2,833 results on '"Takahashi, I."'
Search Results
2. Growth Hormone Injection Log Analysis with Electronic Injection Device for Qualifying Adherence to Low-Irritant Formulation and Exploring Influential Factors on Adherence
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Takasawa K, Mabe H, Nagamatsu F, Amano N, Miyakawa Y, Sutani A, Kagawa R, Okada S, Tanahashi Y, Suzuki S, Hiroshima S, Nagasaki K, Dateki S, Takishima S, Takahashi I, and Kashimada K
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gh therapy ,digital health technology ,shared decision- making ,patient autonomy. ,Medicine (General) ,R5-920 - Abstract
Kei Takasawa,1 Hiroyo Mabe,2 Fusa Nagamatsu,2 Naoko Amano,3 Yuichi Miyakawa,4 Akito Sutani,4 Reiko Kagawa,5 Satoshi Okada,5 Yusuke Tanahashi,6 Shigeru Suzuki,6 Shota Hiroshima,7 Keisuke Nagasaki,7 Sumito Dateki,8 Shigeru Takishima,9 Ikuko Takahashi,10 Kenichi Kashimada1 1Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; 2Department of Pediatrics, Kumamoto University Hospital, Kumamoto, Japan; 3Department of Pediatrics, Saitama City Hospital, Saitama, Japan; 4Department of Pediatrics, Kawaguchi Municipal Medical Center, Saitama, Japan; 5Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; 6Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan; 7Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; 8Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 9Department of Pediatrics, Soka Municipal Hospital, Saitama, Japan; 10Department of Pediatrics, Akita University Graduate School of Medicine, Akita, JapanCorrespondence: Kei Takasawa, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan, Tel +81-3-5803-5246, Fax +81-3-5803-5249, Email ktakasawa.ped@tmd.ac.jpIntroduction: Although the treatment success of long-term growth hormone therapy (GHT) is dependent on maintaining patients’ adherence to treatment, marked variations in adherence levels among children with GHT (eg, 7– 71% nonadherence) have been reported. Barriers to or promoters of GHT adherence have been discussed and investigated, and digital health technologies, such as electronic GH injection devices, may have the potential to assess adherence to GHT more accurately. Thus, we conducted a multicenter, retrospective cohort study using GH injection log analysis of an electronic GH device, GROWJECTOR®L, to qualify adherence and explore the factors influencing adherence.Methods: This study enrolled 41 patients (median[range] age, 5.8[3.0 ~ 17.0] years) with short stature from nine Japanese medical institutions. The injection log data (12– 48 weeks) were read by smartphones and collected into the data center through a cloud server.Results: Although cumulative adherence rates remained higher than 95% throughout the observation period, five (12.2%) patients had low adherence (< 85%). Subsequently, subgroup and logistic regression analyses for exploring factors affecting adherence revealed that self-selection of GH device and irregular injection schedule (ie, frequent injections after midnight) significantly affected adherence rate (p=0.034 and 0.048, respectively). In addition, higher rates of irregular injections significantly affected low adherence (median[range], 11.26[0.79 ~ 30.50]% vs 0.26[0.00 ~ 33.33]%, p = 0.029).Discussion: Our study indicated that injection log analysis using an electronic GH device could detect irregular injection schedules due to a night owl or disturbance in lifetime rhythm affecting low adherence and had significant potential to encourage collaborative monitoring of adherence with healthcare providers and patients themselves/caregivers, along with growing autonomy and shared decision-making. Our study suggests the significance of narrative and personal approaches to adherence of patients with GHT and the usefulness of digital devices for such an approach and for removing various barriers to patient autonomy, leading to improvement and maintenance of adherence.Keywords: GH therapy, digital health technology, shared decision- making, patient autonomy
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- 2023
3. Direct Measurement of the Cosmic-Ray Proton Spectrum from 50 GeV to 10 TeV with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Bagliesi, M. G., Berti, E., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Suh, J. E., Sulaj, A., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Terasawa, T., Tomida, H., Torii, S., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., and Yoshida, K.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
In this paper, we present the analysis and results of a direct measurement of the cosmic-ray proton spectrum with the CALET instrument onboard the International Space Station, including the detailed assessment of systematic uncertainties. The observation period used in this analysis is from October 13, 2015 to August 31, 2018 (1054 days). We have achieved the very wide energy range necessary to carry out measurements of the spectrum from 50 GeV to 10 TeV covering, for the first time in space, with a single instrument the whole energy interval previously investigated in most cases in separate subranges by magnetic spectrometers (BESS-TeV, PAMELA, and AMS-02) and calorimetric instruments (ATIC, CREAM, and NUCLEON). The observed spectrum is consistent with AMS-02 but extends to nearly an order of magnitude higher energy, showing a very smooth transition of the power-law spectral index from -2.81 +- 0.03 (50--500 GeV) neglecting solar modulation effects (or -2.87 +- 0.06 including solar modulation effects in the lower energy region) to -2.56 +- 0.04 (1--10 TeV), thereby confirming the existence of spectral hardening and providing evidence of a deviation from a single power law by more than 3 sigma., Comment: main text: 8 pages, 5 figures, supplemental material: 12 pages, 7 figures, 1 table, marked as a PRL Editor's Suggestion
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- 2019
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4. The CALorimetric Electron Telescope (CALET) on the International Space Station: Results from the First Two Years On Orbit
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Asaoka, Y., Adriani, O., Akaike, Y., Asano, K., Bagliesi, M. G., Berti, E., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Bruno, A., Brogi, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Felice, V. Di., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakahira, S., Nishimura, J., Nolfo, G. A. De., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Pal'shin, V., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Sugita, S., Suh, J. E., Sulaj, A., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Torii, S., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., and Yoshida, K.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The CALorimetric Electron Telescope (CALET) is a high-energy astroparticle physics space experiment installed on the International Space Station (ISS), developed and operated by Japan in collaboration with Italy and the United States. The CALET mission goals include the investigation of possible nearby sources of high-energy electrons, of the details of galactic particle acceleration and propagation, and of potential signatures of dark matter. CALET measures the cosmic-ray electron + positron flux up to 20 TeV, gamma-rays up to 10 TeV, and nuclei with Z=1 to 40 up to 1,000 TeV for the more abundant elements during a long-term observation aboard the ISS. Starting science operation in mid-October 2015, CALET performed continuous observation without major interruption with close to 20 million triggered events over 10 GeV per month. Based on the data taken during the first two-years, we present an overview of CALET observations: uses w/o major interruption 1) Electron + positron energy spectrum, 2) Nuclei analysis, 3) Gamma-ray observation including a characterization of on-orbit performance. Results of the electromagnetic counterpart search for LIGO/Virgo gravitational wave events are discussed as well., Comment: 10 pages, 10 figures, a contribution to the proceedings of 26th Extended European Cosmic Ray Symposium, 6-10 July 2018, Russia, which summarizes our recent publications such as arXiv:1712.01711, arXiv:1712.01757, arXiv:1803.05834, arXiv:1806.09728, and arXiv:1807.01435
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- 2019
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5. Search for GeV Gamma-ray Counterparts of Gravitational Wave Events by CALET
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Bagliesi, M. G., Berti, E., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Brogi, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hareyama, M., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Krawczynski, H. S., Krizmanic, J. F., Kohri, K., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Suh, J. E., Sulaj, A., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Torii, S., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., and Yoshida, K.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present results on searches for gamma-ray counterparts of the LIGO/Virgo gravitational-wave events using CALorimetric Electron Telescope ({\sl CALET}) observations. The main instrument of {\sl CALET}, CALorimeter (CAL), observes gamma-rays from $\sim1$ GeV up to 10 TeV with a field of view of nearly 2 sr. In addition, the {\sl CALET} gamma-ray burst monitor (CGBM) views $\sim$3 sr and $\sim2\pi$ sr of the sky in the 7 keV -- 1 MeV and the 40 keV -- 20 MeV bands, respectively, by using two different crystal scintillators. The {\sl CALET} observations on the International Space Station started in October 2015, and here we report analyses of events associated with the following gravitational wave events: GW151226, GW170104, GW170608, GW170814 and GW170817. Although only upper limits on gamma-ray emission are obtained, they correspond to a luminosity of $10^{49}\sim10^{53}$ erg s$^{-1}$ in the GeV energy band depending on the distance and the assumed time duration of each event, which is approximately the order of luminosity of typical short gamma-ray bursts. This implies there will be a favorable opportunity to detect high-energy gamma-ray emission in further observations if additional gravitational wave events with favorable geometry will occur within our field-of-view. We also show the sensitivity of {\sl CALET} for gamma-ray transient events which is the order of $10^{-7}$~erg\,cm$^{-2}$\,s$^{-1}$ for an observation of 100~s duration., Comment: 12 pages, 8 figures, 1 table. Accepted for publication in Astrophysical Journal
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- 2018
