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3. Determination of the relationship between major histocompatibility complex alleles andchildhood onset obsessive-compulsive disorder

Author

Lüleyap, Doğa, Lüleyap, Hüsnü Ümit, Yaman, Akgün, Pazarcı, Perçin, Çetiner, Salih, Alptekin, Davut, Sertdemir, Yaşar, Evyapan, Gülşah, Yolga Tahiroğlu, Ayşegül, and Karacaoğlan, Gökhan

Subjects
Adult, Major Histocompatibility Complex, Obsessive-Compulsive Disorder, Adolescent, Risk Factors, Humans, General Medicine, Child, Alleles
Abstract

About half of the cases of obsessive-compulsive disorder (OCD) occurring in childhood/adolescence occur with similar symptoms both in childhood and adulthood. Immunologic stress is claimed to be a risk factor in the etiology of childhood onset OCD. Our aim was to elucidate the relationship between childhood onset OCD risk and MHC complex I and II alleles.MHC alleles of 49 OCD children together with 277 healthy children (aged 4-12) were analyzed by PCR. Results were evaluated by using univariate analysis and multivariate logistic regression analysis.A2, A29, C4, DRB3.1, and DRB1*16 alleles were found to increase the risk of OCD.The relationship found between DRB locus and OCD in this study was remarkable since there have been studies on different populations reporting similar relationship between DRB locus and rheumatoid arthritis, which is also an AID. MHC class I and class II alleles were found to increase the risk of OCD in our study, which serves as a suitable model for studies suggesting that MHC genes do not work completely independently. Even though the MHC class I and II genes are considered to have different roles in immune response, in fact they tend to work in cooperation. As in previous studies on AIDs, there is a linear relationship between MHC class II alleles and OCD risk.

Published
2022
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4. The impact of maltreatment on symptom severity in patients with attention deficit hyperactivity disorder.

Author

Gamlı, İpek Süzer and Tahiroğlu, Ayşegül Yolga

Subjects
*ATTENTION-deficit hyperactivity disorder, *TEACHER evaluation, *DOMESTIC violence, *SOCIAL services, *SYMPTOMS
Abstract

Purpose This study aimed to compare the impact of maltreatment on the subtype, comorbidity, sociodemographic characteristics, and psychometric characteristics of attention deficit hyperactivity disorder (ADHD). Materials and Methods: The study participants included 150 treatment-naïve children with ADHD with (n=75) and without (n=75) a history of maltreatment by parents. A sociodemographic form, the Conners Parent Rating Scale (CPRS), the Conners Teacher Rating Scale (CTRS), the Family Assessment Device (FAD), and the Stroop Form were applied. Results: Earlier referral, peer discord, and lower parental age were frequent in the maltreated group, while the maternal employment rates were significantly lower. ADHD-combined type and comorbid oppositional defiant disorder were significantly higher in the maltreated group. The CPRS and FAD scores were also significantly higher). Conclusion: A higher incidence of destructive behavioral patterns may increase the risk of maltreatment. Families of children with hyperactivity and defiant characteristics may have difficulties in managing behavioral problems and may exhibit domestic violence, with the Multidisciplinary approaches, including parental education programs and social investigation, should be considered. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Asılsız Bildirim Olarak Ebeveyne Yabancılaştırma Sendromu: Geleneksel Derleme.

Author

ÖKSÜZ, Erhan, ÇAM RAY, Perihan, ÇEKİN, Necmi, YOLGA TAHİROĞLU, Ayşegül, and KARABULUT, Rezan

Abstract

Copyright of Turkiye Klinikleri Journal of Forensic Medicine & Forensic Sciences / Türkiye Klinikleri Adli Tıp ve Adli Bilimler Dergisi is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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10. Role of calcium metabolism in ADHD: The relationship between parathyroid hormone and ADHD symptom severity.

Author

Varmiş, Dilek Altun, Kaypakli, Gamze Yapça, Tahiroğlu, Ayşegül Yolga, Avci, Ayse, Çelik, Gonca Gül, Metin, Özge, Matyar, Selcuk, and Öztürk, Özlem Görüroğlu

Subjects
CALCIUM metabolism, ATTENTION-deficit hyperactivity disorder, PARATHYROID hormone, SYMPTOMS
Abstract

Background: Vitamin D has been found to be associated with the pathogenesis of attention deficit hyperactivity disorder (ADHD). However, the potential role of parathyroid hormone (PTH) is still unclear. Aim: We aimed to investigate the association between calcium metabolism and ADHD symptomatology. Methods: We included 106 participants aged between 7 and 13 years old (51 ADHD patients, mean age: 9.54 ± 1.77, 55 healthy controls mean age: 9.97 ± 0.94) to this study. K-SADS-PL and Conners' Parent/Teacher Rating Scales, Stroop Test were performed. Blood samples to measure serum levels of Vitamin D, PTH, calcium (Ca), magnesium (Mg), phosphorus (P), and alkaline phosphatase (ALP) were collected in the spring (March--April--May) to prevent seasonal variability. Results: PTH, P, and ALP values were significantly lower and Vitamin D, Ca, and Mg values were significantly higher in the ADHD group (P < 0.05, for all). Both groups had Vitamin D deficiency. Control group has lower Vitamin D levels than the ADHD group (respectively; 17.66 ± 9.07, 21.99 ± 10.99, P < 0.05). There was a negative correlation between PTH and CTRS hyperactivity, CGI-RI and CGI-EL sub-scores, CGI-Total, DSM-IV-Inattention, DSM-IV Hyperactivity/Impulsivity, DSM-IV-Total scores (P < 0.05, for all). Conclusions: We found lower PTH levels in ADHD patients and a strong and negative correlation between PTH and symptom severity. Future studies are needed to clarify if these findings are due to the key role of PTH in ADHD pathology or PTH's function in activating vitamin D. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Bir Çocuk Psikiyatri Kliniğinin 6 Yıllık Hasta Kayıt Verilerinin İncelenmesi.

Author

Karcı, Canan Kuygun, Gürbüz, Asiye Arıcı, Güzel, Esra, Sanberk, Satı, Gamli, İpek Suzer, and Tahiroğlu, Ayşegül Yolga

Abstract

Copyright of Turkish Journal of Child & Adolescent Mental Health / Çocuk ve Gençlik Ruh Sagligi Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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12. Determination of the relationship between major histocompatibility complex alleles and childhood onset obsessive-compulsive disorder.

Author

LÜLEYAP, Ümit, KARACAOĞLAN, Gökhan, TAHİROĞLU, Ayşegül Yolga, YAMAN, Akgün, PAZARCI, Perçin, ÇETİNER, Salih, ALPTEKİN, Davut, SERTDEMİR, Yaşar, EVYAPAN, Gülşah, and LÜLEYAP, Doğa

Subjects
MAJOR histocompatibility complex, OBSESSIVE-compulsive disorder, ALLELES, LOGISTIC regression analysis, ADOLESCENCE, UNIVARIATE analysis, RHEUMATOID arthritis
Abstract

Background/aim: About half of the cases of obsessive-compulsive disorder (OCD) occurring in childhood/adolescence occur with similar symptoms both in childhood and adulthood. Immunologic stress is claimed to be a risk factor in the etiology of childhood onset OCD. Our aim was to elucidate the relationship between childhood onset OCD risk and MHC complex I and II alleles. Materials and methods: MHC alleles of 49 OCD children together with 277 healthy children (aged 4-12) were analyzed by PCR. Results were evaluated by using univariate analysis and multivariate logistic regression analysis. Results: A2, A29, C4, DRB3.1, and DRB1*16 alleles were found to increase the risk of OCD. Conclusion: The relationship found between DRB locus and OCD in this study was remarkable since there have been studies on different populations reporting similar relationship between DRB locus and rheumatoid arthritis, which is also an AID. MHC class I and class II alleles were found to increase the risk of OCD in our study, which serves as a suitable model for studies suggesting that MHC genes do not work completely independently. Even though the MHC class I and II genes are considered to have different roles in immune response, in fact they tend to work in cooperation. As in previous studies on AIDs, there is a linear relationship between MHC class II alleles and OCD risk. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Çocukluk çağı tik bozukluklarının sosyodemografik ve klinik özellikleri

Author

Avcı, Ayşe, Ray, Perihan Çam, Çelik, Gonca Gül, Tahiroğlu, Ayşegül, Jaicks, Çağlar Charles Daniel, and Fen Edebiyat Fakültesi

Subjects
Fenomenoloji, Psychiatry, Tik bozuklukları, Çocukluk çağı, mental disorders, Tik bozukluğu,Tourette Sendromu,fenomenoloji,çocukluk çağı, Tourette Sendromu, Psikiyatri
Abstract

