Search

Your search keyword '"Tahir B"' showing total 239 results
Start Over Author "Tahir B"
239 results on '"Tahir B"'

3. NDSP 09: Risk Assessment of Pakistani Individual for Diabetes (RAPID) – Findings from Second National Diabetes Survey of Pakistan (NDSP) 2016–2017

Author

Abdul Basit K, Fawwad A, Riaz M, Tahir B, Khalid M, and Basit A

Subjects
risk score, diabetes, ndsp, rapid, pakistan, Specialties of internal medicine, RC581-951
Abstract

Khalid Abdul Basit,1,2 Asher Fawwad,3,4 Musarrat Riaz,5 Bilal Tahir,4 Maria Khalid,4 Abdul Basit5 1Department of Acute Medicine, Whipps Cross University Hospital, Barts Health NHS Trust, London, England; 2Department of Population Health, University College London, London, England; 3Department of Biochemistry, Baqai Medical University, Karachi, Pakistan; 4Department of Research, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan; 5Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanCorrespondence: Abdul BasitDepartment of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No.: 1-2, II-B, Nazimabad No 2, Karachi, PakistanTel +92 21 36707179Email abdulbasit@bide.edu.pkObjective: To elucidate the effectiveness of Risk Assessment of Pakistani individuals with diabetes (RAPID) tool in epidemiological and population-based second National Diabetes Survey of Pakistan (NDSP) 2016– 2017 for identifying risk of developing type 2 diabetes.Methodology: This observational study was a sub-analysis of the second National Diabetes Survey of Pakistan (NDSP) 2016– 2017 conducted from February 2016 to August 2017 in all four provinces of Pakistan. Ethical approval was obtained from National Bioethics Committee Pakistan. RAPID score, a validated and published scoring scale to assess risk of diabetes, originally developed from community-based surveys was used. The risk score is assessed by parameters namely: age, waist circumference, and positive family history of diabetes. Subjects with score greater ≥ 4 were considered at risk of diabetes.Results: A total of 4904 individuals were assessed (2205 males and 2699 females). Mean age of participants was 41.8± 14.2 years. Positive family history of diabetes was seen in 1379 (28.1%) people. According to RAPID score 1268 (25.9%) individuals scored ≥ 4 and were at risk of diabetes. OGTT status of people at risk of diabetes according to RAPID score showed that 18.1% people with diabetes and 29.2% were prediabetic. Whereas, OGTT status of people not at risk of diabetes showed that only 7.6% people with diabetes, 20% were prediabetic.Conclusion: A simple diabetes risk score can be used for identification of high-risk individuals for diabetes so that timely intervention can be implemented. Community-based awareness programs are needed to educate people regarding healthy lifestyle in order to reduce risk of diabetes.Keywords: risk score, diabetes, NDSP, RAPID, Pakistan

Published
2021

4. Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy

Author

Tahir B. Dar, Regina M. Henson, and Stephen L. Shiao

Subjects
radiation therapy, innate and adaptive immune response, immunotherapy, macrophages, dendritic cells, NK cells, Immunologic diseases. Allergy, RC581-607
Abstract

Radiation continues to play a major role in the treatment of almost every cancer type. Traditional radiation studies focused on its ability to damage DNA, but recent evidence has demonstrated that a key mechanism driving the efficacy of radiation in vivo is the immune response triggered in irradiated tissue. Innate immune cells including macrophages, dendritic cells, and natural killer cells are key mediators of the radiation-induced immune response. They regulate the sensing of radiation-mediated damage and subsequent radiation-induced inflammation. Given the importance of innate immune cells as determinants of the post-radiation anti-tumor immune response, much research has been devoted to identify ways to both enhance the innate immune response and prevent their ability to suppress ongoing immune responses. In this review, we will discuss how the innate immune system shapes anti-tumor immunity following radiation and highlight key strategies directed at the innate immune response to enhance the efficacy of radiation.

Published
2019
Full Text
View/download PDF

5. Competition-exclusion and coexistence in a two-strain SIS epidemic model in patchy environments

Author

Doumatè, Jonas T., Issa, Tahir B., and Salako, Rachidi B.