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6. Extended Measurement of the Cosmic-Ray Electron and Positron Spectrum from 11 GeV to 4.8 TeV with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Bagliesi, M. G., Berti, E., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Brogi, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hareyama, M., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Suh, J. E., Sulaj, A., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Torii, S., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., and Yoshida, K.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Extended results on the cosmic-ray electron + positron spectrum from 11 GeV to 4.8 TeV are presented based on observations with the Calorimetric Electron Telescope (CALET) on the International Space Station utilizing the data up to November 2017. The analysis uses the full detector acceptance at high energies, approximately doubling the statistics compared to the previous result. CALET is an all-calorimetric instrument with a total thickness of 30 $X_0$ at normal incidence and fine imaging capability, designed to achieve large proton rejection and excellent energy resolution well into the TeV energy region. The observed energy spectrum in the region below 1 TeV shows good agreement with Alpha Magnetic Spectrometer (AMS-02) data. In the energy region below $\sim$300 GeV, CALET's spectral index is found to be consistent with the AMS-02, Fermi Large Area Telescope (Fermi-LAT) and Dark Matter Particle Explorer (DAMPE), while from 300 to 600 GeV the spectrum is significantly softer than the spectra from the latter two experiments. The absolute flux of CALET is consistent with other experiments at around a few tens of GeV. However, it is lower than those of DAMPE and Fermi-LAT with the difference increasing up to several hundred GeV. The observed energy spectrum above $\sim$1 TeV suggests a flux suppression consistent within the errors with the results of DAMPE, while CALET does not observe any significant evidence for a narrow spectral feature in the energy region around 1.4 TeV. Our measured all-electron flux, including statistical errors and a detailed breakdown of the systematic errors, is tabulated in the Supplemental Material in order to allow more refined spectral analyses based on our data., Comment: main text: 7 pages, 4 figures, supplemental material: 8pages, 6 figures, 2 tables
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- 2018
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7. On-orbit Operations and Offline Data Processing of CALET onboard the ISS
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Asaoka, Y., Ozawa, S., Torii, S., Adriani, O., Akaike, Y., Asano, K., Bagliesi, M. G., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Brogi, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hareyama, M., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Javaid, A., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Kuramata, S., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Mizutani, K., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Yuda, T.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The CALorimetric Electron Telescope (CALET), launched for installation on the International Space Station (ISS) in August, 2015, has been accumulating scientific data since October, 2015. CALET is intended to perform long-duration observations of high-energy cosmic rays onboard the ISS. CALET directly measures the cosmic-ray electron spectrum in the energy range of 1 GeV to 20 TeV with a 2% energy resolution above 30 GeV. In addition, the instrument can measure the spectrum of gamma rays well into the TeV range, and the spectra of protons and nuclei up to a PeV. In order to operate the CALET onboard ISS, JAXA Ground Support Equipment (JAXA-GSE) and the Waseda CALET Operations Center (WCOC) have been established. Scientific operations using CALET are planned at WCOC, taking into account orbital variations of geomagnetic rigidity cutoff. Scheduled command sequences are used to control the CALET observation modes on orbit. Calibration data acquisition by, for example, recording pedestal and penetrating particle events, a low-energy electron trigger mode operating at high geomagnetic latitude, a low-energy gamma-ray trigger mode operating at low geomagnetic latitude, and an ultra heavy trigger mode, are scheduled around the ISS orbit while maintaining maximum exposure to high-energy electrons and other high-energy shower events by always having the high-energy trigger mode active. The WCOC also prepares and distributes CALET flight data to collaborators in Italy and the United States. As of August 31, 2017, the total observation time is 689 days with a live time fraction of the total time of approximately 84%. Nearly 450 million events are collected with a high-energy (E>10 GeV) trigger. By combining all operation modes with the excellent-quality on-orbit data collected thus far, it is expected that a five-year observation period will provide a wealth of new and interesting results., Comment: 11 pages, 7 figures, published online 27 February 2018
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- 2018
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8. Energy Calibration of CALET Onboard the International Space Station
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Asaoka, Y., Akaike, Y., Komiya, Y., Miyata, R., Torii, S., Adriani, O., Asano, K., Bagliesi, M. G., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Brogi, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hareyama, M., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Javaid, A., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kitamura, H., Krawczynski, H. S., Krizmanic, J. F., Kuramata, S., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Mizutani, K., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakagawa, Y. E., Nakahira, S., Nishimura, J., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Yuda, T.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
In August 2015, the CALorimetric Electron Telescope (CALET), designed for long exposure observations of high energy cosmic rays, docked with the International Space Station (ISS) and shortly thereafter began tocollect data. CALET will measure the cosmic ray electron spectrum over the energy range of 1 GeV to 20 TeV with a very high resolution of 2% above 100 GeV, based on a dedicated instrument incorporating an exceptionally thick 30 radiation-length calorimeter with both total absorption and imaging (TASC and IMC) units. Each TASC readout channel must be carefully calibrated over the extremely wide dynamic range of CALET that spans six orders of magnitude in order to obtain a degree of calibration accuracy matching the resolution of energy measurements. These calibrations consist of calculating the conversion factors between ADC units and energy deposits, ensuring linearity over each gain range, and providing a seamless transition between neighboring gain ranges. This paper describes these calibration methods in detail, along with the resulting data and associated accuracies. The results presented in this paper show that a sufficient accuracy was achieved for the calibrations of each channel in order to obtain a suitable resolution over the entire dynamic range of the electron spectrum measurement., Comment: 13 pages, 11 figures, published online 4 March 2017
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- 2017
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9. Energy Spectrum of Cosmic-ray Electron and Positron from 10 GeV to 3 TeV Observed with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Bagliesi, M. G., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Brogi, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hareyama, M., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Javaid, A., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Krawczynski, H. S., Krizmanic, J. F., Kuramata, S., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Mizutani, K., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Torii, S., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Yuda, T.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
First results of a cosmic-ray electron + positron spectrum, from 10 GeV to 3 TeV, is presented based upon observations with the CALET instrument on the ISS starting in October, 2015. Nearly a half million electron + positron events are included in the analysis. CALET is an all-calorimetric instrument with total vertical thickness of 30 $X_0$ and a fine imaging capability designed to achieve a large proton rejection and excellent energy resolution well into the TeV energy region. The observed energy spectrum over 30 GeV can be fit with a single power law with a spectral index of -3.152 $\pm$ 0.016 (stat.+ syst.). Possible structure observed above 100 GeV requires further investigation with increased statistics and refined data analysis., Comment: 7 pages, 6 figures, published 1 November 2017 in Physical Review Letters
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- 2017
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10. CALET Upper Limits on X-ray and Gamma-ray Counterparts of GW 151226
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Bagliesi, M. G., Bigongiari, G., Binns, W. R., Bonechi, S., Bongi, M., Brog, P., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Di Felice, V., Ebisawa, K., Fuke, H., Guzik, T. G., Hams, T., Hareyama, M., Hasebe, N., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Javaid, A., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kitamura, H., Krawczynski, H. S., Krizmanic, J. F., Kuramata, S., Lomtadze, T., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Mizutani, K., Moiseev, A. A., Mori, K., Mori, M., Mori, N., Motz, H. M., Munakata, K., Murakami, H., Nakagawa, Y. E., Nakahira, S., Nishimura, J., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Palma, F., Papini, P., Penacchioni, A. V., Rauch, B. F., Ricciarini, S., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Sparvoli, R., Spillantini, P., Stolzi, F., Takahashi, I., Takayanagi, M., Takita, M., Tamura, T., Tateyama, N., Terasawa, T., Tomida, H., Torii, S., Tsunesada, Y., Uchihori, Y., Ueno, S., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Yuda, T.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present upper limits in the hard X-ray and gamma-ray bands at the time of the LIGO gravitational-wave event GW 151226 derived from the CALorimetric Electron Telescope (CALET) observation. The main instrument of CALET, CALorimeter (CAL), observes gamma-rays from ~1 GeV up to 10 TeV with a field of view of ~2 sr. The CALET gamma-ray burst monitor (CGBM) views ~3 sr and ~2pi sr of the sky in the 7 keV - 1 MeV and the 40 keV - 20 MeV bands, respectively, by using two different scintillator-based instruments. The CGBM covered 32.5% and 49.1% of the GW 151226 sky localization probability in the 7 keV - 1 MeV and 40 keV - 20 MeV bands respectively. We place a 90% upper limit of 2 x 10^{-7} erg cm-2 s-1 in the 1 - 100 GeV band where CAL reaches 15% of the integrated LIGO probability (~1.1 sr). The CGBM 7 sigma upper limits are 1.0 x 10^{-6} erg cm-2 s-1 (7-500 keV) and 1.8 x 10^{-6} erg cm-2 s-1 (50-1000 keV) for one second exposure. Those upper limits correspond to the luminosity of 3-5 x 10^{49} erg s-1 which is significantly lower than typical short GRBs., Comment: 6 pages, 5 figures, accepted for publication in ApJL, corresponding authors: T. Sakamoto, S. Nakahira, Y. Asaoka
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- 2016
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11. Growth of bulk β-Ga2O3 crystals from melt without precious-metal crucible by pulling from a cold container.