Purpose: In this study, we aimed to investigate the sociodemographic and clinical characteristics of children and adolescents diagnosed with tic disorders. Materials and Methods: The study population included 187 children with tic disorders, aged between 4 and 18 years. The data were obtained by using Yale Global Tic Severity Scale (YGTSS), Screen for Child Anxiety and Related Disorders, Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL). The demographic information, history of familial diseases were recorded. Results: The study included 37 girls (mean 10.9 ± 2.5 years) and 150 boys (mean 10.9 ± 2.7 years) with a mean age of 10.9 ± 2.6 years. Of all cases, 135 were classified as Tourette Syndrome (n=135; 72,2%), 50 as motor tics (n=50; 26,7 %) and 2 as others tic disorders (n=2; 1,1%) according to the diagnostic tic disorders subtype. There was no significant difference between the two groups in terms of mean age and first symptom age according to the subtype of tic disorder. In 91% of the cases, the age of onset of tics was 12 years or younger. The rate of having at least one comorbidity, mean number of comorbidities and comorbid ADHD rates were significantly higher among boys than girls. The most common comorbid diagnoses were ADHD (n=142, 75.9%), OCD (n= 08, 57.8%) and anxiety disorder (n=57, 30.4%). Conclusion: In our study, male cases, early onset and multiple comorbid diagnoses were found to be significantly higher in childhood tic disorders., Amaç: Bu çalışmada, tik bozukluğu tanısı alan çocuk ve ergenlerin sosyodemografik verileri, klinik özellikleri ve eşlik eden diğer ruhsal bozuklukların araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, Tik Bozukluğu tanısı olan 4-18 yaş aralığında 187 olgu alındı. Ruhsal belirtilerin taranması amacı ile Okul Çağı Çocukları İçin Duygulanım Bozuklukları ve Şizofreni Görüşme Çizelgesi-Şimdi ve Yaşam boyu Şekli Türkçe uyarlaması ÇDŞG-ŞY (KSADS-PL), Tik belirti şiddeti için, Yale Genel Tik Ağırlığını Derecelendirme Ölçeği (YGTDÖ) kullanıldı. Olguların demografik bilgileri ve ailesel hastalık öyküleri kaydedildi. Bulgular: Çalışmaya, ortalama yaşı 10,9±2,6 yaş olan, 37 kız (ortalama 10,9±2,5 yaş) ve 150 erkek (ortalama 10,9±2,7 yaş) olgu alındı. Tik Bozukluğu alt tipine göre olguların 135’i (%72,2) Tourette Sendromu, %26,7’si (n=50) motor tik bozukluğu, 2’si (%1,1) bunların dışında bir tik bozukluğu tanısı aldı. Tik Bozukluğu alt tipine göre olguların ortalama yaşı, ilk belirti yaşı açısından iki grup arasında anlamlı fark yoktu. Olguların % 91’inde tiklerin başlangıç yaşı, 12 yaş ve altında idi. Kızlara göre erkekler arasında en az bir eş tanıya sahip olma oranı, ortalama eş tanı sayısı ve dikkat eksikliği hiperaktivite bozukluğu (DEHB) eş tanı oranı anlamlı biçimde daha fazlaydı. En sık görülen eş tanılar, DEHB (n=142, %75,9), obsesif kompulsif bozukluk (OKB) (n=108, %57,8) ve anksiyete bozukluğu (n=57, %30,4) idi. Sonuç: Çalışmamızda, çocukluk çağı tik bozukluklarında erkek olgu, erken başlangıç ve çoklu eş tanıların belirgin düzeyde yüksek olduğu bulunmuştur. Keywords: Tic disorders, Tourette Syndrome, phenomenology, childhood.

Published
2019

14. Can follicular Emmprin and BMP 4 levels predict ICSI outcome?

Author

Yildiz, Nazike, Topal, Zehra, Turk, Tugba, Okumus, Nilufer, Ozbek, Fatih, FOTO ÖZDEMİR, DİLŞAD, Sekmen, Ebru, Sertcelik, Mehmet, SEVGEN, FEYZA HATİCE, Sevince, Oguz, Tekden, Mehmet, Temtek, Seyhan, Ucar, Halit Necmi, Ucar, Filiz, Uygun, Duygu, Uzun, Necati, Vatansever, Zeynep, YAZGILI KAHVECİ, NESLİHAN GÖKÇE, Yildiz, Dilsat Miniksar, Hesapcioglu, Selma Tural, Arman, Ayse Rodopman, Basgulk, Senem, Bilac, Oznur, COŞKUN, Murat, GÜL ÇELİK, GONCA, GÖKÇEN, CEM, GÖRKER, IŞIK, Gormez, Vahdet, Gurkan, Cihat Kaan, HERGÜNER, SABRİ, Kandemir, Hasan, KILIÇ, BİRİM GÜNAY, Kilincaslan, Ayse, Mutluer, Tuba, NASIROĞLU, SERHAT, Yildirim, Veli, Yulaf, Yasemin, YÜCE, DENİZ, YÜKSEL, TUĞBA, AKDEMİR, DEVRİM, Altun, Hatice, ERCAN, EYÜP SABRİ, Polanczyk, Guilherme, Ardic, Ulku Akyol, Karacetin, Gul, Tufan, Ali Evren, Tural, Umit, Aksu, Hatice, AKTEPE, Evrim, Demirkaya, Sevcan Karakoc, Dursun, Burak Onur, Durukan, Ibrahim, Fidan, Tulin, PERDAHLI FİŞ, NEŞE, Gençoğlan, Salih, Gundogdu, Ozlem Yildiz, ÖZCAN, ÖZLEM, Ozturk, Mucahit, Oztop, Didem, Sapmad, Sermin Yalin, Suren, Serkan, Sahin, Nilfer, YOLGA TAHİROĞLU, AYŞEGÜL, Toros, Fevziye, Unal, Fatih, Vural, Pinar, Yazici, Ipek Percinel, YAZICI, KEMAL UTKU, BİLGİÇ, AYHAN, Bozkurt, Ozlem Hekim, Karaman, Dursun, Kinik, Mehmet Fatih, Mazlum, Betul, ÇAKIN MEMİK, NURSU, Sinir, Hayati, İNCE TAŞDELEN, Bedia, Taskin, Beril, Ugur, Cagatay, Uran, Pinar, Uysal, Taciser, Uneri, Ozden, YILMAZ, SAVAŞ, Almaidan, Mahmut, Ari, Fatma Pinar, Aslan, Cihan, Atabay, Ender, Ay, Merve Gunay, Aydemir, Hilal, Ayik, Basak, Cakir, Emine Demirbas, Ceri, Veysi, Demir, Nagehan Ucok, Dinc, Gulser, Irmak, Mustafa Yasin, YILMAZ, SULTAN SEVAL, Acikel, Burak, Aktas, Huseyin, Alaca, Rumeysa, Alic, Betul Gul, Bayram, Ozlem, DİKMEER BEKTAŞ, NEŞE, Berberoglu, Kivanc Kudret, Bostan, Recep, Canli, Merve Arici, Ceylan, Cansin, Firat, Sumeyra Kina, Gules, Zafer, Gunes, Adem, Gunay, Gulay, Ozgur, Borte Gurbuz, Guven, Gokcen, Goksoy, Seyda Celik, KARADAĞ, MEHMET, Kilic, Hilal Tugba, Ayranci, Gulseda, Babadagi, Zehra, Bayar, Hasan, Bayhan, Pelin Con, Cansiz, Mehmet Akif, Cakan, Yasemin, Demir, Ibrahim, Demir, Nuran, Demirdogen, Esen Yildirim, Dogan, Busra, Donmez, Yunus Emre, Donder, Funda, Efe, Aysegul, ERAY, ŞAFAK, Erbilgin, Seda, Erden, Semih, Ersoy, Elif Gokce, Eseroglu, Tugba, Gok, Ezgi Eynalli, Guler, Gulen, Gunes, Serkan, Horozcu, Havvana, IRMAK, Ayşe, IŞIK, Ümit, KAHRAMAN, Özlem, Kalayci, Bilge Merve, Karaaslan, Umut, KILIÇASLAN, FETHİYE, Kinay, Duygu, Kocael, Omer, Koc, Esra Bulanik, Mutlu, Rahime Kadir, Lushi-San, Zejnep, Nalbant, Kevser, Shamkhalova, Ulker, Ozkan, Selcuk, Ozyurt, Esra Yildirim, Polat, Berna, POLAT, Hatice, Suleyman, Funda, Simsek, Nurcan Eren, Tanir, Yasar, Topal, Melike, Acibadem University Dspace, BULUT, Huri, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü

Subjects
Male, 0301 basic medicine, Pregnancy Rate, Bone Morphogenetic Protein 7, medicine.medical_treatment, Bone Morphogenetic Protein 2, Growth Differentiation Factor 9, Oocyte Retrieval, Bone Morphogenetic Protein 4, Intracytoplasmic sperm injection, 0302 clinical medicine, Pregnancy, In vitro fertilization, Follicular phase, TAKMAZ Ö., Yozgatli D., Ozaltin S., ÖZBAŞLI E., Kocyigit Y., Kuran S. B. , BULUT H., GÜNGÖR M., Buyru F., BAŞTU E., -Can follicular Emmprin and BMP 4 levels predict ICSI outcome?-, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.36, ss.1127-1133, 2019, Medicine, Assisted Reproduction Technologies, Genetics (clinical), 030219 obstetrics & reproductive medicine, Obstetrics and Gynecology, General Medicine, Bone morphogenetic protein 7, embryonic structures, Female, Infertility, Female, Adult, Fertilization in Vitro, Follicular fluid, Growth differentiation factor-9, Bone morphogenetic protein, Andrology, 03 medical and health sciences, Ovulation Induction, Genetics, Humans, Sperm Injections, Intracytoplasmic, In vitro fertilisation, BMP 4, business.industry, medicine.disease, 030104 developmental biology, Reproductive Medicine, Oocytes, Basigin, Emmprin, business, Developmental Biology
Abstract

Ozbasli, Esra/0000-0003-0558-7296; Bulut, Huri/0000-0003-2706-9625; Takmaz, Ozguc/0000-0002-3397-7980; Bastu, Ercan/0000-0003-0810-6195 WOS:000473503000011 PubMed ID: 31065945 PurposeTo evaluate the relationship of clinical pregnancy rates with bone morphogenetic proteins 2-4-7 (BMP 2, 4, 7), growth differentiation factor 9 (GDF 9), and Emmprin levels in follicular fluid of intracytoplasmic sperm injection patients.MethodsFollicular fluid of 77 patients who underwent ICSI procedure was collected during the oocyte retrieval procedure. And follicular fluid levels of BMP 2, BMP 4, BMP 7, GDF 9, and Emmprin (Basigin) were measured and compared for clinical pregnancy rates.ResultsFollicular levels of BMP 4 was significantly higher whereas Emmprin levels were lower in patients who had achieved clinically diagnosed pregnancy compared with those who did not achieve clinical pregnancy after ICSI procedure (P=0.007 and P=0.035, respectively). BMP 2, BMP 7, and GDF 9 levels were comparable for both groups.ConclusionClinical pregnancy rates after ICSI may be associated with follicular fluid levels of Emmprin and BMP 4. Follicular levels of Emmprin and BMP 4 can be used as a marker (as markers for predicting ICSI outcomes) for a better ICSI outcome.

Published
2019

15. Bir Orta Okulda Öğrencilerin Zorbalığa Maruziyeti ve İlgili Faktörlerin Değerlendirilmesi

Author

NAZLICAN, Ersin, ÇELİK, Gonca Gül, AKBABA, Muhsin, OKYAY, Ramazan Azim, KURT, Burak, and YOLGA TAHİROĞLU, Ayşegül

Subjects
Health Care Sciences and Services, Student,depression, Öğrenci,depresyon, Sağlık Bilimleri ve Hizmetleri
Abstract

Objective: Bullying that influences health and manyhealth related behaviors in adolescences can lead to negative changes on theirbehaviors even in the later periods of life. The aim of this study is toevaluate the cases of exposure to bullying, depression, anxiety state,relations with the family and school success among the students in a middleschool in Adana.Methods: This cross-sectional study was carried outamong middle school students at 6th, 7th and 8thgrade in the city of Adana. The survey form applied to the students includedsocio-demographic attributes, Child Depression Scale, STAI Scale, CaliforniaBullying Victimization Scale, Family Assessment Scale and Conners TeacherRating Scale.Results: The number of students at 6th, 7thand 8th grade was 53 (44,5%), 29 (24,4%) and 37 (31,1%) respectively. 33 of the students (27,7%) in the study were victims of peer bullying.Students who were subject to violence at home, at lower year levels and withnon-graduate mothers were more exposed to bullying. The ones exposed tobullying were detected to have high levels of depression anxiety andhyperactivity. Discussion: School bullying is an issue which iscommon all over the world and should not be underestimated. This study hasascertained that children exposed to bullying have high levels of anxiety andincidence of depression, also these children were found to be more hyperactive., Amaç: Ergenlerde sağlık ve birçoksağlıkla ilgili davranışları etkileyen zorbalık, yaşamın sonraki dönemlerindebile davranışlarda olumsuz değişikliğe neden olabilir. Bu çalışmanın amacı,Adana'daki ortaokul öğrencilerinde zorbalık, depresyon, kaygı durumu, aileyleilişkiler ve okul başarısı ile ilgili olguların değerlendirilmesidir.Yöntem: Kesitsel tipteki bu çalışma, Adanailinde 6., 7. ve 8. sınıflarda ortaokul öğrencileri arasında yürütülmüştür.Öğrencilere uygulanan anket formu, sosyodemografik özellikler, Çocuk DepresyonÖlçeği, Durumluk Kaygı Ölçeği, Kaliforniya Zorbalık Mağduriyet Ölçeği, AileDeğerlendirme Ölçeği ve Öğretmenlik Derecelendirme Ölçeği'dir.Bulgular: 6., 7. ve 8. sınıf öğrencilerininsayısı sırasıyla 53 (% 44,5), 29 (% 24,4) ve 37 (% 31,1) idi. Araştırmada 33öğrenci (% 27,7) akran zorbalığı kurbanıydı. Evde şiddete maruz kalan, dahadüşük sınıfta okuyan ve anneleri okulbitirmemiş olan öğrenciler, zorbalığa daha çok maruz kalmıştı. Zorbalığa maruzkalanlarda yüksek düzeyde depresyon, kaygı ve hiperaktivite saptanmıştır.Tartışma: Okul zorbalığı, tüm dünyada yaygınolan ve göz ardı edilmemesi gereken bir konudur. Bu çalışma, zorbalığa maruzkalan çocukların yüksek düzeyde kaygı ve depresyon sıklığı taşıdığını ve buçocukların daha hiperaktif olduklarını tespit etmiştir.

