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1. Genetic determinants of serum testosterone concentrations in men.

Author

Ohlsson, Claes, Wallaschofski, Henri, Lunetta, Kathryn L, Stolk, Lisette, Perry, John RB, Koster, Annemarie, Petersen, Ann-Kristin, Eriksson, Joel, Lehtimäki, Terho, Huhtaniemi, Ilpo T, Hammond, Geoffrey L, Maggio, Marcello, Coviello, Andrea D, EMAS Study Group, Ferrucci, Luigi, Heier, Margit, Hofman, Albert, Holliday, Kate L, Jansson, John-Olov, Kähönen, Mika, Karasik, David, Karlsson, Magnus K, Kiel, Douglas P, Liu, Yongmei, Ljunggren, Osten, Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Meitinger, Thomas, Mellström, Dan, Melzer, David, Miljkovic, Iva, Nauck, Matthias, Nilsson, Maria, Penninx, Brenda, Pye, Stephen R, Vasan, Ramachandran S, Reincke, Martin, Rivadeneira, Fernando, Tajar, Abdelouahid, Teumer, Alexander, Uitterlinden, André G, Ulloor, Jagadish, Viikari, Jorma, Völker, Uwe, Völzke, Henry, Wichmann, H Erich, Wu, Tsung-Sheng, Zhuang, Wei Vivian, Ziv, Elad, Wu, Frederick CW, Raitakari, Olli, Eriksson, Anna, Bidlingmaier, Martin, Harris, Tamara B, Murray, Anna, de Jong, Frank H, Murabito, Joanne M, Bhasin, Shalender, Vandenput, Liesbeth, and Haring, Robin

Subjects
EMAS Study Group, Chromosomes, Human, X, Humans, Testosterone, Sex Hormone-Binding Globulin, Nuclear Proteins, Body Mass Index, Polymorphism, Single Nucleotide, Alleles, Adult, Aged, 80 and over, Middle Aged, Male, Genome-Wide Association Study, Aged, and over, Chromosomes, Human, X, Polymorphism, Single Nucleotide, Genetics, Developmental Biology
Abstract

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as

Published
2011

2. Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men

Author

Tajar, Abdelouahid, McBeth, John, Lee, David M., Macfarlane, Gary J., Huhtaniemi, Ilpo T., Finn, Joseph D., Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, O’Neill, Terence W., and Wu, Frederick C.W.

Published
2011
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4. NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus

Author

Chen, Ji-Li, Dawoodji, Amina, Tarlton, Andrea, Gnjatic, Sacha, Tajar, Abdelouahid, Karydis, Ioannis, Browning, Judy, Pratap, Sarah, Verfaille, Christian, Venhaus, Ralph R., Pan, Linda, Altman, Douglas G., Cebon, Jonathan S., Old, Lloyd L., Nathan, Paul, Ottensmeier, Christian, Middleton, Mark, and Cerundolo, Vincenzo

Published
2015
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5. Assessment of Sexual Health in Aging Men in Europe: Development and Validation of the European Male Ageing Study Sexual Function Questionnaire

Author

O'Connor, Daryl B., Corona, Giovanni, Forti, Gianni, Tajar, Abdelouahid, Lee, David M., Finn, Joseph D., Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F., Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, O'Neill, Terence W., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, Wu, Frederick C.W., and European Male Ageing Study group

Published
2008
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8. Identification of late-onset hypogonadism in middle-aged and elderly men

Author

Wu, Frederick C.W., Tajar, Abdelouahid, Beynon, Jennifer M., Pye, Stephen R., Silman, Alan J., O'Neill, Terence W., Bartfai, Gyorgy, Finn, Joseph D., Casanueva, Felipe F., Giwercman, Aleksander, Forti, Gianni, Han, Thang S., Kula, Krzysztof, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Boonen, Steven, Vanderschueren, Dirk, Labrie, Fernand, and Huhtaniemi, Ilpo T.

