1. Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study
- Author
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Raymond W. Lam, Lakshmi N. Yatham, Taj Dhanoa, Wayne Su, Ivan J. Torres, Susanne S. Lee, William G. Honer, Tegan Batres-Y-Carr, and David J. Bond
- Subjects
Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Bipolar I disorder ,Weight Gain ,Temporal lobe ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Bipolar disorder ,Prospective cohort study ,Biological Psychiatry ,Depression ,business.industry ,Repeated measures design ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Temporal Lobe ,Frontal Lobe ,030227 psychiatry ,Psychiatry and Mental health ,Mood ,Case-Control Studies ,Disease Progression ,Cardiology ,Female ,medicine.symptom ,business ,Weight gain ,030217 neurology & neurosurgery - Abstract
OBJECTIVES A sizable fraction of people with bipolar I disorder (BDI) experience a deteriorating clinical course with increasingly frequent mood episodes and chronic disability. This is believed to result from neurobiological illness progression, or neuroprogression. Excessive weight gain predicts neuroprogression across multiple brain illnesses, but no prospective studies have investigated this in BDI. The objective of this study was to determine whether BDI patients who experienced clinically significant weight gain (CSWG; gaining ≥7% of baseline weight) over 12 months had greater 12-month brain volume loss in frontal and temporal regions important to BDI. METHODS In 55 early-stage BDI patients we measured (i) rates of CSWG, (ii) the number of days with mood symptoms, using NIMH LifeCharts, and (iii) baseline and 12-month brain volumes, using 3T MRI. We quantified brain volumes using the longitudinal processing stream in FreeSurfer v6.0. We used general linear models for repeated measures to investigate whether CSWG predicted volume loss, adjusting for potentially confounding clinical and treatment variables. RESULTS After correction for multiple comparisons, CSWG in patients predicted greater volume loss in the left orbitofrontal cortex (effect size [ES; Cohen's d] = -1.01, P = 0.002), left cingulate gyrus (ES = -1.31, P
- Published
- 2018