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Yoshikawa, A., Kochurikhin, V., Tomida, T., Takahashi, I., Kamada, K., Shoji, Y., and Kakimoto, K.
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CRYSTALS ,CRYSTAL growth ,CRUCIBLES ,WIDE gap semiconductors ,PRECIOUS metals ,METAL oxide semiconductor field-effect transistors - Abstract
We report the growth of bulk β-Ga
2 O3 crystals based on crystal pulling from a melt using a cold container without employing a precious-metal crucible. Our approach, named oxide crystal growth from cold crucible (OCCC), is a fusion between the skull-melting and Czochralski methods. The absence of an expensive precious-metal crucible makes this a cost-effective crystal growth method, which is a critical factor in the semiconductor industry. An original construction 0.4–0.5 MHz SiC MOSFET transistor generator with power up to 35 kW was used to successfully grow bulk β-Ga2 O3 crystals with diameters up to 46 mm. Also, an original diameter control system by generator frequency change was applied. In this preliminary study, the full width at half maximum of the X-ray rocking curve from the obtained β-Ga2 O3 crystals with diameters ≤ 46 mm was comparable to those of β-Ga2 O3 produced by edge-defined film fed growth. Moreover, as expected, the purity of the obtained crystals was high because only raw material-derived impurities were detected, and contamination from the process, such as insulation and noble metals, was below the detection limit. Our results indicate that the OCCC technique can be used to produce high-purity bulk β-Ga2 O3 single crystalline substrate. [ABSTRACT FROM AUTHOR]- Published
- 2024
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12. Development of a novel crucible free crystal growth technology andgrowth of 2 inch size b-Ga2O3 single crystal scintillator
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Kamada, K., primary, Sasaki, R., additional, Tomida, T., additional, Takahashi, I., additional, Yoshino, M., additional, Murakami, R., additional, Horiai, T., additional, Kochurikhin, V., additional, Shoji, Y., additional, Kakimoto, K., additional, and Yoshikawa, A., additional
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- 2023
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13. Joint unloading inhibits articular cartilage degeneration in knee joints of a monosodium iodoacetate-induced rat model of osteoarthritis
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Takahashi, I., Matsuzaki, T., Kuroki, H., and Hoso, M.
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- 2019
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14. Spectral Lag Relations in GRB Pulses Detected with HETE-2
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Arimoto, M., Kawai, N., Asano, K., Hurley, K., Suzuki, M., Nakagawa, Y. E., Shimokawabe, T., Pazmino, N. V., Sato, R., Matsuoka, M., Yoshida, A., Tamagawa, T., Shirasaki, Y., Sugita, S., Takahashi, I., Atteia, J. -L., Pelangeon, A., Vanderspek, R., Graziani, C., Prigozhin, G., Villasenor, J., Jernigan, J. G., Crew, G. B., Sakamoto, T., Ricker, G. R., Woosley, S. E., Butler, N., Levine, A., Doty, J. P., Donaghy, T. Q., Lamb, D. Q., Fenimore, E., Galassi, M., Boer, M., Dezalay, J. -P., Olive, J. -F., Braga, J., Manchanda, R., and Pizzichini, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Using a pulse-fit method, we investigate the spectral lags between the traditional gamma-ray band (50-400 keV) and the X-ray band (6-25 keV) for 8 GRBs with known redshifts (GRB 010921, GRB 020124, GRB 020127, GRB 021211, GRB 030528, GRB 040924, GRB 041006, GRB 050408) detected with the WXM and FREGATE instruments aboard the HETE-2 satellite. We find several relations for the individual GRB pulses between the spectral lag and other observables, such as the luminosity, pulse duration, and peak energy (Epeak). The obtained results are consistent with those for BATSE, indicating that the BATSE correlations are still valid at lower energies (6-25 keV). Furthermore, we find that the photon energy dependence for the spectral lags can reconcile the simple curvature effect model. We discuss the implication of these results from various points of view., Comment: 13 pages, 9 figures, accepted for the publication in PASJ (minor corrections)
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- 2010
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15. X-ray Diagnostics of Thermal Conditions of the Hot Plasmas in the Centaurus Cluster
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Takahashi, I., Kawaharada, M., Makishima, K., Matsushita, K., Fukazawa, Y., Ikebe, Y., Kitaguchi, T., Kokubun, M., Nakazawa, K., Okuyama, S., Ota, N., and Tamura, T.
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Astrophysics - Cosmology and Extragalactic Astrophysics - Abstract
X-ray data of the Centaurus cluster, obtained with {\it XMM-Newton} for 45 ksec, were analyzed. Deprojected EPIC spectra from concentric thin shell regions were reproduced equally well by a single-phase plasma emission model, or by a two-phase model developed by {\it ASCA}, both incorporating cool (1.7--2.0 keV) and hot ($\sim 4$ keV) plasma temperatures. However, EPIC spectra with higher statistics, accumulated over 3-dimentional thick shell regions, were reproduced better by the two-phase model than by the singe-phase one. Therefore, hot and cool plasma phases are inferred to co-exist in the cluster core region within $\sim 70$ kpc. The iron and silicon abundances of the plasma were reconfirmed to increase significantly towards the center, while that of oxygen was consistent with being radially constant. The implied non-solar abundance ratios explains away the previously reported excess X-ray absorption from the central region. Although an additional cool ($\sim 0.7$ keV) emission was detected within $\sim 20$ kpc of the center, the RGS data gave tight upper limits on any emission with a tempeartures below $\sim 0.5$ keV. These results are compiled into a magnetosphere model, which interprets the cool phase as confined within closed magnetic loops anchored to the cD galaxy. When combined with so-called Rosner-Tucker-Vaiana mechanism which applies to solar coronae, this model can potentially explain basic properties of the cool phase, including its temperature and thermal stability., Comment: 53 pages, 11 figures, accepted for publication in Astrophysical Journal
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- 2009
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16. In-Orbit Performance of the Hard X-ray Detector on board Suzaku
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Kokubun, M., Makishima, K., Takahashi, T., Murakami, T., Tashiro, M., Fukazawa, Y., Kamae, T., Madejski, G. M., Nakazawa, K., Yamaoka, K., Terada, Y., Yonetoku, D., Watanabe, S., Tamagawa, T., Mizuno, T., Kubota, A., Isobe, N., Takahashi, I., Sato, G., Takahashi, H., Hong, S., Kawaharada, M., Kawano, N., Mitani, T., Murashima, M., Suzuki, M., Abe, K., Miyawaki, R., Ohno, M., Tanaka, T., Yanagida, T., Itoh, T., Ohnuki, K., Tamura, K., Endo, Y., Hirakuri, S., Hiruta, T., Kitaguchi, T., Kishishita, T., Sugita, S., Takeda, S., Enoto, T., Hirasawa, A., Katsuta, J., Matsumura, S., Onda, K., Sato, M., Ushio, M., Ishikawa, S., Murase, K., Odaka, H., Yaji, Y., Yamada, S., Yamasaki, T., and Yuasa, T.
