1,596 results on '"Takala, J"'
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2. Angiotensin II in Septic Shock
- Author
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Corrêa, T. D., Takala, J., Jakob, S. M., and Vincent, Jean-Louis, editor
- Published
- 2015
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3. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III)
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Shehabi, Yahya, primary, Serpa Neto, Ary, additional, Bellomo, Rinaldo, additional, Howe, Belinda D., additional, Arabi, Yaseen M., additional, Bailey, Michael, additional, Bass, Frances E., additional, Bin Kadiman, Suhaini, additional, McArthur, Colin J., additional, Reade, Michael C., additional, Seppelt, Ian M., additional, Takala, Jukka, additional, Wise, Matt P., additional, Webb, Steve A., additional, Mashonganyika, C., additional, McKee, H., additional, Tonks, A., additional, Donnelly, A., additional, Hemmings, N., additional, O’Kane, S., additional, Blakemore, A., additional, Butler, M., additional, Cowdrey, K., additional, Dalton, J., additional, Gilder, E., additional, Long, S., additional, McCarthy, L., additional, McGuinness, S., additional, Parke, R., additional, Chen, Y., additional, McArthur, C., additional, McConnochie, R., additional, Newby, L., additional, Bellomo, R., additional, Eastwood, G., additional, Peck, L., additional, Young, H., additional, Boschert, C., additional, Edington, J., additional, Fletcher, J., additional, Smith, J., additional, Nand, K., additional, Raza, A., additional, Sara, T., additional, Bennett-Britton, J., additional, Bewley, J., additional, Bodenham, V., additional, Cole, L., additional, Driver, K., additional, Grimmer, L., additional, Howie, L., additional, Searles, C., additional, Sweet, K., additional, Webster, D., additional, van Berkel, A., additional, Connor, H., additional, Dennett, J., additional, van Der Graaff, M., additional, Henderson, S., additional, Mehrtens, J., additional, Miller, K., additional, Minto, E., additional, Morris, A., additional, Noble, S., additional, Parker, K., additional, Bulfin, L., additional, Hart, N., additional, Shepherd, K., additional, Vij, S., additional, Dickson, S., additional, Elloway, E., additional, Ferguson, C., additional, Jackson, R., additional, MacNaughton, P., additional, Marner, M., additional, Squire, R., additional, Waddy, S., additional, Wafer, P., additional, Welbourne, J., additional, Ashcroft, P., additional, Chambler, D., additional, Dukes, S., additional, Harris, A., additional, Horton, S., additional, Sharpe, S., additional, Williams, P., additional, Williams, S., additional, Bailey, M., additional, Blazquez, E., additional, France, D., additional, Hutchison, R., additional, O’Connor, A., additional, Comadira, G., additional, Gough, M., additional, Tallott, M., additional, Bastick, M., additional, Cameron, R., additional, Donovan, S., additional, Ellis, K., additional, Gaur, A., additional, Gregory, R., additional, Naumoff, J., additional, Turner, E., additional, White, M., additional, Au, K. F. J., additional, Fratzia, J., additional, Treloar, S., additional, Lim, C. H., additional, Maseeda, Y., additional, Tan, A. P., additional, Tang, C. L., additional, Yong, C. Y., additional, Akaltan, M., additional, Berger, S., additional, Blaser, D., additional, Fazlija, L., additional, Jong, M. L., additional, Lensch, M., additional, Ludwig, R., additional, Merz, T., additional, Nettelbeck, K., additional, Roth, M., additional, Schafer, M., additional, Takala, J., additional, Wehr, A., additional, Zacharias, D., additional, Amran, R., additional, Ashraf, H. N., additional, Azmi, N., additional, Basri, N., additional, Burhanuddin, H., additional, Hadinata, Y., additional, Hamdan, A., additional, Kadiman, S., additional, Rashid, A. I. Y. M., additional, Sabran, I. N., additional, Sulaiman, S., additional, Zabidi, I. N., additional, Al-Dawood, A., additional, Aljuaid, M., additional, Anizi, H. Al, additional, Saeedi, A. Al, additional, Arabi, Y., additional, Dbsawy, M., additional, Deeb, A., additional, Hegazy, M., additional, Magdi, I., additional, Clarey, E., additional, Corcoran, E., additional, Finney, C., additional, Harris, C., additional, Hopkins, P., additional, Noble, H., additional, Thompson, L., additional, Williams, T., additional, Dumlao, L. A., additional, Bassam, R., additional, Hassan, M. A., additional, Naseem, N., additional, Al-Kurdi, M. H., additional, Al-Harthy, A. M., additional, Bernard, S., additional, Sebafundi, L., additional, Serban, C., additional, Lim, S. K., additional, Mazidah, N., additional, Saidin, N., additional, Sjamsuddin, N., additional, Tan, I. T. A., additional, Zabidi, N., additional, Brain, M., additional, Mineall, S., additional, Kanhere, M., additional, Soar, N., additional, Kadir, N. Abd, additional, Abdullah, N. H., additional, Awang, R., additional, Emperan, Z., additional, Husin, N. S., additional, Ismail, N. I., additional, Ismail, S. Z., additional, Khadzali, F. N. A. Mohd, additional, Norddin, M. F., additional, Aguila, J., additional, Bold, C., additional, Clatworthy, B., additional, Dias, A., additional, Hogan, C., additional, Kazemi, A., additional, Lai, V., additional, Song, R., additional, Williams, A., additional, Bhatia, D., additional, Elliot, S., additional, Galt, P., additional, Lavrans, K., additional, Ritchie, P., additional, Wang, A., additional, Gresham, R., additional, Lowrey, J., additional, Masters, K., additional, Palejs, P., additional, Seppelt, I., additional, Symonds, F., additional, Weisbrodt, L., additional, Whitehead, C., additional, Babio-Galan, M., additional, Calder, V., additional, Clement, I., additional, Harrison, A., additional, McCullagh, I., additional, Scott, C., additional, Bevan, R., additional, Caniba, S., additional, Hacking, D., additional, Maher, L., additional, Azzolini, M. L., additional, Beccaria, P., additional, Colombo, S., additional, Landoni, G., additional, Leggieri, C., additional, Luca, C., additional, Mamo, D., additional, Moizo, E., additional, Monti, G., additional, Mucci, M., additional, Zangrillo, A., additional, Albania, M., additional, Arora, S., additional, Shi, Y., additional, Abudayah, A., additional, Almekhlafi, G., additional, Al