of the Anti-Arteriosclerosis and Lipid Lowering with Pitavastatin Evaluation Study in Nippon (ALPEN)

Published
2017
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26. Effect of Novel Stratified Lipid Risk by “LDL-Window” and Flow-Mediated Dilation on the Prognosis of Coronary Artery Disease Using the FMD-J Study A Data

Author

Abe, Shichiro, primary, Haruyama, Yasuo, additional, Kobashi, Gen, additional, Toyoda, Shigeru, additional, Inoue, Teruo, additional, Tomiyama, Hirofumi, additional, Ishizu, Tomoko, additional, Kohro, Takahide, additional, Higashi, Yukihito, additional, Takase, Bonpei, additional, Suzuki, Toru, additional, Ueda, Shinichiro, additional, Yamazaki, Tsutomu, additional, Furumoto, Tomoo, additional, Kario, Kazuomi, additional, Koba, Shinji, additional, Takemoto, Yasuhiko, additional, Hano, Takuzo, additional, Sata, Masataka, additional, Ishibashi, Yutaka, additional, Node, Koichi, additional, Maemura, Koji, additional, Ohya, Yusuke, additional, Furukawa, Taiji, additional, Ito, Hiroshi, additional, and Yamashina, Akira, additional

Published
2022
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27. Development of Non-contact Monitoring System of Heart Rate Variability (HRV) - An Approach of Remote Sensing for Ubiquitous Technology -

Author

Suzuki, Satoshi, Matsui, Takemi, Gotoh, Shinji, Mori, Yasutaka, Takase, Bonpei, Ishihara, Masayuki, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, and Karsh, Ben-Tzion, editor

Published
2009
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32. Effect of Novel Stratified Lipid Risk by “LDL-Window” and Flow-Mediated Dilation on the Prognosis of Coronary Artery Disease Using the FMD-J Study A Data

Author

Abe, Shichiro, Haruyama, Yasuo, Kobashi, Gen, Toyoda, Shigeru, Inoue, Teruo, Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Yamashina, Akira, Abe, Shichiro, Haruyama, Yasuo, Kobashi, Gen, Toyoda, Shigeru, Inoue, Teruo, Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, and Yamashina, Akira

Abstract

Background: Elevated levels of triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) are regarded as a residual lipid risk in low-density lipoprotein cholesterol (LDL-C)-lowering therapy. This study investigated the association between lipid risk stratified by TG and non-HDL-C and the prognosis of patients with coronary artery disease (CAD), and the association between stratified lipid risk and flow-mediated dilatation (FMD) index. Methods and Results: The 624 CAD patients enrolled in flow-mediated dilation (FMD)-J study A were divided into 4 groups: low-risk group (n=413) with TG <150 mg/dL and non-HDL-C <170 mg/dL; hyper-TG group (n=180) with TG ≥150 mg/dL and non-HDL-C <170 mg/dL; hyper-non-HDL group (n=12) with TG <150 mg/dL and non-HDL-C ≥170 mg/dL; and high-risk group (n=19) with TG ≥150 mg/dL and non-HDL-C ≥170 mg/dL. Comparison of the groups showed the cumulative incidence of a 3-point major adverse cardiovascular event (MACE) was different and highest in the high-risk group in all the patients (P=0.009), and in patients with a FMD index ≥7.0% (P=0.021), but not in those with a FMD index <7.0%. Multivariable regression analysis showed that high lipid risk (P=0.019) and FMD <7.0% (P=0.040) were independently correlated with the incidence of a 3-point MACE. Conclusions: Novel stratification of lipid risk, simply using TG and non-HDL-C levels, combined with FMD measurement, is useful for predicting cardiovascular outcomes in patients with CAD.

Published
2022

33. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Binti Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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40. Artificially Created Reentry Circuit by Laser Irradiation Causes Atrial Tachycardia to Persist in Murine Atria

Author

Horii, Shunpei, primary, Yada, Hirotaka, additional, Ito, Kei, additional, Tsujita, Kazuhiro, additional, Osaki, Ayumu, additional, Kagami, Kazuki, additional, Sato, Atsushi, additional, Kimura, Toyokazu, additional, Yasuda, Risako, additional, Toya, Takumi, additional, Namba, Takayuki, additional, Nagatomo, Yuji, additional, Ido, Yasuo, additional, Miyazaki, Koji, additional, Masaki, Nobuyuki, additional, Ishihara, Miya, additional, Takase, Bonpei, additional, and Adachi, Takeshi, additional

Published
2022
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