- Subjects
Astrophysics - Abstract
The in-orbit performance and calibration of the Hard X-ray Detector (HXD) on board the X-ray astronomy satellite Suzaku are described. Its basic performances, including a wide energy bandpass of 10-600 keV, energy resolutions of ~4 keV (FWHM) at 40 keV and ~11% at 511 keV, and a high background rejection efficiency, have been confirmed by extensive in-orbit calibrations. The long-term gains of PIN-Si diodes have been stable within 1% for half a year, and those of scintillators have decreased by 5-20%. The residual non-X-ray background of the HXD is the lowest among past non-imaging hard X-ray instruments in energy ranges of 15-70 and 150-500 keV. We provide accurate calibrations of energy responses, angular responses, timing accuracy of the HXD, and relative normalizations to the X-ray CCD cameras using multiple observations of the Crab Nebula., Comment: 45 pages, 40 figures and 9 tables; accepted for Pulications of the Astronomical Society of Japan
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- 2006
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17. Hard X-ray Detector (HXD) on Board Suzaku
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Takahashi, T., Abe, K., Endo, M., Endo, Y., Ezoe, Y., Fukazawa, Y., Hamaya, M., Hirakuri, S., Hong, S., Horii, M., Inoue, H., Isobe, N., Itoh, T., Iyomoto, N., Kamae, T., Kasama, D., Kataoka, J., Kato, H., Kawaharada, M., Kawano, N., Kawashima, K., Kawasoe, S., Kishishita, T., Kitaguchi, T., Kobayashi, Y., Kokubun, M., Kotoku, J., Kouda, M., Kubota, A., Kuroda, Y., Madejski, G., Makishima, K., Masukawa, K., Matsumoto, Y., Mitani, T., Miyawaki, R., Mizuno, T., Mori, K., Mori, M., Murashima, M., Murakami, T., Nakazawa, K., Niko, H., Nomachi, M., Okada, Y., Ohno, M., Oonuki, K., Ota, N., Ozawa, H., Sato, G., Shinoda, S., Sugiho, M., Suzuki, M., Taguchi, K., Takahashi, H., Takahashi, I., Takeda, S., Tamura, K., Tamura, T., Tanaka, T., Tanihata, C., Tashiro, M., Terada, Y., Tominaga, S., Uchiyama, Y., Watanabe, S., Yamaoka, K., Yanagida, T., and Yonetoku, D.
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Astrophysics - Abstract
The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely low in-orbit back ground based on a combination of new techniques, including the concept of well-type active shield counter. With an effective area of 142 cm^2 at 20 keV and 273 cm2 at 150 keV, the background level at the sea level reached ~1x10^{-5} cts s^{-1} cm^{-2} keV^{-1} at 30 keV for the PI N diodes, and ~2x10^{-5} cts s^{-1} cm^{-2} keV^{-1} at 100 keV, and ~7x10^{-6} cts s^{-1} cm^{-2} keV^{-1} at 200 keV for the phoswich counter. Tight active shielding of the HXD results in a large array of guard counters surrounding the main detector parts. These anti-coincidence counters, made of ~4 cm thick BGO crystals, have a large effective area for sub-MeV to MeV gamma-rays. They work as an excellent gamma-ray burst monitor with limited angular resolution (~5 degree). The on-board signal-processing system and the data transmitted to the ground are also described., Comment: 35 pages, 25 figures and 4 tables; acceted for Publication of the Astronomical Society of Japan
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- 2006
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18. High resolution soft X-ray spectroscopy of the elliptical galaxy NGC 5044. Results from the reflection grating spectrometer on-board XMM-Newton
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Tamura, T., Kaastra, J. S., Makishima, K., and Takahashi, I.
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Astrophysics - Abstract
The results from an X-ray spectroscopic study of the giant elliptical galaxy NGC5044 in the center of a galaxy group are presented. The line dominated soft X-ray spectra (mainly Fe-L and O VIII Ly_a) from the diffuse gas are resolved for the first time in this system with the Reflection Grating Spectrometers on-board XMM-Newton and provide a strong constraint on the temperature structure. The spectra integrated over 2' (\sim 20kpc) in full-width can be described by a two temperature plasma model of 0.7keV and 1.1keV. Most of the latter component is consistent with originating from off-center regions. Compared to the isobaric cooling flow prediction, the observation shows a clear cut-off below a temperature of 0.6 +-0.1keV. Furthermore, the Fe and O abundances within the central 10--20kpc in radius are accurately measured to be 0.55+-0.05 and 0.25+-0.1 times the solar ratios, respectively. The observed cut-off temperature of this galaxy and other central galaxies in galaxy groups and clusters are compared with the scale of the galaxy and properties of the surrounding intra-cluster medium. Based on this comparison, the origin of the lack of predicted cool emission is discussed., Comment: Accepted for publication in Astronomy & Astrophysics
- Published
- 2002
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19. Properties of the background of EPIC-pn onboard XMM-Newton
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Katayama, H., Takahashi, I., Ikebe, Y., Matsushita, K., and Freyberg, M. J.
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Astrophysics - Abstract
We have investigated the background properties of EPIC-pn onboard XMM-Newton to establish the background subtraction method. Count rates of the background vary violently by two orders of magnitude at the maximum, while during the most quiet period, these are stable within 8 % at a 1 $\sigma$ level. The overall spectrum is dominated by particle events above 5 keV, and its spatial variation is also found. The long-term variation of the background is also investigated with CAL CLOSED data, where the filter wheel was in closed position with the internal calibration source illuminating the sensitive area. The average background count rate decreased by 20 % from March 2000 to January 2001, but it regained in February 2001. For the modeling of the background spectrum, we investigate relations between the 2.0--7.0 keV count rate and some characteristic parameters. The 2.0--7.0 keV background count rate shows a good correlation with the count rate of events outside the field of view. This correlation is usable for the modeling of the background., Comment: 9 pages, submitted to A&A
- Published
- 2002
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20. Properties of the background of EPIC onboard XMM-Newton
- Author
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Katayama, H., Takahashi, I., Ikebe, Y., Matsushita, K., Tanaka, Y., and Freyberg, M.
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Astrophysics - Abstract
Understanding a background is crucial in particular for a study of low surface brightness objects. In order to establish the background subtraction method, we have studied properties of the EPIC background. Count rates of the background vary violently by two order of magnitude at the maximum, while during the most quiet period, these are stable within 8 % at a 1 $\sigma$ level. The overall spectrum is dominated by particle events above 5 keV, and its spatial variation is also found. The long-term variation of the background is also investigated with CAL CLOSED data, which is the data of calibration source with filter closed. The average background count rate decreased by 20 % from March 2000 to January 2001, but it regained in February 2001. For the modeling of the background spectrum, we investigate correlations between the 2-10 keV count rate and some characteristic parameters. The PN background shows a good correlation with some parameters. On the other hands, the MOS background does not shows a clear correlation. Further investigation is needed for the MOS background. Our final goal is to establish a method to predict the background, for which these results will be reflected in the background generator., Comment: 4 pages, 24 figures, Proceedings of the Symposium "New Visions of the X-ray Universe in the XMM-Newton and Chandra era", Noordwijk-NL, November 2001
- Published
- 2002
21. AB0778 HISTOPATHOLOGIC FEATURES AND CLINICAL OUTCOMES IN PATIENTS WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS
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Takamasu, E., primary, Yokogawa, N., additional, Takahashi, I., additional, and Shimada, K., additional
- Published
- 2023
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22. Geoelectric Potential Changes: Possible Precursors to Earthquakes in Japan
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Uyeda, S., Nagao, T., Orihara, Y., Yamaguchi, T., and Takahashi, I.
- Published
- 2000
23. Ir(III) complex-based oxygen imaging of living cells and ocular fundus with a gated ICCD camera
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Akiyama, H., Takahashi, I., Shimoda, Y., Mukai, R., Yoshihara, T., and Tobita, S.