Amodi, E., additional, Al Samarrai, S., additional, Badawi, M., additional, Caba, R. Cubio, additional, Elffaki, O., additional, Mandourah, Y., additional, Valerio, J., additional, Joyce, C., additional, Meyer, J., additional, Saylor, E., additional, Venkatesh, B., additional, Venz, E., additional, Walsham, J., additional, Wetzig, K., additional, Khoo, T. M., additional, Liew, J. E. S., additional, Sakthi, A. N., additional, Zulkurnain, A., additional, Bamford, A., additional, Bergin, C., additional, Carrera, R., additional, Cooper, L., additional, Despy, L., additional, Harkett, S., additional, Mee, L., additional, Reeves, E., additional, Snelson, C., additional, Spruce, E., additional, Cooper, G., additional, Hodgson, R., additional, Pearson, D., additional, Rosbergen, M., additional, Ali, M. N., additional, Bahar, N. I., additional, Ismail, A., additional, Ismail, W. N. W., additional, Samat, N. M., additional, Piah, N. S. M., additional, Rahman, R. Abd, additional, Duroux, M., additional, Ratcliffe, M., additional, Warhurst, T., additional, Buehner, U., additional, Williams, E., additional, Jacques, N., additional, Keating, L., additional, Macgill, S., additional, Tamang, K. L., additional, Tolan, N., additional, Walden, A., additional, Bower, R., additional, Cranshaw, J., additional, Molloy, K., additional, Pitts, S., additional, Butler, J., additional, Dunlop, R., additional, Fourie, C., additional, Jarrett, P., additional, Lassig-Smith, M., additional, Livermore, A., additional, O’Donoghue, S., additional, Reade, M., additional, Starr, T., additional, Stuart, J., additional, Campbell, L., additional, Phillips, M., additional, Stephens, D., additional, Thomas, J., additional, Cooper, D., additional, McAllister, R., additional, Andrew, G., additional, Barclay, L., additional, Dawson, H., additional, Griffith, D. M., additional, Hope, D., additional, Wojcik, G., additional, McCulloch, C., additional, Paterson, R., additional, Ascough, L., additional, Paisley, C., additional, Patrick-Heselton, J., additional, Shaw, D., additional, Waugh, V., additional, Williams, K., additional, Welters, I., additional, Barge, D., additional, Jordan, A., additional, MacIsaac, C., additional, Rechnitzer, T., additional, Bass, F., additional, Gatward, J., additional, Hammond, N., additional, Janin, P., additional, Stedman, W., additional, Yarad, E., additional, Razak, N. A., additional, Dzulkipli, N., additional, Jong, S. L., additional, Asen, K., additional, Voon, W. L., additional, Liew, S., additional, Ball, J., additional, Barnes, V., additional, Dalton, C., additional, Farnell-Ward, S., additional, Farrah, H., additional, Maher, K., additional, Mellinghoff, J., additional, Ryan, C., additional, Shirley, P., additional, Conlon, L., additional, Glover, A., additional, Martin-Loeches, I., additional, O’Toole, E., additional, Ewan, J., additional, Ferrier, J., additional, Litton, E., additional, Webb, S. A., additional, Berry, W., additional, Blanco Alonso, U., additional, Bociek, A., additional, Campos, S., additional, Jawara, S., additional, Hanks, F., additional, Kelly, A., additional, Lei, K., additional, McKenzie, C., additional, Ostermann, M., additional, Wan, R., additional, Al-Soufi, S., additional, Leow, S., additional, McCann, K., additional, Reynolds, C., additional, Brickell, K., additional, Fahey, C., additional, Hays, L., additional, Hyde, N., additional, Nichol, A., additional, Ryan, D., additional, Brailsford, J., additional, Buckley, A., additional, Forbes, L., additional, Maguire, T., additional, Moore, J., additional, Murray, L., additional, Ghosh, A., additional, Park, M., additional, Said, S., additional, Visser, A., additional, Abidin, H. Z., additional, Ali, S., additional, Hassan, M. H., additional, Omar, S. C., additional, Shukeri, W. F. W., additional, Brealey, D., additional, Bercades, G., additional, Blackburn, E., additional, Macallum, N., additional, Macklin, A., additional, Ryu, J. H., additional, Tam, K., additional, Smyth, D., additional, Arif, A., additional, Bassford, C., additional, Morgan, C., additional, Swann, C., additional, Ward, G., additional, Wild, L., additional, Bone, A., additional, Elderkin, T., additional, Green, D., additional, Sach, D., additional, Salerno, T., additional, Simpson, N., additional, Brohi, F., additional, Clark, M., additional, Williams, L., additional, Brooks, J., additional, Cocks, E., additional, Cole, J., additional, Curtin, J., additional, Davies, R., additional, Hill, H., additional, Morgan, M., additional, Palmer, N., additional, Whitton, C., additional, Wise, M., additional, Baskaran, P., additional, Hasan, M. S., additional, Tham, L. Y., additional, Sol Cruz, R., additional, Dinsdale, D., additional, Edney, S., additional, Firkin, C., additional, FitzJohn, F., additional, Hill, G., additional, Hunt, A., additional, Hurford, S., additional, Jones, G., additional, Judd, H., additional, Latimer-Bell, C., additional, Lawrence, C., additional, Lesona, E., additional, Navarra, L., additional, Robertson, Y., additional, Smellie, H., additional, Vucago, A. M., additional, Young, P., additional, Clark, P., additional, Kong, J., additional, Ho, J., additional, Nayyar, V., additional, and Skelly, C., additional
- Published
- 2023
- Full Text
- View/download PDF
4. Variability of splanchnic blood flow measurements in patients with sepsis – physiology, pathophysiology or measurement errors?