Subjects
Hypogonadism -- Diagnosis, Hypogonadism -- Surveys, Middle aged men -- Health aspects, Middle aged men -- Surveys, Aged men -- Health aspects, Aged men -- Surveys
Abstract

A questionnaires base survey was conducted among a random population sample of 3369 men between the ages of 40 and 79 years at Eight European centers to determine the link between aging-related testosterone deficiency and late-onset hypogonadism in the general population. The data for the general population indicated that the presence of three sexual symptoms combined with a total testosterone level of less than 11 nmol per liter and a free testosterone level of less than 220 pmol per liter could be considered the minimum criteria for the diagnosis of late-onset hypogonadism in aging men.

Published
2010

10. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men

Author

Lee, David M., Tajar, Abdelouahid, Ulubaev, Aslan, Pendleton, Neil, O'Neill, Terence W., O'Connor, Daryl B., Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E.J., Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, and Wu, Frederick C.W.

Subjects
Vitamin D -- Measurement, Vitamin D -- Physiological aspects, Vitamin D -- Research, Cognition in old age -- Physiological aspects, Cognition in old age -- Research, Calcifediol -- Measurement, Calcifediol -- Physiological aspects, Calcifediol -- Research, Alfacalcidol -- Measurement, Alfacalcidol -- Physiological aspects, Alfacalcidol -- Research, Health, Psychology and mental health
Published
2009

11. Representation and local democracy: Geographical variations in elector to councillor ratios

Author

Norman, Paul, Purdam, Kingsley, Tajar, Abdelouahid, and Simpson, Ludi

Subjects
Local government, Geography, Political science
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.polgeo.2006.10.013 Byline: Paul Norman (a), Kingsley Purdam (b), Abdelouahid Tajar (b), Ludi Simpson (b) Abstract: In a democracy, one person's vote should count as much as another's vote. While a range of factors can affect this, including the electoral system, party support bases, party campaigning, and the effectiveness and identity of representatives, a key principal is that for each political unit the number of electors per representative should be as equal as possible. Only when equality in electorate to representative ratios is established can equity in other demographic infrastructures be pursued. To achieve representation equality in English local authorities the Electoral Commission's Periodic Electoral Review process considers for each electoral ward the number of councillors, current and forecasted electorates and revisions to boundaries. Here, using 2005 boundaries, we examine variations in elector to councillor ratios in England. Comparing these ratios with 2001 Census data, we investigate whether variations relate to ethnic minority population distributions. We found considerable differences in representation ratios between four types of local authority. Generally, County Districts have fewer electors per councillor and therefore better representation ratios. There are progressively higher ratios for Unitary Authorities and London Boroughs; Metropolitan Districts have most electors per councillor. Comparing each ward's ratio with the representation of its associated district we found most wards lie within what might be considered an acceptable range of variation. Sub-district representation variability relates to urban-rural variations in ward extent and the use of one-, two- and three-seat systems. There is no evidence that variations in ward ratios relate systematically to distributions of ethnic minorities. Despite this, to capture local population characteristics, we advise utilising ethnic group demographic characteristics when forecasting electorates. Author Affiliation: (a) School of Geography, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK (b) Cathie Marsh Centre for Census and Survey Research (CCSR), Crawford House (2nd floor), Booth Street East, University of Manchester, Manchester, M13 9PL, UK

Published
2007

12. Frailty and Sexual Health in Older European Men

Author

Lee, David M., Tajar, Abdelouahid, Ravindrarajah, Rathi, Pye, Stephen R., O’Connor, Daryl B., Corona, Giovanni, O’Connell, Matthew, Gielen, Evelien, Boonen, Steven, Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Wu, Frederick C. W., and O’Neill, Terence W.

Published
2013
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13. The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men

Author

Tajar, Abdelouahid, Lee, David M., Pye, Stephen R., OʼConnell, Matthew D. L., Ravindrarajah, Rathi, Gielen, Evelien, Boonen, Steven, Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Wu, Frederick C. W., and OʼNeill, Terence W.

