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3. Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.

Author

Milne, Roger, Burwinkel, Barbara, Michailidou, Kyriaki, Arias-Perez, Jose-Ignacio, Zamora, M, Menéndez-Rodríguez, Primitiva, Hardisson, David, Mendiola, Marta, González-Neira, Anna, Pita, Guillermo, Alonso, M, Dennis, Joe, Wang, Qin, Bolla, Manjeet, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk, Ko, Yon-Dschun, Brauch, Hiltrud, Hamann, Ute, Andrulis, Irene, Knight, Julia, Glendon, Gord, Tchatchou, Sandrine, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tajima, Kazuo, Li, Jingmei, Brand, Judith, Brenner, Hermann, Dieffenbach, Aida, Arndt, Volker, Stegmaier, Christa, Lambrechts, Diether, Peuteman, Gilian, Christiaens, Marie-Rose, Smeets, Ann, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katazyna, Hartman, Mikael, Hui, Miao, Yen Lim, Wei, Wan Chan, Ching, Marme, Federick, Yang, Rongxi, Bugert, Peter, Lindblom, Annika, Margolin, Sara, García-Closas, Montserrat, Chanock, Stephen, Lissowska, Jolanta, Figueroa, Jonine, Bojesen, Stig, Nordestgaard, Børge, Flyger, Henrik, Hooning, Maartje, Kriege, Mieke, van den Ouweland, Ans, Koppert, Linetta, Fletcher, Olivia, Johnson, Nichola, dos-Santos-Silva, Isabel, Peto, Julian, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha, Long, Jirong, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Cox, Angela, Cross, Simon, Reed, Malcolm, Schmidt, Marjanka, Broeks, Annegien, Cornelissen, Sten, Braaf, Linde, Kang, Daehee, Choi, Ji-Yeob, Park, Sue, Noh, Dong-Young, Simard, Jacques, Dumont, Martine, Goldberg, Mark, Labrèche, France, Fasching, Peter, Hein, Alexander, Ekici, Arif, Beckmann, Matthias, Radice, Paolo, and Peterlongo, Paolo

Subjects
A Kinase Anchor Proteins, Adult, Alleles, Ataxin-7, Breast Neoplasms, Case-Control Studies, Cytoskeletal Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, NIMA-Related Kinases, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Protein Serine-Threonine Kinases
Abstract

Candidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most studies have been underpowered to detect associations of a realistic magnitude. We assessed 41 common non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence of association with breast cancer risk had been previously reported. Case-control data were combined from 38 studies of white European women (46 450 cases and 42 600 controls) and analyzed using unconditional logistic regression. Strong evidence of association was observed for three nsSNPs: ATXN7-K264R at 3p21 [rs1053338, per allele OR = 1.07, 95% confidence interval (CI) = 1.04-1.10, P = 2.9 × 10(-6)], AKAP9-M463I at 7q21 (rs6964587, OR = 1.05, 95% CI = 1.03-1.07, P = 1.7 × 10(-6)) and NEK10-L513S at 3p24 (rs10510592, OR = 1.10, 95% CI = 1.07-1.12, P = 5.1 × 10(-17)). The first two associations reached genome-wide statistical significance in a combined analysis of available data, including independent data from nine genome-wide association studies (GWASs): for ATXN7-K264R, OR = 1.07 (95% CI = 1.05-1.10, P = 1.0 × 10(-8)); for AKAP9-M463I, OR = 1.05 (95% CI = 1.04-1.07, P = 2.0 × 10(-10)). Further analysis of other common variants in these two regions suggested that intronic SNPs nearby are more strongly associated with disease risk. We have thus identified a novel susceptibility locus at 3p21, and confirmed previous suggestive evidence that rs6964587 at 7q21 is associated with risk. The third locus, rs10510592, is located in an established breast cancer susceptibility region; the association was substantially attenuated after adjustment for the known GWAS hit. Thus, each of the associated nsSNPs is likely to be a marker for another, non-coding, variant causally related to breast cancer risk. Further fine-mapping and functional studies are required to identify the underlying risk-modifying variants and the genes through which they act.

Published
2014

5. Supplementary Tables 1-3 from Folate Intake along with Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase in Patients with Advanced Gastric Cancer

Author

Shitara, Kohei, primary, Muro, Kei, primary, Ito, Seiji, primary, Sawaki, Akira, primary, Tajika, Masahiro, primary, Kawai, Hiroki, primary, Yokota, Tomoya, primary, Takahari, Daisuke, primary, Shibata, Takashi, primary, Ura, Takashi, primary, Ito, Hidemi, primary, Hosono, Satoyo, primary, Kawase, Takakazu, primary, Watanabe, Miki, primary, Tajima, Kazuo, primary, Yatabe, Yasushi, primary, Tanaka, Hideo, primary, and Matsuo, Keitaro, primary

Published
2023
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6. Supplementary Table and Figures 1-6 from Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population

Author

Oze, Isao, primary, Matsuo, Keitaro, primary, Suzuki, Takeshi, primary, Kawase, Takakazu, primary, Watanabe, Miki, primary, Hiraki, Akio, primary, Ito, Hidemi, primary, Hosono, Satoyo, primary, Ozawa, Taijiro, primary, Hatooka, Shunzo, primary, Yatabe, Yasuhi, primary, Hasegawa, Yasuhisa, primary, Shinoda, Masayuki, primary, Kiura, Katsuyuki, primary, Tajima, Kazuo, primary, Tanimoto, Mitsune, primary, and Tanaka, Hideo, primary

Published
2023
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7. Data from Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population