- Author
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Jakob, S. M., Takala, J., Pinsky, Michael R., editor, Brochard, Laurent, editor, Mancebo, Jordi, editor, and Antonelli, Massimo, editor
- Published
- 2012
- Full Text
- View/download PDF
5. Moderating Effect of Asean Free Trade Agreement between Total Quality Management and Business Performance
- Author
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Ahmad, M.F., Zakuan, N., Jusoh, A., Yusof, S.M., and Takala, J.
- Published
- 2014
- Full Text
- View/download PDF
6. The Role of Hypoxia and Inflammation in the Expression and Regulation of Proteins Regulating Iron Metabolism
- Author
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Brandt, S., Takala, J., Lepper, P. M., and Vincent, Jean-Louis, editor
- Published
- 2008
- Full Text
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7. Effects of Pharmacologic Agents on Splanchnic Blood Flow
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Takala, J., Vincent, Jean-Louis, editor, Rombeau, J. L., editor, and Takala, J., editor
- Published
- 1996
- Full Text
- View/download PDF
8. The Vascular Bed during Critical Illness: Evaluation in Animal Models
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Gorrasi, J., Takala, J., Jakob, S. M., and Vincent, Jean-Louis, editor
- Published
- 2006
- Full Text
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9. The Patient Process as the Basis for the Design of an ICU
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Regli, B., Takala, J., Vincent, Jean-Louis, editor, Fink, Michell P., editor, Suter, Peter M., editor, and Sibbald, William J., editor
- Published
- 2006
- Full Text
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10. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016
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Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. 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- 2016
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11. Self-Inspired Learning Assisted by Eda Tools in the Introductory Digital Design Course
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Linghao, S., Burian, A., Takala, J., Ionescu, Adrian M., editor, Declercq, Michel, editor, Kayal, Maher, editor, and Leblebici, Yusuf, editor
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12. Recycling harvest water to cultivate Chlorella zofingiensis under nutrient limitation for biodiesel production
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Zhu, L.D., Takala, J., Hiltunen, E., and Wang, Z.M.
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13. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
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- Abstract
Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each
- Published
- 2020
14. Lactate, Lactate/Pyruvate Ratio, Low Tissue Perfusion and Outcome
- Author
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Jakob, S. M., Suistomaa, M., Takala, J., and Vincent, Jean-Louis, editor
- Published
- 2001
- Full Text
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15. Interpretation of Changes in Regional and Mucosal PCO2 Gradients: The Haldane Effect
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Jakob, S. M., Takala, J., and Vincent, Jean-Louis, editor
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- 2000
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16. Relationship of TQM and Business Performance with Mediators of SPC, Lean Production and TPM
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Ahmad, M.F., Zakuan, N., Jusoh, A., and Takala, J.
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- 2012
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17. Survival is not Enough: Quality of Life After Intensive Care
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Niskanen, M., Takala, J., and Vincent, Jean-Louis, editor
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- 1999
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18. Navigation algorithm combining building plans with autonomous sensor data
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Davidson, P., Kirkko-Jaakkola, M., Collin, J., and Takala, J.
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- 2015
- Full Text
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19. Knowledge management and analytical modeling for transformational leadership profiles in a multinational company
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Ha-Vikström, T., primary and Takala, J., additional
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- 2016
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20. Contributors
- Author
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Boyle, J., primary, Calabrese, F.A., additional, Chan, Y.E., additional, Earley, S., additional, Edwards, J.S., additional, Erickson, G.S., additional, Filipczyk, B., additional, Gołuchowski, J., additional, Ha-Vikström, T., additional, Hoffman, E., additional, Holsapple, C.W., additional, Hsiao, S.-H., additional, Janas, A., additional, La Londe, R., additional, Larson, S., additional, Levallet, N., additional, Oh, J.-Y., additional, Paliszkiewicz, J., additional, Ribière, V., additional, Rogers, E., additional, Rothberg, H.N., additional, Russell, K.E., additional, Sugumaran, V., additional, Takala, J., additional, Tsui, E., additional, Walters, F., additional, and Wensley, A.K.P., additional
- Published
- 2016
- Full Text
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21. Do We Really Know the Epidemiology and Clinical Course of Sepsis?