Published
2013
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14. Cohort Profile: The European Male Ageing Study

Author

Lee, David M, Pye, Stephen R, Tajar, Abdelouahid, OʼNeill, Terence W, Finn, Joseph D, Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael EJ, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, and Wu, Frederick CW

Published
2013
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15. Population-Based Reference Ranges for Testosterone in Men Derived Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) and Validated in Three Geographically Distinct Cohorts

Author

Bhasin, Shalender, primary, Pencina, Michael M, additional, Jasuja, Guneet K, additional, Travison, Thomas G, additional, Coviello, Andrea D, additional, Orwoll, Eric M, additional, Wang, Patty Y, additional, Nielson, Carrie M, additional, Wu, Frederick M, additional, Tajar, Abdelouahid M, additional, Vesper, Hubert M, additional, Zhang, Anqi M, additional, Ulloor, Jagadish M, additional, Singh, Ravinder M, additional, D'Agostino, Ralph M, additional, and Vasan, Ramachandran S, additional

Published
2011
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16. Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS)

Author

Tajar, Abdelouahid, Huhtaniemi, Ilpo T., OʼNeill, Terence W., Finn, Joseph D., Pye, Stephen R., Lee, David M., Bartfai, György, Boonen, Steven, Casanueva, Felipe F. F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, and Wu, Frederick C. W.

Published
2012

17. The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men

Author

OʼConnor, Daryl B., Lee, David M., Corona, Giovanni, Forti, Gianni, Tajar, Abdelouahid, OʼNeill, Terence W., Pendleton, Neil, Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F., Finn, Joseph D., Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, and Wu, Frederick C. W.

Published
2011

18. Reference Ranges for Testosterone in Men Generated Using Liquid Chromatography Tandem Mass Spectrometry in a Community-Based Sample of Healthy Nonobese Young Men in the Framingham Heart Study and Applied to Three Geographically Distinct Cohorts

Author

Bhasin, Shalender, Pencina, Michael, Jasuja, Guneet Kaur, Travison, Thomas G., Coviello, Andrea, Orwoll, Eric, Wang, Patty Y., Nielson, Carrie, Wu, Frederick, Tajar, Abdelouahid, Labrie, Fernand, Vesper, Hubert, Zhang, Anqi, Ulloor, Jagadish, Singh, Ravinder, DʼAgostino, Ralph, and Vasan, Ramachandran S.

Published
2011

19. Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study

Author

Tajar, Abdelouahid, O'Connell, Matthew D.L., Mitnitski, Arnold B., O'Neill, Terence W., Searle, Samuel D., Huhtaniemi, Ilpo T., Finn, Joseph D., Bartfai, György, Boonen, Steven, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, Rockwood, Kenneth, and Wu, Frederick C.W.

Published
2011
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23. Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study

Author

McBeth, John, Pye, Stephen R, OʼNeill, Terence W, Macfarlane, Gary J, Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva, Felipe, Finn, Joseph D, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, and Wu, Frederick C

Published
2010
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24. Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study

Author

Tajar, Abdelouahid, Forti, Gianni, OʼNeill, Terence W., Lee, David M., Silman, Alan J., Finn, Joseph D., Bartfai, György, Boonen, Steven, Casanueva, Felipe F., Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Huhtaniemi, Ilpo T., and Wu, Frederick C. W.

Published
2010

25. The European Male Ageing Study (EMAS): design, methods and recruitment

Author

Lee, David M., OʼNeill, Terence W., Pye, Stephen R., Silman, Alan J., Finn, Joseph D., Pendleton, Neil, Tajar, Abdelouahid, Bartfai, Gyorgy, Casanueva, Felipe, Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Punab, Margus, Boonen, Steven, Vanderschueren, Dirk, and Wu, Frederick C. W.

Published
2009

27. Assessment of Sexual Health in Aging Men in Europe: Development and Validation of the European Male Ageing Study Sexual Function Questionnaire

Author

OʼConnor, Daryl B., Corona, Giovanni, Forti, Gianni, Tajar, Abdelouahid, Lee, David M., Finn, Joseph D., Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F., Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, OʼNeill, Terence W., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, and Wu, Frederick C.W.