Subjects
Mathematics - Analysis of PDEs, 34D05, 34D23, 91D25, 92D30, 37N25
Abstract

This work examines the dynamics of solutions of a two-strain SIS epidemic model in patchy environments. The basic reproduction number $\mathcal{R}_0$ is introduced, and sufficient conditions are provided to guarantee the global stability of the disease-free equilibrium (DFE). In particular, the DFE is globally stable when either: (i) $\mathcal{R}_0\le \frac{1}{k}$, where $k\ge 2$ is the total number of patches, or (ii) $\mathcal{R}_0<1$ and the dispersal rate of the susceptible population is large. Moreover, the questions of competition-exclusion and coexistence of the strains are investigated when the single-strain reproduction numbers are greater than one. In this direction, under some appropriate hypotheses, it is shown that the strain whose basic reproduction number and local reproduction function are the largest always drives the other strain to extinction in the long run. Furthermore, the asymptotic dynamics of the solutions are presented when either both strain's local reproduction functions are spatially homogeneous or the population dispersal rate is uniform. In the latter case, the invasion numbers are introduced and the existence of coexistence endemic equilibrium (EE) is proved when these invasion numbers are greater than one. Numerical simulations are provided to complement the theoretical results., Comment: 35 pages

Published
2023

6. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Author

Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R

Published
2024
Full Text
View/download PDF

7. Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy

Author

Shiao, Stephen L, Kershaw, Kathleen M, Limon, Jose J, You, Sungyong, Yoon, Junhee, Ko, Emily Y, Guarnerio, Jlenia, Potdar, Alka A, McGovern, Dermot PB, Bose, Shikha, Dar, Tahir B, Noe, Paul, Lee, Jung, Kubota, Yuzu, Maymi, Viviana I, Davis, Madison J, Henson, Regina M, Choi, Rachel Y, Yang, Wensha, Tang, Jie, Gargus, Matthew, Prince, Alexander D, Zumsteg, Zachary S, and Underhill, David M

Subjects
Vaccine Related, Breast Cancer, Digestive Diseases, Cancer, Animals, Antifungal Agents, Bacteria, Breast Neoplasms, Combined Modality Therapy, Down-Regulation, Female, Fungi, Gastrointestinal Microbiome, Gene Expression Regulation, Neoplastic, Humans, Lectins, C-Type, Melanoma, Mice, Symbiosis, T-Lymphocytes, Tumor-Associated Macrophages, Up-Regulation, Xenograft Model Antitumor Assays, T cells, bacteria, dectin-1, fungi, immunotherapy, macrophages, microbiome, mycobiome, radiation, tumor immunology, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on radiation therapy is not as well understood, and the microbiome comprises more than bacteria. Here, we find that intestinal fungi regulate antitumor immune responses following radiation in mouse models of breast cancer and melanoma and that fungi and bacteria have opposite influences on these responses. Antibiotic-mediated depletion or gnotobiotic exclusion of fungi enhances responsiveness to radiation, whereas antibiotic-mediated depletion of bacteria reduces responsiveness and is associated with overgrowth of commensal fungi. Further, elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in patients with breast cancer and is required for the effects of commensal fungi in mouse models of radiation therapy.

Published
2021

9. Competition-exclusion and coexistence in a two-strain SIS epidemic model in patchy environments.

Author

Doumatè, Jonas T., Issa, Tahir B., and Salako, Rachidi B.

Subjects
BASIC reproduction number, EPIDEMICS
Abstract

This work examines the dynamics of solutions of a two-strain SIS epidemic model in patchy environments. The basic reproduction number $ \mathcal{R}_0 $ is introduced, and sufficient conditions are provided to guarantee the global stability of the disease-free equilibrium (DFE). In particular, the DFE is globally stable when either: (ⅰ) $ \mathcal{R}_0\le \frac{1}{k} $, where $ k\ge 2 $ is the total number of patches, or (ⅱ) $ \mathcal{R}_0<1 $ and the dispersal rate of the susceptible population is large. Moreover, the questions of competition-exclusion and coexistence of the strains are investigated when the single-strain reproduction numbers are greater than one. In this direction, under some appropriate hypotheses, it is shown that the strain whose basic reproduction number and local reproduction function are the largest always drives the other strain to extinction in the long run. Furthermore, the asymptotic dynamics of the solutions are presented when either both strain's local reproduction functions are spatially homogeneous or the population dispersal rate is uniform. In the latter case, the invasion numbers are introduced and the existence of coexistence endemic equilibrium (EE) is proved when these invasion numbers are greater than one. Numerical simulations are provided to complement the theoretical results. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. 892 Non-redundant mechanisms of resistance to immunotherapy and radiotherapy converge on innate immunity