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Ilkka, L., Parviainen, I., Takala, J., and Vincent, Jean-Louis, editor
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- 1998
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22. Epidemiology and Clinical Course of Sepsis
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Ilkka, L., Takala, J., Baue, A. E., editor, Berlot, G., editor, and Gullo, A., editor
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- 1998
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23. Costs and Resource Utilization in Intensive Care
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Takala, J., Ruokonen, E., and Vincent, Jean-Louis, editor
- Published
- 1997
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24. Splanchnic Blood Flow
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Takala, J., Vincent, Jean-Louis, editor, and Pinsky, Michael R., editor
- Published
- 1997
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25. Oxygen Consumption and Carbon Dioxide Production: Physiological Basis and Practical Application in Intensive Care
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Takala, J. and Gullo, Antonino, editor
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- 1997
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26. Muscle membrane dysfunction in critical illness myopathy assessed by velocity recovery cycles
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Z’Graggen, W.J., Brander, L., Tuchscherer, D., Scheidegger, O., Takala, J., and Bostock, H.
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- 2011
- Full Text
- View/download PDF
27. Mechanical Ventilation in ARDS: Interaction of Respiratory Mechanics and Gas Exchange
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Takala, J., Valta, P., and Vincent, Jean-Louis, editor
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- 1995
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28. Indoor Localization Methods Using Dead Reckoning and 3D Map Matching
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Bojja, J., Kirkko-Jaakkola, M., Collin, J., and Takala, J.
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- 2014
- Full Text
- View/download PDF
29. Assessment of Systemic and Regional Oxygen Delivery and Consumption
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Takala, J., Ruokonen, E., Vincent, J.-L., editor, and Vincent, Jean-Louis, editor
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- 1993
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- View/download PDF
30. Nutrition and Metabolism in Acute Respiratory Failure
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Takala, J., Vincent, Jean-Louis, editor, Wilmore, Douglas W., editor, and Carpentier, Yvon A., editor
- Published
- 1993
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31. Decision Support Systems in Intensive Care
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Kari, A., Ruokonen, E., Takala, J., and Vincent, Jean-Louis, editor
- Published
- 1992
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32. Blood Flow and Adrenergic Drugs in Septic Shock
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Takala, J., Ruokonen, E., and Vincent, Jean Louis, editor
- Published
- 1991
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33. Vasoactive Drugs and Splanchnic Perfusion
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Takala, J. and Gullo, Antonino, editor
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- 1996
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34. Pedestrian Navigation Based on Inertial Sensors, Indoor Map, and WLAN Signals
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Leppäkoski, H., Collin, J., and Takala, J.
- Published
- 2013
- Full Text
- View/download PDF
35. Algorithm for pedestrian navigation combining IMU measurements and gait models
- Author
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Davidson, P. and Takala, J.
- Published
- 2013
- Full Text
- View/download PDF
36. Improved protection of outdoor workers from solar ultraviolet radiation: position statement
- Author
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John, S.M. Garbe, C. French, L.E. Takala, J. Yared, W. Cardone, A. Gehring, R. Spahn, A. Stratigos, A.
- Subjects
integumentary system ,humanities - Abstract
The vast majority of non-melanoma skin cancer (NMSC) is attributable to excessive exposure to ultraviolet radiation (UVR). Outdoor workers are exposed to an UVR dose at least 2 to 3 times higher than indoor workers and often to daily UVR doses 5 times above internationally recommended limits. The risk of UVR workplace exposure is vastly neglected, and the evident future challenges presented in this statement are contrasted with the current situation regarding legal recognition, patient care and compensation. While prevention is crucial to reduce cancer risks for outdoor workers, it is as much of relevance to better protect them through legally binding rules and regulations. Specific actions are outlined in five recommendations based on a Call to Action (table 1). The role of health professionals, including dermatologists, in this context is crucial. © 2020 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology
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- 2021
37. Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.