Published
2008

28. Oral abstracts 3: RA Treatment and outcomesO13. Validation of jadas in all subtypes of juvenile idiopathic arthritis in a clinical setting

Author

McErlane, Flora, Beresford, Michael W., Baildam, Eileen M., Thomson, Wendy, Hyrich, Kimme, Chieng, Alice, Davidson, Joyce, Foster, Helen E., Gardner-Medwin, Janet, Lunt, Mark, Wedderburn, Lucy, Nikiphorou, Elena, Carpenter, Lewis, Kiely, Patrick, Walsh, David, Dixey, Josh, Young, Adam, Kapoor, Sabrina R., Filer, Andrew, Fitzpatrick, Martin, Fisher, Benjamin A., Taylor, Peter C., Buckley, Christopher, McInnes, Iain, Raza, Karim, Young, Stephen P., Dougados, Maxime, Kissel, Karsten, Amital, Howard, Conaghan, Philip, Martin-Mola, Emilio, Nasonov, Evgeny, Schett, Georg, Troum, Orrin, Veldi, Tiina, Bernasconi, Corrado, Huizinga, Tom, Durez, Patrick, Genovese, Mark C., Richards, Hanno B., Supronik, Jerzy, Dokoupilova, Eva, Aelion, Jacob A., Lee, Sang-Heon, Codding, Christine E., Kellner, Herbert, Ikawa, Takashi, Hugot, Sophie, Ligozio, Gregory, Mpofu, Shephard, Kavanaugh, Arthur, Emery, Paul, Fleischmann, Roy, Van Vollenhoven, Ronald, Pavelka, Karel, Guérette, Benoît, Santra, Sourav, Redden, Laura, Kupper, Hartmut, Smolen, Josef S., Wilkie, Ross, Tajar, Abdelouahid, McBeth, John, Hooper, Lindsey S., Bowen, Catherine J., Gates, Lucy, Culliford, David, Edwards, Christopher J., Arden, Nigel K., Adams, Jo, Ryan, Sarah, Haywood, Hannah, Pain, Helen, Siddle, Heidi J., Redmond, Anthony C., Waxman, Robin, Dagg, Abigail R., Alcacer-Pitarch, Begonya, Wilkins, Richard A., Helliwell, Philip S., Norton, Sam, Williams, Richard, Halls, Serena, Law, Rebecca-Jane, Jones, Jeremy, Markland, David, Maddison, Peter, Thom, Jeanette, Parker, Ben, Urowitz, Murray B., Gladman, Dafna D., Bruce, Ian, Croca, Sara C., Pericleous, Charis, Yong, Harry, Isenberg, David, Giles, Ian, Rahman, Anisur, Ioannou, Yiannis, Warrell, Clare E., Dobarro, David, Handler, Clive, Denton, Christopher P., Schreiber, Benjamin E., Coghlan, John G., Betteridge, Zoe E., Woodhead, Felix, Bunn, Christopher, Abraham, David, Desai, Sujal, du Bois, Roland, Wells, Athol, McHugh, Neil, Abignano, Giuseppina, Aydin, Sibel, Castillo-Gallego, Conception, Woods, Daniel, Meekings, Adam, McGonagle, Dennis, Del Galdo, Francesco, Vila, Josephine, Mitchell, Sheryl, Bowman, Simon, Price, Elizabeth, Pease, Colin T., Andrews, Jacqueline, Bombardieri, Michele, Sutcliffe, Nurhan, Pitzalis, Constantino, Lanyon, Peter, Hunter, John, Gupta, Monica, McLaren, John, Regan, Marian, Cooper, Annie, Vadivelu, Saravanan, Coady, David, Griffiths, Bridget, Lendrem, Dennis, Foggo, Heather, Tarn, Jessica, Ng, Wan-Fai, Goodhead, Charlotte, Shekar, Priya, Kelly, Clive, Francis, Gail, Bailey, Ann-Marie, Thompson, Lynsey, Hamilton, Jennifer, Salisbury, Chris, Foster, Nadine E., Bishop, Annette, Coast, Jo, Franchini, Angelo, Hall, Jeanette, Hollinghurst, Sandra, Hopper, Cherida, Grove, Sean, Kaur, Surinder, Montgomery, Alan, Paskins, Zoe, Sanders, Tom, Croft, Peter R., Hassell, Andy B., Coxon, Domenica E., Frisher, Martin, Jordan, Kelvin P., Jinks, Clare, Peat, George, Monk, Helen L., Muller, Sara, Mallen, Christian, Hider, Samantha L., Roddy, Edward, and Hayward, Richard