Published
2018

16. The epidemology of childhood psychopathology in Turkey. A multicenter nationwide study (EPICPAT-T)

Author

AY, MERVE GÜNAY, YILDIZ MİNİKSAR, DİLŞAD, YAZGILI, NESLİHAN GÖKÇE, VATANSEVER, ZEYNEP, UZUN, NECATİ, UÇAR, FİLİZ, UÇAR, HALİT NECMİ, TÜRK, TUĞBA, TOPAL, ZEHRA, TOPAL, BERNA, TEMTEK, SEYHAN, TEKDEN, MEHMET, TANIR, YAŞAR, ŞİMŞEK EREN, NURCAN, LUSHİ ŞAN, ZEJNEP, ŞAMHALOVA, ÜLKER, SÜLEYMAN, FUNDA, SEVİNCE, OĞUZ, SEVGEN, FEYZA HATİCE, SERTÇELİK, MEHMET, SEKMEN, EBRU, ÖZYURT YILDIRIM, ESRA, ÖZKAN, SELÇUK, ÖZDEMİR, MELİKE, ÖZDEMİR, HANİFE, ÖZBEK, FATİH, OKUMUŞ, NİLÜFER, NALBANT, KEVSER, KADİR MUTLU, RAHİME, KOÇ BULANIK, ESRA, KOCAEL, ÖMER, KINAY, DUYGU, KILIÇASLAN, FETHİYE, KILIÇ, HİLAL TUĞBA, KARADAĞ, MEHMET, KARAASLAN, UMUT, KALAYCI, BİLGE MERVE, KAHRAMAN, ÖZLEM, IRMAK, AYŞE, HOROZCU, HAVVANA, GÖKSOY ÇELİK, ŞEYDA, GÜVEN, GÖKÇEN, GÜRBÜZ, BÖRTE, GÜNAY, GÜLAY, GÜNEŞ, ADEM, GÜNEŞ, SERKAN, GÜLES, ZAFER, GÜLER AKSU, GÜLEN, FIRAT KINA, SÜMEYRA, GÖK EYNALLI, EZGİ, ESEROĞLU, TUĞBA, ERSOY, ELİF GÖKÇE, ERDEN, SEMİH, ERBİLGİN, SEDA, ERAY, ŞAFAK, EFE, AYŞEGÜL, DÖNDER, FUNDA, DÖNMEZ, YUNUS EMRE, DOĞAN, BÜŞRA, DİKMENOĞLU, DUYGU, DEMİRDÖĞEN YILDIRIM, ESEN, DEMİR, NURAN, DEMİR, İBRAHİM, ÇAKAN, YASEMİN, COŞKUN, ŞEYMA, COŞKUN, NEŞE, CEYLAN, CANSIN, CANSIZ, MEHMET AKİF, CANLI ARICI, MERVE, BOSTAN, RECEP, BİLGİÇ, HATİCE, BERBEROĞLU, KIVANÇ KUDRET, DİKMEER BEKTAŞ, NEŞE, BAYRAM, ÖZLEM, BAYHAN ÇON, PELİN, BAYAR, HASAN, BABADAĞI, ZEHRA, AYRANCI, GÜLSEDA, AYDEMİR, HİLAL, ATABAY, ENDER, ASLAN, CİHAN, ARI, FATMA PINAR, ALMAİDAN, MAHMUT, ALIÇ, BETÜL GÜL, ALACA, RÜMEYSA, AKTAŞ, HÜSEYİN, ÖZDEMİR AKKUŞ, FATMA, AK, NAZİKE, AÇIKEL, BURAK, YILMAZ, SULTAN SEVAL, YILMAZ, SAVAŞ, ÜNERİ, ÖZDEN ŞÜKRAN, UYSAL, TACİSER, URAN, PINAR, UĞUR, ÇAĞATAY, TAŞKIN, BERİL, TAŞDELEN İNCE, BEDİA, SINIR, HAYATİ, FOTO ÖZDEMİR, DİLŞAD, ÇAKIN MEMİK, NURSU, MAZLUM, BETÜL, KINIK, MEHMET FATİH, KARAMAN, DURSUN, IRMAK, MUSTAFA YASİN, DİNÇ, GÜLSER, DEMİR ÜÇOK, NAGEHAN, ÇERİ, VEYSİ, ÇAKIR DEMİRBAŞ, EMİNE, BOZKURT, ÖZLEM HEKİM, BİLGİÇ, AYHAN, AYIK, BAŞAK, ALTUN, HATİCE, AKDEMİR, DEVRİM, YÜKSEL, TUĞBA, YÜCE, MURAT, YULAF, YASEMİN, YILDIRIM, VELİ, YAZICI, KEMAL UTKU, PERÇİNEL, İPEK, VURAL, AYŞE PINAR, ÜNAL, MEHMET FATİH, TOROS, FEVZİYE, TAHİROĞLU, AYŞEGÜL, ŞAHİN, NİLFER, SÜREN, SERKAN, YALIN SAPMAZ, ŞERMİN, ÖZTOP, DİDEM BEHİCE, ÖZTÜRK, ÖMER MÜCAHİT, ÖZCAN, ÖZLEM, NASIROĞLU, SERHAT, MUTLUER, TUBA, KILINÇASLAN, AYŞE, KILIÇ, BİRİM GÜNAY, KANDEMİR, HASAN, TURAL HESAPÇIOĞLU, SELMA, HERGÜNER, SABRİ, GÜRKAN, KAĞAN, YILDIZ GÜNDOĞDU, ÖZLEM, GÖRMEZ, VAHDETTİN, GÖRKER, IŞIK, SARI GÖKTEN, EMEL, GÖKÇEN, CEM, GENÇOĞLAN, SALİH, PERDAHLI FİŞ, NEŞE, FİDAN, SANİYE TÜLİN, DURUKAN, İBRAHİM, DURSUN, ONUR BURAK, KARAKOÇ DEMİRKAYA, SEVCAN, ÇELİK, GONCA, COŞKUN, MURAT, BİLAÇ, ÖZNUR, BAŞGÜL, ŞAZİYE SENEM, ARMAN, AYŞE, AKTEPE, EVRİM, AKSU, HATİCE, TURAL, ÜMİT, TUFAN, ALİ EVREN, KARAÇETİN, GÜL, YÜCE, DENİZ, AKYOL ARDIÇ, ÜLKÜ, POLANCZYK, GUILHERME, ERCAN, EYÜP SABRİ, and IŞIK, ÜMİT

Published
2018

21. Düşük doz haloperidol ile tedavi edilen yutma fobisi

Author

Eynallı Gök, Ezgi, Gül Çelik, Gonca, Tahiroğlu, Ayşegül, Avcı, Ayşe, and Taş, Yorum

Subjects
lcsh:R5-920, Health Care Sciences and Services, yutma fobisi, choking phobia, choking phobia,haloperidol, Sağlık Bilimleri ve Hizmetleri, lcsh:Medicine (General), haloperidol
Published
2018

22. Technological addictions in attention deficit hyperactivity disorder: Are they associated with emotional intelligence?

Author

Kaypakli, Gamze, Metin, Özge, Varmiş, Dilek, Ray, Perihan, Çelik, Gonca, Karci, Canan, and Tahiroğlu, Ayşegül

Subjects
COMPULSIVE behavior -- Risk factors, ATTENTION-deficit hyperactivity disorder, INTERNET, INTERPERSONAL relations, MEDICAL technology, QUESTIONNAIRES, STRESS management, EMOTIONAL intelligence, CROSS-sectional method, DESCRIPTIVE statistics
Abstract

Background: The impaired regulation of emotional responses has significant social consequences for patients with attention deficit hyperactivity disorder (ADHD) and can be thought to increase the risk for technological addictions. Aim: Ditto objective of the present research is to investigate the relationship between technological addictions and trait emotional intelligence (EI) in adolescents with ADHD. Methods: This cross-sectional study was conducted in 150 treatment-naïve adolescents with ADHD, aged 12–18 years. The sociodemographic information form, the Emotional Quotient-Inventory: Youth Version (EQ-i: YV), Internet Addiction Test, Smartphone Addiction Scale, and Conners' Parent Rating Scales were used for data collection. Results: The findings revealed that ADHD-C and female patients have lower mean stress management scores on EQ-i: YV. Patients who have smartphone addiction (SA)/problematic internet usage have lower total EI and stress management scores. The oppositional, hyperactivity, and DSM-total scores were negatively correlated with stress management scores. Intrapersonal and stress management scores were negatively correlated to SA symptoms. Conclusion: The stress management dimension was the strongest factor related to ADHD and technological addictions. In adolescents with ADHD, stress management may be the key factor to cope with daily problems. Therefore, the interventions to develop EI can be a therapeutic option in ADHD and technological addictions. [ABSTRACT FROM AUTHOR]

Published
2020
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25. Oral Research Presentations