- Author
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Abidin H.Z., Hassan M.H., Omar S.C., Shukeri W.F.W., Brealey D., Bercades G., Blackburn E., Macallum N., Macklin A., Ryu J.H., Tam K., Smyth D., Arif A., Bassford C., Morgan C., Swann C., Ward G., Wild L., Bone A., Elderkin T., Green D., Sach D., Salerno T., Simpson N., Brohi F., Clark M., Williams L., Brooks J., Cocks E., Cole J., Curtin J., Davies R., Hill H., Morgan M., Palmer N., Whitton C., Wise M., Baskaran P., Hasan M.S., Tham L.Y., Cruz R.S., Dinsdale D., Edney S., Firkin C., FitzJohn F., Hill G., Hunt A., Hurford S., Jones G., Judd H., Latimer-Bell C., Lawrence C., Lesona E., Navarra L., Robertson Y., Smellie H., Vucago A.M., Young P., Dawson H., Griffith D.M., Paterson R., Clark P., Kong J., Ho J., Nayyar V., Skelly C., Shehabi Y., Serpa Neto A., Howe B.D., Arabi Y.M., Bass F.E., Kadiman S.B., McArthur C.J., Reade M.C., Seppelt I.M., Wise M.P., Mashonganyika C., McKee H., Tonks A., Donnelly A., Hemmings N., O'Kane S., Blakemore A., Butler M., Cowdrey K., Dalton J., Gilder E., Long S., McCarthy L., McGuinness S., Parke R., Chen Y., McArthur C., McConnochie R., Newby L., Bellomo R., Eastwood G., Peck L., Young H., Boschert C., Edington J., Fletcher J., Nand K., Raza A., Sara T., Bennett-Britton J., Bewley J., Bodenham V., Cole L., Driver K., Grimmer L., Howie L., Searles C., Sweet K., Webster D., van Berkel A., Connor H., Dennett J., van Der Graaff M., Henderson S., Mehrtens J., Miller K., Minto E., Morris A., Noble S., Parker K., Hart N., Shepherd K., Vij S., Dickson S., Elloway E., Ferguson C., Jackson R., MacNaughton P., Marner M., Squire R., Waddy S., Wafer P., Welbourne J., Ashcroft P., Chambler D., Dukes S., Harris A., Horton S., Sharpe S., Williams P., Williams S., Bailey M., Blazquez E., France D., Hutchison R., Comadira G., Gough M., Tallott M., Bastick M., Cameron R., Donovan S., Gaur A., Gregory R., Naumoff J., Turner E., White M., Au K.F.J., Fratzia J., Treloar S., Lim C.H., Maseeda Y., Tan A.P., Tang C.L., Yong C.Y., Akaltan M., Berger S., Blaser D., Fazlija L., Jong M.L., Lensch M., Ludwig R., Merz T., Nettelbeck K., Roth M., Schafer M., Takala J., Wehr A., Zacharias D., Amran R., Ashraf H.N., Azmi N., Basri N., Burhanuddin H., Hadinata Y., Hamdan A., Kadiman S., Rashid A.I.Y.M., Sabran I.N., Sulaiman S., Zabidi I.N., Al-Dawood A., Aljuaid M., Al Anizi H., Al Saeedi A., Arabi Y., Dbsawy M., Deeb A., Hegazy M., Magdi I., Corcoran E., Finney C., Dumlao L.A., Bassam R., Hassan M.A., Naseem N., Al-Kurdi M.H., Al-Harthy A.M., Bernard S., Sebafundi L., Serban C., Lim S.K., Mazidah N., Saidin N., Sjamsuddin N., Tan I.T.A., Zabidi N., Brain M., Mineall S., Kanhere M., Soar N., Kadir N.A., Abdullah N.H., Awang R., Emperan Z., Husin N.S., Ismail N.I., Ismail S.Z., Khadzali F.N.A.M., Norddin M.F., Aguila J., Bold C., Clatworthy B., Dias A., Hogan C., Kazemi A., Lai V., Song R., Williams A., Bhatia D., Bulfin L., Elliot S., Galt P., Lavrans K., Ritchie P., Wang A., Gresham R., Lowrey J., Masters K., Palejs P., Seppelt I., Symonds F., Weisbrodt L., Whitehead C., Babio-Galan M., Calder V., Clement I., Harrison A., McCullagh I., Scott C., Bevan R., Caniba S., Hacking D., Maher L., Azzolini M.L., Beccaria P., Colombo S., Landoni G., Leggieri C., Luca C., Mamo D., Moizo E., Monti G., Mucci M., Zangrillo A., Albania M., Arora S., Shi Y., Abudayah A., Almekhlafi G., Al Amodi E., Al Samarrai S., Badawi M., Caba R.C., Elffaki O., Mandourah Y., Valerio J., Joyce C., Meyer J., Saylor E., Venkatesh B., Venz E., Walsham J., Wetzig K., Clarey E., Harris C., Hopkins P., Noble H., Thompson L., Williams T., Khoo T.M., Liew J.E.S., Sakthi A.N., Zulkurnain A., Bamford A., Bergin C., Carrera R., Cooper L., Despy L., Ellis K., Harkett S., Mee L., Reeves E., Snelson C., Spruce E., Cooper G., Hodgson R., Pearson D., Rosbergen M., Ali M.N., Bahar N.I., Ismail A., Ismail W.N.W., Samat N.M., Piah N.S.M., Rahman R.A., Duroux M., Ratcliffe M., Warhurst T., Buehner U., Williams E., Jacques N., Keating L., Macgill S., Tamang K.L., Tolan N., Walden A., Bower R., Cranshaw J., Molloy K., Pitts S., Butler J., Dunlop R., Fourie C., Jarrett P., Lassig-Smith M., Livermore A., O'Donoghue S., Reade M., Starr T., Stuart J., Campbell L., Phillips M., Stephens D., Thomas J., Cooper D., McAllister R., Andrew G., Barclay L., Hope D., Wojcik G., McCulloch C., Ascough L., Paisley C., Patrick-Heselton J., Shaw D., Waugh V., Williams K., Welters I., Barge D., Jordan A., MacIsaac C., Rechnitzer T., Bass F., Gatward J., Hammond N., Janin P., O'Connor A., Stedman W., Yarad E., Razak N.A., Dzulkipli N., Jong S.L., Asen K., Voon W.L., Liew S., Ball J., Barnes V., Dalton C., Farnell-Ward S., Farrah H., Maher K., Mellinghoff J., Ryan C., Shirley P., Conlon L., Glover A., Martin-Loeches I., O'Toole E., Ewan J., Ferrier J., Litton E., Webb S.A., Berry