Abstract

Background: Juvenile Arthritis Disease Activity Score (JADAS) is a 4 variable composite disease activity (DA) score for JIA (including active 10, 27 or 71 joint count (AJC), physician global (PGA), parent/child global (PGE) and ESR). The validity of JADAS for all ILAR subtypes in the routine clinical setting is unknown. We investigated the construct validity of JADAS in the clinical setting in all subtypes of JIA through application to a prospective inception cohort of UK children presenting with new onset inflammatory arthritis. Methods: JADAS 10, 27 and 71 were determined for all children in the Childhood Arthritis Prospective Study (CAPS) with complete data available at baseline. Correlation of JADAS 10, 27 and 71 with single DA markers was determined for all subtypes. All correlations were calculated using Spearman's rank statistic. Results: 262/1238 visits had sufficient data for calculation of JADAS (1028 (83%) AJC, 744 (60%) PGA, 843 (68%) PGE and 459 (37%) ESR). Median age at disease onset was 6.0 years (IQR 2.6-10.4) and 64% were female. Correlation between JADAS 10, 27 and 71 approached 1 for all subtypes. Median JADAS 71 was 5.3 (IQR 2.2-10.1) with a significant difference between median JADAS scores between subtypes (p < 0.01). Correlation of JADAS 71 with each single marker of DA was moderate to high in the total cohort (see Table 1). Overall, correlation with AJC, PGA and PGE was moderate to high and correlation with ESR, limited JC, parental pain and CHAQ was low to moderate in the individual subtypes. Correlation coefficients in the extended oligoarticular, rheumatoid factor negative and enthesitis related subtypes were interpreted with caution in view of low numbers. Conclusions: This study adds to the body of evidence supporting the construct validity of JADAS. JADAS correlates with other measures of DA in all ILAR subtypes in the routine clinical setting. Given the high frequency of missing ESR data, it would be useful to assess the validity of JADAS without inclusion of the ESR. Disclosure statement: All authors have declared no conflicts of interest. Table 1Spearman's correlation between JADAS 71 and single markers DA by ILAR subtype ILAR Subtype Systemic onset JIA Persistent oligo JIA Extended oligo JIA Rheumatoid factor neg JIA Rheumatoid factor pos JIA Enthesitis related JIA Psoriatic JIA Undifferentiated JIA Unknown subtype Total cohort Number of children 23 111 12 57 7 9 19 7 17 262 AJC 0.54 0.67 0.53 0.75 0.53 0.34 0.59 0.81 0.37 0.59 PGA 0.63 0.69 0.25 0.73 0.14 0.05 0.50 0.83 0.56 0.64 PGE 0.51 0.68 0.83 0.61 0.41 0.69 0.71 0.9 0.48 0.61 ESR 0.28 0.31 0.35 0.4 0.6 0.85 0.43 0.7 0.5 0.53 Limited 71 JC 0.29 0.51 0.23 0.37 0.14 -0.12 0.4 0.81 0.45 0.41 Parental pain 0.23 0.62 0.03 0.57 0.41 0.69 0.7 0.79 0.42 0.53 Childhood health assessment questionnaire 0.25 0.57 -0.07 0.36 -0.47 0.84 0.37 0.8 0.66 0.47

Published
2017

29. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Author

McCabe, Paul S., Pye, Stephen, Mcbeth, John, Lee, David M, Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C, and O'Neill, Terence

Subjects
GENERAL-POPULATION, Science & Technology, Chronic Widespread pain, Epidemiology, Depression, 1103 Clinical Sciences, R1, PREVALENCE, D DEFICIENCY, PERSISTENT, EMAS Study Group, Orthopedics, Rheumatology, ONSET, Chronic Widespread Pain, Orthopedics and Sports Medicine, Obesity, Chronic Pain, Vitamin D, Life Sciences & Biomedicine, MUSCULOSKELETAL PAIN, MANCHESTER, FIBROMYALGIA, BONE HEALTH
Abstract

BACKGROUND: The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. METHODS: Three thousand three hundred sixty nine men aged 40-79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. RESULTS: Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5%) developed new CWP at follow up and 577 (24.9%) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (

Published
2016

31. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., EMAS Study Group, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., and EMAS Study Group

Abstract

Background The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. Methods Three thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. Results Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95 % CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95 % CI = 0.93-3.02) or depression (OR = 1.77; 95 % CI = 0.98-3.21), however rendered the association non-significant. Conclusions Low vitamin D is linked with the new occurrence of CWP, although this may be explained by underlying adverse health factors, particularly obesity and depression.