Author

Nguyen, Anthony T, primary, Dar, Tahir B, additional, Viramontes, Jolene, additional, Stevens, Satchel, additional, Jang, Julie, additional, Ko, Emily, additional, Chung, Eric M, additional, Zhang, Samuel, additional, Atkins, Katelyn M, additional, Kamrava, Mitchell, additional, Sandler, Howard M, additional, Guarnerio, Jlenia, additional, Knott, Simon, additional, Zumsteg, Zachary, additional, Underhill, David M, additional, and Shiao, Stephen L, additional

Published
2023
Full Text
View/download PDF

13. Abstract 6409: Non-redundant mechanisms of immune resistance to radiotherapy converge on innate immunity

Author

Nguyen, Anthony T., primary, Dar, Tahir B., additional, Viramontes, Jolene, additional, Stevens, Satchel, additional, Jang, Julie K., additional, Ko, Emily Y., additional, Lu, Diana J., additional, Chung, Eric M., additional, Zhang, Samuel C., additional, Atkins, Katelyn M., additional, Kamrava, Mitchell, additional, Sandler, Howard M., additional, Guarnerio, Jlenia, additional, Knott, Simon, additional, Zumsteg, Zachary S., additional, Underhill, David M., additional, and Shiao, Stephen L., additional

Published
2023
Full Text
View/download PDF

16. miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC

Author

Tomohiro Shibata, Duo-Yao Cao, Tahir B. Dar, Faizan Ahmed, Shabir A. Bhat, Luciana C. Veiras, Ellen A. Bernstein, Abdul Arif Khan, Manita Chaum, Stephen L. Shiao, Warren G. Tourtellotte, Jorge F. Giani, Kenneth E. Bernstein, Xiaojiang Cui, Eric Vail, and Zakir Khan

Subjects
Cancer Research, Oncology, head and neck squamous cell carcinoma (HNSCC), miRNAs, miR124-3p, miR766-3p drug resistance, cisplatin, fluorouracil (5-FU), FP chemotherapy, radiotherapy
Abstract

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with poor prognosis, which is mainly due to drug resistance. The biology determining the response to chemo-radiotherapy in HNSCC is poorly understood. Using clinical samples, we found that miR124-3p and miR766-3p are overexpressed in chemo-radiotherapy-resistant (non-responder) HNSCC, as compared to responder tumors. Our study shows that inhibition of miR124-3p and miR766-3p enhances the sensitivity of HNSCC cell lines, CAL27 and FaDu, to 5-fluorouracil and cisplatin (FP) chemotherapy and radiotherapy. In contrast, overexpression of miR766-3p and miR124-3p confers a resistance phenotype in HNSCC cells. The upregulation of miR124-3p and miR766-3p is associated with increased HNSCC cell invasion and migration. In a xenograft mouse model, inhibition of miR124-3p and miR766-3p enhanced the efficacy of chemo-radiotherapy with reduced growth of resistant HNSCC. For the first time, we identified that miR124-3p and miR766-3p attenuate expression of CREBRF and NR3C2, respectively, in HNSCC, which promotes aggressive tumor behavior by inducing the signaling axes CREB3/ATG5 and β-catenin/c-Myc. Since miR124-3p and miR766-3p affect complementary pathways, combined inhibition of these two miRNAs shows an additive effect on sensitizing cancer cells to chemo-radiotherapy. In conclusion, our study demonstrated a novel miR124-3p- and miR766-3p-based biological mechanism governing treatment-resistant HNSCC, which can be targeted to improve clinical outcomes in HNSCC.

Published
2022
Full Text
View/download PDF

17. miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC

Author

Shibata, Tomohiro, primary, Cao, Duo-Yao, additional, Dar, Tahir B., additional, Ahmed, Faizan, additional, Bhat, Shabir A., additional, Veiras, Luciana C., additional, Bernstein, Ellen A., additional, Khan, Abdul Arif, additional, Chaum, Manita, additional, Shiao, Stephen L., additional, Tourtellotte, Warren G., additional, Giani, Jorge F., additional, Bernstein, Kenneth E., additional, Cui, Xiaojiang, additional, Vail, Eric, additional, and Khan, Zakir, additional

Published
2022
Full Text
View/download PDF

18. Physiological assessment of patients with airways dysanapsis using 129Xe MRI

Author

Smith, L, primary, Marshall, H, additional, Jakymelen, D, additional, Biancardi, A, additional, Collier, G J, additional, Chan, H, additional, Hughes, P J C, additional, Brook, M L, additional, Astley, J, additional, Munro, R, additional, Rajaram, S, additional, Swift, A J, additional, Capener, D, additional, Bray, J, additional, Ball, J, additional, Rodgers, O, additional, Smith, I, additional, Tahir, B A, additional, Rao, M, additional, Norquay, G, additional, Weatherley, N D, additional, Armstrong, L, additional, Hardaker, L, additional, Fihn-Wikander, T, additional, Hughes, R, additional, and Wild, J M, additional