Author

Gürbüz, Hatice Gözde Akkın, primary, Turhan, Levent, additional, Şendil, Nilgun, additional, Kaşıkçı, Halim Ömer, additional, Salepçi, Banu, additional, Ipekcioglu, Derya, additional, Karcı, Canan Kuygun, additional, Ray, Perihan Çam, additional, Tahiroğlu, Ayşegül Yolga, additional, Avcı, Ayşe, additional, Çelik, Gonca Gül, additional, Cekin, Necmi, additional, Evliyaoğlu, Nurdan, additional, Alkanat, Mehmet, additional, Özdemir, Hafize, additional, Akgün, Egemen, additional, Demirkol, Mehmet Emin, additional, Tamam, Lut, additional, Esnafoglu, Erman, additional, Sevinçok, Doğa, additional, Memiş, Çağdaş Öykü, additional, Doğan, Bilge, additional, Çakaloz, Burcu, additional, Kutlu, Ayşe, additional, Sevinçok, Levent, additional, Dikmen, Sema Nur Türkoğlu, additional, Şafak, Yasir, additional, Gökçer Tulacı, Rıza, additional, Özdemir, İlker, additional, Baykara, Sema, additional, Alban, Kübra, additional, Aydın, Nazan, additional, Aytaç, Hasan Mervan, additional, Yılmaz, Doğan, additional, Aydın, Pınar Çetinay, additional, Yalçın, Gökşen Yüksel, additional, Canbay, Cana, additional, Terzioğlu, Merve, additional, Özer, Aysel, additional, Altintas, Ebru, additional, Kütük, Meryem Özlem, additional, Tufan, Ali Evren, additional, Bağ, Harika Gözükara, additional, Şenormancı, Güliz, additional, Güçlü, Oya, additional, Çelik, Cemil, additional, Bolu, Abdullah, additional, Öznur, Taner, additional, Aydın, Mehmet Sinan, additional, Tokgöz, Yusuf, additional, Uzun, Özcan, additional, Gıca, Sakır, additional, Poyraz, Burç Çağrı, additional, Fidan, Yağmur Sever, additional, Güleç, Hüseyin, additional, Akça, Erdoğdu, additional, Yıldız, Mesut, additional, Akça, Zeynep Nur Demirok, additional, Öztürk, Yusuf, additional, Özyurt, Gonca, additional, Özdel, Kadir, additional, Elboga, Gulcin, additional, Ozyurek, Muhammet Berkay, additional, Akgün, Abdullah, additional, Coşkun, Ali, additional, Bilgiç, Ayhan, additional, Sivri, Rukiye Çolak, additional, Kılınç, İbrahim, additional, İnal, Ahmet, additional, Eray, Uğur, additional, Acat, Murat, additional, Önder, Arif, additional, Adanır, Aslı Sürer, additional, Kavurma, Canem, additional, Bilaç, Öznur, additional, Doğan, Yakup, additional, Ay, Rukiye, additional, Uğur, Çağatay, additional, Alıç, Betül Gül, additional, Gündüz, Mehmet, additional, Ünal, Özlem, additional, Uçur, Ömer, additional, Özcan, Özlem, additional, Gül, Hasret Karabulut, additional, Aykut, Demet Sağlam, additional, Tiryaki, Ahmet, additional, Arslan, Filiz Civil, additional, Bülbül, Gül Alkan, additional, Yolcu, Ömer, additional, Uysal, Aysel, additional, Özatalay, Esin, additional, Cırrık, Selma, additional, Erdogan, Esin, additional, Delibas, Dursun Hakan, additional, Bozkurt, Hazan Tomar, additional, Tekdemir, Rukiye, additional, Erbasan, Vefa, additional, İmre, Okan, additional, Aydın, Memduha, additional, Altınbaş, Kürşat, additional, Karabucak, Başak, additional, Esen, Halime Tuna Çak, additional, Kültür, Sadriye Ebru Çengel, additional, Karaokur, Remzi, additional, Uysal, Songül Atasavun, additional, Erbil, Nurhan, additional, Kirazlı, Meltem Çiğdem, additional, Kara, Tayfun, additional, Mıhçıoğlu, Ajda Mutlu, additional, Yılmaz, Semra, additional, Akaltun, İsmail, additional, Atli, Abdullah, additional, Can, Zübeyir, additional, Çim, Emine Füsun Akyüz, additional, İbiloğlu, Aslıhan Okan, additional, Şahin, Nilfer, additional, Ertekin, Hülya, additional, Kocagöz, Zehra Başar, additional, Özçetin, Adnan, additional, Ataoğlu, Ahmet, additional, Cangür, Şengül, additional, Ölmez, Safiye Bahar, additional, Yazar, Neslihan, additional, Uçar, Halit Necmi, additional, Murat, Duygu, additional, Eray, Şafak, additional, Tanır, Yaşar, additional, Altun, Hatice, additional, Tanyeri, Mehmet Hanifi, additional, Büyükokuroğlu, Mehmet Emin, additional, Tanyeri, Pelin, additional, Mutlu, Oguz, additional, Akar, Füruzan Yıldız, additional, Ulak, Güner, additional, Erden, Bekir Faruk, additional, Sevgen, Feyza Hatice, additional, Arıcı, Asiye, additional, Kılıçaslan, Fethiye, additional, Erbay, Mehmet Fatih, additional, Darılmaz, Cengiz, additional, Çökmüş, Fikret Poyraz, additional, Yüzeren, Serra, additional, Dikici, Didem Sücüllüoğlu, additional, Aydın, Orkun, additional, Aydın, Pınar Ünal, additional, Akdeniz, Fatma, additional, Öztekin, Siğnem, additional, Çöldür, Emine Özge, additional, Balıkçı, Kuzeymen, additional, Köroğlu, Ertuğrul, additional, Aydemir, Ömer, additional, Kara, Hüseyin, additional, Özçelik, Özgen, additional, Balcı, Mehmet Murat, additional, Kuloğlu, Mehmet Murat, additional, Tomar, Talya, additional, Taneli, Fatma, additional, Oran, Arzu, additional, Ovalı, Gülgün Yılmaz, additional, Kaypaklı, Gamze Yapça, additional, Metin, Özge, additional, Karaş, Hakan, additional, Çetingök, Halil, additional, İlişer, Reşat, additional, Çarpar, Elif, additional, Kaşer, Muzaffer, additional, Can, Güneş Şayan, additional, Ulaş, Gözde, additional, Ildız, Ayşegül, additional, Emiroğlu, Neslihan, additional, Ada, Emel, additional, Özerdem, Ayşegül, additional, Imre, Okan, additional, Mutlu, Oğuz, additional, Akar, Furuzan Yıldız, additional, Tekin, Uğur, additional, Satar, Ayşegül, additional, Aydın, Ayşe Nur, additional, Erermiş, Hatice Serpil, additional, Kocaman, Orhan, additional, Çetin, Nihal Yurteri, additional, Akay, Aynur, additional, Karagöz, Yüksel Sümeyra, additional, Doğan, Özlem, additional, Ülkar, Serenay, additional, Kılıç, Birim Günay, additional, Ceyhun, Hacer Akgül, additional, Aydın, Esat Fahri, additional, Ülkevan, Tuba, additional, Gürbüzer, Nilifer, additional, Aykutlu, Hasan Cem, additional, Görker, Işık, additional, Özen, Emel, additional, Aktepe, Evrim, additional, Aydın, Mustafa Asım, additional, Yavuz, Dudu Dilek, additional, Karaaslan, Umut, additional, Karataş, Abdullah, additional, Sancak, Zehra, additional, Eser, Erhan, additional, Demet, Mehmet Murat, additional, Karadere, Mehmet Emrah, additional, Asafov, Ece Yazla, additional, Ölçüm, Halil İbrahim, additional, Algül, Ayhan, additional, Gündoğmuş, İbrahim, additional, Cetin, Fatih Hilmi, additional, Guler, Hasan Ali, additional, Turkoglu, Serhat, additional, Çolpan, Bahar Keleş, additional, Bayram, Elif, additional, Ateş, Funda Seher Özalp, additional, Teber, Serap Tıraş, additional, Duman, Nagihan Saday, additional, Gökten, Emel Sarı, additional, Sungur, Elif Nurgül, additional, Şengül, Melike Ceyhan Balcı, additional, Kardeşler, Ayşen Çetin, additional, Enli, Yaşar, additional, Kurtul, Neslihan, additional, Aslan, Cihan, additional, Konuşkan, Bahadır, additional, Şener, Burçin, additional, Anlar, Banu, additional, Ünal, Fatih, additional, Akçay, Bülent Devrim, additional, Koç, Güray, additional, Yetkin, Sinan, additional, Bayad, Serkan, additional, Elbir, Müge, additional, Topbaş, Özge Alp, additional, Kocabaş, Tuğba, additional, Aydın, Adem, additional, Avcu Çelik, Pelin, additional, Çıldır, Deniz Argüz, additional, Özbek, Aylin, additional, Mustan, Aybuke Tuğçe, additional, Karadağ, Ayşe Sevgi, additional, Kalenderoğlu, Aysun, additional, Örüm, Mehmet Hamdi, additional, Özen, Murat Eren, additional, Eğilmez, Oğuzhan Bekir, additional, Hamdi Örüm, Mehmet, additional, Aydın, Dilek Bingöl, additional, Elmas, Bahri, additional, Nasıroğlu, Serhat, additional, Aydın, Engin, additional, Özdemir, Öner, additional, Erel, Özcan, additional, Fedai, Ülker, additional, Asoğlu, Mehmet, additional, Elbay, Rümeysa Yeni, additional, Karatepe, Hasan Turan, additional, Ulaşoğlu, Celal, additional, Ayaydın, Hamza, additional, Şahin, Berkan, additional, Karabekiroğlu, Koray, additional, Bozkurt, Abdullah, additional, Usta, Miraç Barış, additional, Aydın, Muazzez, additional, Çobanoğlu, Cansu, additional, Kahya, Yalçın, additional, İnan, Dilara, additional, Altınöz, Ali Ercan, additional, Köşger, Ferdi, additional, Eşsizoğlu, Altan, additional, Arslan, Mehmet, additional, Çalışkan, Ali Metehan, additional, Göktaş, Duygu, additional, İnanlı, İkbal, additional, Çalışır, Saliha, additional, Eren, İbrahim, additional, Tatar, Zeynep Baran, additional, Kurt, Erhan, additional, Unal, Gokhan, additional, Aricioglu, Feyza, additional, Tezcan, Mustafa Esad, additional, Kalyoncu, Tuğba, additional, Ergüvendi, Fazilet, additional, Yektaş, Çigdem, additional, Eroz, Recep, additional, Yurdakul, Gokhan, additional, Cakır, Mahmut, additional, Tasmektepligil, Mehmet Yalcin, additional, Baykal, Saliha, additional, Usta, Mirac Barıs, additional, Karakurt, Melih Nuri, additional, Karabekiroglu, Koray, additional, Yulaf, Yasemin, additional, Gümştaş, Funda, additional, Gökçe, Sebla, additional, Yazgan, Yankı, additional, Sevincok, Doğa, additional, Kalyoncu, Tugba, additional, Ergüvendi, Fazilet Arkat, additional, Yağcı, İbrahim, additional, Avcı, Sema, additional, Kıvrak, Yüksel, additional, Yaşar, Alişan Burak, additional, Sayman, Ceyhun, additional, Taycan, Serap Erdoğan, additional, Çetinkaya, Yılmaz, additional, Gündüz, Anıl, additional, Tireli, Hülya, additional, Yazici, Kemal Utku, additional, Yazici, Ipek Percinel, additional, Kılıçle, Pınar Aksu, additional, Gül, Süleyman, additional, Yazici, Ipek Percınel, additional, Sümer, Ayçin Darıcı, additional, Çöp, Esra, additional, Bilgili, Duygu, additional, Şahin, Müge, additional, Dinç, Gülser Şenses, additional, Hekim, Özlem, additional, Mısırlıoğlu, Emine Dibek, additional, Kurt, Funda, additional, Göker, Zeynep, additional, Üneri, Özden, additional, Atalay, Eray, additional, Yıldırım, İrem, additional, İnaltekin, Ali, additional, Yücens, Bengü, additional, Kotan, Vahap Ozan, additional, Özkayar, Nihal, additional, Dede, Fatih, additional, Yüksel, Rabia Nazik, additional, Bayram, Şenol, additional, Kotan, Zeynep, additional, Göka, Erol, additional, Say, Gökçe Nur, additional, Kalyoncu, Merve, additional, Beğinoğlu, Özlem, additional, Basgoz, Bahadir Bilgin, additional, Ince, Semra, additional, Safer, Umut, additional, and Tasci, İlker, additional