- Published
- 2018
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24. Application of a stratum-specific likelihood ratio analysis in a screen for depression among a community-dwelling population in Japan
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Sugawara N, Kaneda A, Takahashi I, Nakaji S, and Yasui-Furukori N
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Screening ,Depression ,Center for Epidemiologic Studies Depression Scale ,Stratum-Specific Likelihood Ratio ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Norio Sugawara,1,2 Ayako Kaneda,2 Ippei Takahashi,3 Shigeyuki Nakaji,3 Norio Yasui-Furukori2 1Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 2Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, 3Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Background: Efficient screening for depression is important in community mental health. In this study, we applied a stratum-specific likelihood ratio (SSLR) analysis, which is independent of the prevalence of the target disease, to screen for depression among community-dwelling individuals.Method: The Center for Epidemiologic Studies Depression Scale (CES-D) and the Mini International Neuropsychiatric Interview (MINI) were administered to 789 individuals (19–87 years of age) who participated in the Iwaki Health Promotion Project 2011. Major depressive disorder (MDD) was assessed using the MINI.Results: For MDD, the SSLRs were 0.13 (95% CI 0.04–0.40), 3.68 (95% CI 1.37–9.89), and 24.77 (95% CI 14.97–40.98) for CES–D scores of 0–16, 17–20, and above 21, respectively.Conclusion: The validity of the CES-D is confirmed, and SSLR analysis is recommended for its practical value for the detection of individuals with the risk of MDD in the Japanese community. Keywords: screening, depression, Center for Epidemiologic Studies Depression Scale, stratum-specific likelihood ratio
- Published
- 2017
25. Oral conditions and dysphagia in Japanese, community-dwelling middle- and older- aged adults, independent in daily living
- Author
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Inui A, Takahashi I, Kurauchi S, Soma Y, Oyama T, Tamura Y, Noguchi T, Murashita K, Nakaji S, and Kobayashi W
- Subjects
oral dryness ,number of teeth ,swallow ,nutrition ,cognitive status ,Geriatrics ,RC952-954.6 - Abstract
Akinari Inui,1 Ippei Takahashi,2 Sizuka Kurauchi,2 Yuki Soma,2 Toshiaki Oyama,1 Yoshihiro Tamura,1 Takao Noguchi,1 Kouichi Murashita,3 Shigeyuki Nakaji,2 Wataru Kobayashi1 1Department of Oral and Maxillofacial Surgery, 2Department of Social Medicine, 3COI Research Initiatives Organization, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori Prefecture, Japan Purpose: Prevention, early detection and effective rehabilitation of dysphagia are important issues to be considered in an aging society. Previous studies have shown conflicting findings regarding the association between dysphagia and its potential risk factors, including age, malnutrition, oral conditions, lifestyle and medical history. Herein, we assessed the prevalence and association of dysphagia with potential risk factors in 50- to 79-year-old adults dwelling in a community in Japan. Patients and methods: In this study, there were 532 participants (185 males and 347 females). Participants who responded positively to the question “Do you sometimes choke on drinks/food such as tea and soup?” or those who presented with abnormal repetitive saliva swallowing test findings were diagnosed with dysphagia. The data collected from these participants included the following: number of teeth, occurrence of oral dryness, age, body mass index, serum albumin concentration, smoking, drinking and exercise habits, presence of diseases, such as diabetes mellitus and hypertension, and questions from the Mini–Mental State Examination. Results: Dysphagia was observed in 33 males (17.8%) and 76 females (21.9%). To explore the effect of the potential risk factors on the prevalence of dysphagia, a model was built by multivariate logistic regression analysis. Using the forced entry method, oral dryness (odds ratio [OR] =3.683 and P=0.003 in males; OR =1.797 and P=0.032 in females) and the number of teeth (OR =0.946 and P=0.038 in males) were found to be significantly related to dysphagia. Conclusion: This cross-sectional study demonstrated associations between oral conditions and dysphagia. Factors such as oral dryness and number of teeth may contribute to dysphagia more so than aging, lifestyle and comorbidity in community-dwelling adults over the age of 50. Keywords: oral dryness, number of teeth, swallow, nutrition, lifestyle
- Published
- 2017
26. The Influence of Piping Thermal Insulation on Indoor Climate and Exergy Consumption Related to Hot Water Floor Heating in Tokyo
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Takahashi, I. and Nemoto, S.
- Published
- 2015
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27. Prevalence of major depressive disorder among hemodialysis patients compared with healthy people in Japan using the Structured Clinical Interview for DSM-IV
- Author
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Tomita T, Yasui-Furukori N, Sugawara N, Ogasawara K, Katagai K, Saito H, Sawada K, Takahashi I, and Nakamura K
- Subjects
hemodialysis ,depression ,major depressive disorder ,the Center for Epidemiologic Studies for Depression ,the Structured Clinical Interview for Depression ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Tetsu Tomita,1 Norio Yasui-Furukori,1 Norio Sugawara,1,2 Kohei Ogasawara,3 Koki Katagai,3 Hisao Saito,4 Kaori Sawada,5 Ippei Takahashi,5 Kazuhiko Nakamura1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 2Aomori Prefectural Center for Mental Health and Welfare, Aomori, Japan; 3School of Medicine, Hirosaki University, Hirosaki, Japan; 4Department of Urology, Oyokyo Kidney Research Institute, Hirosaki, Japan; 5Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Background: We investigated the prevalence of depression in hemodialysis (HD) patients using the Center for Epidemiologic Studies for Depression (CES-D) scale and the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID) and compared the rates with those of community dwelling people in Japan.Patients and methods: A total of 99 patients undergoing HD were recruited. Blood sampling was performed no later than 2 weeks prior to assessment. As a reference group for SCID and CES-D evaluation, 404 age- and sex-matched healthy controls who had participated in the Iwaki Health Promotion Project were included in this study. The SCID and the CES-D scale were administered to all participants to diagnose their depression. Participants who met the criteria of a major depressive episode according to the SCID were classified as SCID depression and the participants whose CES-D score was 16 or higher were classified as CES-D depression.Results: Ninety-nine HD patients completed the evaluation and data collection. There were no significant differences in age, sex, or CES-D scores between HD patients and controls. There were 12 cases of SCID depression in HD patients and four cases in controls. There was a significant difference between HD patients and controls in the prevalence of SCID depression. There were no significant differences between the two groups with regard to demographic or clinical data. There were 19 HD patients and 24 controls who showed CES-D depression. There was no significant difference between HD patients and controls in the prevalence of CES-D depression. There was a significant difference in potassium level between the two groups, but there were no significant differences in any of the other items.Conclusion: There were significantly more HD patients showing SCID depression than controls in the present study. In clinical settings, the SCID might be useful in surveying cases of depression detected by screening tools among HD patients. Keywords: depression, Center for Epidemiologic Studies for Depression, Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis
- Published
- 2016
28. Teeth and physical fitness in a community-dwelling 40 to 79-year-old Japanese population
- Author
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Inui A, Takahashi I, Sawada K, Naoki A, Oyama T, Tamura Y, Osanai T, Satake A, Nakaji S, and Kobayashi W
- Subjects
number of teeth ,dental occlusion ,timed 10-m walk test ,hand-grip strength ,skeletal muscle mass ,Geriatrics ,RC952-954.6 - Abstract
Akinari Inui,1 Ippei Takahashi,2 Kaori Sawada,2 Akimoto Naoki,2 Toshirou Oyama,1 Yoshihiro Tamura,1 Toshiyuki Osanai,1 Anna Satake,1 Shigeyuki Nakaji,2 Wataru Kobayashi1 1Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 2Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori Prefecture, Japan Purpose: Decline in the number of teeth and physical fitness begins from 40 years of age; however, several epidemiological studies have identified relationships between oral conditions and physical performance parameters in community-dwelling elderly population. The aim of this study was to validate the relationship between the muscle mass and its function and oral conditions (number of teeth and dental occlusion) after 40 years of age in a community-dwelling population in Japan.Materials and methods: The subjects comprised of 552 volunteers (198 males and 354 females, 40–79 years) who participated in the Iwaki Health Promotion Project in 2013. Multiple linear regression analyses were performed with the measures of the muscle mass and its function as objective variables and the measures of the number of teeth, age, body mass index, medical history, serum albumin concentration, smoking status, habitual alcohol intake, marital status, education levels, and exercising habits as explanatory variables. The relationships between the Eichner index and the muscle mass and its function were analyzed using analysis of covariance, with adjustment for confounding factors.Results: After adjusting for confounding factors, the number of teeth was shown to be an independent risk factor for the timed 10 m walk test (in females) and the skeletal muscle mass of the whole body (in males). The results also revealed that the timed 10 m walk test was significantly correlated with the Eichner index (Classes A and C in females were correlated).Conclusion: This cross-sectional study on a Japanese community-dwelling population revealed relationships between oral conditions and the muscle mass and its function. However, the interpretation of our results was hampered by a lack of data, including those on socioeconomic status and longitudinal observations. Future research exploring teeth loss and the muscle mass and its function is warranted. Keywords: number of teeth, sarcopenia, timed 10 m walk test, hand grip strength, skeletal muscle mass
- Published
- 2016
29. Relationship between quality of life and restless legs syndrome among a community-dwelling population in Japan
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Kubo K, Sugawara N, Kaneda A, Takahashi I, Nakamura K, Nakaji S, and Yasui-Furukori N
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cross-sectional study ,schizophrenia ,dietary patterns ,obesity ,Japanese ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Kazutoshi Kubo,1 Norio Sugawara,1,2 Ayako Kaneda,1 Ippei Takahashi,3 Kazuhiko Nakamura,1 Shigeyuki Nakaji,3 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, 2Department of Psychiatry, Aomori Prefectural Center for Mental Health and Welfare, Aomori, 3Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Objectives: Restless legs syndrome (RLS) is a sensorimotor disturbance that causes the production of impulses and dysesthesia and makes the patients feel as though they must move their lower extremities. Because the symptoms of RLS in the lower limbs tend to develop at night, RLS could cause sleep disorders. We investigated an association between the symptoms of RLS and the health-related quality of life among community-dwelling individuals in Japan. Methods: In this cross-sectional survey, we enrolled 985 volunteers who participated in the Iwaki Health Promotion Project in 2013. The symptoms of RLS were evaluated by the criteria of the International Restless Legs Syndrome Study Group. The assessments included an interview to obtain sociodemographic data, the second version of the Short Form Health Survey, the Center for Epidemiological Studies Depression scale, and the Pittsburgh Sleep Quality Index. A multiple regression analysis was used to assess the relationship between the symptoms of RLS and subscores of the Short Form Health Survey, Version 2. Results: The overall prevalence of RLS in our participants was 1.0%. We found a significant and negative association between symptoms of RLS and physical functioning, role – physical functioning, bodily pain, social functioning, and the physical composite summary score. Conclusion: After adjusting for confounders such as age, sex, and comorbidity, the burden of RLS appears to be mainly a physical problem. Impaired health-related quality of life among community individuals with RLS emphasizes the importance of screening for these symptoms and evaluating the need for treatment. Keywords: cross-sectional study, restless legs syndrome, quality of life, Japanese
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- 2016
30. Metadata mapping between disciplinary and general schemas for promotion of data use by a wider community
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Nosé, M., Shinbori, A., Miyoshi, Y., Hori, T., Oohira, T., Hashiba, J., Naoe, C., Okamoto, M., Sagara, T., Aoki, T., Takahashi, I., Hayashi, H., Yamada, K., Tanaka, Y., and Abe, S.