Published
2022
Full Text
View/download PDF

19. 129Xe-MRI and lung function to phenotype ventilation heterogeneity in asthma and/or COPD

Author

Smith, L, primary, Marshall, H, additional, Jakymelen, D, additional, Biancardi, A, additional, Collier, G, additional, Chan, H, additional, Hughes, P, additional, Brook, M, additional, Astley, J, additional, Munro, R, additional, Rajaram, S, additional, Swift, A, additional, Capener, D, additional, Bray, J, additional, Ball, J, additional, Rodgers, O, additional, Smith, I, additional, Tahir, B, additional, Rao, M, additional, Norquay, G, additional, Weatherley, N, additional, Armstrong, L, additional, Hardaker, L, additional, Fihn-Wikander, T, additional, Hughes, R, additional, and Wild, J, additional

Published
2022
Full Text
View/download PDF

22. Abstract 6409: Non-redundant mechanisms of immune resistance to radiotherapy converge on innate immunity

Author

Anthony T. Nguyen, Tahir B. Dar, Jolene Viramontes, Satchel Stevens, Julie K. Jang, Emily Y. Ko, Diana J. Lu, Eric M. Chung, Samuel C. Zhang, Katelyn M. Atkins, Mitchell Kamrava, Howard M. Sandler, Jlenia Guarnerio, Simon Knott, Zachary S. Zumsteg, David M. Underhill, and Stephen L. Shiao

Subjects
Cancer Research, Oncology
Abstract

Multiple studies have demonstrated synergy between immune checkpoint blockade (ICB) and radiotherapy (RT) in preclinical murine models; however, randomized trials of RT/ICB have been inconsistent in patients with solid tumors. To better understand this discordance, we hypothesized that there are non-redundant inhibitory immune pathways that restrain the efficacy of RT beyond T-cell oriented immune checkpoints. To this end, we performed scRNA-seq and CITE-seq analysis of the EO771 syngeneic murine model of breast cancer to characterize the immune landscape following RT±ICB. We found that ICB reprograms the immune response to RT by shifting tumor-associated macrophages (TAMs) from a lipid-associated phenotype (APOE, FABP5) to an M1-like interferon-stimulated state (CXCL10, ISG15). However, ICB also promoted the late recruitment of intratumoral neutrophils, which drive resistance to RT in other contexts. To evaluate whether neutrophils may be limiting antitumor immunity to RT/ICB, we depleted intratumoral neutrophils using two separate antibodies, anti-Ly6G and anti-Gr-1. Compared to RT/ICB alone, both neutrophil depletion strategies enhanced tumor control and prolonged survival in advanced EO771 tumors (P Citation Format: Anthony T. Nguyen, Tahir B. Dar, Jolene Viramontes, Satchel Stevens, Julie K. Jang, Emily Y. Ko, Diana J. Lu, Eric M. Chung, Samuel C. Zhang, Katelyn M. Atkins, Mitchell Kamrava, Howard M. Sandler, Jlenia Guarnerio, Simon Knott, Zachary S. Zumsteg, David M. Underhill, Stephen L. Shiao. Non-redundant mechanisms of immune resistance to radiotherapy converge on innate immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6409.

Published
2023
Full Text
View/download PDF

24. Treatment of Chikungunya Virus (CHIKV) Using Targeted Immunotherapy

Author

Neelakshi Mungra, Arnaud John Kombe Kombe, Tahir B. Dar, Fleury Augustin Nsole Biteghe, Jean De La Croix Ndong, and Chalomie Nyangone Ekome Toung

Subjects
business.industry, virus diseases, Medicine, Chikungunya, business, medicine.disease_cause, Virology, Virus, Targeted immunotherapy
Abstract

Chikungunya virus (CHIKV) is the most common mosquito-borne Alphavirus infecting humans worldwide. Up to date, there are no antiviral treatments or vaccines approved to treat or prevent CHIKV for which treatments remain symptomatic based on clinical manifestations. Hence, designing effective therapies to either prevent or treat CHIKV infection is of paramount importance. Interestingly, monoclonal antibodies (mAbs) are known to be significantly important in mediating protective immunity in CHIV infection. During the last decades, numerous animal studies have reported the protective and prophylactic efficacy of human and mouse anti-CHIKV mAbs isolated from convalescent patients. However, the therapeutic benefits of these anti-CHIKV mAbs can be limited by multiple factors. Thus, it becomes pertinent to better understand the CHIKV infection dynamics, mitigate the undesired mAbs-associated effects and improve therapies. In this review, we critically discuss CHIKV antiviral infectious mechanisms and address how the improved understanding of the latter may pave the way to better targeted immunotherapies.

