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The cyanomethylation of β‐alkoxyaldehydes is described. These elimination‐prone substrates pose a chemoselectivity issue due to the competing elimination and addition pathways. While many commonly used strong Brønsted bases favor elimination, nBuLi effectively promotes the addition of an α‐cyanocarbanion and suppresses the undesired elimination. The cyanomethylated product can be converted to a known intermediate for the synthesis of atorvastatin, an active pharmaceutical ingredient of Lipitor, showcasing the synthetic potential of the current transformation. [ABSTRACT FROM AUTHOR]

B The excess intake b of greasy foods is known to be a key contributing factor for the metabolic syndrome, which is a cluster of several medical conditions such as high blood pressure, high blood sugar, and high serum triglycerides. Statins are representative lipid-lowering agents prescribed for the treatment of dyslipidemia. In this artwork, fatty diets are represented by a glob of oil on a spoon, which is intertwined with atorvastatin, the active pharmaceutical ingredient of Lipitor, illustrating the effectiveness of the drug molecule in lowering blood cholesterol. [Extracted from the article]

The synthesis and characterization of a mixed ligand metal-organic framework (MOF) with good thermal and chemical stability, {[Co( BDC )( L )·2H 2 O]· x G} n ( CoMOF-2 ), involving an aromatic dicarboxylate (H 2 BDC = 1,4-benzenedicarboxylic acid) and an acyl-decorated N-donor linker [ L = ( E )- N '-(pyridin-4-ylmethylene) isonicotinohydrazide] by various physicochemical techniques, including Single crystal X-Ray Diffraction (SXRD), are reported. The MOF showed a good affinity for CO 2 capture, and Grand Canonical Monte Carlo simulation studies exposed strong interactions of CO 2 with the functionalized N-donor ligand of the framework. CoMOF-2 and KI act as an efficient binary catalyst for the sustainable utilization of CO 2 with spiro-epoxy oxindole to spirocyclic carbonate under ambient conditions. Notably, herein we report MOF-based catalysis for the cycloaddition of oxindole-based epoxides with CO 2 for harvesting new spirocyclic carbonates. Interestingly, we could isolate and crystallize six of the spirocyclic carbonate products, and the structure of the newly synthesized molecules has been established by SXRD analysis. We present a plausible proposed catalytic mechanism through activation of the epoxide ring by the Lewis acidic/basic sites present on the framework surface that is validated by molecular modeling.