Published
2018
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26. Corpus Callosum Agenesis Presented With Attention Deficit Hyperactivity Disorder: Two Case Reports

Author

ŞAHPOLAT, Musa, ÇELİK, Gonca, AVCI, Ayşe, and TAHİROĞLU, Ayşegül

Subjects
lcsh:R5-920, Attention Deficit Hyperactivity Disorder, Corpus Callosum Agenesis, lcsh:R, lcsh:Medicine, lcsh:Medicine (General), Attention Deficit Hyperactivity Disorder,Corpus Callosum Agenesis, Dikkat Eksikliği Hiperaktivite Bozukluğu,Korpus Kallozum Agenezisi
Abstract

ADHD is a treatable neuropsychiatric disorder which can continue till adulthood. There have been three subtypes including attention deficiency, hyperactivity and impulsivity. Its etiology remains unclear yet. It is hypothesized that there is an impairment of neurodevelopment in early developmental periods through the interactions between genetic and environmental processes. Corpus callosum provides an integration of cognitive, sensorial and motor functions of brain as a response to the impulses originating from the cortex. The damage of this region may result in deterioration of some cerebral functions such as cognitive functions, speaking, learning ability and impulse control. In this paper, we report two pediatric cases who had comorbid attention deficiency and corpus callosum agenesis without mental retardation., ÖZET: Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) erişkin hayatta da devam edebilen, tedavi edilebilir nöropsikiyatrik bir bozukluktur. Dikkat eksikliği, aşırı hareketlilik ve dürtüsellikle karakterize üç alt tipi bulunmaktadır. DEHB, etiyolojisi halen yeterince aydınlatılamamış bir alandır. DEHB de erken gelişim evrelerinde, çeşitli genetik ve çevresel etkenlerin etkileşimiyle, nörogelişimde bir aksama olduğu öne sürülmektedir. Korpus kallozum, korteksten köken alan uyaranları karşı taraf hemisfere bağlayarak beynin motor, duyusal ve kognitif performansını sağlamaktadır. Bu bölgede meydana gelen bir hasar kognitif beceriler, konuşma, ögrenme ve dürtü kontrol gibi beyin fonksiyonlarında bozulmaya neden olabilir. Bu yazıda; ilk ruhsal belirtileri dikkat eksikliği ve hiperaktivite olan iki çocuk olgudaki, korpus kallozum agenezisi ve DEHB birlikteliğinin olası patofizyolojik mekanizmaları tartışılmaktadır.

Published
2013

27. The influence of pericentric inversion in 10th chromosome on aggressive behavior and hyperactivity

Author

TANRIVERDİ, Nilgün, PAZARBAŞI, Ayfer, KARAHAN, Dilara, AVCI, Ayşe, TAHİROĞLU, Ayşegül Yolga, TUNÇ, Erdal, and DEMİRHAN, Osman

Subjects
Pericentric inversion, lcsh:R5-920, lcsh:R, Pericentric inversion,Chromosome 10p-q,Aggressive behavior,Hyperactivity,Mental retardation, Aggressive behavior, lcsh:Medicine, Mental retardation, Perisentrik inversiyon,Kromozom 10p-q,Agresif davranış,Hiperaktiflik,Mental retardasyon, lcsh:Medicine (General), Chromosome 10p-q, Hyperactivity
Abstract

Aggressive behavior and hyperactivity are neurodevelopmental diseases with unknown pathogenesis. Pericentric inv(10)(p11.2;q21.2) mutation is frequently encountered in cytogenetic laboratories. This mutation is accepted as a polymorphic variant and is phenotypically silent, but in some cases it has been associated with neurodevelopmental diseases like autism. After blood culturing, standard chromosome obtaining procedure was applied to patients. In this study, clinical and cytogenetical findings of a boy with developmental delay, mental and motor retardation, attention deficit and hyperactivity have been reported. As a result of chromosome analysis, on chromosome 10, a large pericentric inversion between p11.1 and q22.q bands has been found. Karyotype analysis was also performed to mother, father and siblings of the patient and they have been found to have normal karyotype. It is plausible to consider a relation between inv(10) and some behavioral problems. Additionally, molecular studies targeting 10p-q critical region will be more informative for the true identification of this disease., Agresif davranış ve hiperaktivite, nedeni ve patogenezi bilinmeyen genetik nörogelişimsel hastalıklardır. Perisentrik inv(10)(p11.2;q21.2) mutasyonu sitogenetik laboratuarlarında sıklıkla tanımlanmaktadır. Bu olgu fenotipik olarak sessizdir ve polimorfik bir varyant olduğu düşünülmektedir ancak bazı hastalarda otizm gibi nörogelişimsel hastalıklarla ilişkilendirilmiştir. Bir erkek çocuğunun, G-bantlama boya tekniği kullanılarak karyotip incelemesi yapıldı. Bu çalışmada; gelişme geriliği, mental motor retardasyonu, dikkat eksikliği ve hiperaktivite hastalığı olan bir erkek çocuğunun klinik ve sitogenetik bulguları rapor edildi. Kromozom analizi sonucunda, 10. kromozomun p11.1 ve q22.1 bantları arasındaki bölgeyi kapsayan geniş bir perisentrik inversiyon saptandı. Probandın anne, baba ve kardeşlerinin karyotiplerinin normal olduğu bulundu. Bulgumuz, inv(10)"un davranış bozukluğu hastalıkları ile ilişkili olabileceğini düşündürmektedir. Bununla birlikte, moleküler çalışmalar, hastalığın patogenezine dahil olan 10p-q kritik bölgesinde yer alan genlerin bulunmasına ve hastalığın daha iyi tanımlanmasına yardımcı olacaktır.

Published
2013

29. Okul reddi tedavisinde metilfenidatin rolü

Author

KARCI, Canan Kuygun, TAHİROĞLU, Ayşegül Yolga, METİN, Özge, ÇELİK, Gonca Gül, and AVCI, Ayşe

Subjects
Health Care Sciences and Services, methylphenidate, Sağlık Bilimleri ve Hizmetleri
Published
2016

34. Çocukluk çağı tik bozukluklarının sosyodemografik ve klinik özellikleri.

Author

Ray, Perihan Çam, Çelik, Gonca Gül, Tahiroğlu, Ayşegül, Daniel Jaicks, Çağlar Charles, and Avcı, Ayşe

Subjects
TIC disorders, TOURETTE syndrome, GENETIC disorders, ANXIETY disorders, AFFECTIVE disorders
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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35. Methylphenidate treatment outcomes and gender differences in attentional deficit and hyperactivity disorder with epilepsy: a follow-up study.

Author

ÇAM RAY, Perihan, GÜL ÇELİK, Gonca, YOLGA TAHİROĞLU, Ayşegül, SÜZER GAMLI, İpek, and MİHRİBAN HERGÜNER, Özlem

Subjects
ATTENTION-deficit hyperactivity disorder, METHYLPHENIDATE, EPILEPSY, TREATMENT effectiveness, TEACHER evaluation
Abstract

Copyright of Anatolian Journal of Psychiatry / Anadolu Psikiyatri Dergisi is the property of Anatolian Journal of Psychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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36. Relationship between human leukocyte antigen (HLA) alleles and pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections (PANDAS).