Published
2022
Full Text
View/download PDF

29. 245P Palbociclib combined with aromatase inhibitors (AIs) in women ≥75 years with oestrogen receptor positive (ER+ve), human epidermal growth factor receptor 2 negative (HER2-ve) advanced breast cancer: A real-world multicentre UK study

Author

El Badri, S., primary, Tahir, B., additional, Balachandran, K., additional, Bezecny, P., additional, Britton, F., additional, DeSouza, K., additional, Hills, D., additional, Moe, M., additional, Pigott, T., additional, Proctor, A., additional, Shah, Y., additional, Simcock, R., additional, Stansfeld, A., additional, Synowiec, A., additional, Theodoulou, M., additional, Verrill, M., additional, Wadhawan, A., additional, Harper-Wynne, C., additional, and Wilson, C., additional

Published
2021
Full Text
View/download PDF

31. Optimal Design of THz NRD Rat-Race Circuit Using Function Expansion Based Topology Optimization Method With CMA-ES

Author

Md. Iquebal Hossain Patwary, Tahir Bashir, Akito Iguchi, and Yasuhide Tsuji

Subjects
Nonradiative dielectric (NRD) waveguide, rat-race circuit, 90 $^{\circ }$ hybrid device, topology optimization, function expansion method, covariance matrix adaptation evolution strategy (CMA-ES), Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

Rat-race circuit devices are crucial components in the design of THz-wave circuits. Although nonradiative dielectric (NRD) waveguides having simple structures and extremely low loss are promising platforms for THz-wave circuits, it may difficult to realize conventional rat-race devices in NRD platform due to the appearance of unwanted LSE$_{01}$ mode in the output ports. Therefore, optimal design of these devices is very essential for THz-wave circuit applications. In this paper, we present topology optimal design of THz NRD rat-race circuit based on function expansion method and covariance matrix adaptation evolution strategy (CMA-ES). The proposed method overcomes the difficulty of appearing unwanted LSE$_{01}$ mode in the output ports, thus the optimized devices achieved the significant improvement in the device performance in comparison with that of conventional NRD rat-race devices. In addition to the NRD rat-race circuit, a 90$^{\circ }$ hybrid device is also designed in order to confirm the validity of the proposed design approach. A thorough discussion of the fabrication tolerance of proposed devices has also been conducted in detail.

Published
2024
Full Text
View/download PDF

32. Can the FIB-4 score predict the severity of acute pancreatitis in NAFLD?

Author

Kutay Kirdok, Özge Yogurtcu, Tahir Buran, and Elmas Kasap

Subjects
NAFLD, Acute pancreatitis, FIB-4, Ranson criteria, Billurbine, Surgery, RD1-811, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a liver pathology. NAFLD’s prevalence is increasing in the world and because of the increase non-invasive methods are gaining importance in diagnosis. The Fibrosis 4 (FIB-4) score is one of the most commonly used non-invasive scoring methods for diagnosing NAFLD today. Acute pancreatitis is a disease with inflammation and high morbidity. There are studies indicating that acute pancreatitis progresses more severely in patients with NAFLD. In our study, it was aimed to define the possible relationship between the FIB-4 score and the severity of acute pancreatitis, which has not been investigated before and contribute to the literature. Methods Our study was conducted by retrospectively scanning 124 patients diagnosed with acute pancreatitis between 2018 and 2020. The patients were compared with the presence of NAFLD and the FIB-4 score results in those with NAFLD. Results The 48th-hour Ranson score was found to be statistically significantly higher in patients with NAFLD compared to those without NAFLD. In patients with NAFLD, the total billurbin, direct billurbin, AST, ALT, ALP, GGT, and Ranson scores were found to be statistically significantly higher in those with FIB-4 score ≥ 2.67. Conclusıon As liver fibrosis increases in patients with NAFLD, it is suggested that liver damage accompanying acute pancreatitis increases, and the prognosis of acute pancreatitis worsens. There is a need for further studies to be conducted while centering more on this subject, which has not been investigated before in the literature.