Published
2016

32. NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus

Author

Chen, Ji-Li, primary, Dawoodji, Amina, additional, Tarlton, Andrea, additional, Gnjatic, Sacha, additional, Tajar, Abdelouahid, additional, Karydis, Ioannis, additional, Browning, Judy, additional, Pratap, Sarah, additional, Verfaille, Christian, additional, Venhaus, Ralph R., additional, Pan, Linda, additional, Altman, Douglas G., additional, Cebon, Jonathan S., additional, Old, Lloyd L., additional, Nathan, Paul, additional, Ottensmeier, Christian, additional, Middleton, Mark, additional, and Cerundolo, Vincenzo, additional

Published
2014
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34. On the monotonicity of some nonparametric dependence measures with respect to concordance ordering

Author

Denuit, Michel, Mesfioui, Mhamed, Tajar, Abdelouahid, and UCL - EUEN/STAT - Institut de statistique

Subjects
Kendall’s [tau], Spearman’s [rho], Concordance order, Fréchet bounds
Abstract

This paper explores the monotonicity with respect to concordance ordering of Kendall’s [tau] and Spearman’s ρ for counting random variables with an unbounded support. This gen- eralizes some results of Schweizer and Wolff (1981) and Tchen (1980).

Published
2001

35. Copula-type representation for random couples with Bernoulli margins

Author

Denuit, Michel, Lambert, Philippe, Tajar, Abdelouahid, and UCL - EUEN/STAT - Institut de statistique

Subjects
Fréchet class, Kendall’s [tau], Somers’d, Spearman’s [rho], Statistics::Methodology, Gamma Measure, Binary Data, Statistics::Other Statistics, Copulas, Odds ratio, Statistics::Computation
Abstract

We propose a copula-type representation for random couples with Bernoulli margins. Some dependence measures for binary data are re-examined. It is stressed that satisfactory dependence measure should only depend on the discrete copula, and not on the margins.

Published
2001

36. Assessment of Sexual Health in Aging Men in Europe: Development and Validation of the European Male Ageing Study Sexual Function Questionnaire

Author

O'Connor, Daryl B, Corona, Giovanni, Forti, Gianni, Tajar, Abdelouahid, Lee, David M, Finn, Joseph D, Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F, Giwercman, Aleksander, Huhtaniemi, Ilpo T, Kula, Krzysztof, O'Neill, Terence W, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, Wu, Frederick CW, O'Connor, Daryl B, Corona, Giovanni, Forti, Gianni, Tajar, Abdelouahid, Lee, David M, Finn, Joseph D, Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F, Giwercman, Aleksander, Huhtaniemi, Ilpo T, Kula, Krzysztof, O'Neill, Terence W, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, and Wu, Frederick CW