W., Alonso U.B., Bociek A., Campos S., Jawara S., Hanks F., Kelly A., Lei K., McKenzie C., Ostermann M., Wan R., Al-Soufi S., Leow S., McCann K., Reynolds C., Brickell K., Fahey C., Hays L., Hyde N., Nichol A., Ryan D., Brailsford J., Buckley A., Forbes L., Maguire T., Moore J., Murray L., Ghosh A., Park M., Said S., Smith J., Visser A., Ali S., Abidin H.Z., Hassan M.H., Omar S.C., Shukeri W.F.W., Brealey D., Bercades G., Blackburn E., Macallum N., Macklin A., Ryu J.H., Tam K., Smyth D., Arif A., Bassford C., Morgan C., Swann C., Ward G., Wild L., Bone A., Elderkin T., Green D., Sach D., Salerno T., Simpson N., Brohi F., Clark M., Williams L., Brooks J., Cocks E., Cole J., Curtin J., Davies R., Hill H., Morgan M., Palmer N., Whitton C., Wise M., Baskaran P., Hasan M.S., Tham L.Y., Cruz R.S., Dinsdale D., Edney S., Firkin C., FitzJohn F., Hill G., Hunt A., Hurford S., Jones G., Judd H., Latimer-Bell C., Lawrence C., Lesona E., Navarra L., Robertson Y., Smellie H., Vucago A.M., Young P., Dawson H., Griffith D.M., Paterson R., Clark P., Kong J., Ho J., Nayyar V., Skelly C., Shehabi Y., Serpa Neto A., Howe B.D., Arabi Y.M., Bass F.E., Kadiman S.B., McArthur C.J., Reade M.C., Seppelt I.M., Wise M.P., Mashonganyika C., McKee H., Tonks A., Donnelly A., Hemmings N., O'Kane S., Blakemore A., Butler M., Cowdrey K., Dalton J., Gilder E., Long S., McCarthy L., McGuinness S., Parke R., Chen Y., McArthur C., McConnochie R., Newby L., Bellomo R., Eastwood G., Peck L., Young H., Boschert C., Edington J., Fletcher J., Nand K., Raza A., Sara T., Bennett-Britton J., Bewley J., Bodenham V., Cole L., Driver K., Grimmer L., Howie L., Searles C., Sweet K., Webster D., van Berkel A., Connor H., Dennett J., van Der Graaff M., Henderson S., Mehrtens J., Miller K., Minto E., Morris A., Noble S., Parker K., Hart N., Shepherd K., Vij S., Dickson S., Elloway E., Ferguson C., Jackson R., MacNaughton P., Marner M., Squire R., Waddy S., Wafer P., Welbourne J., Ashcroft P., Chambler D., Dukes S., Harris A., Horton S., Sharpe S., Williams P., Williams S., Bailey M., Blazquez E., France D., Hutchison R., Comadira G., Gough M., Tallott M., Bastick M., Cameron R., Donovan S., Gaur A., Gregory R., Naumoff J., Turner E., White M., Au K.F.J., Fratzia J., Treloar S., Lim C.H., Maseeda Y., Tan A.P., Tang C.L., Yong C.Y., Akaltan M., Berger S., Blaser D., Fazlija L., Jong M.L., Lensch M., Ludwig R., Merz T., Nettelbeck K., Roth M., Schafer M., Takala J., Wehr A., Zacharias D., Amran R., Ashraf H.N., Azmi N., Basri N., Burhanuddin H., Hadinata Y., Hamdan A., Kadiman S., Rashid A.I.Y.M., Sabran I.N., Sulaiman S., Zabidi I.N., Al-Dawood A., Aljuaid M., Al Anizi H., Al Saeedi A., Arabi Y., Dbsawy M., Deeb A., Hegazy M., Magdi I., Corcoran E., Finney C., Dumlao L.A., Bassam R., Hassan M.A., Naseem N., Al-Kurdi M.H., Al-Harthy A.M., Bernard S., Sebafundi L., Serban C., Lim S.K., Mazidah N., Saidin N., Sjamsuddin N., Tan I.T.A., Zabidi N., Brain M., Mineall S., Kanhere M., Soar N., Kadir N.A., Abdullah N.H., Awang R., Emperan Z., Husin N.S., Ismail N.I., Ismail S.Z., Khadzali F.N.A.M., Norddin M.F., Aguila J., Bold C., Clatworthy B., Dias A., Hogan C., Kazemi A., Lai V., Song R., Williams A., Bhatia D., Bulfin L., Elliot S., Galt P., Lavrans K., Ritchie P., Wang A., Gresham R., Lowrey J., Masters K., Palejs P., Seppelt I., Symonds F., Weisbrodt L., Whitehead C., Babio-Galan M., Calder V., Clement I., Harrison A., McCullagh I., Scott C., Bevan R., Caniba S., Hacking D., Maher L., Azzolini M.L., Beccaria P., Colombo S., Landoni G., Leggieri C., Luca C., Mamo D., Moizo E., Monti G., Mucci M., Zangrillo A., Albania M., Arora S., Shi Y., Abudayah A., Almekhlafi G., Al Amodi E., Al Samarrai S., Badawi M., Caba R.C., Elffaki O., Mandourah Y., Valerio J., Joyce C., Meyer J., Saylor E., Venkatesh B., Venz E., Walsham J., Wetzig K., Clarey E., Harris C., Hopkins P., Noble H., Thompson L., Williams T., Khoo T.M., Liew J.E.S., Sakthi A.N., Zulkurnain A., Bamford A., Bergin C., Carrera R., Cooper L., Despy L., Ellis K., Harkett S., Mee L., Reeves E., Snelson C., Spruce E., Cooper G., Hodgson R., Pearson D., Rosbergen M., Ali M.N., Bahar N.I., Ismail A., Ismail W.N.W., Samat N.M., Piah N.S.M., Rahman R.A., Duroux M., Ratcliffe M., Warhurst T., Buehner U., Williams E., Jacques N., Keating L., Macgill S., Tamang K.L., Tolan N., Walden A., Bower R., Cranshaw J., Molloy K., Pitts S., Butler J., Dunlop R., Fourie C., Jarrett P., Lassig-Smith M., Livermore A., O'Donoghue S., Reade M., Starr T., Stuart J., Campbell L., Phillips M., Stephens D., Thomas J., Cooper D., McAllister R., Andrew G., Barclay L., Hope D., Wojcik G., McCulloch C., Ascough L., Paisley C., Patrick-Heselton J., Shaw D., Waugh V., Williams K., Welters I., Barge D., Jordan A., MacIsaac C., Rechnitzer T., Bass F., Gatward J., Hammond N., Janin P., O'Connor A., Stedman W., Yarad E., Razak N.A., Dzulkipli N., Jong S.L., Asen K., Voon W.L., Liew S., Ball J., Barnes V., Dalton C., Farnell-Ward S., Farrah H., Maher K., Mellinghoff J., Ryan C., Shirley P., Conlon L., Glover A., Martin-Loeches I., O'Toole E., Ewan J., Ferrier J., Litton E., Webb S.A., Berry W., Alonso U.B., Bociek A., Campos S., Jawara S., Hanks F., Kelly A., Lei K., McKenzie C., Ostermann M., Wan R., Al-Soufi S., Leow S., McCann K., Reynolds C., Brickell K., Fahey C., Hays L., Hyde N., Nichol A., Ryan D., Brailsford J., Buckley A., Forbes L., Maguire T., Moore J., Murray L., Ghosh A., Park M., Said S., Smith J., Visser A., and Ali S.