Published
2024
Full Text
View/download PDF

34. Optimization of the Extrusion Process in the Production of Compound Feeds for Dairy Cows

Author

Rabiga Kassymbek, Auyelbek Iztayev, Tahir Balevi, Urishbay Chomanov, Gulzhan Zhumaliyeva, and Assiya Shoman

Subjects
feeding, extrusion, triticale, germinated grain, technology., Technology (General), T1-995, Social sciences (General), H1-99
Abstract

The paper proposes a way of enriching the composition of mixed fodder by combining two promising technologies with known effects: inclusion of germinated grain in the composition and extrusion. Crude and digestible protein, fiber, fat, and mineral elements Ca, K, Na, and P were studied. Inclusion of sprouted grain into mixed fodder and subsequent extrusion contribute to improvements in taste qualities, increased edibility, and assimilation of mixed fodder, as well as nutritive value. Taking into account the obtained knowledge about the influence of temperature regime and content of germinated triticale grain in mixed fodder production, it is advisable to continue research to adapt the technology and develop formulations for different types of animals and farm birds. The purpose of the study was to optimize the process of extrusion of sprouted triticale grain in order to reduce energy consumption and obtain high-quality extrudates. To achieve this goal, the following tasks were set: to analyze the regime factors affecting the fat content based on the optimization of technological modes of extrusion. To optimize the technology of extrusion of triticale grain of the Kozha variety, the fat content was chosen as the target function. Optimization of the technology of extrusion of triticale grain of the Kozha variety was carried out by the method of nonlinear programming. The following optimal technological modes of grain extrusion were obtained: The content of sprouted triticale grain is 15%, and the extrusion temperature is 140°C. With these optimal grain processing modes, the target function was 1.12%. The practical significance of the technology of the production of compound feeds with the use of extrusion in order to improve the quality and increase the shelf life. Doi: 10.28991/ESJ-2023-07-05-08 Full Text: PDF

Published
2023
Full Text
View/download PDF

35. Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis

Author

Tahir Buran, Muhammet Burak Batır, Fethi Sırrı Çam, Elmas Kasap, Fatih Çöllü, Hamide Betül Gerik Çelebi, and Mustafa Şahin

Subjects
Ulcerative colitis, IL-17A, ADAMTS, Inflammation, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated. IL-17 A is a cytokine that is produced by a type of immune cell called Th17 cells and is involved in the immune response and inflammation. On the other hand, ADAMTS-1, -4, and − 5 are enzymes that are involved in the breakdown of extracellular matrix proteins, including proteoglycans, which are important components of the intestinal wall. This study aimed to evaluate the relationship between interleukin 17 (IL-17 A) cytokine, which plays a role in the pathogenesis of ulcerative colitis, and the inflammation-controlled a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1, -4, and − 5 protein members. Methods Bowel tissue samples and blood serum from 51 patients with UC and 51 healthy controls were included in this study. mRNA expression levels of the ADAMTS-1, -4, -5, and IL-17 A were analyzed by RT-qPCR, and immunohistochemical analyses were performed to evaluate ADAMTS-1, -4, -5, and IL-17 A proteins in tissue samples. In addition, ELISA analysis determined serum levels of the ADAMTS-1, -4, -5, and IL-17 A. Results RT-qPCR results reveal that the expression of ADAMTS-1, -4, -5, and IL-17 A genes in the UC tissue samples were significantly high according to the control tissue samples. Also, ADAMTS-1, -4, -5, and IL-17 A proteins revealed enhanced expression pattern UC groups according to the control. Also, ADAMTS-1, -4, -5, and IL-17 A protein showed cytoplasmic localization patterns in both control and UC groups. The serum levels of ADAMTS-1,-5, and IL-17 A were significantly higher in UC samples than in the control group. Conclusions We observed a positive correlation between the ADAMTS-1, -5 and IL17A cytokine expression in UC samples. These results provide a new understanding of controlling crucial ADAMTS family protein members by IL-17 A cytokines with UC.