Abstract

Introduction Assessment of male sexual dysfunction has been the focus of substantial scientific effort. Less research has focused on the development of instruments for the measurement of sexual functioning in aging men. Aims The aims of this study were: (i) to characterize the psychometric properties of a new brief, reliable, and valid measure of male sexual functioning for use in a large population survey of middle-aged and elderly European men; and (ii) specifically, to determine whether the new instrument, the European Male Ageing Study–sexual function questionnaire (EMAS–SFQ), discriminates between men with high and low levels of circulating testosterone (T) (total T, free T, and bioavailable T). Method One thousand six hundred men aged 40–79 years completed the self-administered EMAS–SFQ, the Beck depression inventory, and provided a blood sample for assessment of sex hormones. Eighty-five men aged 35–74 years completed the EMAS–SFQ twice, 2 weeks apart to examine the test–retest reliability of the instrument. Main Outcome Measures Scores on the EMAS–SFQ in relation to age and T levels. Results Principal component analysis showed that the EMAS–SFQ had four distinct domains (overall sexual functioning [OSF], masturbation, sexual functioning-related distress, and change in sexual functioning). The instrument demonstrated excellent internal and test–retest reliability, as well as convergent, divergent, and discriminant validity. Men with the lowest levels of total, free, and bioavailable T reported lower OSF scores compared to men with the highest T levels. Conclusions The EMAS–SFQ is a valid and reproducible instrument, sensitive to age and T levels. It should be suitable for the assessment of sexual health in population samples of men in epidemiological studies of aging. O'Connor DB, Corona G, Forti G, Tajar A, Lee DM, Finn JD, Bartfai G, Boonen S, Casanueva FF, Giwercman A, Huhtaniemi IT, Kula K, O'Neill TW, Pendleton N, Punab M, Silman AJ, Vanderschueren D, Wu

Published
2008

37. The ability of three different models of frailty to predict all-cause mortality: Results from the European Male Aging Study (EMAS)

Author

Ravindrarajah, Rathi, primary, Lee, David M., additional, Pye, Stephen R., additional, Gielen, Evelien, additional, Boonen, Steven, additional, Vanderschueren, Dirk, additional, Pendleton, Neil, additional, Finn, Joseph D., additional, Tajar, Abdelouahid, additional, O’Connell, Matthew D.L., additional, Rockwood, Kenneth, additional, Bartfai, György, additional, Casanueva, Felipe F., additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S., additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Lean, Michael E.J., additional, Punab, Margus, additional, Wu, Frederick C.W., additional, and O’Neill, Terence W., additional

Published
2013
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38. Comprehensive Cardiac Magnetic Resonance Imaging and Spectroscopy Reveal a High Burden of Myocardial Disease in HIV Patients

Author

Holloway, Cameron J., primary, Ntusi, Ntobeko, additional, Suttie, Joseph, additional, Mahmod, Masliza, additional, Wainwright, Emma, additional, Clutton, Genevieve, additional, Hancock, Gemma, additional, Beak, Philip, additional, Tajar, Abdelouahid, additional, Piechnik, Stefan K., additional, Schneider, Jurgen E., additional, Angus, Brian, additional, Clarke, Kieran, additional, Dorrell, Lucy, additional, and Neubauer, Stefan, additional

Published
2013
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41. Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men

Author

Huhtaniemi, Ilpo T, primary, Tajar, Abdelouahid, additional, Lee, David M, additional, O'Neill, Terence W, additional, Finn, Joseph D, additional, Bartfai, György, additional, Boonen, Steven, additional, Casanueva, Felipe F, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Kula, Krzysztof, additional, Labrie, Fernand, additional, Lean, Michael E J, additional, Pendleton, Neil, additional, Punab, Margus, additional, Silman, Alan J, additional, Vanderschueren, Dirk, additional, Forti, Gianni, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2012
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42. Cohort Profile: The European Male Ageing Study

Author

Lee, David M, primary, Pye, Stephen R, additional, Tajar, Abdelouahid, additional, O'Neill, Terence W, additional, Finn, Joseph D, additional, Boonen, Steven, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe F, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Huhtaniemi, Ilpo T, additional, Kula, Krzysztof, additional, Lean, Michael EJ, additional, Pendleton, Neil, additional, Punab, Margus, additional, Silman, Alan J, additional, Vanderschueren, Dirk, additional, and Wu, Frederick CW, additional

Published
2012
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43. Association of hypogonadism with vitamin D status: the European Male Ageing Study

Author

Lee, David M, primary, Tajar, Abdelouahid, additional, Pye, Stephen R, additional, Boonen, Steven, additional, Vanderschueren, Dirk, additional, Bouillon, Roger, additional, O'Neill, Terence W, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe F, additional, Finn, Joseph D, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Huhtaniemi, Ilpo T, additional, Kula, Krzysztof, additional, Lean, Michael E J, additional, Pendleton, Neil, additional, Punab, Margus, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2012
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44. Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