- Abstract
Purpose: To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and identify patients who have a high probability of lower or higher 90-day mortality according to age, and other identified clusters. Method(s): Bayesian analysis of 3904 critically ill adult patients expected to receive invasive ventilation > 24 h and enrolled in a multinational randomized controlled trial comparing early DEX with usual care sedation. Result(s): HTE was assessed according to age and clusters (based on 12 baseline characteristics) using a Bayesian hierarchical models. DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible interval [CrI] 0.68-1.00], with 97.7% probability of reduced mortality across broad categories of illness severity. Conversely, the probability of increased mortality in patients = 65 years was 98.5% (OR 1.26 [95% CrI 1.02-1.56]. Two clusters were identified: cluster 1 (976 patients) mostly operative, and cluster 2 (2346 patients), predominantly non-operative. There was a greater probability of benefit with DEX in cluster 1 (OR 0.86 [95% CrI 0.65-1.14]) across broad categories of age, with 86.4% probability that DEX is more beneficial in cluster 1 than cluster 2. Conclusion(s): In critically ill mechanically ventilated patients, early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status. Conversely, a high probability of increased 90-day mortality was observed in younger patients of non-operative status. Further studies are needed to confirm these findings.Copyright © 2021, Crown.
- Published
- 2021
38. Application of particle filters to a map-matching algorithm
- Author
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Davidson, P., Collin, J., and Takala, J.
- Published
- 2011
- Full Text
- View/download PDF
39. Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients
- Author
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Jakob, S. M., Ruokonen, E., and Takala, J.
- Published
- 2014
- Full Text
- View/download PDF
40. Hemodynamic effects of dexmedetomidine in patients with septic shock: A cohort study of the sedation practice in intensive care evaluation [SPICE III] trial.
- Author
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Cioccari L., Messmer A., Peck L., Howe B., Shehabi Y., Takala J., Jakob S., Bellomo R., Bailey M., Luethi N., Cioccari L., Messmer A., Peck L., Howe B., Shehabi Y., Takala J., Jakob S., Bellomo R., Bailey M., and Luethi N.
- Abstract
Introduction: Septic shock can result in catecholamine hyposensitivity, leading to hemodynamic instability and death. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholamine requirements in septic shock [1]. However, because it can cause hypotension and bradycardia, clinicians may be reluctant to use DEX in such patients. Method(s): In this cohort study of the Sedation Practices in Intensive Care Evaluation (SPICE III) trial, an international randomized trial comparing sedation with DEX to usual care, we studied critically ill patients with septic shock admitted to the Austin Hospital, Melbourne, Australia, and the University Hospital of Bern, Switzerland. The primary outcome was mean noradrenaline requirements in the first 48 hours. Result(s): Between November 2013 and February 2018, 417 patients were recruited into the SPICE III trial at both sites. Eighty-three patients with septic shock were included in this sub-study, of whom 44 (53%) received DEX and 39 (47%) usual care. Mean noradrenaline dose during the first 48 hours was 0.03 [0.01, 0.07] mug/kg/min in the DEX group and 0.05 [0.01, 0.15] mug/kg/min in the usual care group (p= 0.08). Over the first 48 hours, patients in the DEX group had higher mean arterial pressures (MAP) (Figure 1) and lower vasopressor requirements to maintain the target MAP (expressed by the noradrenaline equivalents to MAP ratio: NEq/MAP) compared to the usual care group (ratio of adjusted difference in geometric means 1.4 [1.1, 1.9], p=0.02). Conclusion(s): In critically ill patients with septic shock, sedation with DEX does not increase noradrenaline requirements in the first 48 hours as compared to usual care. In contrast, DEX appears to be associated with lower vasopressor requirements to maintain the target MAP.