Published
2023
Full Text
View/download PDF

36. Balancing commensals

Author

Shikha Bose, Emily Y. Ko, Alexander D. Prince, Viviana I. Maymi, Dermot P.B. McGovern, Stephen L. Shiao, Junhee Yoon, Alka A. Potdar, Madison J. Davis, Yuzu Kubota, Kathleen M. Kershaw, Sungyong You, Jie Tang, Jung Lee, Paul Noe, Tahir B. Dar, Jose J. Limon, Matthew Gargus, Zachary S. Zumsteg, Jlenia Guarnerio, David M. Underhill, Rachel Y. Choi, Wensha Yang, and Regina M. Henson

Subjects
Cancer Research, Antifungal Agents, medicine.medical_treatment, T-Lymphocytes, Down-Regulation, Breast Neoplasms, Microbiology, Article, Mice, Immune system, Breast cancer, Tumor-Associated Macrophages, medicine, Animals, Humans, Lectins, C-Type, Microbiome, Symbiosis, Melanoma, biology, Bacteria, General Immunology and Microbiology, Fungi, Immunotherapy, biology.organism_classification, Commensalism, medicine.disease, Combined Modality Therapy, Xenograft Model Antitumor Assays, Gastrointestinal Microbiome, Up-Regulation, Radiation therapy, Gene Expression Regulation, Neoplastic, Infectious Diseases, Oncology, Female
Abstract

Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on radiation therapy is not as well understood, and the microbiome comprises more than bacteria. Here, we find that intestinal fungi regulate antitumor immune responses following radiation in mouse models of breast cancer and melanoma and that fungi and bacteria have opposite influences on these responses. Antibiotic-mediated depletion or gnotobiotic exclusion of fungi enhances responsiveness to radiation, whereas antibiotic-mediated depletion of bacteria reduces responsiveness and is associated with overgrowth of commensal fungi. Further, elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in patients with breast cancer and is required for the effects of commensal fungi in mouse models of radiation therapy.

Published
2021
Full Text
View/download PDF

38. Single breath-held acquisition of co-registered 3D 129Xe lung ventilation and anatomical proton images of the human lung with compressed sensing

Author

Collier, G., Hughes, P., Horn, F., Chan, H.-F., Tahir, B., Norquay, G., Stewart, N., and Wild, J.

Abstract

Purpose\ud To develop and assess a method for acquiring coregistered proton anatomical and hyperpolarized 129Xe ventilation MR images of the lungs with compressed sensing (CS) in a single breath hold.\ud \ud Methods\ud Retrospective CS simulations were performed on fully sampled ventilation images acquired from one healthy smoker to optimize reconstruction parameters. Prospective same‐breath anatomical and ventilation images were also acquired in five ex‐smokers with an acceleration factor of 3 for hyperpolarized 129Xe images, and were compared to fully sampled images acquired during the same session. The following metrics were used to assess data fidelity: mean absolute error (MAE), root mean square error, and linear regression of the signal intensity between fully sampled and undersampled images. The effect of CS reconstruction on two quantitative imaging metrics routinely reported [percentage ventilated volume (%VV) and heterogeneity score] was also investigated.\ud \ud Results\ud Retrospective simulations showed good agreement between fully sampled and CS‐reconstructed (acceleration factor of 3) images with MAE (root mean square error) of 3.9% (4.5%). The prospective same‐breath images showed a good match in ventilation distribution with an average R2 of 0.76 from signal intensity linear regression and a negligible systematic bias of +0.1% in %VV calculation. A bias of −1.8% in the heterogeneity score was obtained.\ud \ud Conclusion\ud With CS, high‐quality 3D images of hyperpolarized 129Xe ventilation (resolution 4.2 × 4.2 × 7.5 mm3) can be acquired with coregistered 1H anatomical MRI in a 15‐s breath hold. The accelerated acquisition time dispenses with the need for registration between separate breath‐hold 129Xe and 1H MRI, enabling more accurate %VV calculation.

Published
2019

39. Turkish validity and reliability study of the nursing home adjustment scale

Author

Ceren Varer Akpinar, Tahir Belice, Selman Bolukbasi, and Aliye Mandiracioglu

Subjects
Nursing homes, Adjustment, Factor analysis, Turkey, Geriatrics, RC952-954.6
Abstract

Abstract Background Adapting to a nursing home has a significant effect on facilitating the transition to a nursing home. However, a tailored nursing home adjustment scale for Turkish nursing home residents is not yet available. The purpose of this study was to translate the nursing home adjustment scale from English to Turkish and assess its reliability and validity in a sample of nursing home residents in Turkey. Methods A total of 202 older adults from four nursing homes were included in this study. The reliability of the Turkish nursing home adjustment scale was tested using Cronbach’s alpha values for internal consistency. Exploratory and confirmatory factor analyses were used to examine the factor structure, whereas correlation analysis was conducted for convergent validity. Results The Turkish version displayed satisfying internal consistency (Cronbach’s alpha = 0.88) and perfect convergent validity for life satisfaction (r = 0.482). The Turkish scale included five factors: difficulty fitting in, acceptance of new residence, emotional distress, depressed mood, and relationship development. Conclusion The findings indicate that the Turkish version of the scale is a valid and reliable tool for measuring the level of nursing home adjustment among older adults in Turkey.