Author

Boonen, Steven, primary, Pye, Stephen R, additional, O'Neill, Terence W, additional, Szulc, Pawel, additional, Gielen, Evelien, additional, Borghs, Herman, additional, Verschueren, Sabine, additional, Claessens, Frank, additional, Adams, Judith E, additional, Ward, Kate A, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe, additional, Finn, Joseph D, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Huhtaniemi, Ilpo T, additional, Kula, Krzysztof, additional, Labrie, Fernand, additional, Lean, Michael E J, additional, Pendleton, Neil, additional, Punab, Margus, additional, Silman, Alan J, additional, Tajar, Abdelouahid, additional, Wu, Frederick C W, additional, Vanderschueren, Dirk, additional, and _, _, additional

Published
2011
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45. Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study

Author

Han, Thang S, primary, Tajar, Abdelouahid, additional, O'Neill, Terence W, additional, Jiang, Min, additional, Bartfai, György, additional, Boonen, Steven, additional, Casanueva, Felipe, additional, Finn, Joseph D, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Huhtaniemi, Ilpo T, additional, Kula, Krzysztof, additional, Pendleton, Neil, additional, Punab, Margus, additional, Silman, Alan J, additional, Vanderschueren, Dirk, additional, Lean, Michael E J, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2011
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46. Do the Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, And Quality of Life Persist Six Months after Treatment in Intermediate-Frail and Frail Elderly Men?

Author

O'Connell, Matthew D. L., primary, Roberts, Stephen A., additional, Srinivas-Shankar, Upendram, additional, Tajar, Abdelouahid, additional, Connolly, Martin J., additional, Adams, Judith E., additional, Oldham, Jackie A., additional, and Wu, Frederick C. W., additional

Published
2011
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47. The Effect of Musculoskeletal Pain on Sexual Function in Middle-aged and Elderly European Men: Results from the European Male Ageing Study

Author

TAJAR, ABDELOUAHID, primary, O’NEILL, TERENCE W., additional, LEE, DAVID M., additional, O’CONNOR, DARYL B., additional, CORONA, GIOVANNI, additional, FINN, JOSEPH D., additional, BARTFAI, GYORGY, additional, BOONEN, STEVEN, additional, CASANUEVA, FELIPE F., additional, FORTI, GIANNI, additional, GIWERCMAN, ALEKSANDER, additional, HAN, THANG S., additional, HUHTANIEMI, ILPO T., additional, KULA, KRZYSZTOF, additional, LEAN, MICHAEL E.J., additional, PENDLETON, NEIL, additional, PUNAB, MARGUS, additional, PURANDARE, NITIN, additional, SILMAN, ALAN J., additional, VANDERSCHUEREN, DIRK, additional, WU, FREDERICK C.W., additional, and McBETH, JOHN, additional

Published
2010
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48. Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study

Author

Lee, David M, primary, Ulubaev, Aslan, additional, Tajar, Abdelouahid, additional, Pye, Stephen R, additional, Pendleton, Neil, additional, Purandare, Nitin, additional, O'Neill, Terence W, additional, O'Connor, Daryl B, additional, Labrie, Fernand, additional, Platt, Hazel, additional, Payne, Debbie, additional, Bartfai, Gyorgy, additional, Boonen, Steven, additional, Casanueva, Felipe F, additional, Finn, Joseph D, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Huhtaniemi, Ilpo T, additional, Kula, Krzysztof, additional, Lean, Michael E J, additional, Punab, Margus, additional, Silman, Alan J, additional, Vanderschueren, Dirk, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2010
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50. Copula-type representation for random couples with Bernoulli margins

Author

UCL - EUEN/STAT - Institut de statistique, Denuit, Michel, Lambert, Philippe, Tajar, Abdelouahid, UCL - EUEN/STAT - Institut de statistique, Denuit, Michel, Lambert, Philippe, and Tajar, Abdelouahid

Abstract

We propose a copula-type representation for random couples with Bernoulli margins. Some dependence measures for binary data are re-examined. It is stressed that satisfactory dependence measure should only depend on the discrete copula, and not on the margins.

Published
2001

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