Author

Karacaoğlan, Gökhan, Lüleyap, Ümit, Tahiroğlu, Ayşegül Yolga, Pazarcı, Perçin, Yaman, Akgün, Çetiner, Salih, Sertdemir, Yaşar, and Lüleyap, Doğa

Subjects
HLA histocompatibility antigens, STREPTOCOCCAL diseases, NEUROBEHAVIORAL disorders, ALLELES, PANDAS
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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37. School Refusal: Clinical Features, Diagnosis and Treatment

Author

BAHALI, Kayhan and TAHİROĞLU, Ayşegül Yolga

Subjects
Okul Reddi,Çocuk,Psikopatoloji,Tanı,Tedavi, School Refusal,Child,Diagnosis,Psychopathology,Treatment, education
Abstract

Children regularly and voluntarily go to school in order to fulfill the expectations of society from them to continue their education or schooling. School continuation has been made compulsory by laws. Nonetheless, contrary to popular belief, for some children it is distressing to go to school. These children have difficulty continuing school and/or refuse to go to school. Today school refusal is defined as a child's inability to continue school for reasons, such as anxiety and depression. The prevalence of school refusal has been reported to be approximately 1% in school-age children and 5% in child psychiatry samples. The prevalence of school refusal is similar among boys and girls. School refusal can occur at any time throughout the child's academic life and at all socio-economic levels. School refusal is considered a symptom rather than a clinical diagnosis and can manifest itself as a sign of many psychiatric disorders, with anxiety disorders predominant. Separation anxiety disorder, generalized anxiety disorder, social phobia, specific phobia, and adjustment disorder with anxiety symptoms are the most common disorders co-occurring with school refusal. While separation anxiety disorder is associated with school refusal in younger children, other anxiety disorders, especially phobias, are associated with school refusal in adolescents. Children who have parents with psychiatric disorders have a higher incidence of school refusal, and psychiatric disorders are more frequently seen in adult relatives of children with school refusal, which supports a significant role of genetic and environmental factors in th etiology of school refusal. School refusal is a emergency state for child mental health. As it leads to detrimental effects in the short term and the long term, it should be regarded as a serious problem. The long-lasting follow-up studies of school refusing children have revealed that these children have a higher incidence of psychiatric disorders or that they are more likely to require psychological assistance. It is for these reasons that the treatment of school refusal is increasingly gaining impor-tance. The major aim of the treatment is to help the child return to school at the shortest time possible. The treatment should be carried out in cooperation with the child's parents and the school personnel. A widely accepted approach to the treatment of school refusal is one that is concerned with the application of a multi-faceted treatment. Psychosocial and psychopharmacological approaches constitute the crucial parts of the therapeutic process. Today, cognitive behaviour therapy and medication are the most frequently employed approaches in the treatment of school refusal., Toplumun eğitim ve okula devam etme gibi beklentilerini karşılamak için çocuklar düzenli ve gönüllü olarak okula gitmektedir. Okula devam etme yasalar ile de zorunlu hale getirilmiştir. Bununla birlikte, bazı çocuklar için okula gitmek beklenenin ötesinde sıkıntı verici bir durumdur. Bu çocuklar okula devam etmede güçlük çekmekte ve/veya okula gitmeyi reddetmektedir. Günümüzde okul reddi, çocukların anksiyete ve depresyon gibi duygusal sorunlar nedeni ile okula devam edememesi olarak tanımlanmaktadır. Okul reddinin yaygınlığı tüm okul çağındaki çocuklar için yaklaşık % 1 ve kliniğe başvuran tüm çocuklar için % 5 olarak bildirilmektedir. Okul reddi erkek ve kız çocuklarda eşit oranda görülmektedir. Okul hayatının herhangi bir döneminde ortaya çıkabilmektedir. Okul reddinin tüm sosyoekonomik düzeylerde görülebildiği bildirilmektedir. Okul reddi klinik bir tanı olmayıp bir belirti olarak değerlendirilmektedir. Anksiyete bozuklukları başta olmak üzere birçok ruhsal bozukluğun belirtisi olabilmektedir. Ayrılma anksiyetesi bozukluğu, yaygın anksiyete bozukluğu, sosyal fobi, özgül fobi ve anksiyete ile giden uyum bozukluğu okul reddi ile birlikte en sık görülen tanılardır. Tanılarda yaşa bağlı eğilimler görülmektedir. Ayrılma anksiyetesi bozukluğu genelde yaşça daha küçük çocuklardaki okul reddi ile ilişkilendirilirken, diğer anksiyete bozuklukları özellikle de fobiler ergenlerdeki okul reddi ile ilişkilendirilmektedir. Ruhsal bozukluğu olan ebeveynlerin çocuklarında okul reddi sık görülmektedir. Bu, genetik ve çevresel faktörlerin okul reddi gelişimindeki rolünü desteklemektedir. Okul reddi bir çocuk ruh sağlığı acilidir. Kısa ve uzun dönemde olumsuz sonuçlar doğurduğu için ciddi bir sorun olarak değerlendirilmektedir. Okul reddi olan çocukların uzun süreli izlem çalışmalarında, genel toplum ya da kontrol gruplarına göre daha yüksek oranda ruhsal bozuklukların bulunduğu ya da ruhsal yardıma gereksinim duyma olasılıklarının daha yüksek olduğu gösterilmiştir. Bu nedenlerden dolayı okul reddinin tedavisi çok önem kazanmaktadır. Tedavide temel amaç çocuğun en kısa süre içerisinde okula dönmesini sağlamaktır. Tedavi ebeveyn ve okul personeli ile işbirliği içinde yürütülmelidir. Tedavide genel kabul gören yöntem çok eksenli bir tedavi yaklaşımı uygulamaktır. Psikososyal ve psikofarmakolojik yaklaşımlar tedavinin önemli ayaklarını oluşturur. Günümüzde bilişsel davranışçı terapi ve ilaç sağaltımı tedavide en sık kullanılan yaklaşımlar olarak öne çıkmaktadır.

Published
2014

38. Executive Functions in Frontal Lob Syndrome: A Case Report.

Author

METİN, Özge, TUFAN, Ali Evren, CEVHER BİNİCİ, Nagihan, SARAÇLI, Özge, ATALAY, Adnan, and YOLGA TAHİROĞLU, Ayşegül

Subjects
FRONTAL lobe diseases, EXECUTIVE function, NEUROPSYCHOLOGICAL tests, MAGNETIC resonance imaging of the brain, PROBLEM solving
Abstract

Prefrontal cortex in the frontal lobe (FL) is the center of executive functions (EF). FL damage can lead to executive dysfunction by influencing frontal-subcortical circuits (dorsolateral, orbitofrontal, ventromedial). Damage to the dorsolateral prefrontal cortex (DLPFC) can lead to deterioration in EF, whereas damage to the orbitofrontal cortex (OFC) can lead to personality changes with characteristics of disinhibition and irritability. In addition, damage to the anterior cingulate cortex/medial prefrontal cortex (ACC/MPFC) can result in decreased spontaneity. Neuropsychological tests are important components in the assessment of EF including goal-directed behavior, decision-making, risk assessment, future plan management, prioritizing, and organization. Clinical conditions affecting frontal-subcortical connections outside of the FL can also lead to executive dysfunctions and frontal lobe syndrome (FLS). This case report is about an adolescent patient diagnosed with FLS. The clinical symptoms, assessment, and treatment processes of this case are discussed in this report. The case is a 15-year-old boy that was admitted to our clinic with behavioral problems that began after a car accident three years ago. A magnetic resonance imaging (MRI) study of the brain indicated hyper-intense signal increase in the periventricular deep white matter that was associated with traumatic brain damage. Neuropsychological test results (Stroop, Wisconsin Card Sorting Test, Serial Digit Learning Test, Judgement of Line Orientation Test, Verbal Memory Processes Scale) demonstrated impairment in the cognitive flexibility, verbal fluency, prioritizing, inappropriate response inhibition, sustained attention, planning, problem solving, organization, and subcortical memory functions. We thought that cognitive and behavioral symptoms of this case were associated with the dysfunctions of the frontal-subcortical circuits, independently from an obvious frontal lesion. FLS patients after head traumas, with sudden-onset behavioral and cognitive problems, should be kept in mind in differential diagnosis even in the absence of an obvious frontal lesion. [ABSTRACT FROM AUTHOR]

Published
2017
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39. Dikkat eksikliği hiperaktivite bozukluğu tanısı olan çocukların sosyodemografik özellikleri, eşlik eden bozukluklar ve tedavi yaklaşımları

Author

Yolga Tahiroğlu, Ayşegül, Avcı, Ayşe, and Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

ÖZET DİKKAT EKSİKLİĞİ HİPERAKTİVİTE BOZUKLUĞU TANISI ALAN ÇOCUKLARIN SOSYODEMOGRAFİK ÖZELLİKLERİ, EŞLİK EDEN BOZUKLUKLAR VE TEDAVİ YAKLAŞIMLARI Dikkat eksikliği hiperaktivite bozukluğu, okul çağı çocuklarının yaklaşık %3-7'sini etkileyen bir bozukluktur. Dikkatsizlik temel olarak okulda güçlük yaratır. Hiperaktif çocuk yaşıtlarına göre aşın hareketlidir. Ancak yapılandırılmış ortamlarda bunu göstermeyebilirler. Dürtüsellik, davranışın olumsuz sonucunu düşünmeden cevap vermedir. DEHB yüksek ailesel geçiş gösterir, ancak klinik olarak erken çocukluk çağında belirti veren, çoklu etkenlere bağlı bir bozukluktur. Eşlik eden bozukluklar sıklıkla görülür. Dikkatsizlik ve dürtüsellik tanısı alan olguların beyninde, dopaminerjik ve noradrenerjik yolaklarda, normal çocuklara göre bozukluk vardır. Belirtilerde, noradrenerjik ve dopaminerjik nörol yolaklarda değişiklik yapan bir çok ilaçlarla düzelme olduğu gösterilmiştir. Metilfenidat ve amfetamin gibi uyarıcılar DEHB' da en çok kullanılan ilaçlardır. Anahtar sözcük: DEHB. VI ABSTRACT SOCIODEMOGRAPHIC CHARACTERISTICS, COMORBID DISORDERS AND TREATMENT OF CHILDREN DIAGNOSED WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER Attention-deficit/hyperactivity disorder (ADHD) occurs in approximately 3-7% of school-age children. Inattention is mainly impaired inschool. Hyperactive child is more than excessive activity, although the latter has been demonstrated to be present during structured in-seat activity. Impulsivity refers to the inability to delay a response despite the anticipation of negative consequenses for the behavior. ADHD is considered a highly heritable but clinically heterogeneous disorder with onset of symptoms in early childhood. Patients are said to be `comorbid` when they have more than one psychiatric disorder. Its pathophysiology appears to involve alterations in dopaminergic and noradrenergic patways associated with control of attention and impulsivity. Symptoms have been shown to respond favorably to several pharmacological interventions, notably those that affect dopaminergic and noradrenergic neurotransmission. Stimulants such as methylphenidate and amphetamine are currently the most widely used medications for ADHD. Key word: ADHD VII 94

Published
2003

41. Vitamin D Deficiency in Obsessive--Compulsive Disorder Patients with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections: A Case Control Study.