Published
2023
Full Text
View/download PDF

40. Desfechos Hospitalares do Infarto do Miocárdio com Supradesnivelamento do Segmento ST em Pacientes Positivos para COVID-19 que Passaram por Intervenção Percutânea Primária

Author

Nart Zafer Baytuğan, Hasan Çağlayan Kandemir, and Tahir Bezgin

Subjects
COVID-19, Infarto do miocárdio, Mortalidade, Choque cardiogênico, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Resumo Fundamento A infecção concomitante por coronavírus 2019 (COVID-19) e o infarto do miocárdio com supradesnivelamento do segmento ST (IAMCSST) estão associados ao aumento de desfechos adversos hospitalares. Objetivos O estudo teve como objetivo avaliar as diferenças angiográficas, de procedimentos, laboratoriais e prognósticas em pacientes positivos e negativos para COVID-19 com IAMCSST submetidos à intervenção coronária percutânea primária (ICP). Métodos Realizamos um estudo observacional retrospectivo e unicêntrico entre novembro de 2020 e agosto de 2022 em um hospital de nível terciário. De acordo com o seu estado, os pacientes foram divididos em dois grupos (positivo ou negativo para COVID-19). Todos os pacientes foram internados por IAMCSST confirmado e foram tratados com ICP primária. Os desfechos hospitalares e angiográficos foram comparados entre os dois grupos. P-valores bilaterais

Published
2024
Full Text
View/download PDF

41. Existence of solutions for a class of kirchhoff-type problem with triple regime logarithmic nonlinearity

Author

Tahir Boudjeriou

Subjects
Variational methods, p(x)-Kirchhoff-type equation, Nonlocal problems, Probabilities. Mathematical statistics, QA273-280, Instruments and machines, QA71-90
Abstract

In this paper, we use variational methods to study the existence of nontrivial solutions for a class of Kirchhoff-type elliptic problems driven by the p(x)-Laplacian with triple regime and sign-changing nonlinearity. The main novelty of this paper is our ability to establish an existence result for a class of Kirchhoff-type problems in which the reaction term is sign-changing and exhibits a triple regime (subcritical, critical, and supercritical).

Published
2024
Full Text
View/download PDF

48. Mosaic Based Optimization of NRD Guide Devices Using Binary Evolutionary Approaches and 2D-FVFEM

Author

Tahir Bashir, Keita Morimoto, Akito Iguchi, Yasuhide Tsuji, and Tatsuya Kashiwa

Subjects
Genetic algorithm, particle swarm optimization, differential evolution, harmony search, firefly algorithm, full-vectorial finite element method, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

In this paper, efficient optimal design approaches based on mosaic optimization concept are developed for NRD guide devices to realize the high-performance compact millimeter-wave integrated circuit. Binary representation-based genetic algorithm, differential evolution algorithm, harmony search algorithm, firefly algorithm, and particle swarm optimization are developed to efficiently optimize the pixel pattern in the design region of NRD guide devices. To demonstrate the usefulness of these population-based optimizations, a comparative study based on the problem-solving success rate is conducted first. To carry out this study, four NRD circuit components are designed which include low crosstalk waveguide crossing, T-branch power splitter, bending waveguide, and frequency demultiplexer. The proposed optimal devices achieve high transmission efficiencies greater than 99.9%, 49.9%:49.9%, 99.9% at 60 GHz and 96.4%, 98.5% at 59 GHz and 61 GHz. In addition, the same NRD guide components except frequency demultiplexer are also designed at wideband operation and achieve broad bandwidth around 5 GHz, 4 GHz, and 3 GHz. In order to improve the computational efficiency, the originally developed two-dimensional full vectorial finite element method is employed for the numerical simulations. This paper demonstrates the detailed implementation procedure of developed evolutionary approaches for the material distribution in the design region of NRD guide devices, comparative study of developed optimization approaches, and proposed highly attributed NRD circuit components for the realization of NRD based high-performance compact millimeter-wave circuit.

Published
2022
Full Text
View/download PDF

49. Delîlü't-Tefâsîr

Author

RİFAT, Bursalı Mehmed Tahir B. and PAZARBAŞI, Erdoğan

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results