Author

Oze, Isao, primary, Matsuo, Keitaro, primary, Suzuki, Takeshi, primary, Kawase, Takakazu, primary, Watanabe, Miki, primary, Hiraki, Akio, primary, Ito, Hidemi, primary, Hosono, Satoyo, primary, Ozawa, Taijiro, primary, Hatooka, Shunzo, primary, Yatabe, Yasuhi, primary, Hasegawa, Yasuhisa, primary, Shinoda, Masayuki, primary, Kiura, Katsuyuki, primary, Tajima, Kazuo, primary, Tanimoto, Mitsune, primary, and Tanaka, Hideo, primary

Published
2023
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8. Data from Folate Intake along with Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase in Patients with Advanced Gastric Cancer

Author

Shitara, Kohei, primary, Muro, Kei, primary, Ito, Seiji, primary, Sawaki, Akira, primary, Tajika, Masahiro, primary, Kawai, Hiroki, primary, Yokota, Tomoya, primary, Takahari, Daisuke, primary, Shibata, Takashi, primary, Ura, Takashi, primary, Ito, Hidemi, primary, Hosono, Satoyo, primary, Kawase, Takakazu, primary, Watanabe, Miki, primary, Tajima, Kazuo, primary, Yatabe, Yasushi, primary, Tanaka, Hideo, primary, and Matsuo, Keitaro, primary

Published
2023
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9. Data from Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry

Author

Cai, Qiuyin, primary, Wen, Wanqing, primary, Qu, Shimian, primary, Li, Guoliang, primary, Egan, Kathleen M., primary, Chen, Kexin, primary, Deming, Sandra L., primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Gammon, Marilie D., primary, Blot, William J., primary, Matsuo, Keitaro, primary, Haiman, Christopher A., primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Santella, Regina M., primary, Zhang, Lina, primary, Fair, Alecia Malin, primary, Hu, Zhibin, primary, Wu, Pei-Ei, primary, Signorello, Lisa B., primary, Titus-Ernstoff, Linda, primary, Tajima, Kazuo, primary, Henderson, Brian E., primary, Chan, Kelvin Y.K., primary, Kasuga, Yoshio, primary, Newcomb, Polly A., primary, Zheng, Hong, primary, Cui, Yong, primary, Wang, Furu, primary, Shieh, Ya-Lan, primary, Iwata, Hiroji, primary, Le Marchand, Loic, primary, Chan, Sum Yin, primary, Shrubsole, Martha J., primary, Trentham-Dietz, Amy, primary, Tsugane, Shoichiro, primary, Garcia-Closas, Montserrat, primary, Long, Jirong, primary, Li, Chun, primary, Shi, Jiajun, primary, Huang, Bo, primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Lu, Wei, primary, Shu, Xiao-Ou, primary, and Zheng, Wei, primary

Published
2023
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10. Supplementary Methods and Materials from Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry

Author

Cai, Qiuyin, primary, Wen, Wanqing, primary, Qu, Shimian, primary, Li, Guoliang, primary, Egan, Kathleen M., primary, Chen, Kexin, primary, Deming, Sandra L., primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Gammon, Marilie D., primary, Blot, William J., primary, Matsuo, Keitaro, primary, Haiman, Christopher A., primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Santella, Regina M., primary, Zhang, Lina, primary, Fair, Alecia Malin, primary, Hu, Zhibin, primary, Wu, Pei-Ei, primary, Signorello, Lisa B., primary, Titus-Ernstoff, Linda, primary, Tajima, Kazuo, primary, Henderson, Brian E., primary, Chan, Kelvin Y.K., primary, Kasuga, Yoshio, primary, Newcomb, Polly A., primary, Zheng, Hong, primary, Cui, Yong, primary, Wang, Furu, primary, Shieh, Ya-Lan, primary, Iwata, Hiroji, primary, Le Marchand, Loic, primary, Chan, Sum Yin, primary, Shrubsole, Martha J., primary, Trentham-Dietz, Amy, primary, Tsugane, Shoichiro, primary, Garcia-Closas, Montserrat, primary, Long, Jirong, primary, Li, Chun, primary, Shi, Jiajun, primary, Huang, Bo, primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Lu, Wei, primary, Shu, Xiao-Ou, primary, and Zheng, Wei, primary

Published
2023
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37. Ancient HTLV-I provirus DNA in Andean mummies

Author

Li, Hong-Chuan, Fujiyoshi, Toshinobu, Lou, Hong, Yashiki, Shinji, Sonoda, Shunro, Cartier, Luis, Núñez, Lautaro, Muñoz, Iván, Horai, Satoshi, and Tajima, Kazuo

Published
1998

45. Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)

Author

Kim, Claire H., Lee, Yuan-Chin Amy, Hung, Rayjean J., McNallan, Sheila R., Cote, Michele L., Lim, Wei-Yen, Chang, Shen-Chih, Kim, Jin Hee, Ugolini, Donatella, Chen, Ying, Liloglou, Triantafillos, Andrew, Angeline S., Onega, Tracy, Duell, Eric J., Field, John K., Lazarus, Philip, Le Marchand, Loic, Neri, Monica, Vineis, Paolo, Kiyohara, Chikako, Hong, Yun-Chul, Morgenstern, Hal, Matsuo, Keitaro, Tajima, Kazuo, Christiani, David C., McLaughlin, John R., Bencko, Vladimir, Holcatova, Ivana, Boffetta, Paolo, Brennan, Paul, Fabianova, Eleonora, Foretova, Lenka, Janout, Vladimir, Lissowska, Jolanta, Mates, Dana, Rudnai, Peter, Szeszenia-Dabrowska, Neonila, Mukeria, Anush, Zaridze, David, Seow, Adeline, Schwartz, Ann G., Yang, Ping, and Zhang, Zuo-Feng

Published
2014
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