Author

ÇELİK, Gonca, TAŞ, Didem, TAHİROĞLU, Ayşegül, AVCI, Ayşe, YÜKSEL, Bilgin, and ÇAM, Perihan

Subjects
ALKALINE phosphatase, AUTOIMMUNE diseases, CALCIUM, NEUROLOGICAL disorders, OBSESSIVE-compulsive disorder, PHOSPHORUS, STREPTOCOCCAL diseases, VITAMIN D, VITAMIN D deficiency, COMORBIDITY
Abstract

Copyright of Archives of Neuropsychiatry / Nöropsikiyatri Arşivi is the property of Turkish Association of Neuropsychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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45. Ergenlerde adli psikiyatrik değerlendirme: Bir olgu sunumu.

Author

NASIROĞLU, Serhat, KESKİNER, Özlem, TAHİROĞLU, Ayşegül Yolga, and AVCI, Ayşe

Abstract

Copyright of Anatolian Journal of Psychiatry / Anadolu Psikiyatri Dergisi is the property of Anatolian Journal of Psychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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46. Dikkat Eksikliği Hiperaktivite Bozukluğu ile Prezente Olan Corpus Callosum Agenezisi: İki Olgu Bildirimi.

Author

Şahpolat, Musa, Çelik, Gonca, Avcı, Ayşe, and Tahiroğlu, Ayşegül

Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

47. İstismara uğramış çocuk ve ergenlerin yatarak tedavisi.

Author

NASIROĞLU, Serhat, Yolga TahİRoĞLu, Ayşegül, AVCI, Ayşe, GÜL ÇElİK, Gonca, and ÖZTÜRK, Zehra

Subjects
*INPATIENT care, *CHILD sexual abuse, *INSTITUTIONAL care, *REHABILITATION research
Abstract

Objective: Inpatient rehabilitation and treatment systems, the Residential Treatment Centers (RTC) are widely used in the treatment of childhood sexual abuse (CSA) cases and offer the advantages of keeping a combination of several applications. „Oguz Kagan Koksal Social Care and Rehabitation Center' is the first RTC in Turkey providing services to girl CSA victims. In this study, demographic, clinical and follow-up findings of patients treated in this center since the establishment of the six year period will be presented. Methods: This study included 152 girls aged between 8-18 years who had histories of CSA, neglect or other kinds of adverse experiences, and in need for treatment or protecttion. Demographic and abuse-specific data were obtained from file records. The Child Beck Depression Inventory, the Trait-State Anxiety Inventory-1, -2, the Moudsley Obsessive Compulsive Questionnaire, and the Clinical Global Impression Scale were administered at the beginning and at the end of the treatment period. Results: A history of CSA was reported by 120 girls. Almost half of the cases were diagnosed as posttraumatic stress disorder, 23.7% as borderline personality disorder, 21.1% as destructive behavior disorders, and 9.2 as bipolar disorder. In the treatment, 95% of cases taken at least one psychotropic medication. The most commonly used drugs were antipsychotics, and given in treatment of 81.4% of girls. In addition, 51.7% of cases taken mood stabilizers, and 25.5% of them took antidepressants. Mean score of all psychometric tests were improved significantly at the end point compared to the baseline. Conclusion: Our findings support the usefulness of the system presented herein for child and adolescent victims of CSA. This study is important because it involves data from the first RTM in our country in this field. These pioneering results can provide new starting points for similar institutions to be established in Turkey. [ABSTRACT FROM AUTHOR]

Published
2012

48. Çocuk ve Ergenlerde Atipik Antipsikotik İlaçların Metabolik ve Endokrin Yan Etkileri.

Author

Çelik, Gonca Gül, Tahiroğlu, Ayşegül, and Avcı, Ayşe

Subjects
*METABOLIC syndrome risk factors, *MENTAL illness, *COMORBIDITY, *PREVENTIVE pediatrics, *OBESITY, *HYPERTENSION, *ANTIPSYCHOTIC agents, *PEDIATRICS, *WEIGHT gain
Abstract

Comorbid psychiatric disorders, frequent hospitalization, multiple outpatient treatment, prior history of hypertension, obesity and lipid dysregulation are associated with higher risk of metabolic syndrome in children. Side effects of antipsychotic drugs and their management have recently become a major subject of research due to enhanced antipsychotic drug usage in child and adolescents. Prevention strategies are usually preferred to secondary or tertiary strategies in the management of metabolic syndrome associated with antipsychotic drugs. Clinicians should present multidisciplinary approach to endocrine and metabolic side effects due to antipsychotic use in pediatric patient groups and avoid multiple drug use in such patients. In this paper, we briefly reviewed metabolic side effects of second generation antipsychotic drugs in child and adolescent population, possible mechanisms of susceptibility to metabolic syndrome and pharmacological and non pharmacological treatment approach to prevention of weight gain. [ABSTRACT FROM AUTHOR]

Published
2011

49. Neurodevelopmental and Behavioral Effects of Assisted Reproductive Techniques.

Author

ÇElİK, Gonca, TahİRoĞLu, Ayşegül, and Avci, Ayşe

Abstract

Assisted reproductive techniques are used in the treatment of infertility worldwide. Long-term and multidimensional effects of these techniques on the embryo, especially on genetic programming, are still unknown. Moreover, the difficult period before parenting may affect the attachment and, consequently, the child's mental health. The aim of this review is to discuss the neurodevelopmental and behavioral effects of assisted reproductive techniques from fetal and early childhood stages to adolescence. Follow-up studies, case reports, and meta-analyses investigating the neurological, psychiatric and genetic effects of in vitro fertilization techniques were reviewed. Animal studies suggest that the serum content, in which the embryo is preserved, may damage its genetic programming. Cerebral palsy, preterm delivery and low birth weight are the most frequent obstetric complications. Executive functions, memory and attention may be affected, especially in school-age children. Cases of autism have been reported as well. Preimplantation genetic screening has not been commonly used because of its high cost, complex technical procedures and ethical responsibilities. This paper suggests that multidisciplinary approach is needed in order to predict neurological and mental disorders. Parenting education and psychosocial support for infertile couples may facilitate the healthy attachment with their baby. [ABSTRACT FROM AUTHOR]

Published
2010
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50. Yardımcı Üreme Tekniklerinin Nörogelişimsel ve Davranışsal Etkileri.

Author

ÇELİK, Gonca, TAHİROĞLU, Ayşegül, and AVCI, Ayşe

Subjects
*MENTAL illness risk factors, *NEUROLOGICAL disorders, *BEHAVIOR disorders in children, *CHILD development, *FERTILIZATION in vitro, *GENETICS, *PREGNANCY complications, *DISEASE risk factors
Abstract

Assisted reproductive techniques are used in the treatment of infertility worldwide. Long-term and multidimensional effects of these techniques on the embryo, especially on genetic programming, are still unknown. Moreover, the difficult period before parenting may affect the attachment and, consequently, the child's mental health. The aim of this review is to discuss the neurodevelopmental and behavioral effects of assisted reproductive techniques from fetal and early childhood stages to adolescence. Follow-up studies, case reports, and meta-analyses investigating the neurological, psychiatric and genetic effects of in vitro fertilization techniques were reviewed. Animal studies suggest that the serum content, in which the embryo is preserved, may damage its genetic programming. Cerebral palsy, preterm delivery and low birth weight are the most frequent obstetric complications. Executive functions, memory and attention may be affected, especially in school-age children. Cases of autism have been reported as well. Preimplantation genetic screening has not been commonly used because of its high cost, complex technical procedures and ethical responsibilities. This paper suggests that multidisciplinary approach is needed in order to predict neurological and mental disorders. Parenting education and psychosocial support for infertile couples may facilitate the healthy attachment with their baby. [ABSTRACT FROM AUTHOR]

Published
2010
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