- Published
- 2020
41. The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: A subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial.
- Author
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Webb S.A., Cioccari L., Luethi N., Bailey M., Messmer A.S., Proimos H.K., Peck L., Young H., Eastwood G.M., Merz T.M., Jakob S.M., Arabi Y., Erickson S., Shehabi Y., Howe B., Bellomo R., Arabi Y.M., Bass F., Kadiman S., McArthur C., Reade M., Seppelt I., Takala J., Wise M.P., Bailey M.J., Howe B.D., Murray L., Singh V., Webb S.A., Cioccari L., Luethi N., Bailey M., Messmer A.S., Proimos H.K., Peck L., Young H., Eastwood G.M., Merz T.M., Jakob S.M., Arabi Y., Erickson S., Shehabi Y., Howe B., Bellomo R., Arabi Y.M., Bass F., Kadiman S., McArthur C., Reade M., Seppelt I., Takala J., Wise M.P., Bailey M.J., Howe B.D., Murray L., and Singh V.
- Abstract
Background: Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholamine requirements in septic shock. However, DEX may also cause hypotension and bradycardia. Thus, it remains unclear whether DEX is hemodynamically safe or helpful in this setting. Method(s): In this post hoc subgroup analysis of the Sedation Practice in Intensive Care Evaluation (SPICE III) trial, an international randomized trial comparing early sedation with dexmedetomidine to usual care in critically patients receiving mechanical ventilation, we studied patients with septic shock admitted to two tertiary ICUs in Australia and Switzerland. The primary outcome was vasopressor requirements in the first 48 h after randomization, expressed as noradrenaline equivalent dose (NEq [mug/kg/min] = noradrenaline + adrenaline + vasopressin/0.4). Result(s): Between November 2013 and February 2018, 417 patients were recruited into the SPICE III trial at both sites. Eighty-three patients with septic shock were included in this subgroup analysis. Of these, 44 (53%) received DEX and 39 (47%) usual care. Vasopressor requirements in the first 48 h were similar between the two groups. Median NEq dose was 0.03 [0.01, 0.07] mug/kg/min in the DEX group and 0.04 [0.01, 0.16] mug/kg/min in the usual care group (p = 0.17). However, patients in the DEX group had a lower NEq/MAP ratio, indicating lower vasopressor requirements to maintain the target MAP. Moreover, on adjusted multivariable analysis, higher dexmedetomidine dose was associated with a lower NEq/MAP ratio. Conclusion(s): In critically ill patients with septic shock, patients in the DEX group received similar vasopressor doses in the first 48 h compared to the usual care group. On multivariable adjusted analysis, dexmedetomidine appeared to be associated with lower vasopressor requirements to maintain the target
- Published
- 2020
42. Guest Editors’ Introduction to Special Issue on Advances in DSP System Design
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Takala, J., Gross, W. J., and Sung, W.
- Published
- 2013
- Full Text
- View/download PDF
43. Improved protection of outdoor workers from solar ultraviolet radiation: position statement
- Author
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John, S.M., primary, Garbe, C., additional, French, L.E., additional, Takala, J., additional, Yared, W., additional, Cardone, A., additional, Gehring, R., additional, Spahn, A., additional, and Stratigos, A., additional
- Published
- 2020
- Full Text
- View/download PDF
44. Effects of cerebral perfusion pressure and increased fraction of inspired oxygen on brain tissue oxygen, lactate and glucose in patients with severe head injury
- Author
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Reinert, M., Barth, A., Rothen, H. U., Schaller, B., Takala, J., and Seiler, R. W.
- Published
- 2003
- Full Text
- View/download PDF
45. Janus faces of the white coat effect: blood pressure not only rises, it may also fall
- Author
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Kumpusalo, E, Teho, A, Laitila, R, and Takala, J
- Published
- 2002
- Full Text
- View/download PDF
46. Factors related to non-compliance with antihypertensive drug therapy
- Author
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Jokisalo, E, Kumpusalo, E, Enlund, H, Halonen, P, and Takala, J
- Published
- 2002
- Full Text
- View/download PDF
47. Customised prediction models based on APACHE II and SAPS II scores in patients with prolonged length of stay in the ICU
- Author
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Suistomaa, M., Niskanen, M., Kari, A., Hynynen, M., and Takala, J.
- Published
- 2002
- Full Text
- View/download PDF
48. Patients’ perceived problems with hypertension and attitudes towards medical treatment
- Author
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Jokisalo, E, Kumpusalo, E, Enlund, H, and Takala, J
- Published
- 2001
- Full Text
- View/download PDF
49. Variability of splanchnic blood flow measurements in patients with sepsis – physiology, pathophysiology or measurement errors?
- Author
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Jakob, S. and Takala, J.
- Published
- 2001
- Full Text
- View/download PDF
50. Gastric tonometry after subarachnoid hemorrhage
- Author
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Koivisto, T., Vapalahti, M., Parviainen, I., and Takala, J.
- Published
- 2001
- Full Text
- View/download PDF
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