- Abstract
In the Inter-university Upper atmosphere Global Observation NETwork (IUGONET) project, we have been creating metadata for ground observation data in space physics and populating them into the database since 2009 (http://www.iugonet.org/). These metadata followed the IUGONET metadata schema version 2.4.0.1, which is an extension of the SPASE (Space Physics Archive Search and Extract) metadata schema version 2.4.0.The IUGONET metadata database is very useful for researchers to search for data that they need and to obtain detailed information about data, but the metadata search is available only through the IUGONET page or NASA Heliophysics Data Portal. To promote data usage by a wider research community or the general public, it is needed to convert the metadata database from SPASE to more general schema so that the metadata can be ingested into other metadata databases. For that purpose, we developed a mapping table from SPASE to the JPCOAR (Japan Consortium for Open Access Repository) schema, which has been widely used for scholarly communication and data publication in Japan. Based on the mapping table, we converted part of our metadata, which describe data created in Nagoya University, to those in the JPCOAR schema. The converted metadata were registered in the institutional repository of Nagoya University (https://nagoya.repo.nii.ac.jp/). These metadata are consequently harvested by Institutional Repositories DataBase (https://irdb.nii.ac.jp/), Data Catalog Cross-Search System (https://search.ckan.jp/), and Google Dataset Search (https://datasetsearch.research.google.com/). We plan to do the same action for the other IUGONET metadata. This will significantly enhance findability and accessibility of the IUGONET metadata and their describing data., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)
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- 2023
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31. The association between the subjective memory complaints scale and depressive state and cognitive impairment: a factor analysis
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Tomita T, Yasui-Furukori N, Sugawara N, Takahashi I, Sawada K, and Nakamura K
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Tetsu Tomita,1 Norio Yasui-Furukori,1 Norio Sugawara,1,2 Ippei Takahashi,3 Kaori Sawada,3 Kazuhiko Nakamura11Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 2Aomori Prefectural Center for Mental Health and Welfare, Aomori, 3Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanBackground: We aimed to discriminate individuals with depressive state from individuals with cognitive impairment among community-dwelling people using the subjective memory complaints (SMC) scale.Methods: The study group consisted of 289 volunteers (over 60 years old; 104 males and 185 females). Participants’ SMCs were assessed using the SMC scale. The Japanese version of the Center for Epidemiologic Studies for Depression scale and the Mini-Mental State Examination were administered. Participants whose Center for Epidemiologic Studies for Depression scores were 16 or higher were defined as the depressive group and participants whose Mini-Mental State Examination scores were less than 24 were defined as the cognitive impairment group. Exploratory factor analysis was performed to identify the factor structure of the items of the SMC scale. A multiple logistic regression analysis of the association between depressive state and cognitive impairment and the score of each factor was performed.Results: In the final factor analysis model, six items of the SMC scale remained, and a two-factor structure was adequate. Factor 1 included the items 8, 9, and 10 about thought or the ability to think; thus, Factor 1 was defined as “thought disturbance factor”. Factor 2 included the items 1, 2, and 4 about memory or forgetfulness; thus, Factor 2 was defined as “memory disturbance factor”. In the multiple logistic regression analysis, Factor 1 was significantly associated with depressive state and Factor 2 was significantly associated with cognitive impairment.Conclusion: For individuals with SMCs, we might be able to discriminate depressive state or depression from cognitive impairment or dementia through a detailed investigation using the SMC scale.Keywords: geriatric psychiatry, affective disorders, primary care
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- 2015
32. Dietary patterns and schizophrenia: a comparison with healthy controls
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Tsuruga K, Sugawara N, Sato Y, Saito M, Furukori H, Nakagami T, Nakamura K, Takahashi I, Nakaji S, and Yasui-Furukori N
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Koji Tsuruga,1 Norio Sugawara,1 Yasushi Sato,1 Manabu Saito,1 Hanako Furukori,2 Taku Nakagami,3 Kazuhiko Nakamura,1 Ippei Takahashi,4 Shigeyuki Nakaji,4 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan; 2Department of Psychiatry, Kuroishi-Akebono Hospital, Kuroishi, Japan; 3Department of Neuropsychiatry, Odate Municipal General Hospital, Odate, Japan; 4Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Background: It has been reported that the onset of schizophrenia and the physical complications after its onset are related to diet. Diet has been considered as a variable factor of the pathogenesis of schizophrenia. However, the results of studies on this relationship have been inconsistent. Nutrients are consumed as a mixture in the diet. It is difficult to study them in isolation because they may have mutually complementary effects. The aim of this study was to assess the association between dietary patterns and schizophrenia in Japan.Methods: The subjects comprised 237 outpatients aged 30–60 years (123 males and 114 females) with diagnoses of either schizophrenia or schizoaffective disorder. The patient diagnoses were determined based on medical records. Patients were recruited between June 2011 and August 2011. As a reference group, 404 healthy volunteers aged 30–60 years (158 males and 246 females) were also included. Demographic data (age, sex, and level of education) were collected by face-to-face method interviews and self-administered questionnaires. We assessed eating habits over the last month using a validated brief self-administered diet history questionnaire. We detected dietary patterns through a principal component analysis of calorie-adjusted intake; two principal components were retained. The principal components for each dietary pattern and for each individual were divided into tertiles by principal component scores. Results: We derived two dietary patterns by principal component analysis; namely, the “vegetable” dietary pattern and the “cereal” dietary pattern. In the “cereal” dietary pattern, the high tertile was associated with a significantly increased risk of schizophrenia (P
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- 2015
33. Floating Cast Method as a New Growth Method of Silicon Bulk Multicrystals for Solar Cells
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Takahashi, I., Nose, Y., Usami, N., Fujiwara, K., Nakajima, K., Kawazoe, Yoshiyuki, editor, Fujikawa, Yasunori, editor, Nakajima, Kazuo, editor, and Sakurai, Toshio, editor
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- 2008
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34. The Yamaguchi fox/pigeon-imitation test, a brief cognitive performance rating tool, in a community-dwelling population: normative data for Japanese subjects – a preliminary study
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Ishioka M, Sugawara N, Kaneda A, Okubo N, Iwane K, Takahashi I, and Yasui-Furukori N
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Masamichi Ishioka,1 Norio Sugawara,1 Ayako Kaneda,1 Noriyuki Okubo,2 Kaori Iwane,2 Ippei Takahashi,2 Norio Yasui-Furukori1 1Department of Neuropsychiatry, 2Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanIntroduction: Screening tools for dementia should be valid and easy to complete and have a low psychological burden. Consistent with these principles, the Yamaguchi fox/pigeon-imitation test (YFPIT) has been developed. However, there is little information on the utility of the YFPIT for preclinical populations, although the detection of proven prodromal and preclinical states is important.Materials and methods: We recruited 392 volunteers who were at least 60 years old (139 men and 253 women) and had participated in the Iwaki Health Promotion Project. The YFPIT was administered to all participants.Results: Most subjects succeeded in imitating the fox gesture regardless of their cognitive function impairment, while the success rates for the pigeon gesture were 75.3% in the normal group and 56.3% in the cognitive impairment group. The sensitivity, specificity, positive predictive value (PV+), and negative predictive value (PV-) were 43.8%, 75.3%, 7.0%, and 97.0%, respectively. The greatest significant difference between the imitation of the pigeon gesture and cognitive impairment was found in females with subjective memory impairments (P=0.001). In that group, the sensitivity, specificity, PV+, and PV- were 100%, 81.9%, 18.8%, and 100%, respectively.Conclusion: This study suggests that the utility of the YFPIT is limited in the general population, but that it is a useful tool in females with subjective memory impairments in a community-dwelling population.Keywords: dementia, gesture imitation, brief screening
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- 2014
35. A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan
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Tsuruga K, Sugawara N, Yasui-Furukori N, Takahashi I, Tsuchimine S, Kaneda A, Nakaji S, and Nakamura K
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Koji Tsuruga,1 Norio Sugawara,1 Norio Yasui-Furukori,1 Ippei Takahashi,2 Shoko Tsuchimine,1 Ayako Kaneda,1 Shigeyuki Nakaji,2 Kazuhiko Nakamura1 1Department of Neuropsychiatry, 2Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Background: Amyloid beta (Aβ) levels have been associated with an increased risk of Alzheimer’s disease (AD). As depression is common before the onset of AD, serum Aß levels could be associated with depressive symptoms. The aim of this study was to investigate whether serum Aβ levels are associated with depressive symptoms and/or cognitive function in community-dwelling elderly individuals. Methods: We examined the association between serum Aβ levels and depression among 419 Japanese community-dwelling elderly individuals aged 60 years and over. Subjects were divided into two subgroups: younger elderly between 60 and 69 years old and older elderly over 69 years old. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and symptoms of depression were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The ability to perform activities of daily living was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Serum Aβ levels were measured with a human amyloid beta enzyme-linked immunosorbent assay kit. Results: After controlling for potential confounding variables, a multiple linear regression analysis showed that increased levels of serum Aβ40 and Aβ42 were associated with higher CES-D scores in the older elderly subgroup. Under the same condition, multiple regression showed that serum Aβ levels were not associated with MMSE scores among the total subjects, younger elderly, or older elderly. Conclusion: Serum Aβ levels were associated with depressive symptoms in community-dwelling elderly individuals. The present study indicates the possibility that serum Aβ may be involved in the development of late-onset depression. Keywords: Alzheimer’s disease, depression, dementia, Japanese
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- 2014
36. The CALorimetric Electron Telescope (CALET) on the International Space Station: Results from the First Two Years of Operation
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Asaoka Y, Adriani O, Akaike Y, Asano K, Bagliesi MG, Berti E, Bigongiari G, Binns WR, Bonechi S, Bongi M, Bruno A, Brogi P, Buckley J H, Cannady N, Castellini G, Checchia C, Cherry M L, Collazuol G, Di Felice V, Ebisawa K, Fuke H, Guzik T G, Hams T, Hasebe N, Hibinov K, Ichimura M, Ioka K, Ishizaki W, Israel M H, Kasahara K, Kataoka J, Kataoka R, Katayose Y, Kato C, Kawanaka N, Kawakubo Y, Kohri K, Krawczynski H S, Krizmanic J F, Lomtadze T, Maestro P, Marrocchesi P S, Messineo A M, Mitchell J W, Miyake S, Moiseev A A, Mori K, Mori M, Mori N, Motz H M, Munakata K, Murakami H, Nakahira S, Nishimura J, De Nolfo G A, Okuno S, Ormes J F, Ozawa S, Pacini L, Palma F, Pal'shin V, Papini P, Penacchioni A V, Rauch B F, Ricciarini S B, Sakai K, Sakamoto T, Sasaki M, Shimizu Y, Shiomi A, Sparvoli R, Spillantini P, Stolzi F, Sugita S, Suh J E, Sulaj A, Takahashi I, Takayanagi M, Takita M, Tamura T, Tateyama N, Terasawa T, Tomida H, Torii S, Tsunesada Y, Uchihori Y, Ueno S, Vannuccini E, Wefel J P, Yamaoka K, Yanagita S, Yoshida A, and Yoshida K
- Subjects
Physics ,QC1-999 - Abstract
The CALorimetric Electron Telescope (CALET) space experiment, which has been developed by Japan in collaboration with Italy and the United States, is a high-energy astroparticle physics mission on the International Space Station (ISS). The primary goals of the CALET mission include investigation of possible nearby sources of high-energy electrons, detailed study of galactic cosmic-ray acceleration and propagation, and search for dark matter signatures. With a long-term observation onboard the ISS, the CALET experiment measures the flux of cosmic-ray electrons (including positrons) up to 20 TeV, gamma-rays to 10 TeV, and nuclei up to 1,000 TeV based on its charge separation capability from Z = 1 to 40. Since the start of science operation in mid-October, 2015, a continuous observation has been maintained without any major interruptions. The number of triggered events over 10 GeV is nearly 20 million per month. By using the data obtained during the first two-years, here we present a summary of the CALET observations: 1) Electron+positron energy spectrum, 2) Nuclei analysis, 3) Gamma-ray observation with a characterization of the on-orbit performance. The search results for the electromagnetic counterparts of LIGO/Virgo gravitational wave events are also discussed.
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- 2019
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37. HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development
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Kimura, S., primary, Takeshita, N., additional, Oyanagi, T., additional, Seki, D., additional, Jiang, W., additional, Hidaka, K., additional, Fukumoto, S., additional, Takahashi, I., additional, and Takano-Yamamoto, T., additional
- Published
- 2022
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38. Comparison between oscillometric- and Doppler-ABI in elderly individuals
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Takahashi I, Furukawa K, Ohishi W, Takahashi T, Matsumoto M, and Fujiwara S
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Ikuno Takahashi,1,3 Kyoji Furukawa,2 Waka Ohishi,1 Tetsuya Takahashi,3 Masayasu Matsumoto,3 Saeko Fujiwara11Department of Clinical Studies, 2Department of Statistics, Radiation Effects Research Foundation (RERF), Hiroshima, Japan; 3Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, JapanAbstract: Peripheral arterial disease (PAD) generally remains under-recognized, mainly due to the specialized technical skills required to detect the low values of the ankle-brachial index (ABI). As a simpler and faster alternative to the standard method using continuous-wave Doppler ultrasound, we evaluated automated oscillometric ABI measurement by VP-2000 with an elderly cohort of 113 subjects (age range, 61 to 88 years). The standard deviation in ABIs measured by the Doppler method was statistically greater than that measured by the oscillometric method for each of the two legs (P < 0.001). Correlations in ABIs between the two methods were 0.46 for the left leg and 0.61 for the right leg; this result appears to have been caused by interobserver variation in the Doppler ABI measurements. While the trend showing greater differences between average oscillometric- and Doppler-ABIs was significant at the lower ABI ranges, there was little indication of differences in measurements having an average ABI > 1.1. The difference between the methods was suggestively larger in subjects who were smokers than in non-smokers (P = 0.09), but the difference was not affected by other potential atherosclerotic risk factors, including age at examination (P > 0.50). A larger difference at lower ABIs led to better PAD detection by the Doppler method compared to the oscillometric method (sensitivity = 50%, specificity = 100%), although the overall agreement was not small (Cohen's Kappa = 0.65). Our findings indicate that oscillometric devices can provide more accurate estimation of the prevalence of PAD in elderly individuals than the conventional Doppler method.Keywords: ankle-brachial index, oscillometry, Doppler, peripheral arterial disease
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- 2013
39. Relationship between the combination of polyunsaturated fatty acids intake and psychological distress during pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
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Takahashi, I, primary, Obara, T, additional, Aizawa, M, additional, Yonezawa, Y, additional, Ueno, F, additional, Noda, A, additional, Onuma, T, additional, Matsuzaki, F, additional, Murakami, K, additional, Ishikuro, M, additional, and Kuriyama, S, additional
- Published
- 2022
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40. sj-docx-1-jdr-10.1177_00220345221111971 – Supplemental material for HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development
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Kimura, S., Takeshita, N., Oyanagi, T., Seki, D., Jiang, W., Hidaka, K., Fukumoto, S., Takahashi, I., and Takano-Yamamoto, T.
- Subjects
110599 Dentistry not elsewhere classified ,FOS: Materials engineering ,FOS: Clinical medicine ,91299 Materials Engineering not elsewhere classified - Abstract
Supplemental material, sj-docx-1-jdr-10.1177_00220345221111971 for HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development by S. Kimura, N. Takeshita, T. Oyanagi, D. Seki, W. Jiang, K. Hidaka, S. Fukumoto, I. Takahashi and T. Takano-Yamamoto in Journal of Dental Research
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- 2022
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41. Prevalence of Adult-Onset Multifactorial Disease among Offspring of Atomic Bomb Survivors
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Fujiwara, S., Suyama, A., Cologne, J. B., Akahoshi, M., Yamada, M., Suzuki, G., Koyama, K., Takahashi, N., Kasagi, F., Grant, E. J., Lagarde, F., Hsu, W. L., Furukawa, K., Ohishi, W., Tatsukawa, Y., Neriishi, K., Takahashi, I., Ashizawa, K., Hida, A., Imaizumi, M., Nagano, J., Cullings, H. M., Katayama, H., Ross, N. P., and Kodama, K.
- Published
- 2008
42. Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population
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Inoue, R., Ishibashi, Y., Tsuda, E., Yamamoto, Y., Matsuzaka, M., Takahashi, I., Danjo, K., Umeda, T., Nakaji, S., and Toh, S.
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- 2011
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43. High resolution X-ray photoemission study of nitrogen doped TiO 2 rutile single crystals
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Takahashi, I., Payne, D.J., Palgrave, R.G., and Egdell, R.G.
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- 2008
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44. Specific Character of Material Flow in Near-Surface Layer during Friction Stir Processing of AZ31 Magnesium Alloy
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Mironov, S., Yang, Q., Takahashi, H., Takahashi, I., Okamoto, K., Sato, Y.S., and Kokawa, H.
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- 2010
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45. Properties of EHD pump with combination of rod-to-rod and meshy parallel plates electrode assemblies
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Hanaoka, R., Takahashi, I., Takata, S., Fukami, T., and Kanamaru, Y.
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Pumping machinery -- Design and construction ,Pumping machinery -- Properties ,Insulating materials -- Research ,Insulation (Heat) -- Research ,Electrodes -- Properties ,Electrodes -- Usage ,Direct current -- Research ,Voltage -- Research ,Business ,Electronics ,Electronics and electrical industries - Abstract
A high pressure required to drive the liquid can be generated by the compact electrohydrodynamic (EHD) pumps with multiple pairs of the rod-to-rod and meshy parallel plates electrode assemblies arranged in series. In this work, the performance of EHD pumps with electrodes up to nine pairs has been examined as a function of the applied voltage using a semi-insulating liquid. The pressure generated by energized electrodes gives rise to the vigorous liquid flow and the liquid ejects from the pump outlet. The flow direction always is from the cathode toward the anode. The pressure increases with nearly the square of the applied voltage and in proportion to the number of electrode pairs. The maximum pressure head achieved with a series of nine electrode pairs is 25.3 kPa at 18 kV with maximum power consumption of 7.2 W. The generated pressure is maintained stably at constant level of the corresponding value. EHD pumping is attributed to conduction pumping based on an unbalance of heterocharges with single ionic polarity in the vicinity of the anode and cathode. Index Terms--EHD pump, conduction pumping, semi-insulating liquid, pressure head, dc voltage, potential distribution, flow rate.
- Published
- 2009
46. An analysis of the ultrastructure of matured HIV
- Author
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Takahashi, I., Takama, M., Ladhoff, A. M., Aretz, Anke, editor, Hermanns-Sachweh, Benita, editor, and Mayer, Joachim, editor
- Published
- 2008
- Full Text
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47. CALET on the International Space Station: The first three years of observations
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Brogi, P, Adriani, O, Akaike, Y, Asano, K, Asaoka, Y, Bagliesi, Mg, Berti, E, Bigongiari, G, Binns, Wr, Bonechi, S, Bongi, M, Bruno, A, Buckley, Jh, Cannady, N, Castellini, G, Checchia, C, Cherry, Ml, Collazuol, G, Di Felice, V, Ebisawa, K, Fuke, H, Guzik, Tg, Hams, T, Hibino, K, Ichimura, M, Ioka, K, Ishizaki, W, Israel, Mh, Kasahara, K, Kataoka, J, Kataoka, R, Katayose, Y, Kato, C, Kawanaka, N, Kawakubo, Y, Kohri, K, Krawczynski, Hs, Krizmanic, Jf, Link, J, Maestro, P, Marrocchesi, Ps, Messineo, Am, Mitchell, Jw, Miyake, S, Moiseev, Aa, Mori, M, Mori, N, Motz, Hm, Munakata, K, Murakami, H, Nakahira, S, Nishimura, J, De Nolfo, Ga, Okuno, S, Ormes, Jf, Ospina, N, Ozawa, S, Pacini, L, Palma, F, Papini, P, Rauch, Bf, Ricciarini, Sb, Sakai, K, Sakamoto, T, Sasaki, M, Shimizu, Y, Shiomi, A, Sparvoli, R, Spillantini, P, Stolzi, F, Sugita, S, Suh, Je, Sulaj, A, Takahashi, I, Takita, M, Tamura, T, Terasawa, T, Torii, S, Tsunesada, Y, Uchihori, Y, Vannuccini, E, Wefel, Jp, Yamaoka, K, Yanagita, S, Yoshida, A, and Yoshida, K
- Subjects
Physics ,electron ,Spectrometer ,DARK MATTER ,Settore FIS/04 ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Astronomy ,Cosmic ray ,CALET ,Electron ,Condensed Matter Physics ,Electromagnetic radiation ,Atomic and Molecular Physics, and Optics ,Spectral line ,ANTIPROTONS ,gamma rays ,Cosmic rays ,nuclei ,International Space Station ,Measuring instrument ,Mathematical Physics - Abstract
The CALorimetric Electron Telescope CALET is a space instrument designed to carry out precision measurements of high energy cosmic-rays on the JEM-EF external platform on the International Space Station, where it has been collecting science data continuously since mid October 2015. In addition to its primary goal of identifying nearby sources of high-energy electrons and possible signatures of dark matter in the electron spectrum, CALET is carrying out extensive measurements of the energy spectra, relative abundances and secondary-to-primary ratios of elements from proton to iron, and even above (up to Z = 40), studying the details of galactic particle propagation and acceleration. An overview of CALET based on the data taken during the first three years of observations is presented, including a direct measurement of the electron+positron energy spectrum from 11 GeV to 4.8 TeV. The proton spectrum has been measured from 50 GeV to 10 TeV covering, for the first time with a single space-borne instrument, the whole energy interval previously investigated in separate sub-ranges by magnetic spectrometers and calorimetric instruments. Preliminary spectra of cosmic-ray nuclei are also presented, together with gamma-ray observations and searches for an e.m. counterpart of LIGO/Virgo GW events.
- Published
- 2020
48. Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement
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Kanzaki, H, Chiba, M, Arai, K, Takahashi, I, Haruyama, N, Nishimura, M, and Mitani, H
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- 2006
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49. Relationship between intracellular localization of p34cdc2 protein and differentiation of esophageal squamous cell carcinoma
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Nozoe, T., Takahashi, I., Baba, H., and Maehara, Y.
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- 2005
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50. Deformation measurement by phase-shifting digital holography
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Morimoto, Y., Nomura, T., Fujigaki, M., Yoneyama, S., and Takahashi, I.
- Published
- 2005
- Full Text
- View/download PDF
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